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1. 发明授权

US5216130A Complex for in-vivo target localization 失效
标题翻译：复杂的目标目标定位
公开(公告)号：US5216130A
公开(公告)日：1993-06-01
申请号：US525258
申请日：1990-05-17
申请人： Bruce R. Line , Peter B. Weber
发明人： Bruce R. Line , Peter B. Weber
IPC分类号： A61K47/48 , A61K51/10 , A61K51/12
CPC分类号： A61K51/1255 , A61K47/48884 , A61K51/1093 , A61K2123/00 , A61N5/1069
摘要： To localize targets within the body (i.e., fixed intravascular antigens on emboli, neovascular endothelium, endothelium altered by regional inflammation) antibodies are linked via dextran spacer arms to rapidly cleared, Tc-99m labeled, microspheres. A micron-sized, albumin microsphere has been synthesized that is designed to enhance target surface interaction and to have a high antibody loading capacity. Stable, hydrophilic microspheres are produced from a pH dependent refolding of albumin followed by heat annealing. To couple dextran, the microspheres are derivatized with succinic anhydride and then linked via carbodiimide to succinic dihydrazide. After periodate oxidized dextran forms hydrazone linkages to the microspheres, additional dihydrazide coupled to the dextran spacer arm is used to link periodate oxidized IgG via its Fc domain carbohydrate. A milligram of the resulting 0.5-1.0 micron microspheres contains 50 to 350 ug of dextran and up to 10.sup.5 covalently bound IgG molecules per microsphere. Microspheres exposed to SnCl.sub.2 can be labeled with 90 Mci/mg of Tc-99m. Spheres with high levels of dextran SDH clear the blood rapidly (T.sub.1/2 =2.6-4 min) compared to those coated with native dextran (T.sub.1/2 =35-50 min). These labelled albumin targeting microspheres may be used to detect a variety of sites of clinical interest using non-invasive external imaging devices and may be employed to carry therapeutic agents to these sites.
摘要翻译：为了使体内的靶标定位（即栓塞上的固定血管内抗原，新生血管内皮，由区域炎症改变的内皮）抗体通过葡聚糖间隔臂连接到快速清除的Tc-99m标记的微球体上。已经合成了微米级的白蛋白微球，其被设计用于增强靶表面相互作用并具有高抗体负载能力。稳定的亲水性微球由pH值依赖的白蛋白再折叠产生，随后进行热退火。为了结合葡聚糖，将微球体用琥珀酸酐衍生化，然后通过碳二亚胺与琥珀酸二酰肼连接。高碘酸氧化葡聚糖与微球形成腙键后，与葡聚糖间隔臂结合的附加二酰肼用于通过其Fc结构域碳水化合物连接高碘酸氧化的IgG。得到的0.5-1.0微米微球的毫克每微球含有50至350μg葡聚糖和多达105个共价结合的IgG分子。暴露于SnCl 2的微球可用90Mc / mg Tc-99m标记。与天然葡聚糖（T1 / 2 = 35-50分钟）相比，具有高水平葡聚糖SDH的球体快速清除血液（T1 / 2 = 2.6-4分钟）。这些标记的白蛋白靶向微球可用于使用非侵入性外部成像装置检测各种临床感兴趣的部位，并且可以用于将治疗剂携带到这些部位。

