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1. 发明授权

US10399083B2 Flow disrupters for use with homogenization tubes for beadless interrupted flow 有权
公开(公告)号：US10399083B2
公开(公告)日：2019-09-03
申请号：US14590656
申请日：2015-01-06
申请人： OMNI INTERNATIONAL, INC.
发明人： Karl Jahn , Voya Vidakovic , John Hancock , Thomas Gray
IPC分类号： B02C17/06 , B02C17/14 , B01F11/00 , B01L3/00 , B01F5/06 , G01N1/38 , B01L9/06
摘要： A flow disrupter in a tube chamber of a tube assembly for homogenizing sample materials includes a flow-disrupting body that extends generally transversely into the tube chamber and divides the tube chamber into two sub-chambers. The flow-disrupting body includes at least one narrowed flow passageway through which the sample flows back and forth in both axially reciprocating directions as the tube assembly is vigorously shaken at high speeds faster and more reliably than what can be accomplished by hand shaking. And the flow-disrupting body includes at least two flow-interrupting surfaces facing generally in opposite axial directions and against which the sample impacts in each respective axially reciprocating direction as the tube assembly is vigorously shaken. In this way, the vigorous high-speed shaking of the tube assembly including the flow disrupter results in significant particle-size reduction of the sample by mechanical shear, fluid shear, cavitation, and/or pressure differentials.

2. 发明授权

US10118176B2 Sample-tube holder for easy tube insertion and removal 有权
公开(公告)号：US10118176B2
公开(公告)日：2018-11-06
申请号：US14884989
申请日：2015-10-16
申请人： OMNI INTERNATIONAL, INC.
发明人： Thomas Gray , John Hancock , Spencer Smith , Voya Vidakovic
IPC分类号： B01L3/00 , G01N37/00 , B01F11/00 , B01L9/00
摘要： A tube holder for mounting a sample-tube assembly to a homogenizing device includes at least one clamp, at least one retainer, and a mount. The mount couples the tube holder to the homogenizing device. Each clamp defines a tube channel and a transverse ledge surface, with the tube channel having a lateral opening through which a tube of the tube assembly can be easily inserted and removed for example with one hand. And each retainer defines a retaining surface that extends over the respective tube channel and opposes the respective ledge surface to cooperatively form a receptacle that receives/retains a cap of the tube assembly against axial tube motion during homogenization. In some embodiments, multiple retaining surfaces are included for retaining different types of tube assemblies, multiple clamps and retainers are included for holding multiple tube assemblies simultaneously, and/or ejection mechanisms are included for ease of ejecting the tube assemblies.

3. 发明申请

US20160199800A1 HOMOGENIZER PROCESSING PLATE FOR SELF-SECURING OF SAMPLE TUBES 审中-公开
标题翻译：用于自动安装样品管的均质加工板
公开(公告)号：US20160199800A1
公开(公告)日：2016-07-14
申请号：US14993912
申请日：2016-01-12
申请人： OMNI INTERNATIONAL, INC.
发明人： Voya VIDAKOVIC , Thomas GRAY , John HANCOCK , Spencer SMITH , Alan VAUGHN
IPC分类号： B01F9/00 , B01L9/06
CPC分类号： B01F9/003 , B01F9/0005 , B01L9/06 , B01L2200/023 , B01L2200/025 , B01L2300/0609 , B01L2300/0832 , B01L2400/0409
摘要： A processing plate assembly for mounting to a homogenizer and for holding tubes containing samples to be homogenized. The processing plate assembly includes a mounting structure and one or plural tube holders. The mounting structure removably or permanently mounts to the homogenizer and can be provided by for example a flat plate-like mounting structure. The tube holders are attached to the mounting structure and hold the tubes in generally tangential use positions with a centroid of each tube positioned along a longitudinal axis of the tube and axially offset from a radius line of the processing plate that is perpendicular to the tube axis. In this way, the homogenizer imparts sinusoidal swashing forces on the tubes that urge the tubes forward into securement in their tube holders and that produces improved homogenization in the tubes.
摘要翻译：一种处理板组件，用于安装到均化器并用于容纳含有要均化的样品的管。处理板组件包括安装结构和一个或多个管保持器。安装结构可移除地或永久地安装到均化器，并且可以由例如平板状安装结构提供。管保持器附接到安装结构并且将管保持在大致切向使用位置，每个管的质心沿着管的纵向轴线定位并且与处理板的垂直于管轴线的半径线轴向偏移。以这种方式，均化器在管上施加正弦的冲击力，其将管向前推进到其管夹中的固定中，并且在管中产生改善的均匀化。

