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1. 发明申请

US20060293330A1 Hiv replication inhibiting purine derivatives 有权
标题翻译： Hiv复制抑制嘌呤衍生物
公开(公告)号：US20060293330A1
公开(公告)日：2006-12-28
申请号：US10573364
申请日：2004-09-21
申请人： Paul Janssen , Marc De Jonge , Lucien Koymans , Frederik Daeyaert , Jan Heeres , Hendrik Vinkers , Ruben Leenders , Dirk Vandenput , Paul Janssen
发明人： Paul Janssen , Marc De Jonge , Lucien Koymans , Frederik Daeyaert , Jan Heeres , Hendrik Vinkers , Ruben Leenders , Dirk Vandenput , Paul Janssen
IPC分类号： A61K31/519 , A61K31/525 , C07D487/02
CPC分类号： A61K31/52 , C07D473/00 , C07D473/16 , C07D473/18
摘要： The present invention relates to the use of a compound of formula (I) for the manufacture of a medicament for the prevention or the treatment of HIV infection wherein the compound of formula (I) is a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein A and B each represents a radical of formula and wherein —C-D- represents a bivalent radical of formula —N═CH—NR17— (c-1); or —NR7—CH═N— (c-2); provided that when A represents a radical of formula (a) then B represents a radical of formula (b) and when A represents a radical of formula (b) then B represents a radical of formula (a).
摘要翻译：本发明涉及式（I）化合物在制备用于预防或治疗HIV感染的药物中的用途，其中式（I）化合物为式I化合物，N-氧化物，药学上其中A和B各自表示下式的基团，其中-CD-表示式<β的二价基团。在线式描述=“在线式” - 末端=“铅”→N-CH-NR 17 - （c-1）; 或<？in-line-formula description =“In-line Formulas”end =“tail”？> <？in-line-formula description =“In-line Formulas”end =“lead”？> - NR < 7 -CH-N-（c-2）; 条件是当A表示式（a）的基团时，B表示式（b）的基团，并且当A表示基团时，<？in-line-formula description =“In-line Formulas”end =“tail” 式（b）所示的B为式（a）的基团。

2. 发明申请

US20130207012A1 PRESSURE BALANCED SOLENOID OPERATED VALVE 有权
标题翻译：压力平衡式电磁阀操作阀
公开(公告)号：US20130207012A1
公开(公告)日：2013-08-15
申请号：US13396202
申请日：2012-02-14
申请人： Kevin C. Williams , Eric Paul Janssen
发明人： Kevin C. Williams , Eric Paul Janssen
IPC分类号： F16K31/02 , F16K11/07 , F15B13/044
CPC分类号： F16K31/0658 , F16K31/0693 , Y10T137/8667
摘要： A pressure balanced solenoid operated valve includes a solenoid portion having a coil in a coil retainer. A valve member portion defines a body connected to the solenoid portion. A slidable valve member in the body has opposed first and second ends and a shoulder between the ends. The first end with the coil energized is magnetically drawn toward the coil retainer moving the valve member between a valve closed and a valve open position. A pressure equalizing passage extends in the valve member from the second end. An inlet passage communicates a pressurized fluid at a valve inlet port to the pressure equalizing passage. A connecting passage communicates between the pressure equalizing passage and the shoulder. The pressurized fluid in the pressure equalizing passage acts against the second end and equally and oppositely against both the shoulder and the first end in both the open and closed positions.
摘要翻译：压力平衡电磁阀包括在线圈保持器中具有线圈的螺线管部分。阀构件部分限定连接到螺线管部分的主体。主体中的可滑动的阀构件具有相对的第一端和第二端以及端部之间的肩部。线圈通电的第一端被磁力吸引到线圈保持器，以使阀构件在阀关闭和阀打开位置之间移动。压力平衡通道在阀构件中从第二端延伸。入口通道将阀入口处的加压流体连通到均压通道。连接通道在压力平衡通道和肩部之间连通。压力平衡通道中的加压流体在打开位置和关闭位置两者相对于肩部和第一端相对地抵靠第二端作用。

