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1. 发明授权

US06216049B1 Computerized method and apparatus for analyzing nucleic acid assay readings 有权
标题翻译：用于分析核酸测定读数的计算机化方法和装置
公开(公告)号：US06216049B1
公开(公告)日：2001-04-10
申请号：US09196123
申请日：1998-11-20
申请人： Harry Yang , Daniel L. Schwarz , Christopher M. Embres , Richard L. Moore , Perry D. Haaland , Paula V. Johnson
发明人： Harry Yang , Daniel L. Schwarz , Christopher M. Embres , Richard L. Moore , Perry D. Haaland , Paula V. Johnson
IPC分类号： G05B1302
CPC分类号： G06F19/20
摘要： A computerized method and apparatus are disclosed for analyzing numerical data pertaining to a sample assay comprising at least one biological or chemical sample. The data include a set of data pertaining to each respective sample, with each set of data including a plurality of values each representing a condition of the sample at a given time. The method and apparatus assign a respective numerical value to each of the data values, mathematically combine the numerical values to generate a total value, compare the total value to a threshold value, and control the system to indicate whether the sample has a predetermined characteristic based on a result of the comparison. Prior to calculation of the sample value, filtering, normalizing and other correcting operations can be performed on the data to correct anomalous values in the data which could adversely affect the accuracy of the results. The method and apparatus perform the described functions by representing the data values as points on a graph having a vertical axis representing the magnitudes of the values and a horizontal axis representing a period of time during which readings of the sample were taken to obtain the data values, identifying points on the graph having an anomalous characteristic, and correcting the anomalous points to produce a corrected plot of points on the graph, with each of the points of the corrected plot representing a magnitude of a corresponding one of the values. An area value is then calculated which represents an approximate area between at least a portion of the corrected plot of points on the graph and the horizontal axis. The area value is compared to a threshold value to determine whether a certain condition exists in the sample to which the set of data pertains.
摘要翻译：公开了一种用于分析与包含至少一种生物或化学样品的样品测定有关的数值数据的计算机化方法和装置。数据包括与每个相应样本相关的一组数据，每组数据包括多个值，每个值表示在给定时间的样本的状况。该方法和装置为每个数据值分配相应的数值，数学地组合数值以产生总值，将总值与阈值进行比较，并且控制系统以指示样本是否具有基于预定特征的比较的结果。在计算样本值之前，可以对数据执行滤波，归一化和其他校正操作，以纠正数据中可能对结果准确性产生不利影响的异常值。该方法和装置通过将数据值表示为具有表示值的大小的垂直轴的图形的数据值和表示采样的读数以获得数据值的时间段的水平轴来执行所述功能识别具有异常特征的图上的点，并且校正异常点以产生曲线图上的点的校正图，其中校正曲线的每个点表示对应的一个值的大小。然后计算面积值，其表示曲线图上的点的校正曲线的至少一部分与水平轴之间的近似面积。将面积值与阈值进行比较，以确定在该组数据所属的样本中是否存在特定条件。

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