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1. 发明授权

US08163306B2 Oral drug delivery system 有权
标题翻译：口服药物输送系统
公开(公告)号：US08163306B2
公开(公告)日：2012-04-24
申请号：US10572502
申请日：2004-06-30
申请人： Nitin Bhalachandra Dharmadhikari , Yashoraj Rupsinh Zala , Amarjit Singh
发明人： Nitin Bhalachandra Dharmadhikari , Yashoraj Rupsinh Zala , Amarjit Singh
IPC分类号： A61K9/24
CPC分类号： A61K9/2072
摘要： An oral drug delivery system comprising a coated tablet having one or more surfaces. The coated tablet further comprises a core and a coating surrounding the core. The core comprises an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient and a composition selected from a swellable composition and a reactive composition located in an immediate vicinity of one or more preselected surfaces. The coating is operable to be reliably removed fully from the one or more of the preselected surfaces of the tablet upon contact with an aqueous environment, but not removed from at least one of the surfaces.
摘要翻译：一种口服药物递送系统，其包含具有一个或多个表面的包衣片剂。涂布的片剂还包括芯和围绕芯的涂层。核心包括活性成分组合物，其包含至少一种活性成分和药学上可接受的赋形剂，以及选自位于一个或多个预选表面附近的可溶胀组合物和反应性组合物的组合物。涂层可操作以在与水性环境接触时从片剂的一个或多个预选表面完全可靠地移除，但不从至少一个表面移除。

2. 发明申请

US20080213381A1 Oral Drug Delivery System 审中-公开
标题翻译：口服药物输送系统
公开(公告)号：US20080213381A1
公开(公告)日：2008-09-04
申请号：US11886220
申请日：2006-03-14
申请人： Nitin Bhalachandra Dharmadhikari , Yashoraj Rupsinh Zala
发明人： Nitin Bhalachandra Dharmadhikari , Yashoraj Rupsinh Zala
IPC分类号： A61K9/50 , A61P25/24
CPC分类号： A61K9/2086 , A61K9/2866
摘要： The present invention provides an oral drug delivery system comprising— a. a core comprising an active ingredient composition comprising therapeutically effective amount of at least one active ingredient and a pharmaceutically acceptable excipient, and b. a coating surrounding the core, said coating comprising a water-insoluble polymer and a pH-dependent polymer, wherein the oral drug delivery system is in the form of a coated tablet and includes a feature such that after a predetermined delay the coating is reliably removed fully or partially from one or more of the tablet surfaces upon contact with intestinal fluids, further wherein the feature is that the core further comprises a composition selected from a swellable composition and a reactive composition located in the immediate vicinity of one or more preselected surfaces from which the coating is desired to be fully or partially removed, wherein the coating is not removed from at least one of the surfaces.
摘要翻译：本发明提供一种口服药物递送系统，其包括：a。核心，其包含活性成分组合物，其包含治疗有效量的至少一种活性成分和药学上可接受的赋形剂，和b。围绕芯的涂层，所述涂层包含水不溶性聚合物和pH依赖性聚合物，其中所述口服药物递送系统为涂层片剂的形式，并且包括特征，使得在预定延迟之后，涂层被可靠地移除在与肠液接触时完全或部分地从一个或多个片剂表面完全或部分地进一步地，其特征在于，芯还包含选自可溶胀组合物和反应性组合物的组合物，其位于紧邻一个或多个预选表面的附近期望该涂层被完全或部分去除，其中该涂层不从至少一个表面移除。

3. 发明申请

US20080138403A1 PHARMACEUTICAL DOSAGE FORMS OF OXCARBAZEPINE 审中-公开
标题翻译： OXCARBAZEPINE的药物剂量形式
公开(公告)号：US20080138403A1
公开(公告)日：2008-06-12
申请号：US11924041
申请日：2007-10-25
申请人： Ashish Prabhakar Mungre , Nitin Bhalachandra Dharmadhikari
发明人： Ashish Prabhakar Mungre , Nitin Bhalachandra Dharmadhikari
IPC分类号： A61K31/55 , A61K9/14 , A61K9/20 , A61K9/48
CPC分类号： A61K31/55 , A61K9/1635 , A61K9/1641 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2077 , A61K9/284
摘要： A pharmaceutical dosage form comprising a mixture of a therapeutically effective amount of oxcarbazepine having median particle size ranging from about 15 μm to about 26 μm and one or more hydrophilic polymers, said mixture being formed by subjecting a suspension comprising said oxcarbazepine and a hydrophilic polymer in a solvent, to mixing in a homogenizer, optionally removing the solvent and converting the said mixture into a dosage form.
摘要翻译：一种药物剂型，其包含治疗有效量的中等粒度范围为约15μm至约26μm的奥卡西平与一种或多种亲水性聚合物的混合物，所述混合物通过将包含所述奥卡西平和亲水性聚合物的悬浮液溶剂，在均化器中混合，任选地除去溶剂并将所述混合物转化成剂型。