2. 发明申请

US20110171073A1 SYSTEM AND METHOD FOR TREATING INFECTIOUS WASTE MATTER 审中-公开
标题翻译：用于处理感染性废物的系统和方法
公开(公告)号：US20110171073A1
公开(公告)日：2011-07-14
申请号：US13053927
申请日：2011-03-22
申请人： Joseph H. Wilson , Gordon I. Kaye , Robert L. Hahn , Peter B. Weber , Kevin A. Morris
发明人： Joseph H. Wilson , Gordon I. Kaye , Robert L. Hahn , Peter B. Weber , Kevin A. Morris
IPC分类号： B01J19/00
CPC分类号： A62D3/35 , A61L2/04 , A61L2/18 , A61L2/24 , A61L11/00 , A62D2101/02 , A62D2101/04 , A62D2101/20 , A62D2101/28 , A62D2203/10 , B09B3/00 , B09B3/0075 , B09B3/0083 , G21F9/34
摘要： In accordance with the present invention, a system and method is provided for producing a safely disposable end product from waste matter containing undesirable materials, such as infectious, biohazardous, hazardous, or radioactive elements. The method comprises the steps of providing a highly basic solvent, immersing the waste matter containing the undesirable materials within the highly basic solvent, and heating the solvent. The waste matter containing the undesirable materials is allowed to remain within the solvent until digested, thereby forming a solution void of any infectious or biohazardous elements and/or containing a concentration of radioisotope below the maximum permissible concentration (MPC) for release to a sanitary sewer as defined in applicable federal regulations. The invention further provides a system for producing a safely disposable end product void of any infectious or biohazardous elements and/or containing only a concentration of radioisotope below the MPC for release to a sanitary sewer as defined in applicable federal regulations from waste matter containing such materials. The system comprises a tank or vessel capable of containing a highly basic solvent during a closed digestion reaction, heating means for heating the solvent within the vessel, filtering means, and means for removing the post-digestion aqueous solution and solid waste materials from within the vessel. The post-digestion product in both aqueous and solid form can then by disposed of by conventional means.
摘要翻译：根据本发明，提供了一种系统和方法，用于从含有不希望的材料（例如感染性，生物危害性的，危险的或放射性的）元素的废物中产生安全的一次性最终产品。该方法包括提供高碱性溶剂，将含有不需要的物质的废物浸入高碱性溶剂中并加热溶剂的步骤。允许含有不需要的材料的废物保留在溶剂中直到消化，从而形成无法感染或生物危害的元素的溶液和/或含有低于最大允许浓度（MPC）的放射性同位素浓度以释放到卫生污水管如适用的联邦法规所定义。本发明还提供了一种用于生产无任何传染性或生物危害元素的安全的一次性终端产品和/或仅在MPC下方仅含有放射性同位素浓度的系统，用于根据适用的联邦法规从含有这种材料的废物中定义的卫生下水道。该系统包括能够在封闭的消化反应期间容纳高碱性溶剂的罐或容器，用于加热容器内的溶剂的加热装置，过滤装置和用于从消化反应器内部除去消化后水溶液和固体废物的装置船只。然后可以通过常规方法处理水和固体形式的消化后产物。

3. 发明申请

US20110048086A1 METHOD FOR CHEMICALLY REDUCING WASTE MATERIALS 审中-公开
标题翻译：用于化学还原废物的方法
公开(公告)号：US20110048086A1
公开(公告)日：2011-03-03
申请号：US12942619
申请日：2010-11-09
申请人： Gordon I. Kaye , Peter B. Weber , Kevin A. Morris , Joseph H. Wilson , Robert L. Hahn
发明人： Gordon I. Kaye , Peter B. Weber , Kevin A. Morris , Joseph H. Wilson , Robert L. Hahn
IPC分类号： A61L2/18 , A62D3/36 , C05F1/00
CPC分类号： B09B3/00 , A61L11/00 , B01J4/002 , B01J19/26 , B01J2208/00814 , B09B3/0075 , B09B3/0083
摘要： In accordance with the present invention, a system, method and apparatus is provided for chemically reducing waste. The apparatus includes a substantially alkaline-resistant vessel having a temperature sensor positioned in thermal communication therewith, a heater in thermal communication with the vessel, a substantially alkaline-resistant magnetic stir rod adapted to be positioned within the vessel, and a magnetic stirrer adapted to produce a rotating magnetic field within the vessel capable of spinning a magnetic stir rod positioned therein. The apparatus further includes a water inlet valve operationally connected to the vessel and a water outlet valve operationally connected to the vessel. An electronic controller is connected in electric communication to the heater, to the magnetic stirrer, to the water inlet valve, to the water outlet valve, and to the temperature sensor and is adapted to maintain the temperature of the substantially alkaline resistant vessel substantially at a predetermined value.
摘要翻译：根据本发明，提供了用于化学还原废物的系统，方法和装置。该设备包括基本上耐碱的容器，其具有与其连通的温度传感器，与容器热连通的加热器，适于定位在容器内的基本上耐碱的磁力搅拌棒，以及适于在容器内产生旋转的磁场，能够旋转位于其中的磁力搅拌棒。该装置还包括可操作地连接到容器的进水阀和可操作地连接到容器的出水阀。电子控制器电连接到加热器，磁力搅拌器，进水阀，出水阀和温度传感器，并且适于将基本上耐碱的容器的温度基本保持在预定值。

