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1. 发明授权

US09023858B2 Substituted pyrido[2,3-d]pyrimidines as delta-5-desaturase inhibitors 有权
标题翻译：取代的吡啶并[2,3-d]嘧啶作为δ-5-去饱和酶抑制剂
公开(公告)号：US09023858B2
公开(公告)日：2015-05-05
申请号：US13811755
申请日：2011-07-22
申请人： Nobuyuki Matsunaga , Hideo Suzuki , Kouhei Asano , Hidekazu Tokuhara , Takeshi Yamamoto , Rei Okamoto
发明人： Nobuyuki Matsunaga , Hideo Suzuki , Kouhei Asano , Hidekazu Tokuhara , Takeshi Yamamoto , Rei Okamoto
IPC分类号： A61K31/519 , C07D487/04 , C07D471/04 , C07D475/02 , C07D513/04
CPC分类号： C07D471/04 , C07D475/02 , C07D487/04 , C07D513/04
摘要： The present invention provides a compound useful for the prophylaxis or treatment of eicosanoid-associated diseases such as atherosclerosis, atherothrombosis, diabetes, obesity, asthma, fever, pain, cancer, rheumatism, osteoarthritis, atopic dermatitis and the like, and having superior pharmacological action, physicochemical properties and the like.The present invention relates to a compound represented by the following formula: wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译：本发明提供了可用于预防或治疗类二十烷酸相关疾病如动脉粥样硬化，动脉粥样硬化血栓形成，糖尿病，肥胖症，哮喘，发烧，疼痛，癌症，风湿病，骨关节炎，特应性皮炎等的化合物，并且具有优异的药理作用，物理化学性质等。本发明涉及由下式表示的化合物：其中每个符号如说明书中所定义，或其盐。

2. 发明授权

US08461348B2 Heterocyclic derivative and use thereof 失效
标题翻译：杂环衍生物及其用途
公开(公告)号：US08461348B2
公开(公告)日：2013-06-11
申请号：US12936291
申请日：2009-04-03
申请人： Nobuyuki Matsunaga , Yoshihisa Nakada , Yusuke Ohba , Hideyuki Nakagawa
发明人： Nobuyuki Matsunaga , Yoshihisa Nakada , Yusuke Ohba , Hideyuki Nakagawa
IPC分类号： C07D277/20 , C07D277/62 , A61K31/425
CPC分类号： C07D263/32 , C07D271/04 , C07D271/10 , C07D277/20 , C07D277/30 , C07D285/12 , C07D307/54 , C07D417/04 , C07D417/06 , C07D417/14
摘要： The present invention aims to provide a compound having superior pharmacological action, physicochemical properties and the like and useful as an sGC activation drug, or an agent for the prophylaxis and/or treatment of diseases such as hypertension, ischemic cardiac disease, cardiac failure, kidney disease, arteriosclerotic disease, atrial fibrillation, pulmonary hypertension, diabetes, diabetic complications, metabolic syndrome, peripheral arterial obstruction, erectile dysfunction and the like.An sGC activation drug containing a compound represented by the formula (II): wherein each symbol is as defined in the specification, or a salt thereof, as an active ingredient.
摘要翻译：本发明旨在提供具有优异的药理作用，理化特性等并可用作sGC活化药物或用于预防和/或治疗高血压，缺血性心脏病，心力衰竭，肾脏等疾病的药剂的化合物疾病，动脉硬化疾病，心房颤动，肺动脉高压，糖尿病，糖尿病并发症，代谢综合征，外周动脉阻塞，勃起功能障碍等。含有由式（II）表示的化合物的sGC活化药物：其中每个符号如说明书中所定义，或其盐作为活性成分。

