会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 2. 发明授权
    • Phenoxyacetic acid derivatives and medicinal compositions containing the same
    • 苯氧乙酸衍生物和含有它们的药物组合物
    • US06538152B1
    • 2003-03-25
    • US09720976
    • 2001-01-03
    • Nobuyuki TanakaTetsuro TamaiHarunobu MukaiyamaAkihito HirabayashiHideyuki MuranakaMasaaki SatoMasuo Akahane
    • Nobuyuki TanakaTetsuro TamaiHarunobu MukaiyamaAkihito HirabayashiHideyuki MuranakaMasaaki SatoMasuo Akahane
    • C07C22900
    • C07C217/60C07C233/43C07C235/06C07C235/60C07C255/59
    • The present invention provides novel phenoxyacetic acid derivatives represented by the general formula: wherein R1 represents a hydroxy group, a lower alkoxy group, an aralkoxy group, an amino group, or a mono or di(lower alkyl)amino group; one of R2 and R3 is a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group, while the other is a hydrogen atom; R4 represents a halogen atom, a lower alkyl group, a halo(lower alkyl) group, a hydroxy group, a lower alkoxy group, an aralkoxy group, a cyano group, a nitro group, an amino group, a mono or di(lower alkyl)amino group, a carbamoyl group, a mono or di(lower alkyl)carbamoyl group or a group represented by the general formula: —NHCOR5 (wherein R5 represents a hydrogen atom or a lower alkyl group); the carbon atom marked with (R) represents a carbon atom in R configuration; and the carbon atom marked with (S) represents a carbon atom in S configuration, and pharmaceutically acceptable salts thereof, which have excellent &bgr;3-adrenoceptor stimulating effects and are useful as agents for the prevention or treatment of obesity, hyperglycemia, the diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression, or the diseases caused by biliary calculi or hypermotility of biliary tract.
    • 本发明提供由通式表示的新型苯氧基乙酸衍生物:其中R1表示羟基,低级烷氧基,芳烷氧基,氨基或单或二(低级烷基)氨基; R2和R3中的一个是氢原子,卤素原子,低级烷基或低级烷氧基,而另一个是氢原子; R4表示卤原子,低级烷基,卤代(低级烷基),羟基,低级烷氧基,芳烷氧基,氰基,硝基,氨基,单或二(低级) 烷基)氨基,氨基甲酰基,一或二(低级烷基)氨基甲酰基或由通式表示的基团:其中R5表示氢原子或低级烷基; 用(R)标记的碳原子表示R构型的碳原子; 标记有(S)的碳原子表示S构型的碳原子及其药学上可接受的盐,其具有优异的β3肾上腺素能受体刺激作用,并且可用作预防或治疗肥胖,高血糖,由高血糖引起的疾病 肠蠕动过多,尿频尿失禁,抑郁症,胆汁结石或胆汁运动障碍引起的疾病。
    • 5. 发明授权
    • Phenylaminoalkylcarboxylic acid derivatives and pharmaceutical compositions comprising the same
    • 苯基氨基烷基羧酸衍生物和包含它们的药物组合物
    • US06353025B1
    • 2002-03-05
    • US09581851
    • 2000-06-19
    • Tetsuro TamaiNobuyuki TanakaHarunobu MukaiyamaAkihito HirabayashiHideyuki MuranakaMasaaki SatoMasuo Akahane
    • Tetsuro TamaiNobuyuki TanakaHarunobu MukaiyamaAkihito HirabayashiHideyuki MuranakaMasaaki SatoMasuo Akahane
    • A01N3712
    • C07D295/185C07C229/18C07C237/06
    • The present invention provides novel phenylaminoalkyl-carboxylic acid derivatives represented by the general formula: (wherein R1 represents a hydroxy group, a lower alkoxy group, an aralkoxy group, an amino group, an alicyclic amino group or a mono or di(lower alkyl)amino group which may have a hydroxy group or a lower alkoxy group as a substituent; R2 represents a hydrogen atom or a lower alkyl group; R3 represents a hydrogen atom or a halogen atom; R4 and R5 are the same or different and each represents a hydrogen atom, a halogen atom or a lower alkyl group; A represents a lower alkylene group; the carbon atom marked with (R) represents a carbon atom in (R) configuration; and the carbon atom marked with (S) represents a carbon atom in (S) configuration) and pharmaceutically acceptable salts thereof, which have excellent &bgr;3-adrenoceptor stimulating effects and are useful as agents for the prevention or treatment of obesity, hyperglycemia, the diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression, or the diseases caused by biliary calculi or hypermotility of biliary tract.
    • 本发明提供由通式(其中R1表示羟基,低级烷氧基,芳烷氧基,氨基,脂环族氨基或单或二(低级烷基))表示的新型苯基氨基烷基 - 羧酸衍生物, 可以具有羟基或低级烷氧基作为取代基的氨基; R2表示氢原子或低级烷基; R3表示氢原子或卤素原子; R4和R5相同或不同,表示 氢原子,卤素原子或低级烷基; A表示低级亚烷基;(R)表示的碳原子表示(R)构型的碳原子,(S)表示的碳原子表示碳原子 (S)构型)及其药学上可接受的盐,其具有优异的β3肾上腺素能受体刺激作用,并且可用作预防或治疗肥胖症,高血糖症,由肠道超嗜热引起的疾病 遗尿,尿频,尿失禁,抑郁症或由胆汁结石或胆汁运动障碍引起的疾病。