4. 发明授权

US08187633B2 Controlled release coated tablets having prolonged gastric retention 失效
标题翻译：具有延长胃滞留的控释片剂
公开(公告)号：US08187633B2
公开(公告)日：2012-05-29
申请号：US12092632
申请日：2006-11-03
申请人： Nitin Bhalachandra Dharmadhikari , Yashoraj Rupsinh Zala
发明人： Nitin Bhalachandra Dharmadhikari , Yashoraj Rupsinh Zala
IPC分类号： A61K9/24 , A61K9/20 , A61K9/36
CPC分类号： A61K9/0065 , A61K9/0004 , A61K9/209 , A61K9/2866 , A61K31/192 , A61K31/198
摘要： The present invention relates to a tablet composed of a core and a coating; said core is formed by two or more layers, wherein at least one of them contains an active agent (3). Wherein one of said layers is formulated as a swellable composition (2), the other one (4) is composed of inert compounds retaining its size at least until the coated tablet is emptied from the stomach. The coating composition is selected from the group comprising water insoluble polymers, ph dependent polymers or mixtures thereof. The active agent is released after rupture of the coating.
摘要翻译：本发明涉及由芯和涂层组成的片剂; 所述芯由两层或更多层形成，其中至少一层包含活性剂（3）。其中一个所述层被配制成可溶胀组合物（2），另一个（4）由惰性化合物组成，至少保持其尺寸直到涂覆的片剂从胃排空。涂料组合物选自水不溶性聚合物，ph依赖性聚合物或其混合物。活性剂在涂层破裂后释放。

5. 发明授权

US07964216B2 Spaced drug delivery system 失效
标题翻译：间隔药物输送系统
公开(公告)号：US07964216B2
公开(公告)日：2011-06-21
申请号：US10466036
申请日：2002-01-11
申请人： Dilip Shantilal Shanghvi , Kirti Wardhaman Ganorkar , Yashoraj Rupsinh Zala , Nitin Bhalachandra Dharmadhikari , Satish C Khanna
发明人： Dilip Shantilal Shanghvi , Kirti Wardhaman Ganorkar , Yashoraj Rupsinh Zala , Nitin Bhalachandra Dharmadhikari , Satish C Khanna
IPC分类号： A61K9/20 , A61K9/22 , A61K9/24 , A61K9/26
CPC分类号： A61K9/4808 , A61K9/1623 , A61K9/1652 , A61K9/2054 , A61K9/5047 , A61K9/5084 , A61K31/155 , A61K31/64 , A61K45/06 , A61K2300/00
摘要： The present invention provides to a method of administration of two or more therapeutically active agents comprising orally administering to a patient a spaced drug delivery system, wherein the time of release of the two or more therapeutically active agents is designed to provide desired control on the disease condition. The present invention also provides a method of administration of two or more therapeutically active agents comprising orally administering to a patient a spaced drug delivery system at a specified time prior to food intake by the patient. The present invention further provides a spaced drug delivery system that releases two or more antidiabetic agents at different times after oral administration, for the treatment of diabetes mellitus or conditions associated with diabetes mellitus. More particularly, the present invention provides a spaced drug delivery system that immediately releases one or more antidiabetic agents after oral administration of the system, and releases as a pulse one or more antidiabetic agents in a reliable manner at about a predetermined time after oral administration of the system.
摘要翻译：本发明提供给予两种或更多种治疗活性剂的方法，其包括向患者口服施用间隔开的药物递送系统，其中两种或更多种治疗活性剂的释放时间被设计成提供对疾病的所需控制条件。本发明还提供了一种施用两种或更多种治疗活性剂的方法，其包括在病人食物摄取之前的指定时间向患者口服施用间隔的药物递送系统。本发明还提供了一种间隔开的药物递送系统，其在口服给药后不同时间释放两种或更多种抗糖尿病药物，用于治疗糖尿病或与糖尿病相关的病症。更具体地说，本发明提供了间隔药物递送系统，其在口服给药系统之后立即释放一种或多种抗糖尿病药物，并且在口服给药后大约预定时间以可靠的方式作为脉冲释放一种或多种抗糖尿病药物系统。

