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1. 发明授权

US07547768B2 Anti-TAT 113 antibodies 失效
标题翻译：抗TAT 113抗体
公开(公告)号：US07547768B2
公开(公告)日：2009-06-16
申请号：US11943454
申请日：2007-11-20
申请人： Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan D. Spencer , Thomas D. Wu , Zemin Zhang
发明人： Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan D. Spencer , Thomas D. Wu , Zemin Zhang
IPC分类号： C07K16/00 , C12P21/08 , C12P21/04 , A61K39/395 , C07H21/04
CPC分类号： C07K16/30 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/18 , C07K2317/73
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译：本发明涉及可用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。

2. 发明申请

US20080124739A1 COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR 失效
公开(公告)号：US20080124739A1
公开(公告)日：2008-05-29
申请号：US11943454
申请日：2007-11-20
申请人： Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan D. Spencer , Thomas D. Wu , Zemin Zhang
发明人： Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan D. Spencer , Thomas D. Wu , Zemin Zhang
IPC分类号： G01N33/53 , C07K16/46 , C12N5/06
CPC分类号： C07K16/30 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/18 , C07K2317/73
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

3. 发明申请

US20070048825A1 COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR 审中-公开
公开(公告)号：US20070048825A1
公开(公告)日：2007-03-01
申请号：US11538517
申请日：2006-10-04
申请人： Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan Spencer , Thomas Wu , Zemin Zhang
发明人： Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan Spencer , Thomas Wu , Zemin Zhang
IPC分类号： C07K14/82 , C07H21/04 , C12P21/06 , C12N1/21 , C12N1/18 , C12N5/06
CPC分类号： C07K16/30 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/18 , C07K2317/73
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

4. 发明授权

US3544506A Boron containing coating compositions 失效
标题翻译：含硼的涂料组合物
公开(公告)号：US3544506A
公开(公告)日：1970-12-01
申请号：US3544506D
申请日：1968-02-09
申请人： JAMES PATRICK DOWD
发明人： DOWD JAMES PATRICK
IPC分类号： C08G77/22 , C08G51/04 , C08G47/00
CPC分类号： C08G77/22

5. 发明申请

US20110274690A1 COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR 失效
标题翻译：用于诊断和治疗肿瘤的组合物和方法
公开(公告)号：US20110274690A1
公开(公告)日：2011-11-10
申请号：US12422424
申请日：2009-04-13
申请人： Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan D. Spencer , Thomas D. Wu , Zemin Zhang
发明人： Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan D. Spencer , Thomas D. Wu , Zemin Zhang
IPC分类号： A61K39/395 , A61P35/00 , C12N5/09 , G01N33/566 , C07K16/18
CPC分类号： C07K16/30 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/18 , C07K2317/73
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译：本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。

6. 发明申请

US20050170368A1 Compositions and methods for the diagnosis and treatment of tumor 审中-公开
公开(公告)号：US20050170368A1
公开(公告)日：2005-08-04
申请号：US10884070
申请日：2004-07-02
申请人： Avi Ashkenazi , Belinda Caims , Patrick Dowd , Gretchen Frantz , Dorothy French , Lino Gonzalez , Paul Polakis , Victoria Smith , Beni Wolf , Thomas Wu , Zemin Zhang
发明人： Avi Ashkenazi , Belinda Caims , Patrick Dowd , Gretchen Frantz , Dorothy French , Lino Gonzalez , Paul Polakis , Victoria Smith , Beni Wolf , Thomas Wu , Zemin Zhang
IPC分类号： A61K47/48 , C07H21/04 , C07K14/47 , C07K14/82 , C07K16/30 , C12Q1/68 , G01N33/574
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

7. 发明授权

US4177591A Copy holder 失效
标题翻译：副本持有人
公开(公告)号：US4177591A
公开(公告)日：1979-12-11
申请号：US882161
申请日：1978-02-28
申请人： John J. Thompson , Paul D. Gorman , Patrick Dowd
发明人： John J. Thompson , Paul D. Gorman , Patrick Dowd
IPC分类号： B41J29/15 , B41J11/36
CPC分类号： B41J29/15
摘要： The invention contemplates improved means of control for a copy holder, for example, a roll-operated positioning device for a data draft or the like sheet to be copied by a typist, so that the eye can be guided correctly on a line-by-line basis. The improved control provides precise electric-motor drive for each of a plurality of selected different paper-displacing increments, at least one of the increments being selectively adjustable to exactly match the line spacing unique to the particular paper from which the copy is to be made.
摘要翻译：本发明考虑了用于复印架的改进的控制装置，例如用于由打字员复制的数据稿或类似纸张的滚动操作的定位装置，使得可以逐个引导正确地引导眼睛，行基础。改进的控制为多个选定的不同纸张移位增量中的每一个提供精确的电动机驱动，至少一个增量可选择性地可调整以精确地匹配要由其复制的特定纸张所特有的行间距。