3. 发明申请

US20060252764A1 HIV inhibiting pyrimidines derivatives 有权
公开(公告)号：US20060252764A1
公开(公告)日：2006-11-09
申请号：US11474855
申请日：2006-06-26
申请人： Jerome Guillemont , Patrice Palandijian , Marc De Jonge , Lucien Koymans , Hendrik Vinkers , Frederik Daeyaert , Jan Heeres , Koen Van Aken , Paulus Lewi , Paul Janssen , Frank Xavier Arts
发明人： Jerome Guillemont , Patrice Palandijian , Marc De Jonge , Lucien Koymans , Hendrik Vinkers , Frederik Daeyaert , Jan Heeres , Koen Van Aken , Paulus Lewi , Paul Janssen , Frank Xavier Arts
IPC分类号： A61K31/506 , C07D403/02
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06 , C07C255/42 , C07C257/12 , C07D239/47 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： This invention concerns HIV replication inhibitors of formula the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms thereof, wherein the ring containing -a1=a2-a3=a4- and -b1=b2-b3=b4- represents phenyl, pyridyl, pyrimidinyl, pirazinyl, pyridazinyl;n is 0 to 5; m is 1 to 4; R1 is hydrogen; aryl; formyl; C1-6alkylcarbonyl; C1-6alkyl; C1-6alkyloxycarbonyl; substituted C1-6alkyl, C1-6alkylcarbonyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonyloxy; substituted C1-6alkyloxyC1-6alkylcarbonyl; R2 is hydroxy, halo, optionally substituted C1-6alkyl, C3-7cycloalkyl, optionally substituted C2-6alkenyl, optionally substituted C2-6alkynyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, —S(═O)pR6, —NH—S(═O)pR6, —C(═O)R6, —NHC(═O)H, —C(═O)NHNH2, —NHC(═O)R6, —C(═NH)R6 or a 5-membered heterocycle; X1 is —NR5—, —NH—NH—, —N═N—, —O—, —C(═O)—, C1-4alkanediyl, —CHOH—, —S—, —S(═O)p—, —X2—C1-4alkanediyl- or —C1-4alkanediyl-X2—; R3 is NHR13; NR13R14; —C(═O)—NHR13; —C(═O)—NR13R14; —C(═O)—R15; —CH═N—NH—C(═O)—R16; substituted C1-6alkyl; optionally substituted C1-6alkyloxyC1-6alkyl; substituted C2-6alkenyl; substituted C2-6alkynyl; C1-6alkyl substituted with hydroxy and a second substituent; —C(═N—O—R8)—C1-4alkyl; R7; or —X3—R7; R4 is halo, hydroxy, C1-6alkyl, C3-7cycloalkyl, C1-6alkyloxy, cyano, nitro, polyhaloC1-6alkyl, polyhaloC1-6alkyloxy, aminocarbonyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonyl, formyl, amino, mono- or di(C1-4alkyl)amino; their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them.

