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1. 发明授权

US5696100A Method for controlling O-desulfation of heparin and compositions produced thereby 失效
标题翻译：用于控制肝素O-脱硫的方法及由此制备的组合物
公开(公告)号：US5696100A
公开(公告)日：1997-12-09
申请号：US384298
申请日：1995-02-06
申请人： Kevin R. Holme , Weisheng Liang , Patrick N. Shaklee
发明人： Kevin R. Holme , Weisheng Liang , Patrick N. Shaklee
IPC分类号： A61K31/727 , A61P7/02 , A61P9/00 , A61P35/00 , C08B37/00 , C08B37/10 , A61K31/725
CPC分类号： A61K31/715 , A61K31/727 , C08B37/0075
摘要： Methods of making and using, as prophylactics or therapeutics for preventing or treating certain diseases including cancer, O-desulfated heparin compositions, preferably 2-O, 3-O desulfated heparin compositions, wherein the methods permit regulating the degree of 2-O, 3-O desulfation to produce compositions that are variably desulfated upto about and 75% desulfated at the 2-O and 3-O positions, respectively.
摘要翻译：制备和使用预防或治疗某些疾病包括癌症的方法，O-脱硫酸肝素组合物，优选2-O，3-O脱硫酸盐的肝素组合物，其中所述方法允许调节2-O 3的程度 -O脱硫以分别产生在2-O和3-O位置可变地脱硫至约75％和75％脱硫的组合物。

2. 发明授权

US08748595B2 Methods for fucoidan purification from sea weed extracts 有权
标题翻译：海藻提取物中岩藻依聚糖纯化方法
公开(公告)号：US08748595B2
公开(公告)日：2014-06-10
申请号：US12449712
申请日：2008-02-01
申请人： Patrick N. Shaklee , Jennifer Bahr-Davidson , Srinivasa Prasad , Kirk Johnson
发明人： Patrick N. Shaklee , Jennifer Bahr-Davidson , Srinivasa Prasad , Kirk Johnson
IPC分类号： C07H15/04 , A61K31/715
CPC分类号： C08B37/0063 , A61K31/726 , A61K31/737 , A61K36/03 , A61K45/06 , C08B37/0036
摘要： Methods for purifying fucoidan in extracts from brown seaweed are disclosed. In particular, methods of purifying fucoidan in the extract to remove heavy metal ions, bacterial and endotoxin contaminants, and other impurities are disclosed. The methods include the use of a chelating agent, selective precipitation, and filtration.
摘要翻译：公开了褐藻提取物中岩藻多糖的纯化方法。特别地，公开了提取物中去除重金属离子，细菌和内毒素污染物以及其它杂质的岩藻依聚糖的纯化方法。所述方法包括使用螯合剂，选择性沉淀和过滤。

3. 发明授权

US5795875A Therapeutic methods of using O-desulfated heparin derivatives 失效
标题翻译：使用O-脱硫酸肝素衍生物的治疗方法
公开(公告)号：US5795875A
公开(公告)日：1998-08-18
申请号：US781098
申请日：1997-01-09
申请人： Kevin R. Holme , Patrick N. Shaklee , Masayuki Ishihara
发明人： Kevin R. Holme , Patrick N. Shaklee , Masayuki Ishihara
IPC分类号： C08B37/10 , A61K31/715 , A61K31/727 , A61P9/00 , A61P9/08 , A61P9/10 , A61P29/00 , A61P35/00 , C08B37/00 , A61K31/725
CPC分类号： A61K31/727 , C08B37/0075 , Y10S514/921
摘要： Compositions and methods of making selectively O-desulfated heparin compositions, preferably 6-O-desulfated heparin compositions, wherein the methods permit regulating the degree of 6-O-desulfation. The compositions are useful for treating various diseases, including cancer, angiogenesis, shock, ischemia reperfusion injury, inflammation, and cardiovascular diseases including restenosis.
摘要翻译：制备选择性O-脱硫酸肝素组合物，优选6-O-脱硫酸肝素组合物的组合物和方法，其中所述方法允许调节6-O-脱硫的程度。该组合物可用于治疗各种疾病，包括癌症，血管发生，休克，缺血再灌注损伤，炎症和包括再狭窄在内的心血管疾病。

4. 发明授权

US5808021A Method for controlling O-desulfation of heparin 失效
标题翻译：控制肝素O-脱硫的方法
公开(公告)号：US5808021A
公开(公告)日：1998-09-15
申请号：US835733
申请日：1997-04-10
申请人： Kevin R. Holme , Weisheng Liang , David J. Tyrrell , Patrick N. Shaklee
发明人： Kevin R. Holme , Weisheng Liang , David J. Tyrrell , Patrick N. Shaklee
IPC分类号： A61K31/727 , A61P7/02 , A61P9/00 , A61P35/00 , C08B37/00 , C08B37/10 , A61K31/725
CPC分类号： A61K31/715 , A61K31/727 , C08B37/0075
摘要： Methods of making and using, as prophylactics or therapeutics for preventing or treating certain diseases including cancer, O-desulfated heparin compositions, preferably 2-O, 3-O desulfated heparin compositions, wherein the methods permit regulating the degree of 2-O, 3-O desulfation to produce compositions that are variably desulfated upto about 99% and 75% desulfated at the 2-O and 3-O positions, respectively.
摘要翻译：制备和使用预防或治疗某些疾病包括癌症的方法，O-脱硫酸肝素组合物，优选2-O，3-O脱硫酸盐的肝素组合物，其中所述方法允许调节2-O 3的程度 -O脱硫以产生分别在2-O和3-O位置脱硫至约99％和75％可变地脱硫的组合物。

