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1. 发明授权

US09957558B2 Methods and compositions for multiplex PCR 有权
公开(公告)号：US09957558B2
公开(公告)日：2018-05-01
申请号：US13458739
申请日：2012-04-27
申请人： John Leamon , Mark Andersen , Michael Thornton
发明人： John Leamon , Mark Andersen , Michael Thornton
IPC分类号： C12Q1/68 , C12N15/10
CPC分类号： C12Q1/686 , C12N15/1065 , C12Q1/6806 , C12Q1/6855 , C12Q1/6874 , C12Q1/6886 , C12Q2600/16 , C12Q2521/307 , C12Q2525/101 , C12Q2525/191 , C12Q2537/143
摘要： The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex PCR of one or more nucleic acids present in a sample. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences. In one aspect, the invention relates to target-specific primers useful for the selective amplification of one or more target sequences associated with cancer or inherited disease. In some aspects, amplified target sequences obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing and used to detect the presence of genetic variants.

2. 发明申请

US20150316626A1 METHOD AND SYSTEM FOR ESTIMATING THE SPECIFIC ABSORPTION RATE OF A TISSUE REGION PRIOR TO A MAGNETIC RESONANCE IMAGING SCAN 审中-公开
标题翻译：用于估计磁共振成像扫描前的组织区域的特定吸收率的方法和系统
公开(公告)号：US20150316626A1
公开(公告)日：2015-11-05
申请号：US14704369
申请日：2015-05-05
申请人： Michael Thornton , Paul Picot , Brian Rutt , Simone Winkler
发明人： Michael Thornton , Paul Picot , Brian Rutt , Simone Winkler
IPC分类号： G01R33/28 , G01R33/58 , G01R33/54 , A61B5/055
CPC分类号： A61B5/055 , A61B5/7225 , G01R33/288 , G01R33/54 , G01R33/58
摘要： A method and system for estimating a specific; absorption rate of a tissue region prior to performing a magnetic resonance (MR) imaging scan on the tissue region. The method comprises radiating the tissue region with a plurality of short pulses, wherein the tissue region emits thermoacoustic signals responsive to the short pulses, receiving the thermoacoustic signals by at least one ultrasonic transducer, calculating a temperature rise of the tissue region based on the received thermoacoustic signals, scaling the temperature rise to estimate a temperature rise of the tissue region resulting from an MR imaging scan, and estimating the specific absorption rate of the tissue region based on the estimated temperature rise.
摘要翻译：用于估计特定的方法和系统; 在对组织区域进行磁共振（MR）成像扫描之前的组织区域的吸收率。该方法包括用多个短脉冲辐射组织区域，其中组织区域响应于短脉冲发射热声信号，由至少一个超声波换能器接收热声信号，基于接收到的计算组织区域的温度升高热声信号，缩放温度上升以估计由MR成像扫描产生的组织区域的温度升高，并且基于估计的温度升高来估计组织区域的比吸收率。

3. 发明申请

US20110211343A1 Recessed Sealed Lighting Fixture 有权
标题翻译：嵌入式密封照明灯具
公开(公告)号：US20110211343A1
公开(公告)日：2011-09-01
申请号：US13104707
申请日：2011-05-10
申请人： Casey Chung , Jill Cody , Brandon Stolte , Marcelino Pena , Michael Thornton
发明人： Casey Chung , Jill Cody , Brandon Stolte , Marcelino Pena , Michael Thornton
IPC分类号： F21S4/00 , F21V15/01 , F21V11/00 , B23P17/04
CPC分类号： F21V17/164 , F21S8/02 , F21V3/04 , F21V5/02 , F21V15/015 , F21V17/14 , F21W2131/20 , F21Y2103/00 , F21Y2113/00 , Y10T29/49826
摘要： In an embodiment, a recessed light fixture includes a structural reflector and two end caps that form a light fixture housing. A first, second and third optics areas are provided. At least one first light source type is mounted near the first optics area. A second light source type is mounted near the second optics area and the second light source type is mounted near the third optics areas, the second light source type having a light output level substantially lower than the light output level of the first light source type. A diffuser is configured to sealably mount to the light fixture housing so as to substantially seal an interior portion of the light fixture. In operation, the light fixture can be switch between an ambient mode and an examination mode while providing a cost effective and attractive design.
摘要翻译：在一个实施例中，嵌入式灯具包括结构反射器和形成灯具壳体的两个端盖。提供第一，第二和第三光学区域。至少一个第一光源类型安装在第一光学区域附近。第二光源类型安装在第二光学区域附近，第二光源类型安装在第三光学区域附近，第二光源类型的光输出电平基本上低于第一光源类型的光输出电平。扩散器被配置为可密封地安装到灯具壳体，以便基本上密封灯具的内部部分。在操作中，灯具可以在环境模式和检查模式之间切换，同时提供成本有效和有吸引力的设计。

