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1. 发明授权

US07964216B2 Spaced drug delivery system 失效
标题翻译：间隔药物输送系统
公开(公告)号：US07964216B2
公开(公告)日：2011-06-21
申请号：US10466036
申请日：2002-01-11
申请人： Dilip Shantilal Shanghvi , Kirti Wardhaman Ganorkar , Yashoraj Rupsinh Zala , Nitin Bhalachandra Dharmadhikari , Satish C Khanna
发明人： Dilip Shantilal Shanghvi , Kirti Wardhaman Ganorkar , Yashoraj Rupsinh Zala , Nitin Bhalachandra Dharmadhikari , Satish C Khanna
IPC分类号： A61K9/20 , A61K9/22 , A61K9/24 , A61K9/26
CPC分类号： A61K9/4808 , A61K9/1623 , A61K9/1652 , A61K9/2054 , A61K9/5047 , A61K9/5084 , A61K31/155 , A61K31/64 , A61K45/06 , A61K2300/00
摘要： The present invention provides to a method of administration of two or more therapeutically active agents comprising orally administering to a patient a spaced drug delivery system, wherein the time of release of the two or more therapeutically active agents is designed to provide desired control on the disease condition. The present invention also provides a method of administration of two or more therapeutically active agents comprising orally administering to a patient a spaced drug delivery system at a specified time prior to food intake by the patient. The present invention further provides a spaced drug delivery system that releases two or more antidiabetic agents at different times after oral administration, for the treatment of diabetes mellitus or conditions associated with diabetes mellitus. More particularly, the present invention provides a spaced drug delivery system that immediately releases one or more antidiabetic agents after oral administration of the system, and releases as a pulse one or more antidiabetic agents in a reliable manner at about a predetermined time after oral administration of the system.
摘要翻译：本发明提供给予两种或更多种治疗活性剂的方法，其包括向患者口服施用间隔开的药物递送系统，其中两种或更多种治疗活性剂的释放时间被设计成提供对疾病的所需控制条件。本发明还提供了一种施用两种或更多种治疗活性剂的方法，其包括在病人食物摄取之前的指定时间向患者口服施用间隔的药物递送系统。本发明还提供了一种间隔开的药物递送系统，其在口服给药后不同时间释放两种或更多种抗糖尿病药物，用于治疗糖尿病或与糖尿病相关的病症。更具体地说，本发明提供了间隔药物递送系统，其在口服给药系统之后立即释放一种或多种抗糖尿病药物，并且在口服给药后大约预定时间以可靠的方式作为脉冲释放一种或多种抗糖尿病药物系统。

2. 发明申请

US20110250271A1 SPACED DRUG DELIVERY SYSTEM 审中-公开
标题翻译：间隔药物递送系统
公开(公告)号：US20110250271A1
公开(公告)日：2011-10-13
申请号：US13163168
申请日：2011-06-17
申请人： Dilip Shantilal Shanghvi , Kirti Wardhaman Ganorkar , Yashoraj Rupsinh Zala , Nitin Bhalachandra Dharmadhikari , Satish C. Khanna
发明人： Dilip Shantilal Shanghvi , Kirti Wardhaman Ganorkar , Yashoraj Rupsinh Zala , Nitin Bhalachandra Dharmadhikari , Satish C. Khanna
IPC分类号： A61K9/28 , A61K9/36 , A61K31/426 , A61P3/10 , A61K31/4965 , A61K31/18
CPC分类号： A61K9/4808 , A61K9/1623 , A61K9/1652 , A61K9/2054 , A61K9/5047 , A61K9/5084 , A61K31/155 , A61K31/64 , A61K45/06 , A61K2300/00
摘要： The present invention provides to a method of administration of two or more therapeutically active agents comprising orally administering to a patient a spaced drug delivery system, wherein the time of release of the two or more therapeutically active agents is designed to provide desired control on the disease condition. The present invention also provides a method of administration of two or more therapeutically active agents comprising orally administering to a patient a spaced drug delivery system at a specified time prior to food intake by the patient. The present invention further provides a spaced drug delivery system that releases two or more antidiabetic agents at different times after oral administration, for the treatment of diabetes mellitus or conditions associated with diabetes mellitus. More particularly, the present invention provides a spaced drug delivery system that immediately releases one or more antidiabetic agents after oral administration of the system, and releases as a pulse one or more antidiabetic agents in a reliable manner at about a predetermined time after oral administration of the system.
摘要翻译：本发明提供给予两种或更多种治疗活性剂的方法，其包括向患者口服施用间隔开的药物递送系统，其中两种或更多种治疗活性剂的释放时间被设计成提供对疾病的所需控制条件。本发明还提供了一种施用两种或更多种治疗活性剂的方法，其包括在病人食物摄取之前的指定时间向患者口服施用间隔的药物递送系统。本发明还提供了一种间隔开的药物递送系统，其在口服给药后不同时间释放两种或更多种抗糖尿病药物，用于治疗糖尿病或与糖尿病相关的病症。更具体地说，本发明提供了间隔药物递送系统，其在口服给药系统之后立即释放一种或多种抗糖尿病药物，并且在口服给药后大约预定时间内以可靠的方式作为脉冲释放一种或多种抗糖尿病药物系统。

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