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1. 发明授权

US08519708B2 Small magnet and RF coil for magnetic resonance relaxometry 有权
标题翻译：小磁铁和射频线圈用于磁共振放松测量
公开(公告)号：US08519708B2
公开(公告)日：2013-08-27
申请号：US12741789
申请日：2008-11-06
申请人： Pablo J. Prado , Thomas J. Lowery, Jr.
发明人： Pablo J. Prado , Thomas J. Lowery, Jr.
IPC分类号： G01V3/00
CPC分类号： G01R33/448 , G01N24/08 , G01R33/243 , G01R33/302 , G01R33/307 , G01R33/34053 , G01R33/3806 , G01R33/383 , G01R33/44 , G01R33/465
摘要： Small and inexpensive probeheads for use in nuclear magnetic resonance systems, in particular, magnetic resonance relaxometry systems are provided. The design of the magnet-radiofrequency coil configurations within the probeheads is guided by an excitation bandwidth associated with radiofrequency pulses to be applied to a sample.
摘要翻译：提供了用于核磁共振系统的小型廉价的探头，特别是磁共振弛豫系统。探头内的磁 - 射频线圈配置的设计由与要施加到样品的射频脉冲相关联的激发带宽引导。

2. 发明申请

US20140225614A1 DETECTING HAZARDOUS MATERIALS IN CONTAINERS UTILIZING NUCLEAR MAGNETIC RESONANCE BASED MEASUREMENTS 审中-公开
标题翻译：使用核磁共振测量检测集装箱中的危险材料
公开(公告)号：US20140225614A1
公开(公告)日：2014-08-14
申请号：US14345917
申请日：2012-09-02
申请人： Pablo J. Prado
发明人： Pablo J. Prado
IPC分类号： G01N24/08 , G01R33/46
CPC分类号： G01N24/084 , G01R33/448 , G01R33/4616
摘要： A method of detecting hazardous materials in containers utilizing nuclear magnetic resonance (NMR) technology. The presence of precursors (e.g., H202) and/or nitrogen in the liquid in the container is determined by placing the container in a static magnetic field, exciting the container with electromagnetic pulses having a frequency corresponding to proton NMR and 14N NMR, and receiving radio frequency (RF) signals through a probe. The excitation pulses are configured to enable detection of the presence of precursors and nitrogen in the container, and may comprise a sequence of short RF pulses. The presence of nitrogen and/or explosive precursors is determined by detecting and evaluating NMR measurement signal amplitudes and relaxation times from the received RF signals. An apparatus comprising a magnet that generates a magnetic field and a probe that generates RF pulses and receives NMR measurement signals from the sampled container in accordance with the aforementioned method.
摘要翻译：一种使用核磁共振（NMR）技术检测容器中有害物质的方法。通过将容器放置在静态磁场中来确定容器中液体中的前体（例如H 2 O 2）和/或氮的存在，用具有对应于质子NMR和14N NMR的频率的电磁脉冲激发容器，并接收射频（RF）信号通过探头。激励脉冲被配置为能够检测容器中前体和氮的存在，并且可以包括短的RF脉冲序列。通过从接收的RF信号中检测和评估NMR测量信号幅度和弛豫时间来确定氮和/或爆炸性前体的存在。一种包括产生磁场的磁体和产生RF脉冲并根据上述方法从采样容器接收NMR测量信号的探针的装置。