4. 发明申请

US20060063789A1 Aminobenzamide derivatives as glycogen synthase kinase 3 beta inhibitors 审中-公开
标题翻译：氨基苯甲酰胺衍生物作为糖原合酶激酶3β抑制剂
公开(公告)号：US20060063789A1
公开(公告)日：2006-03-23
申请号：US10493446
申请日：2002-10-29
申请人： Eddy Jean Freyne , Peter Antonius , Marc Willems , Werner Johan , Paul Janssen , Paulus Joannes , Jan Heeres , Marc de Jonge , Lucien Koymans , Frederik Daeyaert , Michael Kukla , Hugo Gabriel , Bony Nuydens , Marc Mercken , Donald Ludovici , Herwig Janssen , Paul Maria , Graziella Janssen , Jasmine Werner , Maroussia Janssen , Theodora Arts
发明人： Eddy Jean Freyne , Peter Antonius , Marc Willems , Werner Johan , Paul Janssen , Paulus Joannes , Jan Heeres , Marc de Jonge , Lucien Koymans , Frederik Daeyaert , Michael Kukla , Hugo Gabriel , Bony Nuydens , Marc Mercken , Donald Ludovici , Herwig Janssen , Paul Maria , Graziella Janssen , Jasmine Werner , Maroussia Janssen , Theodora Arts
IPC分类号： A61K31/655 , A61K31/50 , A61K31/4965 , A61K31/513 , C07D241/18 , C07D239/47
CPC分类号： C07D239/42 , A61K31/506 , C07D239/47 , C07D239/48 , C07D239/50 , C07D403/12
摘要： This invention concerns a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A represents a 6-membered heterocycle; R1 is hydrogen; aryl; formyl; C1-6alkylcarbonyl; optionally substituted C1-6alkyl; C1-6alkyloxycarbonyl; optionally substituted C1-6alkyloxyC1-6alkylcarbonyl; X is a direct bond or a linker atom or group; Z is O or S; R2 is hydrogen, C1-10alkyl, C2-10alkenyl, C2-10alkynyl, a carbocycle or a heterocycle, each of said groups may optionally be substituted; R3 is hydrogen; hydroxy; halo; optionally substituted C1-6alkyl or C2-6alkenyl or C2-6alkynyl; C1-6alkyloxy; C1-6alkylthio; C1-6alkyloxycarbonyl; C1-6alkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or di(C1-6alkyl)amino; polyhaloC1-6alkyl; polyhaloC1-6alkyloxy; polyhaloC1-6alkylthio; R21; R21—C1-6alkyl; R21—O—; R21—S—; R21—C(═O)—; R21—S(═O)p—; R7—S(═O)p—; R7—S(═O)p—NH—; R21—S(═O)p—NH—; R7—C(═O)—; —NHC(═O)H; —C(═O)NHNH2; R7—C(═O)—NH—; R21—C(═O)—NH—; —C(═NH)R7; —C(═NH)R21; R4a or R4b each independently represent hydrogen, R8, —Y1—NR9—Y2—NR10R11, —Y1—NR9—Y1—R8, —Y1—NR9R10; provided that —X—R2 and/or R3 is other than hydrogen; their use, pharmaceutical compositions comprising them and processes for their preparation.
摘要翻译：本发明涉及式的化合物

5. 发明申请

US20050288278A1 HIV replication inhibiting pyrimidines 审中-公开
公开(公告)号：US20050288278A1
公开(公告)日：2005-12-29
申请号：US11204513
申请日：2005-08-16
申请人： Bart De Corte , Marc De Jonge , Jan Heeres , Chih Ho , Paul Janssen , Robert Kavash , Lucien Koymans , Michael Kukla , Donald Ludovici , Koen Van Aken
发明人： Bart De Corte , Marc De Jonge , Jan Heeres , Chih Ho , Paul Janssen , Robert Kavash , Lucien Koymans , Michael Kukla , Donald Ludovici , Koen Van Aken
IPC分类号： C07D239/47 , A61K20060101 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/551 , A61K31/5513 , A61K31/675 , A61K31/715 , A61P31/18 , C07D20060101 , C07D239/42 , C07D239/46 , C07D239/48 , C07D239/50 , C07D239/80 , C07D401/12 , C07D403/12
CPC分类号： A61K31/505 , A61K31/5513
摘要： This invention concerns the use of compounds of formula the N-oxides, the pharmaceutically acceptable addition salts, quaternary amines and the stereochemically isomeric forms thereof, wherein -a1=a2-a3=a4- forms a phenyl, pyridinyl, pyrimidinyl, pyridazinyl or pyrazinyl with the attached vinyl group; n is 0 to 4; and where possible 5; R1 is hydrogen, aryl, formyl, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxy-carbonyl, substituted C1-6alkyl, or substituted C1-6alkyloxyC1-6alkylcarbonyl; each R2 independently is hydroxy, halo, optionally substituted C1-6alkyl, C2-6alkenyl or C2-6alkynyl, C3-7cycloalkyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalo-methylthio, —S(═O)pR6, —NH—S(═O)pR6, —C(═O)R6, —NHC(═O)H, —C(═O)NHNH2, —NHC(═O)R6, —C(═NH)R6 or a 5-membered heterocyclic ring; p is 1 or 2; L is optionally substituted C1-10alkyl, C2-10alkenyl, C2-10alkynyl or C3-7cycloalkyl; or L is —X—R3 wherein R3 is optionally substituted phenyl, pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl; X is —NR1—, —NH—NH—, —N═N—, —O—, —C(═O)—, —CHOH—, —S—, —S(═O)— or —S(═O)2—; Q is hydrogen, C1-6alkyl, halo, polyhalo-C1-6alkyl or an optionally substituted amino group; Y represents hydroxy, halo, C3-7cycloalkyl, optionally substituted C1-6alkyl, C2-6alkenyl or C2-6alkynyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, —S(═O)pR6, —NH—S(═O)pR6, —C(═O)R6, —NHC(═O)H, —C(═O)NHNH2, —NHC(═O)R6, —C(═NH)R6 or aryl; aryl is optionally substituted phenyl. Het is an optionally substituted heterocyclic radical; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection.