4. 发明授权

US07829755B2 System and method for treating infectious waste matter 有权
标题翻译：感染性废物处理系统及方法
公开(公告)号：US07829755B2
公开(公告)日：2010-11-09
申请号：US12364012
申请日：2009-02-02
申请人： Joseph H. Wilson , Gordon I. Kaye , Robert L. Hahn , Peter B. Weber , Kevin A. Morris
发明人： Joseph H. Wilson , Gordon I. Kaye , Robert L. Hahn , Peter B. Weber , Kevin A. Morris
IPC分类号： A62D3/37
CPC分类号： A61L11/00 , B09B3/0075
摘要： A system and method is provided for producing a safely disposable end product from waste matter containing undesirable materials, such as infectious, biohazardous, hazardous, or radioactive elements. The method comprises the steps of providing a highly alkaline solvent, immersing the waste matter containing the undesirable materials within the highly alkaline solvent, and heating the solvent. The waste matter containing the undesirable materials is allowed to remain within the solvent until digested, thereby forming a solution void of any infectious or biohazardous elements and/or containing a decreased concentration of radioisotope.
摘要翻译：提供了一种系统和方法，用于从含有不希望的材料（例如感染性，生物危害性的，危险的或放射性的）元素的废物产生安全的一次性最终产品。该方法包括提供高碱性溶剂，将含有不需要的物质的废物浸入高碱性溶剂中并加热溶剂的步骤。允许含有不需要的材料的废物保留在溶剂中直到消化，从而形成任何感染性或生物危害性元素的溶液和/或含有降低浓度的放射性同位素的溶液。

5. 发明授权

US5332532A Method for disposing of radioactively labeled animal carcasses 失效
标题翻译：处理放射性标记动物尸体的方法
公开(公告)号：US5332532A
公开(公告)日：1994-07-26
申请号：US988209
申请日：1992-12-09
申请人： Gordon I. Kaye , Peter B. Weber
发明人： Gordon I. Kaye , Peter B. Weber
IPC分类号： G21F9/28 , G21F9/32 , G21F9/16
CPC分类号： G21F9/28 , G21F9/32
摘要： A method for disposing of animal tissue containing radioactive materials by producing a solution containing a substantially de minimis concentration of radioactive materials through alkaline hydrolysis and dilution of the animal tissue containing the radioactive materials followed by disposing of the de minimis solution in a sewage system or septic system. Additionally, an apparatus for practicing the above method which comprises a tank capable of forming a closed reaction vessel with a highly basic solvent therein. The apparatus further comprises a means for heating the highly basic solvent and means for filtering and removing the solution of de minimis radioactivity formed within the tank.
摘要翻译：通过生产含有基本上最小浓度的放射性物质的溶液，通过碱性水解和稀释含有放射性物质的动物组织，然后将微量溶液处理在污水系统或化粪池中来处理含有放射性物质的动物组织的方法系统。另外，用于实施上述方法的装置包括能够形成其中具有高碱性溶剂的封闭反应容器的罐。该装置还包括用于加热高碱性溶剂的装置和用于过滤和除去在罐内形成的最小放射性溶液的装置。