3. 发明申请

US20110028493A1 HETEROCYCLIC DERIVATIVE AND USE THEREOF 失效
标题翻译：杂环衍生物及其用途
公开(公告)号：US20110028493A1
公开(公告)日：2011-02-03
申请号：US12936291
申请日：2009-04-03
申请人： Nobuyuki Matsunaga , Yoshihisa Nakada , Yusuke Ohba , Hideyuki Nakagawa
发明人： Nobuyuki Matsunaga , Yoshihisa Nakada , Yusuke Ohba , Hideyuki Nakagawa
IPC分类号： A61K31/506 , C07D417/04 , A61K31/427 , C07D417/14 , C07D413/14 , A61K31/4245 , C07D417/12 , C07D403/06 , A61K31/4155 , A61K31/4439 , C07D413/06 , A61K31/422 , C07D307/46 , A61K31/341 , A61P9/12 , A61P9/00 , A61P13/12 , A61P11/00 , A61P3/00
CPC分类号： C07D263/32 , C07D271/04 , C07D271/10 , C07D277/20 , C07D277/30 , C07D285/12 , C07D307/54 , C07D417/04 , C07D417/06 , C07D417/14
摘要： The present invention aims to provide a compound having superior pharmacological action, physicochemical properties and the like and useful as an sGC activation drug, or an agent for the prophylaxis and/or treatment of diseases such as hypertension, ischemic cardiac disease, cardiac failure, kidney disease, arteriosclerotic disease, atrial fibrillation, pulmonary hypertension, diabetes, diabetic complications, metabolic syndrome, peripheral arterial obstruction, erectile dysfunction and the like.An sGC activation drug containing a compound represented by the formula (II): wherein each symbol is as defined in the specification, or a salt thereof, as an active ingredient.
摘要翻译：本发明旨在提供具有优异的药理作用，理化特性等并可用作sGC活化药物或用于预防和/或治疗高血压，缺血性心脏病，心力衰竭，肾脏等疾病的药剂的化合物疾病，动脉硬化疾病，心房颤动，肺动脉高压，糖尿病，糖尿病并发症，代谢综合征，外周动脉阻塞，勃起功能障碍等。含有由式（II）表示的化合物的sGC活化药物：其中每个符号如说明书中所定义，或其盐作为活性成分。

4. 发明授权

US06960586B2 Imidazole derivatives, process for their preparation and their use 失效
标题翻译：咪唑衍生物，其制备方法及其应用
公开(公告)号：US06960586B2
公开(公告)日：2005-11-01
申请号：US10416998
申请日：2001-11-19
申请人： Akihiro Tasaka , Nobuyuki Matsunaga , Akio Ojida , Masami Kusaka
发明人： Akihiro Tasaka , Nobuyuki Matsunaga , Akio Ojida , Masami Kusaka
IPC分类号： A61P13/08 , A61P15/00 , A61P35/00 , A61P43/00 , C07D233/54 , C07D401/06 , C07D403/06 , A01N43/58 , A01N43/42 , A01N43/60 , A61K31/495 , A61K31/50
CPC分类号： C07D403/06 , C07D401/06 , Y02P20/55
摘要： The present invention provides a compound having a steroid C17,20-lyase inhibitory activity, which is useful as a prophylactic or therapeutic agent of prostatism and tumor such as breast cancer and the like.A compound represented by the formula: wherein R is a hydrogen atom or a protecting group, R1 is a lower alkyl group or a cyclic alkyl group, and ring A and ring B are each an optionally substituted 5-membered or 6-membered ring having an amide bond in the ring, or a salt thereof.
摘要翻译：本发明提供具有类固醇C 17-20半胱氨酸酶抑制活性的化合物，其可用作前列腺素和肿瘤如乳腺癌等的预防或治疗剂。由下式表示的化合物：其中R是氢原子或保护基，R 1是低级烷基或环状烷基，并且环A和环B各自为任选取代的5 环或其中具有酰胺键的六元环或其盐。

5. 发明授权

US5502093A Polyacetal resin composition 失效
标题翻译：聚缩醛树脂组合物
公开(公告)号：US5502093A
公开(公告)日：1996-03-26
申请号：US345697
申请日：1994-11-21
申请人： Toru Katsumata , Nobuyuki Matsunaga
发明人： Toru Katsumata , Nobuyuki Matsunaga
IPC分类号： C08K5/00 , C08K5/17 , C08L33/00 , C08L59/00 , C08L71/00 , C08K5/34 , C08K5/07
CPC分类号： C08L59/00 , C08L33/00 , C08L71/00
摘要： Polyacetal resin compositions have excellent weather resistance and environment resistance, which suppress resin deterioration/discoloration, crack and discoloration caused by additive bleeding during extended exposure to light while maintaining the initial molded product surface condition. The polyacetal compositions include a blend of (A) 100 parts by weight of a polyacetal resin, with the specific amounts of (B) an acrylic resin, (C) an oxyalkylene polymer having chains of 2 to 8 consecutive carbon atoms, (D) a UV absorber and (E) two kinds of the hindered amine compounds each having a different molecular weight.
摘要翻译：聚缩醛树脂组合物具有优异的耐候性和耐环境性，其在保持初始模塑产品表面状态的同时，在延长曝光期间抑制由添加剂渗色引起的树脂劣化/变色，裂纹和变色。聚缩醛组合物包括（A）100重量份的聚缩醛树脂与（B）丙烯酸树脂的特定量的混合物，（C）具有2至8个连续碳原子的链的氧化烯聚合物，（D） UV吸收剂和（E）各自具有不同分子量的两种受阻胺化合物。