6. 发明申请

US20050176713A1 Amide derivatives as glycogen synthase kinase 3-beta inhibitors 有权
公开(公告)号：US20050176713A1
公开(公告)日：2005-08-11
申请号：US10493454
申请日：2002-10-29
申请人： Eddy Jean Freyne , Peter Jacobus Johannes Buijnsters , Marc Willems , Werner Constant Embrechts , Jean Fernand Lacrampe , Paul Adriaan Janssen , Herwig Josephus Janssen , Paul Janssen , Graziella Janssen , Jasmine Janssen , Maroussia Godelieve Janssen , Theodora Joanna Arts , Paulus Lewi , Jan Heeres , Marc de Jonge , Lucien Maria Koymans , Frederik Frans Daeyaert , Rony Nuydens , Marc Mercken
发明人： Eddy Jean Freyne , Peter Jacobus Johannes Buijnsters , Marc Willems , Werner Constant Embrechts , Jean Fernand Lacrampe , Paul Adriaan Janssen , Herwig Josephus Janssen , Paul Janssen , Graziella Janssen , Jasmine Janssen , Maroussia Godelieve Janssen , Theodora Joanna Arts , Paulus Lewi , Jan Heeres , Marc de Jonge , Lucien Maria Koymans , Frederik Frans Daeyaert , Rony Nuydens , Marc Mercken
IPC分类号： A61K31/44 , A61K31/4409 , A61K31/505 , A61K31/506 , A61K31/5377 , A61P3/10 , A61P7/00 , A61P17/00 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P35/00 , A61P43/00 , C07D213/81 , C07D213/82 , C07D239/42 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/12 , C07D413/12 , C07D413/14 , C07D417/12 , A61K31/655 , A61K31/4965
CPC分类号： C07D213/81 , C07D213/82 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12
摘要： This invention concerns a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A represents a 6-membered heterocycle; R1 is hydrogen; aryl; formyl; C1-6alkylcarbonyl; optionally substituted C1-6alkyl; C1-6alkyloxycarbonyl; optionally substituted C1-6alkyloxyC1-6alkylcarbonyl; X is a direct bond or a linker atom or group; Z is O or S; R2 is hydrogen, C1-10alkyl, C2-10alkenyl, C2-10alkynyl, a carbocycle or a heterocycle, each of said groups may optionally be substituted; R3 is hydrogen; hydroxy; halo; optionally substituted C1-6alkyl or C2-6alkenyl or C2-6alkynyl; C1-6alkyloxy; C1-6alkylthio; C1-6alkyloxycarbonyl; C1-6alkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or di(C1-6alkyl)amino; polyhaloC1-6alkyl; polyhaloC1-6alkyloxy; polyhaloC1-6alkylthio; R21; R21-C1-6alkyl; R21—O—; R21—S—; R21—C(═O)—; R21—S(═O)p—; R7—S(═O)p—; R7—S(═O)p—NH—; R21—S(═O)p—NH—; R7—C(═O)—; —NHC(═O)H; —C(═O)NHNH2; R7—C(═O)—NH—; R21—C(═O)—NH—; —C(═NH)R7; —C(═NH)R21; R4a or R4b each independently represent hydrogen, R8, —Y1—NR9—Y2—NR10R11, —Y1—NR9—Y1—R8, —Y1—NR9R10; provided that —X—R2 and/or R3 is other than hydrogen; their use, pharmaceutical compositions comprising them and processes for their preparation.

