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1. 发明申请

US20070232595A1 Method for accelerating cutaneous barrier recovery 审中-公开
标题翻译：加速皮肤屏障恢复的方法
公开(公告)号：US20070232595A1
公开(公告)日：2007-10-04
申请号：US11727436
申请日：2007-03-27
申请人： Kazuyuki Ikeyama , Shigeyoshi Fuziwara , Mitsuhiro Denda
发明人： Kazuyuki Ikeyama , Shigeyoshi Fuziwara , Mitsuhiro Denda
IPC分类号： A61K31/542 , A61K31/5383 , A61K31/498
CPC分类号： A61K31/498 , A61K31/5383 , A61K31/542
摘要： A method for accelerating cutaneous barrier recovery and a method for preventing epidermal hyperplasia by inhibiting production of Nitric Oxide by an epidermal cell are provided.
摘要翻译：提供加速皮肤屏障恢复的方法和通过抑制表皮细胞产生一氧化氮来预防表皮增生的方法。

2. 发明授权

US06315980B1 Skin barrier function recovery and promotion composition and evaluation method thereof 有权
标题翻译：皮肤屏障功能恢复及促进作用及其评价方法
公开(公告)号：US06315980B1
公开(公告)日：2001-11-13
申请号：US09400534
申请日：1999-09-21
申请人： Mitsuhiro Denda , Toru Tsuchiya , Masahiro Tanida , Ken Shoji
发明人： Mitsuhiro Denda , Toru Tsuchiya , Masahiro Tanida , Ken Shoji
IPC分类号： A61K5100
CPC分类号： A61Q17/00 , A61K8/33 , A61K8/34 , A61K8/342 , A61K8/37 , A61K2800/77 , A61Q13/00
摘要： A skin barrier function recovery and promotion composition containing, as an active ingredient, a fragrance which is effective when evaluated by applying a predetermined stress to a model experimental animal, in a system to which the tested fragrance is not applied, to thereby reduce the skin barrier function of the animal and using this data of the degree of recovery of the skin barrier function as an indicator and evaluating the capability by the difference between this data and data of the degree of recovery of the skin barrier function in a system to which the tested fragrance is applied.
摘要翻译：一种皮肤屏障功能恢复和促进组合物，其包含作为有效成分的香料，其通过在模拟实验动物施加预定的压力，在未施用测试香料的系统中进行评估时有效，从而减少皮肤使用该皮肤屏障功能恢复程度的数据作为指标，并且通过该数据与皮肤屏障功能的恢复程度的数据之间的差异来评估能力，所述系统中测试香料。

3. 发明授权

US08247382B2 Method for increasing oxytocin release in the epidermis 有权
标题翻译：增加表皮中催产素释放的方法
公开(公告)号：US08247382B2
公开(公告)日：2012-08-21
申请号：US12616908
申请日：2009-11-12
申请人： Sumiko Denda , Mitsuhiro Denda , Kazuyuki Ikeyama
发明人： Sumiko Denda , Mitsuhiro Denda , Kazuyuki Ikeyama
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： A61K31/23 , A61K31/7072 , A61K31/7076
摘要： A method for increasing oxytocin release through direct action on the epidermal keratinocytes is provided. The method for increasing oxytocin release in the epidermis includes increasing the calcium ion concentration in the epidermal cells. In the method of the present invention, the increase of the calcium ion concentration in the epidermal cells may be achieved by physically stimulating the skin. The physical stimulation may be achieved by applying a heat stimulus and/or a massage. The increase of the calcium ion concentration in the epidermal cells may be achieved by stimulating the epidermal cells by at least one agent selected from the group consisting of ATP, UTP, 4 alpha-phorbol 12,13-didecanoate, and pharmaceutically acceptable salts thereof.
摘要翻译：提供了通过对表皮角质形成细胞的直接作用增加催产素释放的方法。增加表皮中催产素释放的方法包括增加表皮细胞中的钙离子浓度。在本发明的方法中，表皮细胞中钙离子浓度的增加可以通过物理刺激皮肤来实现。物理刺激可以通过施加热刺激和/或按摩来实现。表皮细胞中钙离子浓度的增加可以通过至少一种选自ATP，UTP，4α-佛波醇12,13-十一酸酯的药剂及其药学上可接受的盐来刺激表皮细胞来实现。