6. 发明授权

US5173532A Anti-friction and wear-resistant polyacetal molding compositions, and molded sliding members formed thereof 失效
标题翻译：抗摩擦和耐磨聚缩醛成型组合物，以及由其形成的模制滑动构件
公开(公告)号：US5173532A
公开(公告)日：1992-12-22
申请号：US847885
申请日：1992-03-10
申请人： Toshihiko Endo , Osamu Kanoto , Katsunori Takayama , Nobuyuki Matsunaga
发明人： Toshihiko Endo , Osamu Kanoto , Katsunori Takayama , Nobuyuki Matsunaga
IPC分类号： C08K3/00 , C08L51/00 , C08L59/02
CPC分类号： C08K3/0033 , C08L59/02 , C08L51/00
摘要： Polyacetal resin molding compositions and sliding members formed thereof exhibit anti-friction and abrasion-resistance properties. The polyacetal resin molding compositions include (A) 100 parts by weight of a polyacetal base resin, (B) between 0.5 to 40 parts by weight of a branched or cross-linked graft copolymer which is a graft-reaction product of (a) an olefin polymer, and (b) a vinyl or ether polymer, (C) between 0.1 to 20 parts by weight of a lubricant, and (D) between 0.5 to 30 parts by weight of an inorganic powder having a mean particle diameter of 50 .mu.m or less and a content of particles having a particle diameter of 100 .mu.m or less of at least 95%.
摘要翻译：聚缩醛树脂成型组合物和由其形成的滑动构件具有抗摩擦和耐磨性。聚缩醛树脂成型用组合物包含（A）100重量份的聚缩醛基树脂，（B）0.5〜40重量份的支链或交联接枝共聚物，其为（a）烯烃聚合物，和（b）乙烯基醚或醚聚合物，（C）0.1-20重量份的润滑剂，和（D）0.5-30重量份平均粒径为50微米的无机粉末 m以下，粒径为100μm以下的粒子的含量为95％以上。

7. 发明授权

US4879331A Self-lubricating thermoplastic resin wear part 失效
标题翻译：自润滑热塑性树脂磨损部位
公开(公告)号：US4879331A
公开(公告)日：1989-11-07
申请号：US197873
申请日：1988-05-24
申请人： Toshihiko Endo , Nobuyuki Matsunaga
发明人： Toshihiko Endo , Nobuyuki Matsunaga
IPC分类号： C08L59/00 , C08L67/00 , C08L67/02 , C08L83/04
CPC分类号： C08L59/00 , C08L67/02 , C08L83/04
摘要： A thermoplastic resin composition comprises (A) 99.9 to 60 parts by weight of a thermoplastic polyester or a polyacetal, (B) 0.05 to 20 parts by weight of a silicone oil having a viscosity of 150,000 cSt or larger and (C) 0.05 to 20 parts by weight of a lubricating oil having a viscosity of 3,000 cSt or smaller and is improved in durability to abrasion.
摘要翻译：热塑性树脂组合物包含（A）99.9〜60重量份的热塑性聚酯或聚缩醛，（B）0.05〜20重量份粘度为150,000cSt以上的硅油，（C）0.05〜20 重量份粘度为3,000cSt以下的润滑油，耐磨性提高。

8. 发明授权

US4874807A Self-lubricating thermoplastic resin wear part 失效
标题翻译：自润滑热塑性树脂磨损部位
公开(公告)号：US4874807A
公开(公告)日：1989-10-17
申请号：US191304
申请日：1988-05-06
申请人： Toshihiko Endo , Nobuyuki Matsunaga
发明人： Toshihiko Endo , Nobuyuki Matsunaga
IPC分类号： C08L59/00 , C08L67/00 , C08L67/02 , C08L83/04
CPC分类号： C08L59/00 , C08L67/02 , C08L83/04
摘要： A self-lubricating wear part is formed of a thermoplastic resin composition which exhibits improved durability to abrasion. The resin composition includes a thermoplastic polyester resin or polyacetal resin in an amount between 99.9 to 80.0 parts by weight, and a silicon oil having a viscosity of 150,000 cSt or more in an amount between 0.1 to 20 parts by weight.
摘要翻译：自润滑耐磨部由耐磨性提高的热塑性树脂组合物形成。树脂组合物包含99.9〜80.0重量份的热塑性聚酯树脂或聚缩醛树脂，粘度为15万cSt以上的硅油的含量为0.1〜20重量份。

