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1. 发明申请

US20140112891A1 AUTOLOGOUS HUMAN ADULT PLURIPOTENT VERY SMALL EMBRYONIC-LIKE (hVSEL) STEM CELL REGENERATION OF BONE AND CARTILAGE 审中-公开
标题翻译：自体人类成年人非常小的胚胎样（hVSEL）骨细胞再生骨骼和成熟
公开(公告)号：US20140112891A1
公开(公告)日：2014-04-24
申请号：US14110230
申请日：2012-04-09
申请人： Russell Taichman , Paul H. Krebsbach , Aaron Havens , Anjali Mishra , Denis Rodgerson , Jingcheng Wang , Yusuke Shiozawa , Younghun Jung
发明人： Russell Taichman , Paul H. Krebsbach , Aaron Havens , Anjali Mishra , Denis Rodgerson , Jingcheng Wang , Yusuke Shiozawa , Younghun Jung
IPC分类号： A61K35/28
CPC分类号： A61K35/28 , A61K35/545 , A61K38/1875 , A61L27/24 , A61L27/3834 , A61L27/3847 , A61L27/3852 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/414 , A61L2430/02 , A61L2430/06 , C12N5/0607 , A61K2300/00
摘要： The invention provides methods and compositions for the repair or regeneration of osteochondral tissue. The methods and compositions provide an effective amount of isolated differentiable human Very Small Embryonic Like Stem Cells (hVSELs) sufficient for regeneration or repair of an osteochondral tissue. The compositions can be administered directly to the tissue or administered systemically.
摘要翻译：本发明提供了用于修复或再生骨软骨组织的方法和组合物。所述方法和组合物提供了足够用于骨软骨组织再生或修复的有效量的可分离的人类非常小的类似胚胎干细胞（hVSEL）。组合物可以直接施用于组织或全身施用。

2. 发明授权

US07087200B2 Controlled local/global and micro/macro-porous 3D plastic, polymer and ceramic/cement composite scaffold fabrication and applications thereof 有权
公开(公告)号：US07087200B2
公开(公告)日：2006-08-08
申请号：US10178292
申请日：2002-06-24
申请人： Juan Taboas , Rachel D Maddox , Paul H Krebsbach , Scott J Hollister , Tien-Min Gabriel Chu
发明人： Juan Taboas , Rachel D Maddox , Paul H Krebsbach , Scott J Hollister , Tien-Min Gabriel Chu
IPC分类号： B29C33/38 , B29C39/02 , B29C44/02
CPC分类号： C04B35/6264 , A61F2/062 , A61F2/08 , A61F2/0811 , A61F2/28 , A61F2/30756 , A61F2/30942 , A61F2002/0086 , A61F2002/0894 , A61F2002/30199 , A61F2002/30678 , A61F2002/30766 , A61F2002/3092 , A61F2002/3093 , A61F2002/30948 , A61F2002/30952 , A61F2002/30957 , A61F2230/0063 , A61F2240/002 , A61F2240/004 , A61F2310/00293 , B22C9/00 , B29C33/3835 , B29C33/3842 , B29C33/52 , B29C39/021 , B29C43/006 , B29C64/165 , B29C64/40 , B29C2791/001 , B29K2105/04 , B29K2995/0094 , B29L2031/7532 , B33Y70/00 , B33Y80/00 , C04B35/447 , C04B35/63 , C04B35/632 , C04B35/634 , G05B19/4099 , G05B2219/45204
摘要： An indirect solid free form scaffold manufacturing technique is provided. More particularly, the present invention provides a set of molds, casting methods, mold removals, and surface modification techniques that are compatible with image-based design methods and with solvent, melt, and slurry casting of polymers and ceramics.

3. 发明授权

US07509240B2 Solid freeform fabrication of structurally engineered multifunctional devices 有权
标题翻译：结构设计的多功能设备的固体自由形成
公开(公告)号：US07509240B2
公开(公告)日：2009-03-24
申请号：US10268359
申请日：2002-10-10
申请人： Suman Das , Scott J Hollister , Paul H Krebsbach , James K Santosa
发明人： Suman Das , Scott J Hollister , Paul H Krebsbach , James K Santosa
IPC分类号： G06F17/50
CPC分类号： B29C64/153 , B33Y10/00 , B33Y30/00 , B33Y50/02 , B33Y80/00
摘要： A selective laser sintering technique and system are provided for producing a heterogeneous product. The selective laser sintering technique and system is generally comprised of generating a computer model of the product and processing the model to obtain numerous cross-sectional representations of the model. The cross-sectional representations are manufactured layer by layer to create the product. Specifically, numerous different powders having a variety of properties are placed within nozzles positioned above a deposition bed using a hopper. Using the computer model as a guide, the different powders are placed at different positions on the deposition bed to form each layer of the device. The deposited powders are consolidated, micromachined, and milled using one or more lasers to create the product. Using this selective laser sintering technique a wide variety of heterogenous products may be produced, such as the following: 1) bio-implants, 2) small scale energy production, storage and conversion devices, 3) devices that exploit anomalous material behavior, and 4) nanocomposites.
摘要翻译：提供选择性激光烧结技术和系统用于生产异质产品。选择性激光烧结技术和系统通常包括产生产品的计算机模型并处理模型以获得模型的许多横截面表示。横截面表示逐层制造以产生产品。具体而言，使用料斗将多种具有各种性质的不同粉末放置在位于沉积床上方的喷嘴内。使用计算机模型作为指导，将不同的粉末放置在沉积床上的不同位置以形成装置的每一层。使用一个或多个激光将沉积的粉末固结，微加工和研磨以产生产物。使用这种选择性激光烧结技术可以产生各种各样的异质产物，例如：1）生物植入物，2）小规模能量产生，储存和转化装置，3）利用异常材料行为的装置，以及4 ）纳米复合材料。

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