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1. 发明授权

US08744778B2 Methods for characterizing agonists and partial agonists of target molecules 失效
标题翻译：表征目标分子的激动剂和部分激动剂的方法
公开(公告)号：US08744778B2
公开(公告)日：2014-06-03
申请号：US13209156
申请日：2011-08-12
申请人： Yejun Tan , Hongyue Dai , Pek Yee Lum , John Ryan Thompson , Joel Peter Berger , Eric Stanley Muise , Richard F. Raubertas , Kenny Kin Chung Wong
发明人： Yejun Tan , Hongyue Dai , Pek Yee Lum , John Ryan Thompson , Joel Peter Berger , Eric Stanley Muise , Richard F. Raubertas , Kenny Kin Chung Wong
IPC分类号： G01N33/48 , C12Q1/68 , G06G7/58
CPC分类号： C12Q1/6876 , C12Q2600/136 , C12Q2600/142 , C12Q2600/158
摘要： In one aspect, the present invention provides methods of determining whether an agent is more like a partial agonist of a target molecule than a full agonist of the same target molecule. In another aspect, the present invention provides methods to select a candidate compound that may reduce blood plasma glucose concentration in a mammal. Populations of genes are provided that are useful in the practice of the present invention.
摘要翻译：在一个方面，本发明提供了确定试剂是否更像靶分子的部分激动剂而不是相同靶分子的完全激动剂的方法。另一方面，本发明提供了选择可降低哺乳动物血浆葡萄糖浓度的候选化合物的方法。提供了可用于本发明实践的基因群体。

2. 发明授权

US5902531A Apparatus and method for spinning polymeric yarns 失效
标题翻译：聚合纱线纺丝装置及方法
公开(公告)号：US5902531A
公开(公告)日：1999-05-11
申请号：US954812
申请日：1997-10-21
申请人： Peter Berger , Egon Gathmann , Wolfgang Imping , Klaus Schafer , Rahim Gross , Georg Stausberg
发明人： Peter Berger , Egon Gathmann , Wolfgang Imping , Klaus Schafer , Rahim Gross , Georg Stausberg
IPC分类号： D01D1/06 , D01D5/08
CPC分类号： D01D1/06
摘要： An apparatus and method for melt spinning polymeric yarns, wherein a main melt flow is generated by an extruder and supplied to a spin head. The spin head is enclosed in a heated spinning beam and comprises a mixer, a distributor pump and a plurality of spinnerets. A feed device generates a secondary flow which is supplied to the main melt flow for the purpose of additive admixture. The secondary flow and the main melt flow are combined inside the spinning beam.
摘要翻译：用于熔融纺丝聚合物纱线的装置和方法，其中通过挤出机产生主熔体流并供应到旋转头。旋转头被封闭在加热的纺丝束中，并包括混合器，分配器泵和多个喷丝头。进料装置产生二次流，其被提供给用于添加剂混合物的主熔体流。二次流和主熔体流合在纺纱束内。

3. 发明授权

US5876050A Transportable musical instrument amplifier cart and stand 失效
标题翻译：可运输乐器放大器和支架
公开(公告)号：US5876050A
公开(公告)日：1999-03-02
申请号：US873519
申请日：1997-06-12
申请人： Ronald Peter Berger
发明人： Ronald Peter Berger
IPC分类号： B62B3/00 , B62B1/00
CPC分类号： B62B3/006
摘要： A cart for transporting and supporting electronic equipment such as musical instrument amplifiers includes a wheeled open frame which defines an amplifier-receiving space therein. The frame rotatably supports an amplifier support chassis so that the support chassis is pivotable about a pivot axis for varying the angular orientation of a piece of equipment supported on the support chassis. The support chassis includes inner and outer members telescopingly interconnected for adjusting the depth of the support chassis. A fulcrum bar rotatably supported by the frame is affixed to the support chassis for providing the pivotal capability to the support chassis. A locking mechanism is provided for fixing the support chassis in a selected orientation, and a restraint is attached to the frame for encircling and restraining a piece of equipment supported in the cart.
摘要翻译：用于运输和支持诸如乐器放大器的电子设备的推车包括在其中限定放大器容纳空间的轮式开放框架。框架可旋转地支撑放大器支撑底盘，使得支撑底盘可围绕枢转轴线枢转，以改变支撑在支撑底盘上的一件设备的角度定向。支撑底盘包括可伸缩地互连的内部和外部构件，用于调节支撑底盘的深度。由框架可旋转地支撑的支杆被固定到支撑底盘上，以将枢转能力提供给支撑底盘。提供了一种锁定机构，用于将支撑底盘固定在选定的方向上，并且约束件附接到框架，以围绕和限制支撑在推车中的一件设备。

