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1. 发明授权

US08865427B2 Perifusion device 有权
标题翻译：灌注装置
公开(公告)号：US08865427B2
公开(公告)日：2014-10-21
申请号：US13595697
申请日：2012-08-27
申请人： Ramon E. Poo , Camillo Ricordi , Felipe Echeverri , Over Cabrera , Per-Olof Berggren
发明人： Ramon E. Poo , Camillo Ricordi , Felipe Echeverri , Over Cabrera , Per-Olof Berggren
IPC分类号： C12Q1/18 , C12M3/00 , C12M1/34 , C12M1/00 , C12M1/32
CPC分类号： C12M41/48 , B33Y80/00 , C12M23/12 , C12M23/40 , C12M23/42 , C12M41/00 , Y10T137/87249
摘要： A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be provided. A receptacle housing has a plurality of receptacles. A drive is connected to the receptacle housing for moving the receptacle housing. A programmable controller can be provided to control movement of the receptacle housing. The test liquid includes at least one stimuli for the cells. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.
摘要翻译：渗出装置包括用于细胞的至少一个样品容器，样品容器具有入口和出口。容器通过入口接收测试液体，并通过出口排出液体。可以提供具有多个液体入口，控制阀和液体出口的歧管。插座壳体具有多个插座。驱动器连接到插座壳体以移动插座壳体。可以提供可编程控制器来控制插座壳体的运动。测试液体包括用于细胞的至少一种刺激物。分析收集在容器中的液体以确定细胞对刺激的反应。

2. 发明授权

US08263389B2 Perifusion device 有权
标题翻译：灌注装置
公开(公告)号：US08263389B2
公开(公告)日：2012-09-11
申请号：US12827703
申请日：2010-06-30
申请人： Ramon E. Poo , Camillo Ricordi , Felipe Echeverri , Over Cabrera , Per-Olof Berggren
发明人： Ramon E. Poo , Camillo Ricordi , Felipe Echeverri , Over Cabrera , Per-Olof Berggren
IPC分类号： C12M3/00 , C12M1/36
CPC分类号： C12M41/48 , B33Y80/00 , C12M23/12 , C12M23/40 , C12M23/42 , C12M41/00 , Y10T137/87249
摘要： A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be provided so that the flow of liquids from source containers to the sample containers can be varied and controlled. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A programmable controller can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles. The test liquid includes at least one stimuli for the cells, which can be the presence, absence, or concentration of a compound in the liquid, or a physical property of the liquid such as temperature. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.
摘要翻译：渗出装置包括用于细胞的至少一个样品容器，样品容器具有入口和出口。容器通过入口接收测试液体，并通过出口排出液体。可以提供具有多个液体入口，控制阀和液体出口的歧管，使得可以改变和控制从源容器到样品容器的液体流。插座壳体具有多个用于从样品容器的出口接收流体的容器。驱动器连接到插座壳体以移动插座壳体，使得液体样品从样品容器的出口依次收集。可以设置可编程控制器以在预定时间控制插座壳体的移动，并且将识别液体样品的数据记录在容器中。测试液体包括细胞的至少一种刺激，其可以是液体中化合物的存在，不存在或浓度，或液体的物理性质如温度。分析收集在容器中的液体以确定细胞对刺激的反应。

3. 发明申请

US20110318325A1 Inositol Pyrophosphates Determine Exocytotic Capacity 审中-公开
公开(公告)号：US20110318325A1
公开(公告)日：2011-12-29
申请号：US13224432
申请日：2011-09-02
申请人： Per-Olof Berggren , Christopher Barker
发明人： Per-Olof Berggren , Christopher Barker
IPC分类号： A61K38/45 , A61K48/00 , A61P3/10 , C12Q1/68
CPC分类号： A61K38/45 , G01N33/507 , G01N2800/042
摘要： The invention provides reagents and methods for treating type II diabetes, as well as methods for identifying compounds for treating type II diabetes.

