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1. 发明授权

US07405301B2 Chemical methods 有权
标题翻译：化学方法
公开(公告)号：US07405301B2
公开(公告)日：2008-07-29
申请号：US10363433
申请日：2001-08-24
申请人： Peter Scammells , Nicholas Gathergood , Justin Ripper
发明人： Peter Scammells , Nicholas Gathergood , Justin Ripper
IPC分类号： C07D489/02 , C07D489/00
CPC分类号： C07D489/02
摘要： This invention relates to a method for N-demethylating an N-methyl morphinane comprising the steps of: (i) treating said N-methyl morphinane with an oxidizing agent to form the N-oxide morphinane; and (ii) treating said N-oxide morphinane with a reducing agent. This invention also relates to a method for oxidizing a Δ7-morphinane compound to a Δ6, Δ8-morphinane compound, comprising the steps of treating said Δ7-morphinane with γ-MnO2 for a time and under conditions sufficient to oxidize said Δ7-morphinane, and treating the γ-MnO2 with glycol or a derivative thereof, and/or an inorganic salt.
摘要翻译：本发明涉及一种N-甲基吗啡烷N-去甲基化方法，包括以下步骤：（i）用氧化剂处理所述N-甲基吗啡烷以形成N-氧化物吗啡烷; 和（ii）用还原剂处理所述N-氧化物吗啡烷。本发明还涉及一种将Delta-D-D-吗啉化合物氧化为DTA 6，D-8'-吗啡烷化合物的方法，包括步骤用γ-MnO 2 2处理所述的δ-7'-吗啉烷一段时间并在足以氧化所述的Δ-7-吗啡烷的条件下进行处理二醇或其衍生物，和/或无机盐的γ-MnO 2。

2. 发明申请

US20120071661A1 Ionic Liquid Solvents 失效
标题翻译：离子液体溶剂
公开(公告)号：US20120071661A1
公开(公告)日：2012-03-22
申请号：US13203133
申请日：2010-02-24
申请人： Nicholas Gathergood , Bruce Pegot , Ian Beadham , Monika Gurbisz , Mukund D. Ghavre , Saibh Morrissey
发明人： Nicholas Gathergood , Bruce Pegot , Ian Beadham , Monika Gurbisz , Mukund D. Ghavre , Saibh Morrissey
IPC分类号： C07D233/58 , C07D213/55 , C07D405/12
CPC分类号： C07D233/58
摘要： A chiral ionic compound comprising an alkyl substituted imidazolium or pyridinium cationic core having an alkyl ester side chain (-alkyl-C(O)O—) directly linked to the core and an associated counter anion, characterized in that the —O— atom of the ester side chain is linked to an alpha, a beta or a gamma hydroxycarboxylic acid functionality via the alpha, beta or gamma hydroxy of the acid functionality and the hydroxycarboxylic acid functionality has at least one asymmetric carbon, or characterized in that an —N═ atom of the alkyl substituted imidazolium or pyridinium cationic core is substituted with an alpha, a beta or a gamma hydroxy group of a alpha, a beta or a gamma hydroxycarboxylic acid functionality and the hydroxycarboxylic acid functionality has at least one asymmetric carbon. The chiral ionic liquids (CILs) may be used as novel solvents, in particular for organic synthesis. The CILs have the potential to induce asymmetry into substrates or catalysts in a variety of organic transformations. A number of the compounds have low antimicrobial and low antifungal toxicities and are also biodegradable CILs.
摘要翻译：一种手性离子化合物，其包含直接与核心连接的烷基酯侧链（ - 烷基-C（O）O-）的烷基取代的咪唑鎓或阳离子阳离子核心及相关的抗衡阴离子，其特征在于：酯侧链通过酸官能团的α，β或γ羟基与α，β或γ羟基羧酸官能团连接，羟基羧酸官能度具有至少一个不对称碳，或其特征在于-N = 烷基取代的咪唑鎓或吡啶鎓阳离子核心的原子被α，β或γ羟基羧酸官能团的α，β或γ羟基取代，羟基羧酸官能团具有至少一个不对称碳。手性离子液体（CIL）可用作新型溶剂，特别用于有机合成。 CILs有可能在各种有机转化中诱导不对称的底物或催化剂。许多化合物具有低抗微生物和低抗真菌毒性，也是可生物降解的CIL。

3. 发明授权

US08785655B2 Ionic liquid solvents 失效
标题翻译：离子液体溶剂
公开(公告)号：US08785655B2
公开(公告)日：2014-07-22
申请号：US13203133
申请日：2010-02-24
申请人： Nicholas Gathergood , Bruce Pegot , Ian Beadham , Monika Gurbisz , Mukund D. Ghavre , Saibh Morrissey
发明人： Nicholas Gathergood , Bruce Pegot , Ian Beadham , Monika Gurbisz , Mukund D. Ghavre , Saibh Morrissey
IPC分类号： C07D233/54
CPC分类号： C07D233/58
摘要： A chiral ionic compound comprising an alkyl substituted imidazolium or pyridinium cationic core having an alkyl ester side chain (-alkyl-C(O)O—) directly linked to the core and an associated counter anion, characterized in that the —O— atom of the ester side chain is linked to an alpha, a beta or a gamma hydroxycarboxylic acid functionality via the alpha, beta or gamma hydroxy of the acid functionality and the hydroxycarboxylic acid functionality has at least one asymmetric carbon, or characterized in that an —N═ atom of the alkyl substituted imidazolium or pyridinium cationic core is substituted with an alpha, a beta or a gamma hydroxy group of a alpha, a beta or a gamma hydroxycarboxylic acid functionality and the hydroxycarboxylic acid functionality has at least one asymmetric carbon. The chiral ionic liquids (CILs) may be used as novel solvents, in particular for organic synthesis. The CILs have the potential to induce asymmetry into substrates or catalysts in a variety of organic transformations. A number of the compounds have low antimicrobial and low antifungal toxicities and are also biodegradable CILs.
摘要翻译：一种手性离子化合物，其包含直接与核心连接的烷基酯侧链（ - 烷基-C（O）O-）的烷基取代的咪唑鎓或阳离子阳离子核心及相关的抗衡阴离子，其特征在于：酯侧链通过酸官能团的α，β或γ羟基与α，β或γ羟基羧酸官能团连接，羟基羧酸官能度具有至少一个不对称碳，或其特征在于-N = 烷基取代的咪唑鎓或吡啶鎓阳离子核心的原子被α，β或γ羟基羧酸官能团的α，β或γ羟基取代，羟基羧酸官能团具有至少一个不对称碳。手性离子液体（CIL）可用作新型溶剂，特别用于有机合成。 CILs有可能在各种有机转化中诱导不对称的底物或催化剂。许多化合物具有低抗微生物和低抗真菌毒性，也是可生物降解的CIL。

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