5. 发明申请

US20100144667A1 METHODS FOR FUCOIDAN PURIFICATION FROM SEA WEED EXTRACTS 有权
标题翻译：从海洋萃取物中获取富马酸的方法
公开(公告)号：US20100144667A1
公开(公告)日：2010-06-10
申请号：US12449712
申请日：2008-02-01
申请人： Patrick N. Shaklee , Jennifer Bahr-Davidson , Srinivasa Prasad , Kirk Johnson
发明人： Patrick N. Shaklee , Jennifer Bahr-Davidson , Srinivasa Prasad , Kirk Johnson
IPC分类号： A61K31/715 , C07H1/06
CPC分类号： C08B37/0063 , A61K31/726 , A61K31/737 , A61K36/03 , A61K45/06 , C08B37/0036
摘要： Methods for purifying fucoidan in extracts from brown seaweed are disclosed. In particular, methods of purifying fucoidan in the extract to remove heavy metal ions, bacterial and endotoxin contaminants, and other impurities are disclosed. The methods include the use of a chelating agent, selective precipitation, and filtration.
摘要翻译：公开了褐藻提取物中岩藻多糖的纯化方法。特别地，公开了提取物中去除重金属离子，细菌和内毒素污染物以及其它杂质的岩藻依聚糖的纯化方法。所述方法包括使用螯合剂，选择性沉淀和过滤。

6. 发明授权

US5767269A Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics 失效
标题翻译：用于制备低亲和力低分子量肝素的方法，可用作抗血栓药物
公开(公告)号：US5767269A
公开(公告)日：1998-06-16
申请号：US722408
申请日：1996-10-01
申请人： Jack Hirsh , Patrick N. Shaklee , James E. Knobloch , Jeffrey I. Weitz , Edward Young
发明人： Jack Hirsh , Patrick N. Shaklee , James E. Knobloch , Jeffrey I. Weitz , Edward Young
IPC分类号： C08B37/00 , C07H1/00 , A61K31/725 , C07H5/04
CPC分类号： C08B37/0078
摘要： The present invention generally relates to a processes for preparing low affinity, low molecular weight heparins (LA-LWM-heparins) which are endowed with pharmacological and therapeutic properties that are surprisingly advantageous. In one embodiment, the process comprises: (1) nitrous acid depolymerization of unfractionated heparin to yield low molecular weight heparin (LMWH); (2) oxidation of the resulting LMWH to open the ring structures the nonsulfated uronic acid moieties using, for example, sodium periodate; and (3) reduction of the oxidized LMWH to reduce the aldehydes (to alcohols) formed during the depolymerization and oxidation steps using, for example, sodium borohydride. The resulting LA-LMW-heparins are capable of inactivating thrombin bound to fibrin within a thrombus or clot, whereby the ability of clot-bound thrombin to catalytically promote further clot accretion is substantially diminished or eliminated. As such, the resulting LA-LMW-heparins are useful for preventing thrombosis in the circuit of cardiac bypass apparatus and in patients undergoing renal dialysis, and for treating patients suffering from or at risk of suffering from thrombus-related cardiovascular conditions, such as unstable angina, acute myocardial infarction (heart attack), cerebrovascular accidents (stroke), pulmonary embolism, deep vein thrombosis, arterial thrombosis, etc.
摘要翻译：本发明一般涉及一种制备低亲和力低分子量肝素（LA-LWM-肝素）的方法，其具有惊人的有利的药理学和治疗学特性。在一个实施方案中，该方法包括：（1）未分级肝素的亚硝酸解聚以产生低分子量肝素（LMWH）; （2）使用例如高碘酸钠将所得LMWH氧化以打开非结构化的糖醛酸部分的环结构; 和（3）减少氧化的LMWH以还原在解聚和氧化步骤期间使用例如硼氢化钠形成的醛（对醇）。所得到的LA-LMW-肝素能够使血栓或凝块内与纤维蛋白结合的凝血酶失活，从而基本上减少或消除凝块结合凝血酶催化促进进一步凝块增生的能力。因此，所得到的LA-LMW-肝素可用于预防心脏旁路装置和肾透析患者的血栓形成，并且用于治疗患有血栓相关心血管疾病或患有血栓相关心血管疾病的风险的患者，例如不稳定心绞痛，急性心肌梗死（心脏病发作），脑血管意外（中风），肺栓塞，深静脉血栓形成，动脉血栓形成等。

7. 发明授权

US5296471A Method for controlling o-desulfation of heparin and compositions produced thereby 失效
标题翻译：用于控制肝素脱硫的方法及其制备的组合物
公开(公告)号：US5296471A
公开(公告)日：1994-03-22
申请号：US994804
申请日：1992-12-22
申请人： Kevin R. Holme , Patrick N. Shaklee , David J. Tyrrell
发明人： Kevin R. Holme , Patrick N. Shaklee , David J. Tyrrell
IPC分类号： A61K31/727 , C08B37/00 , A61K31/725 , C08R37/10
CPC分类号： A61K31/715 , A61K31/727 , C08B37/0075
摘要： Methods of making and using, as prophylatics or therapeutics for preventing or treating certain diseases including cancer, O-desulfated heparin compositions, preferably 2-O, 3-O desulfated heparin compositions, wherein the methods permit regulating the degree of 2-O, 3-O desulfation to produce compositions that are variably desulfated including about 99% and 75% desulfated at the 2-O and 3-O positions, respectively.
摘要翻译：制备和使用作为预防或治疗预防或治疗某些疾病包括癌症的方法，O-脱硫酸肝素组合物，优选2-O，3-O脱硫酸盐肝素组合物，其中所述方法允许调节2-O 3的程度 -O脱硫以产生可变地脱硫的组合物，包括分别在2-O和3-O位置脱硫的约99％和75％。

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