6. 发明授权

US07776345B2 Gastric retention controlled drug delivery system 有权
标题翻译：胃滞留控制药物输送系统
公开(公告)号：US07776345B2
公开(公告)日：2010-08-17
申请号：US10482770
申请日：2002-07-04
申请人： Kamlesh Mohanlal Dudhara , Nitin Bhalachandra Dharmadhikari , Vaishali Vijay Dhavse
发明人： Kamlesh Mohanlal Dudhara , Nitin Bhalachandra Dharmadhikari , Vaishali Vijay Dhavse
IPC分类号： A61K9/00 , A61K9/24
CPC分类号： A61K9/0007 , A61K9/0065 , A61K9/209 , A61K31/197
摘要： The present invention provides a gastric retention controlled drug delivery system comprising: (a) a controlled release core comprising a drug, a highly swellable polymer and a gas generating agent, said core being capable of swelling and achieving floatation rapidly while maintaining its physical integrity in gastrointestinal fluids for prolonged periods, and (b) a rapidly releasing coat composition comprising the same drug as in the core and pharmaceutically acceptable excipients, wherein the coating composition surrounds the core such that the system provides a biphasic release of the drug in gastrointestinal fluids.
摘要翻译：本发明提供了一种胃滞留控制药物递送系统，包括：（a）包含药物，高度可溶胀聚合物和气体发生剂的控释核心，所述核心能够在保持其物理完整性的同时膨胀并实现浮选胃肠道液体延长的时间，和（b）快速释放的包衣组合物，其包含与核心和药学上可接受的赋形剂相同的药物，其中所述包衣组合物包围所述核心，使得所述系统提供所述药物在胃肠道液体中的双相释放。

7. 发明申请

US20090123541A1 Pharmaceutical Composition 有权
标题翻译：药物组成
公开(公告)号：US20090123541A1
公开(公告)日：2009-05-14
申请号：US11884770
申请日：2006-02-22
申请人： Yashoraj Rupsinh Zala , Nitin Bhalachandra Dharmadhikari
发明人： Yashoraj Rupsinh Zala , Nitin Bhalachandra Dharmadhikari
IPC分类号： A61K31/4015 , A61K9/24
CPC分类号： A61K9/209 , A61K31/4015
摘要： The present invention relates to an oral controlled release pharmaceutical composition in the form of a unit dosage form comprising: (a) a highly soluble high dose active ingredient consisting essentially of therapeutically effective amount of levetiracetam or a pharmaceutically acceptable derivative thereof, and (b) a rate controlling means comprising a rate-controlling agent and/or a coating selected from (i) a active ingredient permeable coating surrounding the unit dosage form, and (ii) an active ingredient impermeable coating covering one or more surfaces but not all the surfaces of the unit dosage form, wherein the composition is in the form of a compact tablet and the levetiracetam or a pharmaceutically acceptable derivative thereof is present in an amount ranging from about 55% to about 90% by weight of the tablet.
摘要翻译：本发明涉及一种单位剂型形式的口服抑释药物组合物，其包含：（a）主要由治疗有效量的左乙拉西坦或其药学上可接受的衍生物组成的高度可溶的高剂量活性成分，和（b）速率控制装置，包括速率控制剂和/或涂层，其选自（i）围绕单位剂型的活性成分可渗透涂层，和（ii）覆盖一个或多个表面但不是全部表面的活性成分不可渗透涂层的单位剂型，其中所述组合物为致密片剂的形式，并且左乙拉西坦或其药学上可接受的衍生物的存在量为片剂重量的约55％至约90％。

