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1. 发明授权

US5395305A Multilayer wound covering materials comprising a supporting layer and a moisture permeation controlling layer and method for their manufacture 失效
标题翻译：包括支撑层和水分渗透控制层的多层缠绕覆盖材料及其制造方法
公开(公告)号：US5395305A
公开(公告)日：1995-03-07
申请号：US745889
申请日：1991-08-16
申请人： Mikio Koide , Jun Konishi , Kazuhito Ikegami , Ken-ichi Osaki
发明人： Mikio Koide , Jun Konishi , Kazuhito Ikegami , Ken-ichi Osaki
IPC分类号： A61L15/52 , A61L15/60 , A61F13/00
CPC分类号： A61L15/52 , A61L15/60
摘要： Wound-covering materials comprising two layers, a first support layer which is to be in contact with a wound and a second moisture permeation-controlling layer which may optionally contain an antimicrobial agent are taught. The support layer is formed from a biocompatible highly aqueous gel-forming substance, e.g., carboxymethylcelluloses, alginates, hyaluronates, poly(meth)acrylates, chitosan derivatives and chitin derivatives, and at least a portion of the support layer which is to be in contact with a wound is coated with a water-repellant substance, e.g., silicones, polyurethanes, styrene-butadiene-styrene block copolymers and polytetrafluoroethylenes. The moisture permeation controlling layer may, e.g., be formed from steam permeable resin films made of silicone or polyurethane elastomers. The resultant wound-covering materials inhibit infection and pain, maintain adequate water retention, and do not produce bioincompatibility responses when applied to the site of wounds.
摘要翻译：教导包括两层的缠绕覆盖材料，与伤口接触的第一支撑层和可选地含有抗微生物剂的第二湿度渗透控制层。支撑层由生物相容性高含水凝胶形成物质形成，例如羧甲基纤维素，藻酸盐，透明质酸盐，聚（甲基）丙烯酸酯，壳聚糖衍生物和几丁质衍生物，以及至少一部分待接触的载体层用伤口涂覆防水物质，例如硅氧烷，聚氨酯，苯乙烯 - 丁二烯 - 苯乙烯嵌段共聚物和聚四氟乙烯。水分渗透控制层可以例如由由硅氧烷或聚氨酯弹性体制成的透湿树脂膜形成。所得的伤口覆盖材料抑制感染和疼痛，保持足够的保水性，并且当施用于伤口部位时不产生生物相容性反应。

2. 发明授权

US5350583A Cell-penetrable medical material and artificial skin 失效
标题翻译：细胞穿透性医疗材料和人造皮肤
公开(公告)号：US5350583A
公开(公告)日：1994-09-27
申请号：US970955
申请日：1992-11-03
申请人： Katsutoshi Yoshizato , Jun Konishi , Mikio Koide , Kaori Oyamada , Ken-ichi Ohsaki , Takeo Katakura , Yuichi Mori , Ken Tatebe
发明人： Katsutoshi Yoshizato , Jun Konishi , Mikio Koide , Kaori Oyamada , Ken-ichi Ohsaki , Takeo Katakura , Yuichi Mori , Ken Tatebe
IPC分类号： A61F2/00 , A61L15/32 , A61L27/24 , A61L27/36 , A61L27/56 , A61L27/60 , C12N5/00 , A61F2/10
CPC分类号： A61L27/3683 , A61L15/325 , A61L27/24 , A61L27/56 , A61L27/60 , C12N5/0062 , C12N5/0068 , A61F2310/00365 , Y10S128/08 , Y10S623/901
摘要： Cell-penetrable medical material made of denatured collagen which is prepared by heating, in the presence of water is disclosed, the collagen having cross-linking structure. Artificial skin prepared by using this medical material as a wound-contacting layer (2) is also disclosed.
摘要翻译：通过在水存在下加热制备的由变性胶原制成的细胞穿透性医疗材料公开了具有交联结构的胶原蛋白。还公开了通过使用该医用材料作为伤口接触层（2）制备的人造皮肤。

