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1. 发明授权

US5571901A Insecticide and miticide compositions containing A83543 compounds 失效
标题翻译：含有A83543化合物的杀虫剂和杀螨剂组合物
公开(公告)号：US5571901A
公开(公告)日：1996-11-05
申请号：US479500
申请日：1995-06-07
申请人： LaVerne D. Boeck , Hang Chio , Tom E. Eaton , Otis W. Godfrey, Jr. , Karl H. Michel , Walter M. Nakatsukasa , Raymond C. Yao
发明人： LaVerne D. Boeck , Hang Chio , Tom E. Eaton , Otis W. Godfrey, Jr. , Karl H. Michel , Walter M. Nakatsukasa , Raymond C. Yao
IPC分类号： A01N43/22 , A01N43/90 , C07H17/08 , C12N1/20 , C12P1/06 , C12P19/62 , C12R1/01 , C07H7/06
CPC分类号： C07H17/08 , C12N1/20 , C12P1/06 , C12P19/62 , Y10S435/822
摘要： Fermentation product A83543, comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A83543F, A83543G, A83543H and A83543J, is produced by a newly described species, Saccharopolyspora spinosa. The A83543 components and their acid-addition salts (A83543 compounds) are useful as insecticides, particularly against Lepidoptera and Diptera species. Insecticidal, miticidal or ectoparasiticidal combinations, compositions and methods are provided.
摘要翻译：包含主要成分A83543A和A83543D以及次要成分A83543B，A83543C，A83543E，A83543F，A83543G，A83543H和A83543J的发酵产品A83543由新描述的种类，酿酒酵母（Saccharopolyspora spinosa）生产。 A83543组分及其酸加成盐（A83543化合物）可用作杀虫剂，特别是鳞翅目和双翅目物种。提供杀虫，杀螨或外寄生疫苗组合，组合物和方法。

2. 发明授权

US5292647A Strain of streptomyces for producing avermectins and processes therewith 失效
标题翻译：用于产生除虫菌素的链霉菌的菌株和其过程
公开(公告)号：US5292647A
公开(公告)日：1994-03-08
申请号：US984078
申请日：1992-11-30
申请人： Rosanne Bonjouklian , Otis W. Godfrey , Tim A. Smitka , Raymond C. Yao
发明人： Rosanne Bonjouklian , Otis W. Godfrey , Tim A. Smitka , Raymond C. Yao
IPC分类号： C12N1/20 , A61K31/7048 , A61P33/00 , C12P1/06 , C12P17/08 , C12P17/18 , C12P19/62 , C12R1/465 , A01N43/02 , C12P17/02
CPC分类号： C12R1/465 , C12P19/623
摘要： A new microorganism, Streptomyces avermitilis subspecies niger NRRL 21005, and processes using the microorganism for producing known avermectins are provided.
摘要翻译：提供了一种新的微生物，阿维链霉菌亚种Niger NRRL 21005，以及使用微生物生产已知的除虫菌素的方法。

3. 发明授权

US4180564A A-38533 Antibiotics and process for production thereof 失效
标题翻译： A-38533抗生素及其生产方法
公开(公告)号：US4180564A
公开(公告)日：1979-12-25
申请号：US909582
申请日：1978-05-25
申请人： Otis W. Godfrey , Ronald D. Johnson , Ralph E. Kastner
发明人： Otis W. Godfrey , Ronald D. Johnson , Ralph E. Kastner
IPC分类号： C07G11/00 , A61K35/74 , A61K38/00 , A61P31/04 , C07K4/04 , C12P1/06 , A61K35/00
CPC分类号： C07K4/04 , C12P1/06 , A61K38/00 , Y10S435/886
摘要： Antibiotic A-38533 complex, comprising microbiologically active, related factors A.sub.1, A.sub.2, B and C, is produced by submerged, aerobic fermentation of a new Streptomyces sp., NRRL 11298. The A-38533 antibiotics are closely related antibiotics. The individual A-38533 factors are separated by chromatography. The A-38533 factors are antibacterial agents which have a unique activity against Pseudomonas species.
摘要翻译：抗生素A-38533复合物，包括微生物活性相关因子A1，A2，B和C，通过新型链霉菌属，NRRL 11298的浸没式好氧发酵产生.A-38533抗生素是紧密相关的抗生素。单独的A-38533因子通过色谱分离。 A-38533因子是对假单胞菌属物种具有独特活性的抗菌剂。

