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1. 发明授权

US07037260B2 Method and apparatus for determining attention deficit hyperactivity disorder (ADHD) medication dosage and for monitoring the effects of ADHD medication on people who have ADHD using complementary tests 失效
标题翻译：用于确定注意力缺陷多动障碍（ADHD）药物用量的方法和装置，并用于使用补充测试监测ADHD药物对ADHD患者的影响
公开(公告)号：US07037260B2
公开(公告)日：2006-05-02
申请号：US10832824
申请日：2004-04-27
申请人： Richard S. Keirsbilck , Peter A. Parks , David L. Patton , Richard N. Blazey , Paige Miller
发明人： Richard S. Keirsbilck , Peter A. Parks , David L. Patton , Richard N. Blazey , Paige Miller
IPC分类号： A61B5/00
CPC分类号： A61B5/01 , A61B5/168 , A61B5/7257 , A61B5/726 , G06F19/00
摘要： A method for determining the appropriate dosage of a medication to treat Attention Deficit Hyperactivity Disorder (ADHD) in an individual who has ADHD. The method comprises sampling the peripheral skin temperature of left and right like extremities of an individual during a predetermined time interval when the individual is in a sensory deprived state to provide respective left and right sampled peripheral skin temperature data, processing the sampled peripheral skin temperature data; processing the sampled peripheral skin temperature data including filtering, differentiation, and conversion to the frequency domain to derive spectral signatures whose magnitudes are indicative of the level of ADHD manifestation. The effectiveness of the medication is calculated by comparison to predetermined threshold values.
摘要翻译：用于确定在具有ADHD的个体中治疗注意力缺陷多动障碍（ADHD）的药物的适当剂量的方法。该方法包括当个体处于感觉剥夺状态时在预定时间间隔期间对个体的左右四肢的周边皮肤温度进行采样，以提供相应的左和右采样的外周皮肤温度数据，处理采样的外周皮肤温度数据 ; 处理采样的外围皮肤温度数据，包括滤波，微分和转换到频域，以导出其幅度表示ADHD表现水平的光谱特征。通过与预定阈值进行比较来计算药物的有效性。

2. 发明授权

US06843774B2 Technique for diagnosing attention deficit hyperactivity disorder 失效
标题翻译：诊断注意缺陷多动障碍的技术
公开(公告)号：US06843774B2
公开(公告)日：2005-01-18
申请号：US10301072
申请日：2002-11-21
申请人： Gregory B. Foust , David L. Patton , Richard N. Blazey , Paige Miller
发明人： Gregory B. Foust , David L. Patton , Richard N. Blazey , Paige Miller
IPC分类号： A61B5/01 , A61B5/00 , A61B5/16 , A61B10/00
CPC分类号： A61B5/01 , A61B5/168 , A61B5/7257 , A61B5/726
摘要： This invention features a method of determining whether an individual has Attention Deficit Hyperactivity Disorder by sampling the peripheral skin temperature of an individual in an inactive state and manipulating the resulting temperature data to produce a value which is indicative of whether or not the individual has ADHD.
摘要翻译：本发明的特征在于一种通过对处于非活动状态的个体的外周皮肤温度进行取样来确定个体是否具有注意缺陷多动障碍的方法，并且操纵所产生的温度数据以产生指示个体是否具有ADHD的值。