6. 发明申请

US20110040138A1 SYSTEM AND METHOD FOR TREATING INFECTIOUS WASTE MATTER 审中-公开
标题翻译：用于处理感染性废物的系统和方法
公开(公告)号：US20110040138A1
公开(公告)日：2011-02-17
申请号：US12913830
申请日：2010-10-28
申请人： Joseph H. Wilson , Gordon I. Kaye , Robert L. Hahn , Peter B. Weber , Kevin A. Morris
发明人： Joseph H. Wilson , Gordon I. Kaye , Robert L. Hahn , Peter B. Weber , Kevin A. Morris
IPC分类号： A62D3/30 , A62D3/35
CPC分类号： A61L11/00 , B09B3/0075
摘要： A system and method is provided for producing a safely disposable end product from waste matter containing undesirable materials, such as infectious, biohazardous, hazardous, or radioactive elements. The method comprises the steps of providing a highly alkaline solvent, immersing the waste matter containing the undesirable materials within the highly alkaline solvent, and heating the solvent. The waste matter containing the undesirable materials is allowed to remain within the solvent until digested, thereby forming a solution void of any infectious or biohazardous elements and/or containing a decreased concentration of radioisotope.
摘要翻译：提供了一种系统和方法，用于从含有不希望的材料（例如感染性，生物危害性的，危险的或放射性的）元素的废物产生安全的一次性最终产品。该方法包括提供高碱性溶剂，将含有不需要的物质的废物浸入高碱性溶剂中并加热溶剂的步骤。允许含有不需要的材料的废物保留在溶剂中直到消化，从而形成任何感染性或生物危害性元素的溶液和/或含有降低浓度的放射性同位素的溶液。

7. 发明申请

US20090137858A1 SYSTEM AND METHOD FOR TREATING INFECTIOUS WASTE MATTER 有权
标题翻译：用于处理感染性废物的系统和方法
公开(公告)号：US20090137858A1
公开(公告)日：2009-05-28
申请号：US12364012
申请日：2009-02-02
申请人： Joseph H. Wilson , Gordon I. Kaye , Robert L. Hahn , Peter B. Weber , Kevin A. Morris
发明人： Joseph H. Wilson , Gordon I. Kaye , Robert L. Hahn , Peter B. Weber , Kevin A. Morris
IPC分类号： A62D3/36
CPC分类号： A61L11/00 , B09B3/0075
摘要： A system and method is provided for producing a safely disposable end product from waste matter containing undesirable materials, such as infectious, biohazardous, hazardous, or radioactive elements. The method comprises the steps of providing a highly alkaline solvent, immersing the waste matter containing the undesirable materials within the highly alkaline solvent, and heating the solvent. The waste matter containing the undesirable materials is allowed to remain within the solvent until digested, thereby forming a solution void of any infectious or biohazardous elements and/or containing a decreased concentration of radioisotope.
摘要翻译：提供了一种系统和方法，用于从含有不希望的材料（例如感染性，生物危害性的，危险的或放射性的）元素的废物产生安全的一次性最终产品。该方法包括提供高碱性溶剂，将含有不需要的物质的废物浸入高碱性溶剂中并加热溶剂的步骤。允许含有不需要的材料的废物保留在溶剂中直到消化，从而形成任何感染性或生物危害性元素的溶液和/或含有降低浓度的放射性同位素的溶液。

8. 发明申请

US20090105517A1 METHOD FOR CHEMICALLY REDUCING WASTE MATERIAL 审中-公开
标题翻译：用于化学还原废物的方法
公开(公告)号：US20090105517A1
公开(公告)日：2009-04-23
申请号：US12341375
申请日：2008-12-22
申请人： Gordon I. Kaye , Peter B. Weber , Kevin A. Morris , Joseph H. Wilson , Robert L. Hahn
发明人： Gordon I. Kaye , Peter B. Weber , Kevin A. Morris , Joseph H. Wilson , Robert L. Hahn
IPC分类号： A62D3/36 , A62D101/20
CPC分类号： B09B3/00 , A61L11/00 , B01J4/002 , B01J19/26 , B01J2208/00814 , B09B3/0075 , B09B3/0083
摘要： In accordance with the present invention, a system, method and apparatus is provided for chemically reducing waste. The apparatus includes a substantially alkaline-resistant vessel having a temperature sensor positioned in thermal communication therewith, a heater in thermal communication with the vessel, a substantially alkaline-resistant magnetic stir rod adapted to be positioned within the vessel, and a magnetic stirrer adapted to produce a rotating magnetic field within the vessel capable of spinning a magnetic stir rod positioned therein. The apparatus further includes a water inlet valve operationally connected to the vessel and a water outlet valve operationally connected to the vessel. An electronic controller is connected in electric communication to the heater, to the magnetic stirrer, to the water inlet valve, to the water outlet valve, and to the temperature sensor and is adapted to maintain the temperature of the substantially alkaline resistant vessel substantially at a predetermined value.
摘要翻译：根据本发明，提供了用于化学还原废物的系统，方法和装置。该设备包括基本上耐碱的容器，其具有与其连通的温度传感器，与容器热连通的加热器，适于定位在容器内的基本上耐碱的磁力搅拌棒，以及适于在容器内产生旋转的磁场，能够旋转位于其中的磁力搅拌棒。该装置还包括可操作地连接到容器的进水阀和可操作地连接到容器的出水阀。电子控制器电连接到加热器，磁力搅拌器，进水阀，出水阀和温度传感器，并且适于将基本上耐碱的容器的温度基本保持在预定值。