4. 发明申请

US20120148690A1 SKIN BARRIER FUNCTION RECOVERY ACCELERATOR 审中-公开
标题翻译：皮肤障碍功能恢复加速器
公开(公告)号：US20120148690A1
公开(公告)日：2012-06-14
申请号：US12964986
申请日：2010-12-10
申请人： Mitsuhiro Denda , Moe Tsutsumi , Sumiko Denda
发明人： Mitsuhiro Denda , Moe Tsutsumi , Sumiko Denda
IPC分类号： A61K36/31 , A61K31/26 , A61P17/00 , C07C47/232 , A61K31/11 , C07D239/10 , A61K31/513 , C07C47/22 , C07C233/05 , A61K31/16 , C07C49/437 , A61K31/125 , C07C35/12 , A61K31/045 , C07C69/84 , A61K31/60 , C07C321/18 , A61K31/105 , C07C331/22
CPC分类号： A61K31/045 , A61K31/105 , A61K31/11 , A61K31/125 , A61K31/16 , A61K31/26 , A61K31/513 , A61K31/60
摘要： A novel skin barrier function recovery acceleration method and accelerator are provided. The present invention provides a skin barrier function recovery accelerator that comprises a TRPA1 agonist capable of activating TRPA1 in epidermal cells.
摘要翻译：提供了一种新颖的皮肤屏障功能恢复加速方法和加速器。本发明提供一种皮肤屏障功能恢复促进剂，其包括能够在表皮细胞中活化TRPA1的TRPA1激动剂。

5. 发明申请

US20070270336A1 Method for accelerating cutaneous barrier recovery 审中-公开
标题翻译：加速皮肤屏障恢复的方法
公开(公告)号：US20070270336A1
公开(公告)日：2007-11-22
申请号：US11797997
申请日：2007-05-09
申请人： Mitsuhiro Denda , Kaori Inoue
发明人： Mitsuhiro Denda , Kaori Inoue
IPC分类号： A61K38/11 , A61K38/12 , A61K31/513 , A61K31/655
CPC分类号： A61K38/12 , A61K31/513 , A61K31/655
摘要： A method for accelerating cutaneous barrier recovery by inducing efflux of potassium ion from an epidermal cell as well as a method for preventing epidermal hyperplasia induced by inducing efflux of potassium ion from an epidermal cell are provided.
摘要翻译：提供了一种通过诱导来自表皮细胞的钾离子的外排促进皮肤屏障恢复的方法，以及通过诱导来自表皮细胞的钾离子的外排而诱导的表皮增生的方法。

6. 发明申请

US20080138853A1 Method for evaluating the degree of maturity of corneocytes 审中-公开
标题翻译：评价角膜细胞成熟程度的方法
公开(公告)号：US20080138853A1
公开(公告)日：2008-06-12
申请号：US11987872
申请日：2007-12-05
申请人： Tetsuji Hirao , Mitsuhiro Denda , Motoji Takahashi , Tadashi Terui , Hachiro Tagami
发明人： Tetsuji Hirao , Mitsuhiro Denda , Motoji Takahashi , Tadashi Terui , Hachiro Tagami
IPC分类号： G01N1/30
CPC分类号： G01N33/5005 , G01N1/30 , G01N33/5091 , G01N33/56966
摘要： Disclosed is an evaluating method for the properties of a corneocyte in a horny layer sample originating in the skin. In the above method, detected and evaluated are selective staining of a cornified envelope in a corneocyte, selective staining of a nuclear component and the antigenicity.
摘要翻译：公开了一种来自皮肤的角质层样品中的角质细胞的性质的评价方法。在上述方法中，检测和评估是在角质细胞中的角质化包膜的选择性染色，核成分的选择性染色和抗原性。

7. 发明申请

US20070098665A1 Effects of skin surface temperature on the epidermal permeability barrier homeostasis 审中-公开
标题翻译：皮肤表面温度对表皮渗透屏障体内平衡的影响
公开(公告)号：US20070098665A1
公开(公告)日：2007-05-03
申请号：US11585229
申请日：2006-10-24
申请人： Mitsuhiro Denda , Kaori Inoue
发明人： Mitsuhiro Denda , Kaori Inoue
IPC分类号： A61K8/64 , A61K8/65
CPC分类号： A61Q19/00 , A61K8/375 , A61K8/46 , A61K2800/70
摘要： A method for accelerating barrier recovery of skin by activating the TRPV4 and/or by blocking the TRPV1 on epidermal cell is provided.
摘要翻译：提供了通过激活TRPV4和/或通过阻断表皮细胞上的TRPV1促进皮肤屏障恢复的方法。

8. 发明申请

US20050209201A1 Method and composition for suppression of inflammation 审中-公开
标题翻译：抑制炎症的方法和组成
公开(公告)号：US20050209201A1
公开(公告)日：2005-09-22
申请号：US11077389
申请日：2005-03-11
申请人： Kaori Inoue , Mitsuhiro Denda , Shigeyoshi Fujiwara
发明人： Kaori Inoue , Mitsuhiro Denda , Shigeyoshi Fujiwara
IPC分类号： C12N15/09 , A61K8/00 , A61K8/30 , A61K8/46 , A61K31/185 , A61K31/655 , A61K45/00 , A61P17/16 , A61P29/00 , A61Q19/00
CPC分类号： A61K31/655 , A61K8/466 , A61K2800/75 , A61Q17/00 , A61Q19/004
摘要： The present invention provides a method and composition which ameliorate inflammation, and suppress its onset, by allowing ATP receptor antagonists to act on ATP receptors of cells to block them and thereby inhibit the release of inflammatory cytokines, particularly interleukin-6 (IL-6) and/or interleukin-8 (IL-8), by the cells.
摘要翻译：本发明提供了通过使ATP受体拮抗剂作用于细胞的ATP受体以阻断它们并由此抑制炎性细胞因子（特别是白细胞介素-6（IL-6））的释放来改善炎症并抑制其发作的方法和组合物，和/或白细胞介素-8（IL-8））。