4. 发明申请

US20160107158A1 SAMPLE-TUBE HOLDER FOR EASY TUBE INSERTION AND REMOVAL 审中-公开
标题翻译：用于容易插入和拆卸的样品管支架
公开(公告)号：US20160107158A1
公开(公告)日：2016-04-21
申请号：US14884989
申请日：2015-10-16
申请人： OMNI INTERNATIONAL, INC.
发明人： Thomas GRAY , John HANCOCK , Spencer SMITH , Voya VIDAKOVIC
IPC分类号： B01L3/00
CPC分类号： B01L3/5082 , B01F11/0008 , B01L9/50
摘要： A tube holder for mounting a sample-tube assembly to a homogenizing device includes at least one clamp, at least one retainer, and a mount. The mount couples the tube holder to the homogenizing device. Each clamp defines a tube channel and a transverse ledge surface, with the tube channel having a lateral opening through which a tube of the tube assembly can be easily inserted and removed for example with one hand. And each retainer defines a retaining surface that extends over the respective tube channel and opposes the respective ledge surface to cooperatively form a receptacle that receives/retains a cap of the tube assembly against axial tube motion during homogenization. In some embodiments, multiple retaining surfaces are included for retaining different types of tube assemblies, multiple clamps and retainers are included for holding multiple tube assemblies simultaneously, and/or ejection mechanisms are included for ease of ejecting the tube assemblies.
摘要翻译：用于将样品管组件安装到均质装置的管保持器包括至少一个夹具，至少一个保持器和安装件。该安装件将管夹连接到均质装置。每个夹具限定管通道和横向突出表面，其中管通道具有侧向开口，管组件的管可以容易地用一只手容易地插入和移除。并且每个保持器限定保持表面，该保持表面在相应的管通道上延伸并且与相应的凸缘表面相对配合地形成容纳件，该容器在均质化过程中接收/保持管组件的帽抵抗轴向管的运动。在一些实施例中，包括多个保持表面以保持不同类型的管组件，包括多个夹具和保持器以同时保持多个管组件，和/或包括弹出机构以便于弹出管组件。

5. 发明授权

US11774329B2 Active grinding media for processing samples 有权
公开(公告)号：US11774329B2
公开(公告)日：2023-10-03
申请号：US17969065
申请日：2022-10-19
申请人： OMNI INTERNATIONAL, INC.
发明人： William Z. Todd , Karl Jahn
IPC分类号： B02C17/20 , G01N1/28 , B02C17/24 , B02C17/04
CPC分类号： G01N1/286 , B02C17/04 , B02C17/20 , B02C17/24 , G01N2001/2866
摘要： An active/resilient grinding media inside a tube containing a sample is oscillated rapidly by a homogenizer so that the active media is driven in a first direction until it impacts a first end of the tube, which causes it to deform and store an energy charge as it decelerates and stops, and it then accelerates rapidly in the second opposite direction under the discharging force of the stored energy toward the opposite second end of the tube. This cycle of the active media decelerating/charging and then discharging/accelerating is repeated throughout the entire oscillatory processing of the sample. The result is much higher velocities of the active media and therefore much greater impact forces when the sample and active media collide, producing increased efficiency in disruption and size-reduction of the sample particles.

6. 发明授权

US11519830B2 Active grinding media for processing samples 有权
公开(公告)号：US11519830B2
公开(公告)日：2022-12-06
申请号：US16940025
申请日：2020-07-27
申请人： OMNI INTERNATIONAL, INC.
发明人： William Z. Todd , Karl Jahn
IPC分类号： B02C17/24 , G01N1/28 , B02C17/04 , B02C17/20
摘要： An active/resilient grinding media inside a tube containing a sample is oscillated rapidly by a homogenizer so that the active media is driven in a first direction until it impacts a first end of the tube, which causes it to deform and store an energy charge as it decelerates and stops, and it then accelerates rapidly in the second opposite direction under the discharging force of the stored energy toward the opposite second end of the tube. This cycle of the active media decelerating/charging and then discharging/accelerating is repeated throughout the entire oscillatory processing of the sample. The result is much higher velocities of the active media and therefore much greater impact forces when the sample and active media collide, producing increased efficiency in disruption and size-reduction of the sample particles.