4. 发明申请

US20110020856A1 PERIFUSION DEVICE 有权
标题翻译： PERIFUSION设备
公开(公告)号：US20110020856A1
公开(公告)日：2011-01-27
申请号：US12827703
申请日：2010-06-30
申请人： RAMON E. POO , CAMILLO RICORDI , FELIPE ECHEVERRI , Over Cabrera , PER-OLOF BERGGREN
发明人： RAMON E. POO , CAMILLO RICORDI , FELIPE ECHEVERRI , Over Cabrera , PER-OLOF BERGGREN
IPC分类号： C12Q1/02 , C12M1/36
CPC分类号： C12M41/48 , B33Y80/00 , C12M23/12 , C12M23/40 , C12M23/42 , C12M41/00 , Y10T137/87249
摘要： A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be provided so that the flow of liquids from source containers to the sample containers can be varied and controlled. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A programmable controller can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles. The test liquid includes at least one stimuli for the cells, which can be the presence, absence, or concentration of a compound in the liquid, or a physical property of the liquid such as temperature. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.
摘要翻译：渗出装置包括用于细胞的至少一个样品容器，样品容器具有入口和出口。容器通过入口接收测试液体，并通过出口排出液体。可以提供具有多个液体入口，控制阀和液体出口的歧管，使得可以改变和控制从源容器到样品容器的液体流。插座壳体具有多个用于从样品容器的出口接收流体的容器。驱动器连接到插座壳体以移动插座壳体，使得液体样品从样品容器的出口依次收集。可以设置可编程控制器以在预定时间控制插座壳体的移动，并且将识别液体样品的数据记录在容器中。测试液体包括细胞的至少一种刺激，其可以是液体中化合物的存在，不存在或浓度，或液体的物理性质如温度。分析收集在容器中的液体以确定细胞对刺激的反应。

5. 发明申请

US20090060843A1 Non-Invasive In Vivo Imaging and Methods for Treating Type I Diabetes 审中-公开
标题翻译：非侵入性体内成像和治疗I型糖尿病的方法
公开(公告)号：US20090060843A1
公开(公告)日：2009-03-05
申请号：US12199473
申请日：2008-08-27
申请人： Per-Olof Berggren , Alejandro Caicedo
发明人： Per-Olof Berggren , Alejandro Caicedo
IPC分类号： A61K49/00 , A61K35/12 , A61P7/12
CPC分类号： A61K49/0008 , A01K67/0271 , A01K2217/05 , A01K2227/105 , A01K2267/0325 , A61K35/39 , C12N2830/008
摘要： The present invention provides novel drug discovery platforms and methods for treating type I diabetes.
摘要翻译：本发明提供了用于治疗I型糖尿病的新型药物发现平台和方法。

6. 发明授权

US08785178B2 Perifusion device 有权
标题翻译：灌注装置
公开(公告)号：US08785178B2
公开(公告)日：2014-07-22
申请号：US11653193
申请日：2007-01-12
申请人： Ramon E. Poo , Camillo Ricordi , Felipe Echeverri , Over Cabrera , Per-Olof Berggren
发明人： Ramon E. Poo , Camillo Ricordi , Felipe Echeverri , Over Cabrera , Per-Olof Berggren
IPC分类号： C12M3/00 , C12M1/16 , C12M1/34 , C12M1/32 , C12M1/00 , C12M1/42 , C12M1/26
CPC分类号： C12M41/36 , C12M23/12 , C12M29/10 , C12M33/10 , C12M35/04 , C12M41/00 , C12M41/14 , C12M41/46
摘要： A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A computer can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles. The test liquid includes at least one stimuli for the cells, which can be the presence, absence, or concentration of a compound in the liquid, or a physical property of the liquid such as temperature. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.
摘要翻译：渗出装置包括用于细胞的至少一个样品容器，样品容器具有入口和出口。容器通过入口接收测试液体，并通过出口排出液体。插座壳体具有多个用于从样品容器的出口接收流体的容器。驱动器连接到插座壳体以移动插座壳体，使得液体样品从样品容器的出口依次收集。可以提供计算机以在预定时间控制插座壳体的运动，并且将识别液体样品的数据记录在容器中。测试液体包括细胞的至少一种刺激，其可以是液体中化合物的存在，不存在或浓度，或液体的物理性质如温度。分析收集在容器中的液体以确定细胞对刺激的反应。

7. 发明申请

US20130217738A1 Methods and Assays for Detecting and Treating Hypoglycemia 审中-公开
标题翻译：检测和治疗低血糖的方法和分析
公开(公告)号：US20130217738A1
公开(公告)日：2013-08-22
申请号：US13847212
申请日：2013-03-19
申请人： Per-Olof Berggren , Alejandro Caicedo , Over Cabrera
发明人： Per-Olof Berggren , Alejandro Caicedo , Over Cabrera
IPC分类号： A61K31/42 , A61K31/198 , A61K31/40
CPC分类号： A61K31/42 , A61K31/19 , A61K31/195 , A61K31/198 , A61K31/40 , G01N33/502 , G01N2500/04 , G01N2500/10
摘要： Methods for regulating glucagon release and of treating hypoglycemia, and for screening drug candidates for treating hypoglycemia. The methods are useful for treating diabetes mellitus and screening drug candidates for potential efficacy.
摘要翻译：用于调节胰高血糖素释放和治疗低血糖的方法，以及用于筛选候选药物用于治疗低血糖症的方法。该方法可用于治疗糖尿病并筛选候选药物以获得潜在的疗效。