8. 发明申请

US20080138410A1 Oral drug delivery system 有权
标题翻译：口服药物输送系统
公开(公告)号：US20080138410A1
公开(公告)日：2008-06-12
申请号：US11946575
申请日：2007-11-28
申请人： Nitin Bhalachandra DHARMADHIKARI , Yashoraj Rupsinh Zala , Amarjit Singh
发明人： Nitin Bhalachandra DHARMADHIKARI , Yashoraj Rupsinh Zala , Amarjit Singh
IPC分类号： A61K9/24 , A61K9/28 , A61K9/36
CPC分类号： A61K9/2072
摘要： An oral drug delivery system comprising a coated tablet having one or more surfaces. The coated tablet further comprises a core and a coating surrounding the core. The core comprises an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient and a composition selected from a swellable composition and a reactive composition located in an immediate vicinity of one or more preselected surfaces. The coating comprising water insoluble polymer(s) and leachable component(s) is operable to be reliably removed fully from the one or more of the preselected surfaces of the tablet upon contact with an aqueous environment, but not removed from at least one of the surfaces.
摘要翻译：一种口服药物递送系统，其包含具有一个或多个表面的包衣片剂。涂布的片剂还包括芯和围绕芯的涂层。核心包括活性成分组合物，其包含至少一种活性成分和药学上可接受的赋形剂，以及选自位于一个或多个预选表面附近的可溶胀组合物和反应性组合物的组合物。包含水不溶性聚合物和可浸出组分的涂层可操作以在与水性环境接触时可靠地从片剂的一个或多个预选表面完全去除，但不从至少一个表面。

9. 发明授权

US08535717B2 Pharmaceutical composition 有权
公开(公告)号：US08535717B2
公开(公告)日：2013-09-17
申请号：US13102328
申请日：2011-05-06
申请人： Yashoraj Rupsinh Zala , Nitin Bhalachandra Dharmadhikari
发明人： Yashoraj Rupsinh Zala , Nitin Bhalachandra Dharmadhikari
IPC分类号： A61K9/24 , A61K31/40
CPC分类号： A61K9/209 , A61K31/4015
摘要： The present invention relates to an oral controlled release pharmaceutical composition in the form of a unit dosage form comprising: (a) a highly soluble high dose active ingredient consisting essentially of therapeutically effective amount of levetiracetam or a pharmaceutically acceptable derivative thereof, and (b) a rate controlling means comprising a rate-controlling agent and/or a coating selected from (i) a active ingredient permeable coating surrounding the unit dosage form, and (ii) an active ingredient impermeable coating covering one or more surfaces but not all the surfaces of the unit dosage form, wherein the composition is in the form of a compact tablet and the levetiracetam or a pharmaceutically acceptable derivative thereof is present in an amount ranging from about 55% to about 90% by weight of the tablet.

10. 发明授权

US08470367B2 Oral drug delivery system 有权
标题翻译：口服药物输送系统
公开(公告)号：US08470367B2
公开(公告)日：2013-06-25
申请号：US11946575
申请日：2007-11-28
申请人： Nitin Bhalachandra Dharmadhikari , Yashoraj Rupsinh Zala , Amarjit Singh
发明人： Nitin Bhalachandra Dharmadhikari , Yashoraj Rupsinh Zala , Amarjit Singh
IPC分类号： A61K9/24
CPC分类号： A61K9/2072
摘要： An oral drug delivery system comprising a coated tablet having one or more surfaces. The coated tablet further comprises a core and a coating surrounding the core. The core comprises an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient and a composition selected from a swellable composition and a reactive composition located in an immediate vicinity of one or more preselected surfaces. The coating comprising water insoluble polymer(s) and leachable component(s) is operable to be reliably removed fully from the one or more of the preselected surfaces of the tablet upon contact with an aqueous environment, but not removed from at least one of the surfaces.
摘要翻译：一种口服药物递送系统，其包含具有一个或多个表面的包衣片剂。涂布的片剂还包括芯和围绕芯的涂层。核心包括活性成分组合物，其包含至少一种活性成分和药学上可接受的赋形剂，以及选自位于一个或多个预选表面附近的可溶胀组合物和反应性组合物的组合物。包含水不溶性聚合物和可浸出组分的涂层可操作以在与水性环境接触时可靠地从片剂的一个或多个预选表面完全去除，但不从至少一个表面。

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