3. 发明授权

US06743182B2 Method for determining attention deficit hyperactivity disorder (ADHD) medication dosage and for monitoring the effects of (ADHD) medication 失效
标题翻译：确定注意力缺陷多动障碍（ADHD）药物用量和监测（ADHD）药物效果的方法
公开(公告)号：US06743182B2
公开(公告)日：2004-06-01
申请号：US10301401
申请日：2002-11-21
申请人： Paige Miller , David L. Patton , Richard N. Blazey
发明人： Paige Miller , David L. Patton , Richard N. Blazey
IPC分类号： A61B500
CPC分类号： A61B5/01 , A61B3/113 , A61B5/0002 , A61B5/168 , A61B5/7257 , A61B5/726 , G06F19/00 , G16H15/00
摘要： A method for determining the appropriate dosage of a medication to treat Attention Deficit Hyperactivity Disorder (ADHD) in an individual who has ADHD comprising: sampling the peripheral skin temperature of a human subject during a predetermined time interval when the subject is in an inactive state to provide sampled peripheral skin temperature data; analyzing the sampled peripheral skin temperature data for a pre-selected parameter to determine whether the pre-selected parameter has a value indicative of ADHD; and determining the proper dosage of a medication to treat ADHD based upon the determined value of the pre-selected parameter. At a time subsequent to administering the dosage, it is determined if a previously administered dosage of a medication is effective at removing the effects of ADHD as measured by this pre-selected parameter.
摘要翻译：一种用于确定在具有ADHD的个体中治疗注意力缺陷多动障碍（ADHD）的药物的适当剂量的方法，包括：在受试者处于非活动状态的预定时间间隔内对人类受试者的外周皮肤温度进行取样，提供取样的周边皮肤温度数据; 分析采样的外围皮肤温度数据以获得预选参数，以确定预先选择的参数是否具有指示ADHD的值; 以及基于所确定的预先选择的参数值，确定用于治疗ADHD的药物的适当剂量。在施用剂量之后的一段时间，确定先前给药的药物剂量是否有效除去通过该预选参数测量的ADHD的作用。

4. 发明申请

US20050025704A1 Method and apparatus for determining attention deficit hyperactivity disorder (ADHD) medication dosage and for monitoring the effects of ADHD medication on people who have ADHD using complementary tests 失效
标题翻译：用于确定注意力缺陷多动障碍（ADHD）药物用量的方法和装置，并用于使用补充测试监测ADHD药物对ADHD患者的影响
公开(公告)号：US20050025704A1
公开(公告)日：2005-02-03
申请号：US10832824
申请日：2004-04-27
申请人： Richard Keirsbilck , Peter Parks , David Patton , Richard Blazey , Paige Miller
发明人： Richard Keirsbilck , Peter Parks , David Patton , Richard Blazey , Paige Miller
IPC分类号： A61B5/00 , A61B5/01 , A61B5/16 , A61B10/00 , A61K49/00 , A61K31/445
CPC分类号： A61B5/01 , A61B5/168 , A61B5/7257 , A61B5/726 , G06F19/00
摘要： A method for determining the appropriate dosage of a medication to treat Attention Deficit Hyperactivity Disorder (ADHD) in an individual who has ADHD. The method comprises sampling the peripheral skin temperature of left and right like extremities of an individual during a predetermined time interval when the individual is in a sensory deprived state to provide respective left and right sampled peripheral skin temperature data, processing the sampled peripheral skin temperature data; processing the sampled peripheral skin temperature data including filtering, differentiation, and conversion to the frequency domain to derive spectral signatures whose magnitudes are indicative of the level of ADHD manifestation. The effectiveness of the medication is calculated by comparison to predetermined threshold values.
摘要翻译：用于确定在具有ADHD的个体中治疗注意力缺陷多动障碍（ADHD）的药物的适当剂量的方法。该方法包括当个体处于感觉剥夺状态时在预定时间间隔期间对个体的左右四肢的周边皮肤温度进行采样，以提供相应的左和右采样的外周皮肤温度数据，处理采样的外周皮肤温度数据 ; 处理采样的外围皮肤温度数据，包括滤波，微分和转换到频域，以导出其幅度表示ADHD表现水平的光谱特征。通过与预定阈值进行比较来计算药物的有效性。