9. 发明授权

US07183453B2 Method for treating infectious waste matter 有权
标题翻译：感染性废物处理方法
公开(公告)号：US07183453B2
公开(公告)日：2007-02-27
申请号：US10201121
申请日：2002-07-23
申请人： Joseph H. Wilson , Gordon I. Kaye , Robert L. Hahn , Peter B. Weber , Kevin A. Morris
发明人： Joseph H. Wilson , Gordon I. Kaye , Robert L. Hahn , Peter B. Weber , Kevin A. Morris
IPC分类号： A62D3/00
CPC分类号： A61L11/00 , B09B3/0075
摘要： A system and method is provided for producing a safely disposable end product from waste matter containing undesirable materials, such as infectious, biohazardous, hazardous, or radioactive elements. The method comprises the steps of providing a highly basic solvent, immersing the waste matter containing the undesirable materials within the highly basic solvent, and heating the solvent. The waste matter containing the undesirable materials is allowed to remain within the solvent until digested, thereby forming a solution void of any infectious or biohazardous elements and/or containing a decreased concentration of radioisotope.
摘要翻译：提供了一种系统和方法，用于从含有不希望的材料（例如感染性，生物危害性的，危险的或放射性的）元素的废物产生安全的一次性最终产品。该方法包括提供高碱性溶剂，将含有不需要的物质的废物浸入高碱性溶剂中并加热溶剂的步骤。允许含有不需要的材料的废物保留在溶剂中直到消化，从而形成任何感染性或生物危害性元素的溶液和/或含有降低浓度的放射性同位素的溶液。

10. 发明授权

US06437211B2 Methods for treatment and disposal of regulated medical waste 有权
标题翻译：治疗和处置受管制医疗废物的方法
公开(公告)号：US06437211B2
公开(公告)日：2002-08-20
申请号：US09882806
申请日：2001-06-14
申请人： Gordon I. Kaye , Peter B. Weber
发明人： Gordon I. Kaye , Peter B. Weber
IPC分类号： A61L218
CPC分类号： A61L11/00 , B09B3/0075
摘要： A method for safely treating and disposing of infectious biomedical waste and other hazardous materials is disclosed. The method involves alkaline hydrolysis of infectious agents contained in regulated medical waste or hazardous waste solutions. The infectious waste is immersed into a highly basic solvent (>130° C.,>2.79 atm) until the hydrolyzable matter is fully digested, thereby forming a sterile solution and sterile solid waste. The sterile solution and solid waste may then be disposed of through standard means, such as in a sanitary sewage system or local landfill facility. The method also provides for the treatment of lipid soluble hazardous material contained in the regulated medical waste.
摘要翻译：公开了一种用于安全处理和处理感染性生物医学废物和其他有害物质的方法。该方法包括对受规管医疗废物或危险废物溶液中含有的感染因子的碱性水解。将感染性废物浸入高碱性溶剂（> 130℃，> 2.79大气压）中直至水解物完全消化，从而形成无菌溶液和无菌固体废物。然后，无菌溶液和固体废物可以通过标准方法处理，例如在生活污水系统或当地垃圾填埋场。该方法还提供了治疗受监管医疗废物中含有的脂溶性有害物质。

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