4. 发明授权

US4229412A Apparatus for the determination of bond forms of gases 失效
标题翻译：用于测定气体键合形式的装置
公开(公告)号：US4229412A
公开(公告)日：1980-10-21
申请号：US969004
申请日：1978-12-13
申请人： Kurt Orths , Roland Prumbaum , Peter Berger
发明人： Kurt Orths , Roland Prumbaum , Peter Berger
IPC分类号： G01N33/20 , G01N31/12
CPC分类号： G01N33/203
摘要： Apparatus for the determination of bond forms of gases, such as a sample containing oxygen or nitrogen in solid or liquid small metal samples (e.g. from 0.8 to 1.2 g).The apparatus includes a furnace to heat the sample to a temperature of about 3000.degree. C. maximum in less than five minutes, a control device to control the rate at a value between 20.degree. C./sec and 350.degree. C./sec, a gas analyzer coupled to the furnace to indicate as a function of the supplied gas the quantities of gas released from the furnace in equal periods of time, and a computer coupled to the furnace and to the gas analyzer for receiving therefrom a measured value sequence in the form of a curve (Evologram) related to the gas quantities released per unit time to the computer for the determination of the bond forms of the gases contained in the sample, and the computer forms a first derivative curve and a second derivative curve from the measured value curve (Evologram) to form measured values between successive points in a minimum position and/or points which occur as a second inflection point immediately after a first inflection point on the measured value curve, these point positions being identified by zero indications and extreme positions on the derivative curves.
摘要翻译：用于确定气体的键形式的装置，例如在固体或液体小金属样品中含有氧或氮的样品（例如0.8至1.2g）。该装置包括一个炉子，用于在不到5分钟的时间内将样品加热至约3000℃的最高温度，控制装置将速率控制在20℃/秒至350℃/秒之间的值，耦合到炉子的气体分析器，以指示所供应的气体的功能，在相同的时间段内从炉中释放的气体的量，以及耦合到炉子和气体分析器的计算机，以从其接收测量值序列与计算机单位时间释放的气体量相关的曲线形式（Evologram）用于确定样品中包含的气体的键合形式，并且计算机从第一导数曲线和第二导数曲线测量值曲线（Evologram），以在最小位置的连续点之间形成测量值，和/或在紧接测量值曲线上的第一拐点之后作为第二拐点出现的点，这些点通过零指示和衍生曲线上的极端位置来识别情景。

5. 发明申请

US20110294696A1 METHODS FOR CHARACTERIZING AGONISTS AND PARTIAL AGONISTS OF TARGET MOLECULES 失效
标题翻译：表征目标分子的激素和部分激素的方法
公开(公告)号：US20110294696A1
公开(公告)日：2011-12-01
申请号：US13209156
申请日：2011-08-12
申请人： Yejun Tan , Hongyue Dai , Pek Yee Lum , John Ryan Thompson , Joel Peter Berger , Eric Stanley Muise , Richard F. Raubertas , Kenny Kin Chung Wong
发明人： Yejun Tan , Hongyue Dai , Pek Yee Lum , John Ryan Thompson , Joel Peter Berger , Eric Stanley Muise , Richard F. Raubertas , Kenny Kin Chung Wong
IPC分类号： C40B30/04
CPC分类号： C12Q1/6876 , C12Q2600/136 , C12Q2600/142 , C12Q2600/158
摘要： In one aspect, the present invention provides methods of determining whether an agent is more like a partial agonist of a target molecule than a full agonist of the same target molecule. In another aspect, the present invention provides methods to select a candidate compound that may reduce blood plasma glucose concentration in a mammal. Populations of genes are provided that are useful in the practice of the present invention.
摘要翻译：在一个方面，本发明提供了确定试剂是否更像靶分子的部分激动剂而不是相同靶分子的完全激动剂的方法。另一方面，本发明提供了选择可降低哺乳动物血浆葡萄糖浓度的候选化合物的方法。提供了可用于本发明实践的基因群体。