7. 发明授权

US4057552A Production of cyanopyridines from piperidines 失效
标题翻译：从哌啶生产氰基吡啶
公开(公告)号：US4057552A
公开(公告)日：1977-11-08
申请号：US701694
申请日：1976-07-01
申请人： Hermann Richtzenhain , Paul Janssen, deceased
发明人： Hermann Richtzenhain , Paul Janssen, deceased
IPC分类号： C07D213/133 , B01J21/00 , B01J23/22 , B01J35/10 , C07D213/84 , C07D213/57
CPC分类号： C07D213/84 , B01J23/22 , B01J35/1014 , B01J35/1038
摘要： Nicotinonitrile is produced from a piperidine having an alkyl substituent in the three position by contact with ammonia, in the absence of molecular oxygen, and in the presence of oxidized vanadia supported on a porous support, containing from 25% to 75%, by weight, of the vanadia, the vanadia having been placed in molten form substantially entirely within the pores of the support, with the support having a surface area greater than 50 m.sup.2 /gm and a porosity greater than 0.4 cc/gm, with the support being either gamma-alumina or silica-alumina.
摘要翻译：在不存在分子氧的情况下，在不存在分子氧的情况下，通过与氨接触，在三位上具有烷基取代基的哌啶，在负载在多孔载体上的氧化的氧钒的存在下，含有25重量％〜75重量％的氧化钒，氧化钒已基本上完全放置在支撑体的孔内的熔融形式中，载体的表面积大于50m 2 / gm，孔隙率大于0.4cc / gm，载体为γ - 氧化铝或二氧化硅 - 氧化铝。

8. 发明授权

US09103463B2 Pressure balanced solenoid operated valve 有权
标题翻译：压力平衡电磁阀
公开(公告)号：US09103463B2
公开(公告)日：2015-08-11
申请号：US13396202
申请日：2012-02-14
申请人： Kevin C. Williams , Eric Paul Janssen
发明人： Kevin C. Williams , Eric Paul Janssen
IPC分类号： F16K31/06
CPC分类号： F16K31/0658 , F16K31/0693 , Y10T137/8667
摘要： A pressure balanced solenoid operated valve includes a solenoid portion having a coil in a coil retainer. A valve member portion defines a body connected to the solenoid portion. A slidable valve member in the body has opposed first and second ends and a shoulder between the ends. The first end with the coil energized is magnetically drawn toward the coil retainer moving the valve member between a valve closed and a valve open position. A pressure equalizing passage extends in the valve member from the second end. An inlet passage communicates a pressurized fluid at a valve inlet port to the pressure equalizing passage. A connecting passage communicates between the pressure equalizing passage and the shoulder. The pressurized fluid in the pressure equalizing passage acts against the second end and equally and oppositely against both the shoulder and the first end in both the open and closed positions.
摘要翻译：压力平衡电磁阀包括在线圈保持器中具有线圈的螺线管部分。阀构件部分限定连接到螺线管部分的主体。主体中的可滑动的阀构件具有相对的第一端和第二端以及端部之间的肩部。线圈通电的第一端被磁力吸引到线圈保持器，以使阀构件在阀关闭和阀打开位置之间移动。压力平衡通道在阀构件中从第二端延伸。入口通道将阀入口处的加压流体连通到均压通道。连接通道在压力平衡通道和肩部之间连通。压力平衡通道中的加压流体在打开位置和关闭位置两者相对于肩部和第一端相对地抵靠第二端作用。