8. 发明授权

US08398982B2 Compositions and methods for the diagnosis and treatment of tumor 失效
标题翻译：用于诊断和治疗肿瘤的组合物和方法
公开(公告)号：US08398982B2
公开(公告)日：2013-03-19
申请号：US12422424
申请日：2009-04-13
申请人： Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan D. Spencer , Thomas D. Wu , Zemin Zhang
发明人： Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan D. Spencer , Thomas D. Wu , Zemin Zhang
IPC分类号： A61K39/00
CPC分类号： C07K16/30 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/18 , C07K2317/73
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. TAT113 polypeptides comprising the amino acid sequence of SEQ ID NO: 2 are disclosed. Antibodies that bind TAT113 polypeptides, including monoclonal, chimeric, humanized, single chain, and other antibodies, and fragments thereof, are disclosed. Methods of identifying antibodies that bind epitopes bound by such antibodies, including the antibodies produced by hybridoma cell lines disclosed in the application, are provided, wherein the ability of one antibody to block the binding of another antibody to a TAT113 polypeptide indicates that one antibody binds to an epitope bound by the other antibody. Methods of diagnosing the presence of a tumor in a mammal using such antibodies are disclosed, wherein detection of the formation of a complex between an antibody and a protein in a test sample is indicative of the presence of a tumor in said mammal. Methods of inhibiting the growth of a cancer cell that expresses a protein comprising the amino acid sequence of SEQ ID NO: 2, are disclosed, where the binding of the antibody to the protein inhibits the growth of the cell. Methods of inhibiting the growth of a cancer cell include methods wherein the antibody binds to the epitope bound by an antibody produced by a disclosed hybridoma cell line.
摘要翻译：本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。公开了包含SEQ ID NO：2的氨基酸序列的TAT113多肽。公开了结合TAT113多肽，包括单克隆，嵌合，人源化，单链和其他抗体及其片段的抗体。提供了鉴定结合这些抗体结合表位的抗体的方法，包括由本申请中公开的杂交瘤细胞系产生的抗体，其中一种抗体阻断另一种抗体与TAT113多肽的结合的能力表明一种抗体结合到由另一抗体结合的表位。公开了使用这种抗体诊断哺乳动物肿瘤存在的方法，其中检测样品中抗体与蛋白质之间的复合物的形成是指示所述哺乳动物中肿瘤的存在。公开了抑制表达包含SEQ ID NO：2的氨基酸序列的蛋白质的癌细胞的生长的方法，其中抗体与蛋白质的结合抑制细胞的生长。抑制癌细胞生长的方法包括其中抗体结合由所公开的杂交瘤细胞系产生的抗体结合的表位的方法。

9. 发明申请

US20130011402A9 COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR 失效
公开(公告)号：US20130011402A9
公开(公告)日：2013-01-10
申请号：US12422424
申请日：2009-04-13
申请人： Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan D. Spencer , Thomas D. Wu , Zemin Zhang
发明人： Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan D. Spencer , Thomas D. Wu , Zemin Zhang
IPC分类号： A61K39/395 , A61P35/00 , C12N5/09 , G01N33/566 , C07K16/18
CPC分类号： C07K16/30 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/18 , C07K2317/73
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

10. 发明申请

US20070212735A1 Compositions and Methods for the Diagnosis and Treatment of Tumor 审中-公开
公开(公告)号：US20070212735A1
公开(公告)日：2007-09-13
申请号：US11534850
申请日：2006-09-25
申请人： Avi Ashkenazi , Belinda Caims , Patrick Dowd , Gretchen Frantz , Dorothy French , Lino Gonzalez , Paul Polakis , Victoria Smith , Beni Wolf , Thomas Wu , Zemin Zhang
发明人： Avi Ashkenazi , Belinda Caims , Patrick Dowd , Gretchen Frantz , Dorothy French , Lino Gonzalez , Paul Polakis , Victoria Smith , Beni Wolf , Thomas Wu , Zemin Zhang
IPC分类号： G01N33/574 , C07K16/30 , C07K14/82
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

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