5. 发明授权

US06565518B2 Technique for diagnosing attention deficit hyperactivity disorder 失效
标题翻译：诊断注意缺陷多动障碍的技术
公开(公告)号：US06565518B2
公开(公告)日：2003-05-20
申请号：US09865902
申请日：2001-05-25
申请人： Richard N. Blazey , Peter A. Parks , David L. Patton , Paige Miller
发明人： Richard N. Blazey , Peter A. Parks , David L. Patton , Paige Miller
IPC分类号： A61B500
CPC分类号： A61B5/01 , A61B5/168 , A61B5/7257 , A61B5/726
摘要： A method for determining a threshold value of a parameter used to determine whether an individual has Attention Deficit Hyperactivity Disorder (ADHD). The method includes: providing a group of individuals a segment of which is known to have ADHD and a segment of which is known to be normal and not have ADHD; testing each individual in the group by sampling the peripheral skin temperature of the individual during a pre-determined time interval when the individual is in an inactive state to provide sampled peripheral skin temperature data, and analyzing the sampled peripheral skin data to produce a parameter value for that individual. The method further includes: processing the individual parameter values for all of the members of the group to determine a threshold parameter value which is acceptable for determining whether or not an individual has ADHD when tested by the testing procedure.
摘要翻译：用于确定用于确定个体是否具有注意缺陷多动障碍（ADHD）的参数的阈值的方法。该方法包括：提供一组个体，其一部分已知具有ADHD，其一部分已知是正常的且没有ADHD; 通过在个体处于非活动状态的预定时间间隔期间对个体的周边皮肤温度进行采样来提供组中的每个个体以提供采样的周边皮肤温度数据，并分析采样的外围皮肤数据以产生参数值对于那个人所述方法还包括：处理组的所有成员的各个参数值，以确定当通过测试程序测试时可以判断个体是否具有ADHD的阈值参数值。

6. 发明授权

US06726624B2 METHOD AND APPARATUS FOR DETERMINING ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD) MEDICATION DOSAGE AND FOR MONITORING THE EFFECTS OF ADHD MEDICATION ON PEOPLE WHO HAVE ADHD USING COMPLEMENTARY TESTS 失效
标题翻译：用于确定缺陷性高血压疾病（ADHD）药物剂量和用于监测ADHD药物对具有ADHD的患者使用补充测试的方法和装置
公开(公告)号：US06726624B2
公开(公告)日：2004-04-27
申请号：US10092284
申请日：2002-03-06
申请人： Richard S. Keirsbilck , Peter A. Parks , David L. Patton , Richard N. Blazey , Paige Miller
发明人： Richard S. Keirsbilck , Peter A. Parks , David L. Patton , Richard N. Blazey , Paige Miller
IPC分类号： A61B500
CPC分类号： A61B5/01 , A61B5/168 , A61B5/7257 , A61B5/726 , G06F19/00
摘要： A method for determining the appropriate dosage of a medication to treat Attention Deficit Hyperactivity Disorder (ADHD) in an individual who has ADHD. The method comprises sampling the peripheral skin temperature of left and right like extremities of an individual during a predetermined time interval when the individual is in a sensory deprived state to provide respective left and right sampled peripheral skin temperature data; processing the sampled peripheral skin temperature data; processing the sampled peripheral skin temperature data including filtering, differentiation, and conversion to the frequency domain to derive spectral signatures whose magnitudes are indicative of the level of ADHD manifestation. The effectiveness of the medication is calculated by comparison to predetermined threshold values.
摘要翻译：用于确定在具有ADHD的个体中治疗注意力缺陷多动障碍（ADHD）的药物的适当剂量的方法。该方法包括当个体处于感觉剥夺状态时在预定时间间隔期间对个体的左右四肢的周边皮肤温度进行采样，以提供相应的左和右采样的外周皮肤温度数据; 处理采样的外围皮肤温度数据; 处理采样的外围皮肤温度数据，包括滤波，微分和转换到频域，以导出其幅度表示ADHD表现水平的光谱特征。通过与预定阈值进行比较来计算药物的有效性。