9. 发明申请

US20070191407A1 PROCESSES FOR THE PREPARATION OF 4-[[4-[[4-(2-CYANOETHENYL)-2,6-DIMETHYLPHENYL]-2-PYRIMIDINYL]AMINO]BENZONITRILE 有权
标题翻译：制备4 - [[4 - [[4-（2-氰基乙基）-2,6-二甲基苯基] -2-吡啶基]氨基]苯并噻唑的方法
公开(公告)号：US20070191407A1
公开(公告)日：2007-08-16
申请号：US11738688
申请日：2007-04-23
申请人： Didier Schils , Joannes Willems , Bart Petrus Anna Medaer , Elisabeth Therese Pasquier , Paul Janssen , Jan Heeres , Ruben Gerardus Leenders , Jerome Guillemont
发明人： Didier Schils , Joannes Willems , Bart Petrus Anna Medaer , Elisabeth Therese Pasquier , Paul Janssen , Jan Heeres , Ruben Gerardus Leenders , Jerome Guillemont
IPC分类号： A61K31/505 , C07D239/48
CPC分类号： C07D239/48 , C07C253/20 , C07C253/30 , C07C255/42
摘要： Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]amino]benzonitrile of formula (I), a N-oxide, a pharmaceutically acceptable acid addition salt, a quaternary amine or a stereochemically isomeric form thereof are provided, said processes comprise: a) reacting 4-(2-cyanoethenyl)-2,6-dimethylbenzenamine with an intermediate of formula (III) in the presence of a suitable solvent; b) reacting an intermediate of formula (IV) with acrylonitrile in the presence of a suitable palladium catalyst, a suitable base and a suitable solvent; c) dehydrating the corresponding amide of the compound of formula (I).
摘要翻译：用于制备式（I）的4 - [[4 - [[4-（2-氰基乙烯基）-2,6-二甲基苯基] - 氨基] -2-嘧啶基]氨基]苄腈的方法，N-氧化物，提供药学上可接受的酸加成盐，季胺或其立体化学异构形式，所述方法包括：a）使4-（2-氰基乙烯基）-2,6-二甲基苯胺与式（III）的中间体在合适的溶剂; b）在合适的钯催化剂，合适的碱和合适的溶剂的存在下使式（Ⅳ）的中间体与丙烯腈反应; c）使相应的式（I）化合物的酰胺脱水。

10. 发明申请

US20070037811A1 Hiv inhibiting 1,2,4-triazines 有权
标题翻译：抑制1,2,4-三嗪
公开(公告)号：US20070037811A1
公开(公告)日：2007-02-15
申请号：US10544584
申请日：2004-02-05
申请人： Paulus Lewi , Paul Janssen , Marc de Jonge , Lucien Maria Koymans , Hendrik Vinkers , Frederik Daeyaert , Jan Heeres , Ruben Leenders , Georges Hoomaert , Amuri Kilonda , Donald Ludovici
发明人： Paulus Lewi , Paul Janssen , Marc de Jonge , Lucien Maria Koymans , Hendrik Vinkers , Frederik Daeyaert , Jan Heeres , Ruben Leenders , Georges Hoomaert , Amuri Kilonda , Donald Ludovici
IPC分类号： A61K31/53 , C07D403/14
CPC分类号： A61K31/53 , C07D253/07 , C07D253/075
摘要： The present invention relates to HIV replication inhibitors of formula (I) as defined in the specification their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them.
摘要翻译：本发明涉及如本说明书中定义的式（I）的HIV复制抑制剂，其用作药物，其制备方法和包含它们的药物组合物。

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