4. 发明授权

US4745068A Dispersion tool 失效
标题翻译：分散工具
公开(公告)号：US4745068A
公开(公告)日：1988-05-17
申请号：US44150
申请日：1987-04-30
申请人： Otis W. Godfrey , Walter A. Raas , James R. Ayres
发明人： Otis W. Godfrey , Walter A. Raas , James R. Ayres
IPC分类号： B01F7/00 , B01F13/10 , B01F15/00 , C12M3/08 , C12M1/02
CPC分类号： B01F15/00012 , B01F13/1041 , B01F7/00816 , B01F2013/108
摘要： A device for homogenizing a liquid containing a mixture of single cells and cell clusters is provided. The device includes a shroud for channeling the liquid and suspended particles. The shroud defines an inner bore that is formed to include an axial inlet opening and at least one spaced apart outlet opening. A homogenizing bit is provided that is disposed within the inner bore for dispersing the suspended particles in the liquid to form a homogenized substance. The bit includes a shear blade fixed to the bit at a location near the axial inlet opening, with the shear blade configured to cooperate with adjacent shear ports to shear a portion of the suspended particles. The bit also includes a spiral portion that is configured to draw the liquid and suspended particles axially into and through the inner bore from the inlet opening.
摘要翻译：提供了用于使含有单细胞和细胞簇的混合物的液体均质化的装置。该装置包括用于引导液体和悬浮颗粒的护罩。护罩限定内孔，其形成为包括轴向入口开口和至少一个间隔开的出口开口。提供均质钻头，其设置在内孔内，用于将悬浮颗粒分散在液体中以形成均质物质。该钻头包括固定在靠近轴向入口开口的位置处的钻头的剪切刀片，剪切刀片被配置成与相邻的剪切端口配合以剪切一部分悬浮颗粒。钻头还包括螺旋部分，其被构造成从入口开口将液体和悬浮颗粒轴向地吸入和穿过内孔。

5. 发明授权

US5496931A Insecticide and miticide A83543 compounds and their method of production by fermentation 失效
标题翻译：杀虫剂和杀螨剂A83543化合物及其发酵方法
公开(公告)号：US5496931A
公开(公告)日：1996-03-05
申请号：US406760
申请日：1995-03-17
申请人： LaVerne D. Boeck , Hang Chio , Tom E. Eaton , Otis W. Godfrey, Jr. , Karl H. Michel , Walter M. Nakatsukasa , Raymond C. Yao
发明人： LaVerne D. Boeck , Hang Chio , Tom E. Eaton , Otis W. Godfrey, Jr. , Karl H. Michel , Walter M. Nakatsukasa , Raymond C. Yao
IPC分类号： A01N43/22 , A01N43/90 , C07H17/08 , C12N1/20 , C12P1/06 , C12P19/62 , C12R1/01 , A01N27/00
CPC分类号： C07H17/08 , C12N1/20 , C12P1/06 , C12P19/62 , Y10S435/822
摘要： Fermentation product A83543, comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A983543F, A83543G, A83543H and A83543J, is produced by a newly described species, Saccharopolyspora spinosa. The A83543 components and their acid-addition salts (A83543 compounds) are useful as insecticides, particularly against Lepidoptera and Diptera species. Insecticidal, miticidal or ecto-parasiticidal combinations, compositions and methods are provided.
摘要翻译：包含主要组分A83543A和A83543D以及次要组分A83543B，A83543C，A83543E，A983543F，A83543G，A83543H和A83543J的发酵产物A83543由新近描述的种类，多孢裂孢酵母（Saccharopolyspora spinosa）生产。 A83543组分及其酸加成盐（A83543化合物）可用作杀虫剂，特别是鳞翅目和双翅目物种。提供杀虫剂，杀螨剂或除虫杀虫剂组合，组合物和方法。

