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1. 发明授权

US6033396A Apparatus and method for performing laser thermal keratoplasty with minimized regression 失效
标题翻译：用最小化回归进行激光热角膜移植术的装置和方法
公开(公告)号：US6033396A
公开(公告)日：2000-03-07
申请号：US744936
申请日：1996-11-06
申请人： David Huang , Peter J. McDonnell
发明人： David Huang , Peter J. McDonnell
IPC分类号： A61F9/007 , A61F9/01 , A61N5/02
CPC分类号： A61F9/008 , A61F2009/00853 , A61F2009/00872
摘要： Noncontact apparatus and method for preforming laser thermal keratoplasty capable of scanning of treatment areas with shapes that reduce regression. The apparatus includes laser sources, a projection optical system, observation system, and control system The projection system uses two steering mirrors to control laser beam position on the cornea. This projection system enables precise control of the area of corneal heat shrinkage using relatively low-powered lasers, such as diode lasers. Desired changes in corneal refractive power are produced by selected patterns of photothermal shrinkage of corneal collagen tissue. The selected patterns are arrangements of oblong shapes that are preferably tapered at the ends of the long axis. The oblong shape and tapering distribute tension in the cornea over a wider area of collagen shrinkage and improve the stability of refractive correction. The long axes of the oblong treatment areas are preferably oriented radially for hyperopia correction and circumferentially for astigmatism correction.
摘要翻译：用于预激光热角膜移植术的非接触式装置和方法，其能够扫描具有减少回归的形状的治疗区域。该装置包括激光源，投影光学系统，观察系统和控制系统。投影系统使用两个转向镜来控制角膜上的激光束位置。该投影系统能够使用诸如二极管激光器的相对低功率的激光器来精确地控制角膜热收缩的面积。角膜屈光力的期望变化由角膜胶原组织的光热收缩的选择图案产生。所选择的图案是长轴形状的布置，其优选在长轴的端部处是锥形的。椭圆形和锥形分布在角膜的更大面积的胶原收缩中分布张力，并提高屈光矫正的稳定性。长圆形处理区域的长轴优选径向地进行远视校正，并且周向地用于散光校正。

2. 发明授权

US5279611A Laser shaping of ocular surfaces using ablation mask formed in situ 失效
标题翻译：使用原位形成的消融掩模对眼表进行激光成形
公开(公告)号：US5279611A
公开(公告)日：1994-01-18
申请号：US850726
申请日：1992-03-13
申请人： Peter J. McDonnell , Stephen L. Trokel
发明人： Peter J. McDonnell , Stephen L. Trokel
IPC分类号： A61B17/00 , A61F9/00 , A61F9/008 , A61F9/01 , A61N5/06
CPC分类号： A61F9/0017 , A61F9/00819 , A61B2017/00061 , A61F2009/00872 , A61F9/00804
摘要： A method for modification of the corneal surface, in which a gel is applied to the cornea and molded in situ to create an ablation mask. This ablation mask has a posterior surface substantially identical to that of the surface to be treated. A shaping means (such as a contact lens) having a posterior curvature corresponding to the desired final profile of the cornea is superimposed on the gel prior to the setting of the gel; the anterior curvature of the ablation mask is equal to that of the posterior curvature of the shaping means. The gel has essentially the identical ablation properties of the cornea, which is generally not the case when other non-biological materials (such as plastics materials) are used. A preferred gel for use in forming the ablation mask is collagen gel.
摘要翻译：角膜表面改性方法，其中将凝胶施加到角膜并原位成型以产生消融掩模。该消融掩模具有与被处理表面大致相同的后表面。在凝胶凝固之前，将具有对应于角膜所需最终轮廓的后曲率的成形装置（例如隐形眼镜）叠加在凝胶上; 消融掩模的前曲率等于成形装置的后曲率的前曲率。凝胶基本上具有与角膜相同的消融性质，当使用其它非生物材料（例如塑料材料）时，通常不是这种情况。用于形成消融掩模的优选凝胶是胶原凝胶。

3. 发明申请

US20120321719A1 Sustained Delivery of Therapeutic Agents to an Eye Compartment 有权
标题翻译：持续递送治疗剂到眼部隔室
公开(公告)号：US20120321719A1
公开(公告)日：2012-12-20
申请号：US13581454
申请日：2011-02-25
申请人： Peter J. McDonnell , Yasin A. Khan , Samuel K. Lai , Renata T. Kashiwabuchi , Ashley Behrens , Justin S. Hanes
发明人： Peter J. McDonnell , Yasin A. Khan , Samuel K. Lai , Renata T. Kashiwabuchi , Ashley Behrens , Justin S. Hanes
IPC分类号： A61K9/14 , A61K31/56 , A61P27/02 , A61K39/395
CPC分类号： A61K9/1676 , A61K9/0048 , A61K9/0051 , A61K9/1641 , A61K9/1647 , A61K9/5026 , A61K9/5031 , A61K9/5146 , A61K9/5153 , A61K31/519 , A61K31/52 , A61K45/06 , A61K47/58 , A61K47/60 , A61K47/6921 , A61K47/6931
摘要： Compositions and methods for treating eye disorders by administering a drug delivery system into an eye compartment of the patient, wherein the drug delivery system contains a particle containing a core; a coating associated with the particle, wherein the wherein the coating is covalently or non-covalently associated with the particle and presents a hydrophilic region to the environment around the particle; and a therapeutic agent are disclosed. The eye compartment can exhibit reduced inflammation or IOP after administration of the drug delivery systems to a patient than if a drug delivery system including an uncoated particle were administered to the patient.
摘要翻译：通过将药物递送系统施用到患者的眼部隔室中来治疗眼睛疾病的组合物和方法，其中所述药物递送系统含有含有核心的颗粒; 与所述颗粒相关的涂层，其中所述涂层与所述颗粒共价或非共价缔合，并且对所述颗粒周围的环境呈现亲水区域; 和治疗剂。如果向患者施用包括未涂覆的颗粒的药物递送系统，则眼部隔室可以在向患者施用药物递送系统之后表现出减少的炎症或IOP。