8. 发明申请

US20110244509A1 ApoIII and the Treatment and Diagnosis of Diabetes 有权
标题翻译： ApoIII和糖尿病的治疗和诊断
公开(公告)号：US20110244509A1
公开(公告)日：2011-10-06
申请号：US13105559
申请日：2011-05-11
申请人： Per-Olof Berggren
发明人： Per-Olof Berggren
IPC分类号： C12Q1/02
CPC分类号： G01N33/92 , C07K16/18 , C07K2317/76 , C12N15/113 , C12N2310/11 , C12N2310/14 , G01N30/02 , G01N33/5041 , G01N33/507 , G01N33/564 , G01N2333/775 , G01N2440/38 , G01N2500/10 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： The present invention provides methods of identifying candidate compounds for the treatment of type I diabetes comprising contacting pancreatic β cells with an amount of apolipoprotein CIII (“apoCIII”) effective to increase intracellular calcium concentration, in the presence of one or more test compounds, and identifying those test compounds that inhibit an apoCIII-induced increase in intracellular calcium concentration in the pancreatic β cells. The present invention also provides methods for treating patients with type I diabetes comprising administering to the patient an amount effective of an inhibitor of apoCIII to reduce apoCIII-induced increase in intracellular calcium concentration in pancreatic β cells.
摘要翻译：本发明提供了鉴定用于治疗I型糖尿病的候选化合物的方法，包括使胰腺和/ 具有一定量的载脂蛋白CIII（“apoCIII”）的细胞在一种或多种测试化合物的存在下有效增加细胞内钙浓度，并鉴定抑制apoCIII诱导的胰腺内细胞内钙浓度增加的测试化合物; 细胞。本发明还提供了用于治疗I型糖尿病患者的方法，包括向患者施用有效的apoCIII抑制剂的量，以减少apoCIII诱导的胰腺细胞内钙浓度的增加; 细胞。

9. 发明授权

US08030288B2 Methods for identifying compounds for the treatment of type 1 diabetes 有权
标题翻译：识别用于治疗1型糖尿病的化合物的方法
公开(公告)号：US08030288B2
公开(公告)日：2011-10-04
申请号：US12196536
申请日：2008-08-22
申请人： Per-Olof Berggren
发明人： Per-Olof Berggren
IPC分类号： A01N43/04 , A61K31/70 , A61K39/00 , A61K39/38
CPC分类号： G01N33/92 , C07K16/18 , C07K2317/76 , C12N15/113 , C12N2310/11 , C12N2310/14 , G01N30/02 , G01N33/5041 , G01N33/507 , G01N33/564 , G01N2333/775 , G01N2440/38 , G01N2500/10 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： The present invention provides methods of identifying candidate compounds for the treatment of type I diabetes comprising contacting pancreatic β cells with an amount of apolipoprotein CIII (“apoCIII”) effective to increase intracellular calcium concentration, in the presence of one or more test compounds, and identifying those test compounds that inhibit an apoCIII-induced increase in intracellular calcium concentration in the pancreatic β cells. The present invention also provides methods for treating patients with type I diabetes comprising administering to the patient an amount effective of an inhibitor of apoCIII to reduce apoCIII-induced increase in intracellular calcium concentration in pancreatic β cells.
摘要翻译：本发明提供了鉴定用于治疗I型糖尿病的候选化合物的方法，包括使胰腺和/ 具有一定量的载脂蛋白CIII（“apoCIII”）的细胞在一种或多种测试化合物的存在下有效增加细胞内钙浓度，并鉴定抑制apoCIII诱导的胰腺内细胞内钙浓度增加的测试化合物; 细胞。本发明还提供了用于治疗I型糖尿病患者的方法，包括向患者施用有效的apoCIII抑制剂的量，以减少apoCIII诱导的胰腺细胞内钙浓度的增加; 细胞。

10. 发明申请

US20110021584A1 Methods and Assays for Detecting and Treating Hypoglycemia 有权
标题翻译：检测和治疗低血糖的方法和分析
公开(公告)号：US20110021584A1
公开(公告)日：2011-01-27
申请号：US12921483
申请日：2009-03-12
申请人： Per-Olof Berggren , Alejandro Caicedo , Over Cabrera
发明人： Per-Olof Berggren , Alejandro Caicedo , Over Cabrera
IPC分类号： A61K31/42 , A61P3/08 , A61K31/40 , C07D207/16 , C12Q1/02 , C07D261/12
CPC分类号： A61K31/42 , A61K31/19 , A61K31/195 , A61K31/198 , A61K31/40 , G01N33/502 , G01N2500/04 , G01N2500/10
摘要： Methods for regulating glucagon release and of treating hypoglycemia, and for screening drug candidates for treating hypoglycemia. The methods are useful for treating diabetes mellitus and screening drug candidates for potential efficacy.
摘要翻译：用于调节胰高血糖素释放和治疗低血糖的方法，以及用于筛选候选药物用于治疗低血糖症的方法。该方法可用于治疗糖尿病并筛选候选药物以获得潜在的疗效。

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