6. 发明授权

US08014954B2 Methods for characterizing agonists and partial agonists of target molecules 有权
标题翻译：表征目标分子的激动剂和部分激动剂的方法
公开(公告)号：US08014954B2
公开(公告)日：2011-09-06
申请号：US11397327
申请日：2006-04-04
申请人： Yejun Tan , Hongyue Dai , Pek Yee Lum , John Ryan Thompson , Joel Peter Berger , Eric Stanley Muise , Richard F Raubertas , Kenny Kin Chung Wong
发明人： Yejun Tan , Hongyue Dai , Pek Yee Lum , John Ryan Thompson , Joel Peter Berger , Eric Stanley Muise , Richard F Raubertas , Kenny Kin Chung Wong
IPC分类号： G01N33/48 , C12Q1/68 , G06G7/58
CPC分类号： C12Q1/6876 , C12Q2600/136 , C12Q2600/142 , C12Q2600/158
摘要： In one aspect, the present invention provides methods of determining whether an agent is more like a partial agonist of a target molecule than a full agonist of the same target molecule. In another aspect, the present invention provides methods to select a candidate compound that may reduce blood plasma glucose concentration in a mammal. Populations of genes are provided that are useful in the practice of the present invention.
摘要翻译：在一个方面，本发明提供了确定试剂是否更像靶分子的部分激动剂而不是相同靶分子的完全激动剂的方法。另一方面，本发明提供了选择可降低哺乳动物血浆葡萄糖浓度的候选化合物的方法。提供了可用于本发明实践的基因群体。

7. 发明授权

US5628176A Heating apparatus for heating an advancing yarn 失效
标题翻译：用于加热前进纱线的加热装置
公开(公告)号：US5628176A
公开(公告)日：1997-05-13
申请号：US612668
申请日：1996-03-08
申请人： Siegried Morhenne , Peter Berger
发明人： Siegried Morhenne , Peter Berger
IPC分类号： D02J13/00 , D01H7/92 , D01H7/46
CPC分类号： D02J13/001 , D02J13/00
摘要： A yarn heating apparatus for use in a yarn false twisting machine, which has an axial channel in which the yarn advances along a zigzagged path. To guide the yarn in the axial channel, yarn guides are provided, which are shaped as spaced apart protuberances on two metal strips. The metal strips are supported in contact with the side walls of the axial channel.
摘要翻译：一种用于纱线假捻机的纱线加热装置，其具有沿着锯齿形路径前进的轴向通道。为了将纱线引导到轴向通道中，提供导纱器，其在两个金属条上成形为间隔开的突起。金属条被支撑成与轴向通道的侧壁接触。

8. 发明授权

US4406769A Electrode edge protector, electrode provided with such protector and electrodeposits and/or products of electrolysis manufactured by employing such electrodes 失效
标题翻译：电极边缘保护器，设置有这种保护器的电极和电沉积物和/或通过使用这种电极制造的电解产物
公开(公告)号：US4406769A
公开(公告)日：1983-09-27
申请号：US280466
申请日：1981-07-06
申请人： Peter Berger
发明人： Peter Berger
IPC分类号： C25C7/02 , C25D1/00
CPC分类号： C25C7/02
摘要： An edge protector 7 for electrodes 1, comprises first and second elongate elements 8, 9, both of superficially electrically insulating material, the first element 8 having a generally "H"-shaped cross-section so as to provide open slots on opposite sides, one slot defined between a pair of outer jaws 12 and the other slot defined between a pair of inner jaws 10, a bare or suitably gasketed edge 6 of an electrode 1 being insertable into and located within the inner jaws 10, and the second element 9 being constituted by a member so dimensioned as to be an interference fit within the outer jaws 12, whereby the outer jaws 12 are forced further apart with the result that the outer jaws 12 endeavour to close the inner jaws 10 to form a seal to prevent electrolyte from wetting the edge 6 of the electrode 1.
摘要翻译：用于电极1的边缘保护器7包括表面电绝缘材料的第一和第二细长元件8,9，第一元件8具有大致“H”形横截面，以便在相对侧上提供开口槽，限定在一对外钳口12之间的一个槽和限定在一对内钳口10之间的另一个槽，电极1的裸露或适当的垫圈边缘6可插入并位于内钳口10内，并且第二元件9 由尺寸为在外夹爪12内的过盈配合的构件构成，由此外夹爪12被迫进一步分开，结果是外卡爪12努力闭合内爪10以形成密封以防止电解质从而润湿电极1的边缘6。