3. 发明申请

US20100308822A1 Small Magnet and RF Coil for Magnetic Resonance Relaxometry 有权
标题翻译：用于磁共振放松测量的小磁体和RF线圈
公开(公告)号：US20100308822A1
公开(公告)日：2010-12-09
申请号：US12741789
申请日：2008-11-06
申请人： Pablo J. Prado , Thomas J. Lowery
发明人： Pablo J. Prado , Thomas J. Lowery
IPC分类号： G01R33/44
CPC分类号： G01R33/448 , G01N24/08 , G01R33/243 , G01R33/302 , G01R33/307 , G01R33/34053 , G01R33/3806 , G01R33/383 , G01R33/44 , G01R33/465
摘要： Small and inexpensive probeheads for use in nuclear magnetic resonance systems, in particular, magnetic resonance relaxometry systems are provided. The design of the magnet-radiofrequency coil configurations within the probeheads is guided by an excitation bandwidth associated with radiofrequency pulses to be applied to a sample.
摘要翻译：提供了用于核磁共振系统的小型廉价的探头，特别是磁共振弛豫系统。探头内的磁 - 射频线圈配置的设计由与要施加到样品的射频脉冲相关联的激发带宽引导。

4. 发明授权

US06977503B2 System and method for single-sided magnetic resonance imaging 失效
标题翻译：单侧磁共振成像的系统和方法
公开(公告)号：US06977503B2
公开(公告)日：2005-12-20
申请号：US10361410
申请日：2003-02-10
申请人： Pablo J. Prado
发明人： Pablo J. Prado
IPC分类号： G01R33/38 , G01R33/48 , G01V3/00
CPC分类号： G01R33/3806 , G01R33/48
摘要： A magnetic resonance imaging apparatus and method having a magnet assembly, which provides substantially flat surfaces of constant magnetic field outside the assembly and a set of magnetic field gradients. One-, two-, and three-dimensional images are rendered. The static magnetic field is virtually uniform within horizontal degrees of freedom and decreases monotonically in a direction away from the surface. An RF probe, for example, a coil, located adjacent the surface, produces a field substantially perpendicular to the static magnetic field. A magnetic field gradient is set to horizontally scan a given level within the sensitive volume. Received magnetic resonance signals are detected by the coil for a depth corresponding to the excitation frequency. As the tuning and excitation frequency is switched to lower values, signals are generated for layers progressively farther from the surface. The RF probe is automatically tuned. Depth profiles are rendered by concatenating the signals collected at various frequencies. Horizontal resolution is attained by the use of controlled magnetic field gradients.
摘要翻译：一种具有磁体组件的磁共振成像装置和方法，该磁体组件在组件外部提供基本平坦的恒定磁场表面和一组磁场梯度。渲染一维，二维和三维图像。静态磁场在水平自由度内几乎是均匀的，并且在远离表面的方向上单调减小。位于邻近表面的RF探针，例如线圈，产生基本垂直于静磁场的场。设置磁场梯度以水平扫描敏感体积内的给定水平。接收到的磁共振信号被线圈检测到与激励频率对应的深度。随着调谐和激励频率被切换到较低的值，对于逐渐离开表面的层，生成信号。 RF探头自动调谐。通过连接以各种频率收集的信号来渲染深度分布。通过使用受控磁场梯度可以获得水平分辨率。

5. 发明授权

US06489767B1 Apparatus for and method of single-sided magnetic resonance imaging with palm-size probe 失效
标题翻译：手掌式探头单侧磁共振成像装置及方法
公开(公告)号：US06489767B1
公开(公告)日：2002-12-03
申请号：US09655739
申请日：2000-09-06
申请人： Pablo J. Prado , Bernhard Blümich
发明人： Pablo J. Prado , Bernhard Blümich
IPC分类号： G01V300
CPC分类号： G01R33/383 , G01R33/3808
摘要： An apparatus for and a method of single-sided MRI with a palm-sized probe. The probe includes a planar permanent magnet having a gap between the north and south poles of the magnet. Positioned in the gap are an RF coil and a pair of gradient coils. The gradient coils are located on either side of the RF coil. The probe further includes an RF tuning circuit and a gradient input. In use, the pair of gradient coils produce a controlled magnetic field gradient over the field of view thereby improving image resolution.
摘要翻译：用于手掌大小的探针的单侧MRI的装置和方法。探头包括在磁体的北极和南极之间具有间隙的平面永磁体。位于间隙中的是RF线圈和一对梯度线圈。梯度线圈位于RF线圈的任一侧。探头还包括RF调谐电路和梯度输入。在使用中，该对梯度线圈在视场上产生受控的磁场梯度，从而提高图像分辨率。