6. 发明授权

US5362634A Process for producing A83543 compounds 失效
标题翻译：生产A83543化合物的方法
公开(公告)号：US5362634A
公开(公告)日：1994-11-08
申请号：US773754
申请日：1991-10-10
申请人： LaVerne D. Boeck , Hang Chio , Tom E. Eaton , Otis W. Godfrey, Jr. , Karl H. Michel , Walter M. Nakatsukasa , Raymond C. Yao
发明人： LaVerne D. Boeck , Hang Chio , Tom E. Eaton , Otis W. Godfrey, Jr. , Karl H. Michel , Walter M. Nakatsukasa , Raymond C. Yao
IPC分类号： C07H17/08 , C12N1/20 , C12P1/06 , C12P19/62
CPC分类号： C07H17/08 , C12N1/20 , C12P1/06 , C12P19/62 , Y10S435/822
摘要： Fermentation product A83543, comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A983543F, A83543G, A83543H and A83543J, is produced by a newly described species, Saccharopolyspora spinosa. The A83543 components and their acid-addition salts (A83543 compounds) are useful as insecticides, particularly against Lepidoptera and Diptera species. Insecticidal, miticidal or ecto-parasiticidal combinations, compositions and methods are provided.
摘要翻译：包含主要组分A83543A和A83543D以及次要组分A83543B，A83543C，A83543E，A983543F，A83543G，A83543H和A83543J的发酵产物A83543由新近描述的种类，多孢裂孢酵母（Saccharopolyspora spinosa）生产。 A83543组分及其酸加成盐（A83543化合物）可用作杀虫剂，特别是鳞翅目和双翅目物种。提供杀虫剂，杀螨剂或除虫杀虫剂组合，组合物和方法。

7. 发明授权

US5286631A Process for producing the A10255 complex and corresponding microorganism 失效
标题翻译：生产A10255复合物及相应微生物的方法
公开(公告)号：US5286631A
公开(公告)日：1994-02-15
申请号：US663194
申请日：1991-02-28
申请人： LaVerne D. Boeck , Otis W. Godfrey, Jr. , Karl H. Michel
发明人： LaVerne D. Boeck , Otis W. Godfrey, Jr. , Karl H. Michel
IPC分类号： A61K20060101 , C07K20060101 , C12N1/20 , C12P1/06 , C12P19/54 , C12P21/04
CPC分类号： C12P1/06 , Y10S435/822 , Y10S435/886
摘要： Newly-discovered antibiotic A10255 factors B, C, E, and F are produced by submerged aerobic fermentation of previously-unknown Streptomyces gardneri strain NRRL 15922, or an A10255-producing variant, mutant or recombinant thereof. The antibiotics are active against a wide variety of pathogenic bacteria, and also enhance feed-utilization efficiency in chickens, weanling pigs and cattle.
摘要翻译：新发现的抗生素A10255因子B，C，E和F通过先前未知的前列腺链球菌菌株NRRL 15922或其产生A10255的突变体或重组体的潜在需氧发酵产生。抗生素对各种致病菌具有活性，并且还提高了鸡，断奶仔猪和牛的饲料利用效率。