9. 发明申请

US20130131050A1 FUSED HETEROCYCLIC COMPOUND AND APPLICATION THEREOF 有权
标题翻译：熔融杂环化合物及其应用
公开(公告)号：US20130131050A1
公开(公告)日：2013-05-23
申请号：US13811755
申请日：2011-07-22
申请人： Nobuyuki Matsunaga , Hideo Suzuki , Kouhei Asano , Hidekazu Tokuhara , Takeshi Yamamoto , Rei Okamoto
发明人： Nobuyuki Matsunaga , Hideo Suzuki , Kouhei Asano , Hidekazu Tokuhara , Takeshi Yamamoto , Rei Okamoto
IPC分类号： C07D471/04 , A61K31/542 , C07D487/04 , C07D513/04 , A61K31/519 , A61K31/5383 , C07D495/04
CPC分类号： C07D471/04 , C07D475/02 , C07D487/04 , C07D513/04
摘要： The present invention provides a compound useful for the prophylaxis or treatment of eicosanoid-associated diseases such as atherosclerosis, atherothrombosis, diabetes, obesity, asthma, fever, pain, cancer, rheumatism, osteoarthritis, atopic dermatitis and the like, and having superior pharmacological action, physicochemical properties and the like.The present invention relates to a compound represented by the following formula: wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译：本发明提供了可用于预防或治疗类二十烷酸相关疾病如动脉粥样硬化，动脉粥样硬化血栓形成，糖尿病，肥胖症，哮喘，发烧，疼痛，癌症，风湿病，骨关节炎，特应性皮炎等的化合物，并且具有优异的药理作用，物理化学性质等。本发明涉及由下式表示的化合物：其中每个符号如说明书中所定义，或其盐。

10. 发明申请

US20080176906A1 Substituted Pyrrole Derivative 审中-公开
标题翻译：取代的吡咯衍生物
公开(公告)号：US20080176906A1
公开(公告)日：2008-07-24
申请号：US11793113
申请日：2005-12-13
申请人： Nobuyuki Matsunaga , Takenori Hitaka
发明人： Nobuyuki Matsunaga , Takenori Hitaka
IPC分类号： A61K31/4439 , C07D401/06 , C07D413/12 , A61P35/00 , A61K31/40 , C07D207/32
CPC分类号： C07D207/327 , C07D207/34 , C07D401/06 , C07D413/14
摘要： The present invention provides a novel pyrrole derivative having excellent androgen receptor antagonism, which is represented by the formula: wherein R1 represents a hydrogen atom, a cyano group or a group represented by the formula COORA (wherein RA represents an optional substituted C1-6 alkyl group), R2 and R4 are the same or different, and each represents a hydrogen atom, a C1-6 alkyl group, a C3-6 cycloalkyl group, a trifluoromethyl group, an amino-C1-6 alkyl group, a mono- or di-substituted amino-C1-6 alkyl group, an optionally halogenated C1-6 alkyl group substituted with an optionally substituted hydroxyl group, a C2-6 alkenyl group substituted with an optionally substituted hydroxyl group, a C1-6 alkyl group substituted with an optionally substituted and optionally oxidized thiol group, an optionally substituted with and optionally oxidized thiol group, a cyano group, an acyl group, an optionally substituted oxazolyl group or a 1,3-dioxolan-2-yl group, R3 represents a group represented by the formula: (wherein X represents a halogen atom, Y represents a carbon atom or a nitrogen atom, Alk represents an optionally substituted C1-4 alkylene group, and RB represents a hydrogen atom or an acyl group), and R5 represents a phenyl group which has a cyano group at a 4-position or a 3-position thereof, and may be further substituted, or a salt thereof. The present invention also provides an androgen receptor antagonist containing the pyrrole derivative, or a salt thereof.
摘要翻译：本发明提供具有优异雄激素受体拮抗作用的新型吡咯衍生物，其由下式表示：其中R 1表示氢原子，氰基或由式COOR < A （其中R A表示任选的取代的C 1-6烷基），R 2和R 4 各自相同或不同，各自表示氢原子，C 1-6烷基，C 3-6环烷基，三氟甲基氨基-C 1-6烷基，一取代或二取代的氨基-C 1-6烷基，任意卤代的C 1〜被任选取代的羟基取代的6个C 1 -C 6烷基，被任意取代的羟基取代的C 2-6-6烯基，C 1-6烷基被任选取代的和任选被氧化的硫醇基团取代的基团，任选地被任选地被氧化物取代硫醇基，氰基，酰基，任选取代的恶唑基或1,3-二氧戊环-2-基，R 3表示由下式表示的基团：（其中X 表示卤原子，Y表示碳原子或氮原子，Alk表示任选取代的C 1-4 - 亚烷基，R B表示氢原子或酰基），R 5表示在4位或3位具有氰基的苯基，可以进一步被取代，或其盐。本发明还提供含有吡咯衍生物或其盐的雄激素受体拮抗剂。

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