7. 发明授权

US06520921B1 Method for determining attention deficit hyperactivity disorder (ADHD) medication dosage and for monitoring the effects of (ADHD) medication 失效
标题翻译：确定注意力缺陷多动障碍（ADHD）药物用量和监测（ADHD）药物效果的方法
公开(公告)号：US06520921B1
公开(公告)日：2003-02-18
申请号：US09865329
申请日：2001-05-25
申请人： David L. Patton , Paige Miller , Richard N. Blazey
发明人： David L. Patton , Paige Miller , Richard N. Blazey
IPC分类号： A61B500
CPC分类号： A61B5/01 , A61B3/113 , A61B5/0002 , A61B5/168 , A61B5/7257 , A61B5/726 , G06F19/00 , G16H15/00
摘要： A method for determining the appropriate dosage of a medication to treat Attention Deficit Hyperactivity Disorder (ADHD) in an individual who has ADHD comprising: sampling the peripheral skin temperature of a human subject during a predetermined time interval when the subject is in an inactive state to provide sampled peripheral skin temperature data; analyzing the sampled peripheral skin temperature data for a pre-selected parameter to determine whether the pre-selected parameter has a value indicative of ADHD; and determining the proper dosage of a medication to treat ADHD based upon the determined value of the pre-selected parameter.
摘要翻译：一种用于确定在具有ADHD的个体中治疗注意力缺陷多动障碍（ADHD）的药物的适当剂量的方法，包括：在受试者处于非活动状态的预定时间间隔内对人类受试者的外周皮肤温度进行取样，提供取样的周边皮肤温度数据; 分析采样的外围皮肤温度数据以获得预选参数，以确定预先选择的参数是否具有指示ADHD的值; 以及基于所确定的预先选择的参数值，确定用于治疗ADHD的药物的适当剂量。

8. 发明授权

US06309342B1 Management of physiological and psychological state of an individual using images biometric analyzer 失效
标题翻译：使用图像生物识别分析仪管理个体的生理和心理状态
公开(公告)号：US06309342B1
公开(公告)日：2001-10-30
申请号：US09430445
申请日：1999-10-29
申请人： Richard N. Blazey , Paige Miller , Elena A. Fedorovskaya , Girish V. Prabhu , Peter A. Parks , David L. Patton , John R. Fredlund , Cecelia M. Horwitz , Jose M. Mir
发明人： Richard N. Blazey , Paige Miller , Elena A. Fedorovskaya , Girish V. Prabhu , Peter A. Parks , David L. Patton , John R. Fredlund , Cecelia M. Horwitz , Jose M. Mir
IPC分类号： A61M2100
CPC分类号： A61B5/486 , A61B5/16 , A61B5/7257 , A61B5/7264 , G06F19/00
摘要： A method of determining the physiological reactivity of an individual with respect to images, comprising: measuring at least one physiological parameter of an individual during a baseline calm period of time; measuring the said at least one physiological parameter of said individual during a stress period of time and a succeeding rest period of time; dividing said measured data for each of said periods of time into a plurality of predetermined time segments; computing a histogram or Fourier analysis as appropriate on said predetermined time segments for each said period of time; standardizing said computed data; conducting a principal component analysis, a canonical discriminant analysis, or a neural network, on said data to establish a baseline calm or rest period set of scores and a stress period set of scores; measuring the said at least one physiological parameter of said individual during an image presentation period of time; repeating said time segmenting, said histogram or Fourier analysis, and said standardizing steps on said measured physiological data for said image presentation period of time; applying said vectors from said conducting step to said image data to produce an image set of scores which are compared with said baseline and stress sets of scores; and determining whether said presented image is activating, deactivating, or neutral based on said comparison.
摘要翻译：一种确定个体相对于图像的生理反应性的方法，包括：在基线平静时段期间测量个体的至少一个生理参数; 在压力时间段和随后的休息时间段内测量所述个体的所述至少一个生理参数; 将所述每个所述时间段的测量数据划分成多个预定时间段; 在每个所述时间段内在所述预定时间段上适当地计算直方图或傅立叶分析; 对所述计算数据进行标准化; 对所述数据进行主成分分析，规范判别分析或神经网络，以建立基准平静或休息期分数集合和压力周期分数集合; 在图像呈现期间测量所述个体的所述至少一个生理参数; 重复所述时间分割，所述直方图或傅立叶分析，以及针对所述图像呈现时间段的所述测量的生理数据的所述标准化步骤; 将来自所述导电步骤的所述矢量应用于所述图像数据，以产生与所述基线和所述分数的应力集进行比较的分数的图像集合; 以及基于所述比较来确定所述呈现的图像是激活，去激活还是中立。