8. 发明授权

US4885251A Recombinant DNA expression vectors and DNA compounds which encode isopenicillin N synthetase 失效
标题翻译：编码异青霉素N合成酶的重组DNA表达载体和DNA化合物
公开(公告)号：US4885251A
公开(公告)日：1989-12-05
申请号：US895008
申请日：1986-08-08
申请人： Thomas D. Ingolia , Stephen W. Queener , Suellen M. Samson , Paul L. Skatrud , Otis W. Godfrey
发明人： Thomas D. Ingolia , Stephen W. Queener , Suellen M. Samson , Paul L. Skatrud , Otis W. Godfrey
IPC分类号： C12N15/52 , C12N9/00 , C12N15/69 , C12N15/70 , C12N15/74 , C12N15/80
CPC分类号： C12N15/80 , C12N15/69 , C12N9/93
摘要： The present invention comprises novel DNA compounds that encode isopenicillin N synthetase and also comprises related methods, transformants, and polypeptides. The novel isopenicillin N synthetase-encoding DNA, together with its associated transcriptional and translational activating sequence, was isolated from Cephalosporium acremonium and cloned into an E. coli cloning vector. The isopenicillin N synthetase-encoding DNA has been used to construct novel E. coli expression vectors that drive expression of a stable, active, and novel isopenicillin N synthetase in E. coli. The intact C. acremonium isopenicillin N synthetase-encoding DNA and associated transcriptional and translational activating sequence have also been used to construct C. acremonium expression vectors that drive expression of the isopenicillin N synthetase in C. acremonium. The C. acremonium transcriptional and translational activating sequence has further been fused to a hygromycin phosphotransferase-encoding DNA segment and placed onto C. acremonium expression vectors. Useful derivatives of the novel compounds and vectors are also described.
摘要翻译：本发明包括编码异青霉素N合成酶的新型DNA化合物，还包括相关方法，转化体和多肽。编码新的异青霉素N合成酶DNA，连同其相关的转录和翻译活化序列，从头孢霉头孢菌分离并克隆到大肠杆菌克隆载体中。编码异青霉素N合成酶的DNA已经用于构建新的大肠杆菌表达载体，其在大肠杆菌中驱动稳定的，活性的和新的异青霉素N合成酶的表达。编码完整的顶头孢霉素异青霉素N合成酶的DNA和相关的转录和翻译活化序列也被用于构建顶头孢霉表达载体，其驱动顶头孢霉中异青霉素N合成酶的表达。顶头孢霉转录和翻译激活序列进一步融合到编码潮霉素磷酸转移酶的DNA片段并置于顶头孢霉表达载体上。还描述了新化合物和载体的有用衍生物。

9. 发明授权

US4800157A Process for producing the A-21978C antibiotics 失效
标题翻译：生产A-21978C抗生素的方法
公开(公告)号：US4800157A
公开(公告)日：1989-01-24
申请号：US773916
申请日：1985-09-09
申请人： Tom E. Eaton , Lynda M. Ford , Otis W. Godfrey, Jr. , Mary L. B. Huber , Milton J. Zmijewski, Jr.
发明人： Tom E. Eaton , Lynda M. Ford , Otis W. Godfrey, Jr. , Mary L. B. Huber , Milton J. Zmijewski, Jr.
IPC分类号： C07K7/08 , C12P21/04 , C12N1/20 , C12R1/465
CPC分类号： C12R1/465 , C07K7/08 , Y10S435/801 , Y10S435/886
摘要： Improved fermentation process for producing the gram-positive A-21978C antibiotics which comprises cultivating a new strain of Streptomyces roseosporus, NRRL 15998, and the biologically purified culture of this microorganism are provided.
摘要翻译：提供了用于生产革兰氏阳性A-21978C抗生素的改进的发酵方法，其包括培养新的玫瑰孢链霉菌菌株NRRL 15998和该微生物的生物纯化培养物。

10. 发明授权

US5213797A A80407 antibiotics 失效
标题翻译： A80407抗生素
公开(公告)号：US5213797A
公开(公告)日：1993-05-25
申请号：US625394
申请日：1990-12-11
申请人： Lawrence E. Doolin , Richard M. Gale , Otis W. Godfrey , Robert L. Hamill , David F. Mahoney , Raymond C. Yao
发明人： Lawrence E. Doolin , Richard M. Gale , Otis W. Godfrey , Robert L. Hamill , David F. Mahoney , Raymond C. Yao
IPC分类号： A23K1/17 , A23K1/18 , A61K38/00 , C07K4/04 , C07K4/06 , C07K9/00
CPC分类号： C07K4/04 , A23K20/195 , A23K50/30 , C07K9/008 , A61K38/00
摘要： New glycopeptide antibiotic A80407, comprising A80407A and A80407B, is produced by Kibdelosporangium philippinensis strains NRRL 18198, and NRRL 18199 or A80407-producing mutants of these strains. The A80407 antibiotics have excellent activity against Gram-positive bacteria, increase feed-utilization efficiency in monogastric and ruminant animals and improve weight gains in animals.
摘要翻译：包含A80407A和A80407B的新型糖肽抗生素A80407由革兰氏阴性菌属细菌NRRL 18198和NRRL 18199或这些菌株的A80407产生突变体产生。 A80407抗生素对革兰氏阳性菌具有优异的活性，增加单胃和反刍动物的饲料利用效率，改善动物体重增加。

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