6. 发明授权

US09575019B2 Detecting hazardous materials in containers utilizing nuclear magnetic resonance based measurements 有权
标题翻译：使用基于核磁共振的测量法检测容器中的危险物质
公开(公告)号：US09575019B2
公开(公告)日：2017-02-21
申请号：US14345917
申请日：2012-09-02
申请人： Pablo J. Prado
发明人： Pablo J. Prado
IPC分类号： G01V3/00 , G01N24/08 , G01R33/44 , G01R33/46
CPC分类号： G01N24/084 , G01R33/448 , G01R33/4616
摘要： A method of detecting hazardous materials in containers utilizing nuclear magnetic resonance (NMR) technology. The presence of precursors (e.g., H202) and/or nitrogen in the liquid in the container is determined by placing the container in a static magnetic field, exciting the container with electromagnetic pulses having a frequency corresponding to proton NMR and 14N NMR, and receiving radio frequency (RF) signals through a probe. The excitation pulses are configured to enable detection of the presence of precursors and nitrogen in the container, and may comprise a sequence of short RF pulses. The presence of nitrogen and/or explosive precursors is determined by detecting and evaluating NMR measurement signal amplitudes and relaxation times from the received RF signals. An apparatus comprising a magnet that generates a magnetic field and a probe that generates RF pulses and receives NMR measurement signals from the sampled container in accordance with the aforementioned method.
摘要翻译：一种使用核磁共振（NMR）技术检测容器中有害物质的方法。通过将容器放置在静态磁场中来确定容器中液体中的前体（例如H 2 O 2）和/或氮的存在，用具有对应于质子NMR和14N NMR的频率的电磁脉冲激发容器，并接收射频（RF）信号通过探头。激励脉冲被配置为能够检测容器中前体和氮的存在，并且可以包括短的RF脉冲序列。通过从接收的RF信号中检测和评估NMR测量信号幅度和弛豫时间来确定氮和/或爆炸性前体的存在。一种包括产生磁场的磁体和产生RF脉冲并根据上述方法从采样容器接收NMR测量信号的探针的装置。

7. 发明申请

US20120223705A1 MAGNETIC RESONANCE SYSTEM WITH IMPLANTABLE COMPONENTS AND METHODS OF USE THEREOF 审中-公开
标题翻译：具有可植入组件的磁共振系统及其使用方法
公开(公告)号：US20120223705A1
公开(公告)日：2012-09-06
申请号：US12809424
申请日：2008-12-19
申请人： Thomas J. Lowery , Pablo J. Prado
发明人： Thomas J. Lowery , Pablo J. Prado
IPC分类号： G01R33/44
CPC分类号： G01R33/285 , A61B5/055 , A61B5/413 , G01R33/281 , G01R33/34046 , G01R33/34084 , G01R33/341 , G01R33/36 , G01R33/3692 , G01R33/3808 , G01R33/465
摘要： Nuclear magnetic resonance systems and methods of use thereof are provided. The systems employ implantable radiofrequency coils (105) and optionally implantable magnets (101). The systems can employ weak permanent magnets and/or permanent magnets that provide magnetic fields that are much less homogeneous than in conventional systems. This allows, for example, for inexpensive and simple probeheads for nuclear magnetic resonance relaxometry with suitable biosensors. The methods of the present invention allow in-vivo magnetic resonance measurements and, in particular, monitoring of analytes and determination of medical diagnostic information, for example, based on determined magnetic resonance parameters.
摘要翻译：提供了核磁共振系统及其使用方法。该系统采用可植入射频线圈（105）和任选的可植入磁体（101）。这些系统可以采用弱永磁体和/或永磁体，其提供比常规系统小得多的磁场。这允许例如用于具有合适的生物传感器的用于核磁共振放大测量的便宜且简单的探针头。本发明的方法允许体内磁共振测量，特别是基于确定的磁共振参数来监测分析物和医学诊断信息的确定。