9. 发明授权

US06293904B1 Management of physiological and psychological state of an individual using images personal image profiler 失效
标题翻译：使用图像个人图像分析器管理个人的生理和心理状态
公开(公告)号：US06293904B1
公开(公告)日：2001-09-25
申请号：US09429975
申请日：1999-10-29
申请人： Richard N. Blazey , Paige Miller , Elena A. Fedorovskaya , Girish V. Prabhu , Peter A. Parks , David L. Patton , John R. Fredlund , Cecelia M. Horwitz , Jose M. Mir
发明人： Richard N. Blazey , Paige Miller , Elena A. Fedorovskaya , Girish V. Prabhu , Peter A. Parks , David L. Patton , John R. Fredlund , Cecelia M. Horwitz , Jose M. Mir
IPC分类号： A61M2100
CPC分类号： A61B5/486 , A61B5/16 , A61B5/7257 , A61B5/7264 , G06F19/00
摘要： A method of generating a personal image profile based on an individual's physiological and cognitive state compromising: presenting a master set of images to an individual wherein each image in the master set is characterized by a set of scene and image related classifiers that are relevant to producing an effect on an individual; measuring and recording one or more of said individual's physiological parameters while viewing a presented image; measuring the individual's cognitive state from cognitive responses to each presented image; and generating a personal image profile of the individual based on combining the physiological and cognitive measures from said measuring steps, said personal image profile including image classifiers for identifying activating or deactivating images for said individuals.
摘要翻译：一种基于个人的生理和认知状态妥协产生个人图像简档的方法：向个体呈现主组图像，其中主集中的每个图像的特征在于与生成相关的一组场景和图像相关分类器对个人的影响在观看所呈现的图像的同时测量和记录所述个体的生理参数中的一个或多个; 从每个呈现的图像的认知反应测量个体的认知状态; 以及基于从所述测量步骤组合所述生理和认知措施来生成所述个人的个人图像简档，所述个人图像简档包括用于识别所述个人的激活或去激活图像的图像分类器。

10. 发明申请

US20050113713A1 Technique for diagnosing attention deficit hyperactivity disorder 审中-公开
标题翻译：诊断注意缺陷多动障碍的技术
公开(公告)号：US20050113713A1
公开(公告)日：2005-05-26
申请号：US11025460
申请日：2004-12-29
申请人： Gregory Foust , David Patton , Richard Blazey , Paige Miller
发明人： Gregory Foust , David Patton , Richard Blazey , Paige Miller
IPC分类号： A61B5/01 , A61B5/00 , A61B5/16 , A61B10/00 , G06F17/00
CPC分类号： A61B5/01 , A61B5/168 , A61B5/7257 , A61B5/726
摘要： A method for determining a threshold value of a parameter used to determine whether an individual has Attention Deficit Hyperactivity Disorder (ADHD) comprising: providing a group of individuals a segment of which is known to have ADHD and a segment of which is known to be normal and not have ADHD; testing each individual in the group by sampling the peripheral skin temperature of the individual during a pre-determined time interval when the subject is in an inactive state to provide sampled peripheral skin temperature data, and analyzing the sampled peripheral skin data to produce a parameter value for that individual; and processing the individual parameter values for all of the members of the group to determine a threshold parameter value which is acceptable for determining whether or not an individual has ADHD when tested by said testing procedure.
摘要翻译：一种用于确定用于确定个体是否具有注意缺陷多动障碍（ADHD）的参数的阈值的方法，包括：提供一组个体，其一部分已知具有ADHD并且其部分已知是正常的没有ADHD; 通过在受试者处于非活动状态的预定时间间隔期间对个体的外周皮肤温度进行取样来测试组中的每个个体，以提供采样的周边皮肤温度数据，以及分析采样的外围皮肤数据以产生参数值对于那个人以及处理所述组的所有成员的各个参数值，以确定当通过所述测试程序测试时，用于确定个体是否具有ADHD的可接受的阈值参数值。

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