9. 发明授权

US4301578A Process and apparatus for texturing thread 失效
标题翻译：纹理纹理的过程和设备
公开(公告)号：US4301578A
公开(公告)日：1981-11-24
申请号：US17251
申请日：1979-03-05
申请人： Peter Dammann , Hans-Peter Berger , Wilfried Mundelein , Manfred Bussmann , Horst Beifuss
发明人： Peter Dammann , Hans-Peter Berger , Wilfried Mundelein , Manfred Bussmann , Horst Beifuss
IPC分类号： D02G1/12 , D02G1/20 , D02J1/22
CPC分类号： D02G1/122 , D02G1/205
摘要： In the stuffing of synthetic continuous filamentary threads in stuffer boxes, special value is to be placed on the thermal treatment and especially the cooling of the initially crimped filaments. The filaments in the configuration of a compact thread plug, which is formed in the stuffer box, can be wound on a rotatably driven drum in several helical windings, the last thread plug winding can then be disentangled again at the end of the drum, and the finished texturized thread drawn off. The disentangling of the thread plug and the drawing off of the thread is improved by the present invention through an application of axial and/or radial forces or pressures onto the last thread plug winding in the region of the disentangling point. Suitable mechanical and pneumatic devices are provided by the invention for this purpose.
摘要翻译：在填料箱中填充合成的连续丝线时，应特别注意热处理，尤其是初始卷曲长丝的冷却。形成在填塞箱中的紧凑螺纹塞的构型的细丝可以以几个螺旋绕圈卷绕在可旋转的从动滚筒上，然后可以在滚筒的端部再次解开缠绕的最后的螺纹塞，并且完成了纹理化的线程。本发明通过将轴向和/或径向力或压力应用于解缠点的区域中的最后一个螺纹插塞绕组来改善螺纹塞的松开和螺纹脱落。为此，本发明提供合适的机械和气动装置。

10. 发明授权

US4166378A Method and apparatus for the differential thermal analysis of a molten metal 失效
标题翻译：用于熔融金属差分热分析的方法和装置
公开(公告)号：US4166378A
公开(公告)日：1979-09-04
申请号：US863328
申请日：1977-12-22
申请人： Peter Berger , Milan Lampic , Jorg Muller , Kurt Orths
发明人： Peter Berger , Milan Lampic , Jorg Muller , Kurt Orths
IPC分类号： G01N25/04
CPC分类号： G01N25/04
摘要： The invention relates to a method for measuring the cooling curve of a test sample of metal or a metal alloy, in particular cast iron or cast steel, for the differential thermal analysis in which the difference of the cooling curve of the test sample of a fixedly given comparative curve which satisfies Newton's law of cooling (U=U.sub.0 .times.e.sup.-t/RC, the U.sub.0 parameter being the maximum value at the point in time t=0 and the RC parameter being the time constant) is formed, said comparative curve being brought to coincidence with a section of the cooling curve of the sample by adjusting its parameters so that the difference can then be formed between the adjusted comparative curve and the cooling curve.
摘要翻译：本发明涉及一种用于测量金属或金属合金，特别是铸铁或铸钢的试样的冷却曲线的方法，用于差热分析，其中固定样品的冷却曲线的差异给出满足牛顿冷却定律的比较曲线（U = U0xe-t / RC，U0参数为时间点t = 0时的最大值，RC参数为时间常数），形成比较曲线通过调整其参数使样品的冷却曲线的一部分重合，从而可以在调整后的比较曲线和冷却曲线之间形成差异。

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