4. 发明授权

US08889193B2 Sustained delivery of therapeutic agents to an eye compartment 有权
标题翻译：将治疗剂持续递送至眼室
公开(公告)号：US08889193B2
公开(公告)日：2014-11-18
申请号：US13581454
申请日：2011-02-25
申请人： Peter J. McDonnell , Yasin A. Khan , Samuel K. Lai , Renata T. Kashiwabuchi , Ashley Behrens , Justin S. Hanes
发明人： Peter J. McDonnell , Yasin A. Khan , Samuel K. Lai , Renata T. Kashiwabuchi , Ashley Behrens , Justin S. Hanes
IPC分类号： A61K9/50 , A61K9/16 , A61K9/51 , A61K9/00 , A61K47/48 , A61K31/519 , A61K31/52
CPC分类号： A61K9/1676 , A61K9/0048 , A61K9/0051 , A61K9/1641 , A61K9/1647 , A61K9/5026 , A61K9/5031 , A61K9/5146 , A61K9/5153 , A61K31/519 , A61K31/52 , A61K45/06 , A61K47/58 , A61K47/60 , A61K47/6921 , A61K47/6931
摘要： Compositions and methods for treating eye disorders by administering a drug delivery system into an eye compartment of the patient, wherein the drug delivery system contains a particle containing a core; a coating associated with the particle, wherein the wherein the coating is covalently or non-covalently associated with the particle and presents a hydrophilic region to the environment around the particle; and a therapeutic agent are disclosed. The eye compartment can exhibit reduced inflammation or IOP after administration of the drug delivery systems to a patient than if a drug delivery system including an uncoated particle were administered to the patient.
摘要翻译：通过将药物递送系统施用到患者的眼部隔室中来治疗眼睛疾病的组合物和方法，其中所述药物递送系统含有含有核心的颗粒; 与所述颗粒相关的涂层，其中所述涂层与所述颗粒共价或非共价缔合，并且对所述颗粒周围的环境呈现亲水区域; 和治疗剂。如果向患者施用包括未涂覆的颗粒的药物递送系统，则眼部隔室可以在向患者施用药物递送系统之后表现出减少的炎症或IOP。

5. 发明授权

US07336989B2 System and method for quantitative or qualitative measurement of exogenous substances in tissue and other materials using laser-induced fluorescence spectroscopy 有权
标题翻译：使用激光诱导荧光光谱法定量或定性测量组织和其他材料中外源物质的系统和方法
公开(公告)号：US07336989B2
公开(公告)日：2008-02-26
申请号：US10407848
申请日：2003-04-03
申请人： Roy S. Chuck , Peter J. McDonnell , Ramez Emile Necola Shehada
发明人： Roy S. Chuck , Peter J. McDonnell , Ramez Emile Necola Shehada
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0071 , A61B5/0075 , A61B5/411 , A61B5/441 , A61B5/7267 , G01J3/4406 , G01N21/64 , G01N21/6402 , G01N21/6408 , G01N21/645 , G01N21/718 , G01N2021/1782 , G01N2021/6417 , G01N2201/06113 , G01N2201/0633 , G01N2201/0697 , G01N2201/1296
摘要： Methods and systems for determination of one or more substances within a material are described. A flow of fluorescence-exciting/ablative energy (e.g., laser pulse(s), preferably in the ultraviolet region (e.g. 193-nm)), is directed onto the material to ablate a thin layer of the material using photochemical decomposition. Simultaneously, the laser energy induces fluorescence of the substance(s) within the ablated layer of the material. The fluorescence emitted by the substance(s) is then received by a device, which measures the spectrum of the received fluorescence. The fluorescence spectra are then transmitted to a spectral processing device adapted to determine, on the basis of the fluorescence spectra, whether the substance(s) of interest is/are present in the material and/or the concentration at which the substance(s) of interest is/are present in the material. This process may be repeated for each layer of the material to determine the concentration gradient of the substance(s) of interest in the material.
摘要翻译：描述了用于确定材料内的一种或多种物质的方法和系统。荧光激发/消融能量（例如，激光脉冲，优选在紫外区域（例如193nm））的流动被引导到材料上以使用光化学分解来消融材料的薄层。同时，激光能量在材料的烧蚀层中引起物质的荧光。物质发射的荧光然后被测量所接收荧光光谱的装置接收。然后将荧光光谱传输到光谱处理装置，其适于基于荧光光谱确定目的物质是否存在于材料中和/或物质的浓度，感兴趣的是/存在于材料中。可以针对材料的每层重复该过程以确定材料中感兴趣的物质的浓度梯度。

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