7. 发明授权

US10118142B2 Homogenizer processing plate for self-securing of sample tubes 有权
公开(公告)号：US10118142B2
公开(公告)日：2018-11-06
申请号：US14993912
申请日：2016-01-12
申请人： OMNI INTERNATIONAL, INC.
发明人： Voya Vidakovic , Thomas Gray , John Hancock , Spencer Smith , Alan Vaughn
IPC分类号： B01F9/00 , B01L9/06
摘要： A processing plate assembly for mounting to a homogenizer and for holding tubes containing samples to be homogenized. The processing plate assembly includes a mounting structure and one or plural tube holders. The mounting structure removably or permanently mounts to the homogenizer and can be provided by for example a flat plate-like mounting structure. The tube holders are attached to the mounting structure and hold the tubes in generally tangential use positions with a centroid of each tube positioned along a longitudinal axis of the tube and axially offset from a radius line of the processing plate that is perpendicular to the tube axis. In this way, the homogenizer imparts sinusoidal swashing forces on the tubes that urge the tubes forward into securement in their tube holders and that produces improved homogenization in the tubes.

8. 发明申请

US20210371939A1 MECHANICAL LYSIS AND EXPOSURE BY HOMOGENIZATION FOR DIRECT VIRAL NUCLEIC ACID AMPLIFICATION 有权
公开(公告)号：US20210371939A1
公开(公告)日：2021-12-02
申请号：US17330928
申请日：2021-05-26
申请人： OMNI INTERNATIONAL, INC.
发明人： Zachary MOREHOUSE , Caleb Proctor , Rodney Nash
IPC分类号： C12Q1/6888 , C12Q1/6806 , C12Q1/686
摘要： Methods and systems of analyzing a biological sample to detect the presence of a virus are disclosed, that include mechanically homogenizing the biological sample, wherein the biological sample is unprocessed, to lyse the unprocessed biological sample to produce a homogenized sample; amplifying the viral nucleic acids in the homogenized sample, where such amplification occurs without any isolation, separation, purification, or extraction of the viral nucleic acids in the homogenized sample; and analyzing the amplified viral nucleic acids to detect the presence of the virus.

9. 发明公开

US20240240123A1 TISSUE DISSOCIATION USING INTERNALLY THREADED TUBES 审中-公开
公开(公告)号：US20240240123A1
公开(公告)日：2024-07-18
申请号：US18410533
申请日：2024-01-11
申请人： OMNI INTERNATIONAL, INC.
发明人： Rodney NASH , Zachary MOREHOUSE , Paul H. ROBERTS , William Z. TODD , Peter TORTORELLI , Jason PAULSEL , John D. BUNTING , Gabriella RYAN
IPC分类号： C12M1/12 , C12M1/00
CPC分类号： C12M23/06 , C12M23/40
摘要： A laboratory processing tube assembly mounts to a processing unit for dissociating an organically derived sample. The tube assembly includes a tube and a cap that form a tube chamber that contains the sample during dissociation. The tube includes at least one internal thread extending inwardly from and peripherally about its inner surface in a helical arrangement, with the internal helical thread including a ridge defining two impact surfaces facing in generally opposite directions, and with a first one of the impact surfaces impacted by the sample as the sample flows in a first axial direction in the tube chamber and a second one of the impact surfaces impacted by the sample as the sample flows in a second opposite axial direction in the tube chamber during axially-reciprocal tube-assembly motion to dissociate the sample.

10. 发明授权

US10960370B2 Ultrasonic homogenization device with closed-loop amplitude control 有权
公开(公告)号：US10960370B2
公开(公告)日：2021-03-30
申请号：US16002531
申请日：2018-06-07
申请人： OMNI INTERNATIONAL, INC.
发明人： Spencer Smith , Chase Campbell
IPC分类号： B01F15/00 , G01N1/28 , B01F11/02
摘要： An ultrasonic system for homogenizing a sample includes an ultrasonic transducer and a control system. The transducer includes a horn or other probe that oscillates to produce cavitation in the sample and a converter that drives the horn through its oscillatory motion. The control system includes a closed-loop amplitude-control configuration and process. In particular, the control system includes a user interface, a controller, and a high-frequency driver, all connected together in a closed-loop configuration for enabling amplitude-control feedback. Control software includes programming for the closed-loop amplitude-control process including receiving a user-inputted desired amplitude of oscillatory horn motion, driving the transducer at a corresponding power level, determining the actual amplitude of oscillatory horn motion, and automatically adjusting the power level to the transducer to maintain the desired amplitude during operation of the ultrasonic system.

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