会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 7. 发明授权
    • Aromatic amidocarboxylic acids and pharmaceutical compositions thereof
    • 芳族酰胺羧酸及其药物组合物
    • US4026896A
    • 1977-05-31
    • US568423
    • 1975-04-16
    • Kozaburo HaritaYukiyoshi AjisawaKinji IizukaMichio TodaYukihiko KinoshitaTetsuhide KamijoMichihiro Kobayashi
    • Kozaburo HaritaYukiyoshi AjisawaKinji IizukaMichio TodaYukihiko KinoshitaTetsuhide KamijoMichihiro Kobayashi
    • C07D317/60C07C103/84
    • C07D317/60
    • New aromatic amidocarboxylic acid derivatives of the general formula: ##STR1## wherein R.sub.1 and R.sub.2 each represent a hydrogen atom or an alkyl gp with 1-4 carbon atoms; R.sub.3 and R.sub.4 each represent a hydrogen atom or may be combined together to form an additional chemical bond; X represents a hydroxyl group, a halogen atom, a straight or branched chain saturated or unsaturated alkyl group with 1-4 carbon atoms, a straight or branched chain saturated or unsaturated alkoxy group with 1-4 carbon atoms, an acyloxy group with 1-4 carbon atoms, or a cycloalkyl group with up to 6 carbon atoms; n is zero or an integer of 1-3 with the proviso that when n is 2 or 3, X's may be the same or different and that when two X's are commonly the alkyl or alkoxy group, both X's may be combined together to form a ring; and Y represents a straight or branched chain alkylene group or a straight or branched chain oxyalkylene group connected to the benzene nucleus through an oxygen atom, as well as physiologically acceptable salts thereof.The new compounds possess a strong antiallergic effect and are thus useful for the treatment of asthma, hay fever, urticaria and atopic dermatitis.The above-mentioned aromatic amidocarboxylic acid and a salt thereof are prepared, for example, by reacting a reactive functional derivative of the general formula: ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, X and n have the same meanings as given above, with an aminophenylalkylcarboxylic acid derivative or an aminophenoxyalkylcarboxylic acid dervative of the general formula: ##STR3## wherein Y has the same meaning as given above, and if desired, converting the resulting amidocarboxylic acid into a corresponding salt thereof or vice versa.
    • 新的芳族酰胺基羧酸衍生物,其通式如下:其中R 1和R 2各自表示氢原子或具有1-4个碳原子的烷基; R 3和R 4各自表示氢原子,或者可以组合在一起形成附加的化学键; X表示羟基,卤素原子,具有1-4个碳原子的直链或支链饱和或不饱和烷基,具有1-4个碳原子的直链或支链饱和或不饱和烷氧基,具有1- 4个碳原子或具有至多6个碳原子的环烷基; n为0或1-3的整数,条件是当n为2或3时,X可以相同或不同,并且当两个X通常为烷基或烷氧基时,两个X可以组合在一起形成 环; Y表示通过氧原子与苯环连接的直链或支链亚烷基或直链或支链氧化烯基,以及其生理上可接受的盐。