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1. 发明申请

US20050250721A1 Gene therapy for congestive heart failure 有权
标题翻译：充血性心力衰竭的基因治疗
公开(公告)号：US20050250721A1
公开(公告)日：2005-11-10
申请号：US10942072
申请日：2004-09-14
申请人： H. Hammond , Paul Insel , Peipei Ping , Steven Post , Meihua Gao
发明人： H. Hammond , Paul Insel , Peipei Ping , Steven Post , Meihua Gao
IPC分类号： A61K38/17 , A61K38/45 , A61K38/51 , A61K48/00 , C12N9/12 , C12N9/88 , C12N15/85 , C12N15/861 , C12N15/864
CPC分类号： C12N9/1205 , A01K2217/05 , A61K38/00 , A61K38/1787 , A61K48/00 , A61K48/0058 , A61K48/0075 , C12N9/88 , C12N15/86 , C12N2710/10343 , C12N2750/14143 , C12N2799/025 , C12N2830/42
摘要： The present invention relates to methods and compositions for enhancing cardiac function in mammalian hearts by inserting transgenes that increase beta-adrenergic responsiveness within the myocardium. The present invention can thus be used in the treatment of heart disease, especially congestive heart failure.
摘要翻译：本发明涉及通过插入增加心肌内β-肾上腺素能反应性的转基因来增强哺乳动物心脏功能的方法和组合物。因此，本发明可用于治疗心脏病，特别是充血性心力衰竭。

2. 发明授权

US06752987B1 Adenovirus encoding human adenylylcyclase (AC) VI 有权
标题翻译：编码人腺苷酸环化酶（AC）的腺病毒VI
公开(公告)号：US06752987B1
公开(公告)日：2004-06-22
申请号：US09472667
申请日：1999-12-27
申请人： H. Kirk Hammond , Paul A. Insel , Peipei Ping , Steven R. Post , Meihua Gao
发明人： H. Kirk Hammond , Paul A. Insel , Peipei Ping , Steven R. Post , Meihua Gao
IPC分类号： A61K3500
CPC分类号： C12N15/86 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K14/50 , C12N9/88 , C12N2710/10343 , C12N2830/008 , C12N2830/42
摘要： The present invention relates to methods and compositions for enhancing cardiac function in mammalian hearts by inserting transgenes that increase beta-adrenergic responsiveness within the myocardium. The present invention can thus be used in the treatment of heart disease, especially congestive heart failure.
摘要翻译：本发明涉及通过插入增加心肌内β-肾上腺素能反应性的转基因来增强哺乳动物心脏功能的方法和组合物。因此，本发明可用于治疗心脏病，特别是充血性心力衰竭。

3. 发明授权

US06306830B1 Gene therapy for congestive heart failure 失效
标题翻译：充血性心力衰竭的基因治疗
公开(公告)号：US06306830B1
公开(公告)日：2001-10-23
申请号：US09008097
申请日：1998-01-16
申请人： H. Kirk Hammond , Paul A. Insel , Peipei Ping , Steven R. Post , Meihua Gao
发明人： H. Kirk Hammond , Paul A. Insel , Peipei Ping , Steven R. Post , Meihua Gao
IPC分类号： A61K4800
CPC分类号： C12N9/88 , A61K48/00 , C12N2799/022
摘要： The present invention relates to methods and compositions for enhancing cardiac function in mammalian hearts by inserting transgenes that increase &bgr;-adrenergic responsiveness within the myocardium. The present invention can thus be used in the treatment of heart disease, especially congestive heart failure.
摘要翻译：本发明涉及通过插入增加心肌内β-肾上腺素能反应性的转基因来增强哺乳动物心脏功能的方法和组合物。因此，本发明可用于治疗心脏病，特别是充血性心力衰竭。

4. 发明授权

US07235236B2 Polynucleotide encoding human adenylylcyclase VI and uses thereof for enhancing cardiac function 有权
标题翻译：编码人腺苷酸环化酶VI的多核苷酸及其用于增强心脏功能的用途
公开(公告)号：US07235236B2
公开(公告)日：2007-06-26
申请号：US10942072
申请日：2004-09-14
申请人： H. Kirk Hammond , Paul A. Insel , Peipei Ping , Steven R. Post , Meihua Gao
发明人： H. Kirk Hammond , Paul A. Insel , Peipei Ping , Steven R. Post , Meihua Gao
IPC分类号： A01N63/00 , A61K31/70 , C07H21/02
CPC分类号： C12N9/1205 , A01K2217/05 , A61K38/00 , A61K38/1787 , A61K48/00 , A61K48/0058 , A61K48/0075 , C12N9/88 , C12N15/86 , C12N2710/10343 , C12N2750/14143 , C12N2799/025 , C12N2830/42
摘要： The present invention relates to polynucleotides encoding human adenylylcyclase VI and uses thereof for enhancing cardiac function. The present invention can thus be used in the treatment of heart disease, especially congestive heart failure.
摘要翻译：本发明涉及编码人腺苷酸环化酶VI的多核苷酸及其用于增强心脏功能的用途。因此，本发明可用于治疗心脏病，特别是充血性心力衰竭。

5. 发明申请

US20070110751A1 Compositions and methods for reducing infarct size 审中-公开
标题翻译：用于减少梗死面积的组合物和方法
公开(公告)号：US20070110751A1
公开(公告)日：2007-05-17
申请号：US11586326
申请日：2006-10-25
申请人： Robb MacLellan , Peipei Ping , David Liem , Samson Chan
发明人： Robb MacLellan , Peipei Ping , David Liem , Samson Chan
IPC分类号： A61K39/395 , A61K31/55 , A61K31/522 , A61K31/353 , A61K31/513
CPC分类号： C07K16/40 , A61K31/353 , A61K31/513 , A61K31/522 , A61K31/55 , A61K2039/505
摘要： Disclosed are compositions and methods for Disclosed are methods related to the use of Cdk2 inhibitors to reducing myocardial ischemic/reperfusion injury including but not limited to reduced infarct size. It is also disclosed that the same methods are equally appropriate for use in reducing injury following stroke including but not limited to (ischemic strokes (including strokes resulting from cerebral thrombosis, cerebral embolism, and atrial fibrillation), hemorrhagic strokes (including strokes resulting from aneurysm and arteriovenous malformation), and transient ischemic attack), reducing infarct size following pulmonary infarction, reducing renal ischemia injury, reducing ischemic/reperfusion injury occurring during cardiac surgery where a heart lung machine is used such as Coronary artery bypassing, and reducing ischemic/reperfusion injury occurring during the preservation of organs for transplant.
摘要翻译：公开的组合物和方法是与使用Cdk2抑制剂减少心肌缺血/再灌注损伤有关的方法，包括但不限于降低的梗死面积。还公开了相同的方法同样适用于减轻中风后的损伤，包括但不限于（缺血性中风（包括由脑血栓形成，脑栓塞和心房颤动引起的中风）），出血性中风（包括由动脉瘤引起的中风和动静脉畸形）和短暂性脑缺血发作），减少肺梗死后的梗死面积，减少肾缺血损伤，减少在使用心脏肺机器的心脏手术中发生的缺血/再灌注损伤，例如冠状动脉旁路，并减少缺血/再灌注在保存移植器官期间发生的损伤。

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