9. 发明申请

US20050175645A1 Insoluble powder, powder for restoring barrier function of skin, powder for preventing/mitigating skin chapping, and preparation containing the same for external use on skin 有权
标题翻译：不溶性粉末，用于恢复皮肤屏障功能的粉末，用于预防/缓解皮肤裂纹的粉末，以及含有外用皮肤的制剂
公开(公告)号：US20050175645A1
公开(公告)日：2005-08-11
申请号：US10509539
申请日：2003-03-28
申请人： Shigeyoshi Fujiwara , Mitsuhiro Denda , Katsuki Ogawa , Tsuyoshi Miyamoto , Sadaki Takata
发明人： Shigeyoshi Fujiwara , Mitsuhiro Denda , Katsuki Ogawa , Tsuyoshi Miyamoto , Sadaki Takata
IPC分类号： A61K8/19 , A61K8/23 , A61K8/27 , A61Q1/02 , A61Q1/06 , A61Q1/10 , A61Q1/12 , A61Q17/00 , A61Q19/00 , A61Q19/08 , A61K33/24 , A61K7/00
CPC分类号： A61Q1/12 , A61K8/022 , A61K8/19 , A61K8/23 , A61K8/27 , A61K2800/412 , A61K2800/651 , A61Q1/02 , A61Q1/06 , A61Q1/10 , A61Q17/00 , A61Q19/00 , A61Q19/08
摘要： A first subject of the present invention is an insoluble powder characterized in that a zeta-potential is a negative value. It is preferable that barium sulfate is a main ingredient in the insoluble powder. It is preferable that an average primary particle diameter is 3 to 100 μm, and an aspect ratio is 3 to 250 in the insoluble powder. It is preferable that the insoluble powder is a metal-doped barium sulfate powder obtained by reacting a barium ion and a sulfate ion in the presence of a metal ion. It is preferable that the metal ion is one or more selected from the group consisting of a lithium ion, a sodium ion and a zinc ion in the insoluble powder. A second subject of the present invention is a skin barrier function recovering powder, or a skin roughening preventing and improving powder, which comprises the aforementioned powder. A third subject of the present invention is a skin external composition characterized in that a content of the aforementioned powder is 1 to 40% by weight.
摘要翻译：本发明的第一个目标是不溶性粉末，其特征在于ζ电位是负值。优选硫酸钡是不溶性粉末的主要成分。在不溶性粉末中，优选平均一次粒径为3〜100μm，长径比为3〜250。优选不溶性粉末是在金属离子存在下使钡离子和硫酸根离子反应而得到的金属掺杂硫酸钡粉末。金属离子优选在不溶性粉末中选自锂离子，钠离子和锌离子中的一种以上。本发明的第二主题是包含上述粉末的皮肤屏障功能回收粉末或防止和改善皮肤粗糙剂的粉末。本发明的第三主题是皮肤外用组合物，其特征在于上述粉末的含量为1〜40重量％。

10. 发明授权

US08303996B2 Barium sulfate-based powders and cosmetics containing the same 有权
标题翻译：含硫酸钡的粉末和含有相同的化妆品
公开(公告)号：US08303996B2
公开(公告)日：2012-11-06
申请号：US10471087
申请日：2002-03-07
申请人： Tsuyoshi Miyamoto , Katsuki Ogawa , Sadaki Takata , Mitsuhiro Denda
发明人： Tsuyoshi Miyamoto , Katsuki Ogawa , Sadaki Takata , Mitsuhiro Denda
IPC分类号： A61K33/00
CPC分类号： C01F11/462 , A61K8/23 , A61Q1/02 , A61Q1/12 , C01P2004/01 , C01P2004/03 , C01P2004/30 , C01P2004/45
摘要： A barium sulfate-based powder is produced by bringing barium ions (A) into contact with sulfate ions (B) in the presence of one or more metallic ion species (C) selected from the group consisting of lithium ions, sodium ions, potassium ions, magnesium ions, calcium ions, zinc ions, and aluminum ions. Thus, barium sulfate-based powders having various characteristics and thus satisfying functional requirements for cosmetics can be obtained.
摘要翻译：在一种或多种选自锂离子，钠离子，钾离子的金属离子种类（C）的存在下，使钡离子（A）与硫酸根离子（B）接触来制备硫酸钡基粉末，镁离子，钙离子，锌离子和铝离子。因此，可以获得具有各种特性并因此满足化妆品功能要求的硫酸钡基粉末。

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