3. 发明授权

US4560720A Compositions of polyvinyl chloride and tetracarboxylic tetraesters and medical articles thereof 失效
标题翻译：聚氯乙烯和四羧酸四酯的组合物及其医药制品
公开(公告)号：US4560720A
公开(公告)日：1985-12-24
申请号：US542355
申请日：1983-10-17
申请人： Juuro Aoyagi , Toshiji Ichikawa , Mikio Koide , Takeshi Shimomura
发明人： Juuro Aoyagi , Toshiji Ichikawa , Mikio Koide , Takeshi Shimomura
IPC分类号： A61L29/00 , A61J1/00 , A61J1/05 , C08K5/12 , C08K5/375 , C08K5/41 , C08K5/10
CPC分类号： A61J1/10 , C08K5/12 , C08K5/375 , C08K5/41
摘要： Medical articles made of a resin composition comprising a polyvinyl chloride and a tetracarboxylic tetraester are provided. As examples of the tetracarboxylic tetraester are mentioned tetra(2-ethylhexyl) 3,3',4,4'-biphenylethertetracarboxylate, tetra(2-ethylhexyl) 3,3',4,4'-biphenylmethanetetracarboxylate, tetra(n-dodecyl) 2,3,3',4'-biphenyl-1,1-ethanetetracarboxylate, tetra(2-ethylhexyl) 3,3',4,4'-biphenyl-2,2-propanetetracarboxylate and the like. The tetracarboxylic tetraester is incorporated in an amount from 20 to 120, preferably from 30 to 100 parts by weight per 100 parts by weight of the polyvinyl chloride. As dissolution and migration to the surface of the article of the plasticizer tetracarboxylic tetraester are low in the medical articles, said medical articles produce no adverse effects upon body fluids such as blood when contacted. Examples of preferred medical articles are blood preservation vessels, catheters and blood transfusion sets.
摘要翻译：提供由包含聚氯乙烯和四羧酸四酯的树脂组合物制成的医疗制品。提到四羧酸四酯的四（2-乙基己基）3,3'，4,4'-联苯基醚四羧酸四（2-乙基己基）3,3'，4,4'-联苯甲烷四羧酸四（正十二烷基）酯， 2,3,3'，4'-联苯-1,1-乙烷四羧酸酯，3,3'，4,4'-联苯基-2,2-丙烷四羧酸四（2-乙基己基）酯，4,4'-联苯基-2,2-丙烷四羧酸酯等。四羧酸四酯的含量为每100重量份聚氯乙烯20至120重量份，优选30至100重量份。由于溶解和向塑化剂四羧酸四酯的制品的表面迁移到医疗制品中，所以医疗制品在接触时不会对体液如血液产生不利影响。优选医疗制品的实例是保血管，导管和输血组。

4. 发明授权

US5263983A Medical material and prosthetic skin in which cells can invade 失效
标题翻译：医疗材料和细胞可以入侵的假体皮肤
公开(公告)号：US5263983A
公开(公告)日：1993-11-23
申请号：US576493
申请日：1990-09-07
申请人： Katsutoshi Yoshizato , Jun Konishi , Mikio Koide , Kaori Oyamada , Ken-ichi Ohsaki , Takeo Katakura , Yuichi Mori , Ken Tatebe
发明人： Katsutoshi Yoshizato , Jun Konishi , Mikio Koide , Kaori Oyamada , Ken-ichi Ohsaki , Takeo Katakura , Yuichi Mori , Ken Tatebe
IPC分类号： A61F2/00 , A61L27/24 , A61L27/36 , A61L27/56 , A61L27/60 , C12N5/00 , A61F2/04
CPC分类号： A61L27/3695 , A61L27/24 , A61L27/56 , A61L27/60 , C12N5/0062 , C12N5/0068 , A61F2310/00365 , Y10S128/08 , Y10S514/801
摘要： Disclosed is a cell-penetrable medical material in which cells can invade, comprising denatured collagen with helix content of 0 to 80%, and carrier substance having higher resistance to enzyme decomposition than the denatured collagen. An artificial skin in which this medical material is used as the wound contact layer, and its preferred manufacturing methods are also disclosed.
摘要翻译： PCT No.PCT / JP89 / 00257 Sec。 371 1990年9月7日第 102（e）1990年9月7日PCT PCT 1989年3月9日PCT。出版物WO89 / 08465 日期：1989年9月21日。公开是一种细胞侵袭性的医疗材料，其中细胞可以侵入，包括具有0至80％螺旋含量的变性胶原蛋白，以及比变性胶原蛋白具有更高抗酶分解能力的载体物质。还公开了将该医疗材料用作伤口接触层的人造皮肤及其优选的制造方法。

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