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1. 发明授权

US09493451B2 Amine derivatives as potassium channel blockers 有权
标题翻译：胺衍生物作为钾通道阻断剂
公开(公告)号：US09493451B2
公开(公告)日：2016-11-15
申请号：US14118170
申请日：2012-05-16
申请人： Andrew Harvey , Agnes Bombrun , Rachel Cooke , Isabelle Jeanclaude-Etter , Nathan Kuchel , Jerome Molette , Jorgen Mould , Dharam Paul , Rajinder Singh , Cristina Donini , Veronique Colovray , Thomas Avery , Julia Crossman , Justin Ripper
发明人： Andrew Harvey , Agnes Bombrun , Rachel Cooke , Isabelle Jeanclaude-Etter , Nathan Kuchel , Jerome Molette , Jorgen Mould , Dharam Paul , Rajinder Singh , Cristina Donini , Veronique Colovray , Thomas Avery , Julia Crossman , Justin Ripper
IPC分类号： A61K31/497 , C07D451/04 , C07D309/14 , C07D213/89 , C07D231/12 , C07D233/56 , C07D401/12 , C07D237/08 , C07D239/24 , C07D405/12 , C07D411/12 , C07C217/90 , C07D413/12 , C07D241/12 , C07D209/52 , C07D211/16 , C07D211/26 , C07D211/38 , C07D213/16 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/40 , C07D241/18
CPC分类号： C07D213/40 , C07C217/90 , C07D209/52 , C07D211/16 , C07D211/26 , C07D211/38 , C07D213/16 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/89 , C07D231/12 , C07D233/56 , C07D237/08 , C07D239/24 , C07D239/34 , C07D241/12 , C07D241/18 , C07D309/14 , C07D401/12 , C07D405/12 , C07D411/12 , C07D413/12 , C07D451/04
摘要： The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
摘要翻译：本发明涉及可用于调节细胞中钾通道活性的化合物，特别是在T细胞中发现的Kv1.3通道的活性。本发明还涉及这些化合物在治疗或预防自身免疫性和炎性疾病，包括多发性硬化症中的用途，含有这些化合物的药物组合物及其制备方法。

2. 发明授权

US07405301B2 Chemical methods 有权
标题翻译：化学方法
公开(公告)号：US07405301B2
公开(公告)日：2008-07-29
申请号：US10363433
申请日：2001-08-24
申请人： Peter Scammells , Nicholas Gathergood , Justin Ripper
发明人： Peter Scammells , Nicholas Gathergood , Justin Ripper
IPC分类号： C07D489/02 , C07D489/00
CPC分类号： C07D489/02
摘要： This invention relates to a method for N-demethylating an N-methyl morphinane comprising the steps of: (i) treating said N-methyl morphinane with an oxidizing agent to form the N-oxide morphinane; and (ii) treating said N-oxide morphinane with a reducing agent. This invention also relates to a method for oxidizing a Δ7-morphinane compound to a Δ6, Δ8-morphinane compound, comprising the steps of treating said Δ7-morphinane with γ-MnO2 for a time and under conditions sufficient to oxidize said Δ7-morphinane, and treating the γ-MnO2 with glycol or a derivative thereof, and/or an inorganic salt.
摘要翻译：本发明涉及一种N-甲基吗啡烷N-去甲基化方法，包括以下步骤：（i）用氧化剂处理所述N-甲基吗啡烷以形成N-氧化物吗啡烷; 和（ii）用还原剂处理所述N-氧化物吗啡烷。本发明还涉及一种将Delta-D-D-吗啉化合物氧化为DTA 6，D-8'-吗啡烷化合物的方法，包括步骤用γ-MnO 2 2处理所述的δ-7'-吗啉烷一段时间并在足以氧化所述的Δ-7-吗啡烷的条件下进行处理二醇或其衍生物，和/或无机盐的γ-MnO 2。

3. 发明申请

US20140336198A1 Amine Derivatives as Potassium Channel Blockers 有权
标题翻译：胺衍生物作为钾通道阻断剂
公开(公告)号：US20140336198A1
公开(公告)日：2014-11-13
申请号：US14118170
申请日：2012-05-16
申请人： Andrew Harvey , Agnes Bombrun , Rachel Cooke , Isabelle Jeanclaude-Etter , Nathan Kuchel , Jerome Molette , Jorgen Mould , Dharam Paul , Rajinder Singh , Cristina Donini , Veronique Colovray , Thomas Avery , Julia Crossman , Justin Ripper
发明人： Andrew Harvey , Agnes Bombrun , Rachel Cooke , Isabelle Jeanclaude-Etter , Nathan Kuchel , Jerome Molette , Jorgen Mould , Dharam Paul , Rajinder Singh , Cristina Donini , Veronique Colovray , Thomas Avery , Julia Crossman , Justin Ripper
IPC分类号： C07D451/04 , C07D405/12 , C07D411/12 , C07D213/64 , C07D413/12 , C07D237/08 , C07D241/18 , C07D213/40 , C07D401/12
CPC分类号： C07D213/40 , C07C217/90 , C07D209/52 , C07D211/16 , C07D211/26 , C07D211/38 , C07D213/16 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/89 , C07D231/12 , C07D233/56 , C07D237/08 , C07D239/24 , C07D239/34 , C07D241/12 , C07D241/18 , C07D309/14 , C07D401/12 , C07D405/12 , C07D411/12 , C07D413/12 , C07D451/04
摘要： The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
摘要翻译：本发明涉及可用于调节细胞中钾通道活性的化合物，特别是在T细胞中发现的Kv1.3通道的活性。本发明还涉及这些化合物在治疗或预防自身免疫性和炎性疾病，包括多发性硬化症中的用途，含有这些化合物的药物组合物及其制备方法。

4. 发明申请

US20090023728A1 1,2,3,4-Tetrahydroisoquinoline Derivatives, Preparations Thereof and Uses Thereof 审中-公开
标题翻译： 1,2,3,4-四氢异喹啉衍生物及其制备方法及用途
公开(公告)号：US20090023728A1
公开(公告)日：2009-01-22
申请号：US10596546
申请日：2004-12-20
申请人： Justin Ripper , Ian Jenkins , Phuc Van Le , Ron Quinn , Christian Janssen
发明人： Justin Ripper , Ian Jenkins , Phuc Van Le , Ron Quinn , Christian Janssen
IPC分类号： A61K31/4725 , C07D405/06 , C07D409/06 , C07D401/06 , A61K31/5377 , A61P1/00 , A61P25/00 , C07D413/14 , C07D491/056
CPC分类号： C07D405/06 , C07D401/06 , C07D405/12 , C07D409/06 , C07D417/06 , C07D491/056
摘要： Compounds of general formula (I) wherein D, E, R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译：制备其中D，E，R 1，R 2，R 3，R 4，R 5，R 6和R 7如本说明书中所定义的通式（I）的化合物及其盐，对映异构体和包含该化合物的药物组合物。它们可用于治疗，特别是治疗疼痛。

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