8. 发明授权

US07759938B2 Apparatus and method for varying magnetic field strength in magnetic resonance measurements 失效
标题翻译：在磁共振测量中改变磁场强度的装置和方法
公开(公告)号：US07759938B2
公开(公告)日：2010-07-20
申请号：US11966331
申请日：2007-12-28
申请人： Pablo J. Prado , Sankaran Kumar , Erik Edmund Magnuson
发明人： Pablo J. Prado , Sankaran Kumar , Erik Edmund Magnuson
IPC分类号： G01V3/00
CPC分类号： G01R33/3806 , G01N24/08 , G01R33/3802 , G01R33/383 , H01F7/0278
摘要： Apparatus and method for varying field strength in a magnetic resonance system while keeping a relatively uniform magnetic field distribution. In an embodiment, a two-pole, generally u-shaped magnet assembly generates a static and uniform magnetic field. The magnet assembly includes two facing magnet poles separated by an air gap. Holes may be formed with the magnet poles. The field control rods may be placed at a pre-determined distance into these holes and symmetrically or asymmetrically moved across each magnet poles in a controlled manner to change the magnetic field strength while keeping the uniform magnetic field distribution. Maximum magnetic field strength may occur when the rods are removed. Minimum magnetic field strength may occur when the rods are fully inserted.
摘要翻译：在磁共振系统中改变场强的装置和方法，同时保持相对均匀的磁场分布。在一个实施例中，两极通常为u形的磁体组件产生静态和均匀的磁场。磁体组件包括由气隙分开的两个面对的磁极。孔可以形成有磁极。现场控制棒可以以预定距离放置在这些孔中，并且以受控的方式对称地或不对称地移动穿过每个磁极，以改变磁场强度同时保持均匀的磁场分布。当杆被去除时，可能会发生最大的磁场强度。当杆完全插入时，可能会发生最小的磁场强度。

9. 发明申请

US20090167304A1 APPARATUS AND METHOD FOR VARYING MAGNETIC FIELD STRENGTH IN MAGNETIC RESONANCE MEASUREMENTS 失效
标题翻译：用于改变磁共振测量中磁场强度的装置和方法
公开(公告)号：US20090167304A1
公开(公告)日：2009-07-02
申请号：US11966331
申请日：2007-12-28
申请人： Pablo J. PRADO , Sankaran Kumar , Erik Edmund Magnuson
发明人： Pablo J. PRADO , Sankaran Kumar , Erik Edmund Magnuson
IPC分类号： G01V3/00 , H01F7/02
CPC分类号： G01R33/3806 , G01N24/08 , G01R33/3802 , G01R33/383 , H01F7/0278
摘要： Apparatus and method for varying field strength in a magnetic resonance system while keeping a relatively uniform magnetic field distribution. In an embodiment, a two-pole, generally u-shaped magnet assembly generates a static and uniform magnetic field. The magnet assembly includes two facing magnet poles separated by an air gap. Holes may be formed with the magnet poles. The field control rods may be placed at a pre-determined distance into these holes and symmetrically or asymmetrically moved across each magnet poles in a controlled manner to change the magnetic field strength while keeping the uniform magnetic field distribution. Maximum magnetic field strength may occur when the rods are removed. Minimum magnetic field strength may occur when the rods are fully inserted.
摘要翻译：在磁共振系统中改变场强的装置和方法，同时保持相对均匀的磁场分布。在一个实施例中，两极通常为u形的磁体组件产生静态和均匀的磁场。磁体组件包括由气隙分开的两个面对的磁极。孔可以形成有磁极。现场控制棒可以以预定的距离放置在这些孔中，并以受控方式对称或不对称地移动穿过每个磁极，以改变磁场强度同时保持均匀的磁场分布。当杆被去除时，可能会发生最大的磁场强度。当杆完全插入时，可能会发生最小的磁场强度。

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