4. 发明申请

US20100118525A1 Recessed Sealed Lighting Fixture 有权
标题翻译：嵌入式密封照明灯具
公开(公告)号：US20100118525A1
公开(公告)日：2010-05-13
申请号：US12688441
申请日：2010-01-15
申请人： Casey Chung , Jill Cody , Brandon Stolte , Marcelino Pena , Michael Thornton
发明人： Casey Chung , Jill Cody , Brandon Stolte , Marcelino Pena , Michael Thornton
IPC分类号： F21S4/00 , F21V1/00 , F21V15/00
CPC分类号： F21V17/164 , F21S8/02 , F21V3/04 , F21V5/02 , F21V15/015 , F21V17/14 , F21W2131/20 , F21Y2103/00 , F21Y2113/00 , Y10T29/49826
摘要： In an embodiment, a recessed light fixture includes a structural reflector and two end caps that form a light fixture housing. A first, second and third optics areas are provided. At least one first light source type is mounted near the first optics area. A second light source type is mounted near the second optics area and the second light source type is mounted near the third optics areas, the second light source type having a light output level substantially lower than the light output level of the first light source type. A diffuser is configured to sealably mount to the light fixture housing so as to substantially seal an interior portion of the light fixture. In operation, the light fixture can be switch between an ambient mode and an examination mode while providing a cost effective and attractive design.
摘要翻译：在一个实施例中，嵌入式灯具包括结构反射器和形成灯具壳体的两个端盖。提供第一，第二和第三光学区域。至少一个第一光源类型安装在第一光学区域附近。第二光源类型安装在第二光学区域附近，第二光源类型安装在第三光学区域附近，第二光源类型的光输出电平基本上低于第一光源类型的光输出电平。扩散器被配置为可密封地安装到灯具壳体，以便基本上密封灯具的内部部分。在操作中，灯具可以在环境模式和检查模式之间切换，同时提供成本有效和有吸引力的设计。

5. 发明授权

US07540383B2 Self-opening blister package 有权
公开(公告)号：US07540383B2
公开(公告)日：2009-06-02
申请号：US11977061
申请日：2007-10-23
申请人： Scott Huffer , Michael Thornton
发明人： Scott Huffer , Michael Thornton
IPC分类号： B65D83/04
CPC分类号： B65D75/327 , B65D2575/3245 , Y10S206/804
摘要： A self-opening blister package is provided having a packaging sleeve or carton and a formed tray. The tray includes one or more receptacle cups, which are dimensioned to receive one or more products, such as gum or the like. A peelable membrane is sealed to the tray flange. A leading edge of the membrane is attached to the sleeve. The membrane peels away from the tray when the tray is removed from the sleeve. The peeling action exposes the product contained in the one or more cups. Once the desired amount of product is extracted, the tray can be pushed back into the sleeve and the membrane rolls back over the tray.

6. 发明申请

US20090101537A1 Self-opening blister package 有权
标题翻译：自开泡罩包装
公开(公告)号：US20090101537A1
公开(公告)日：2009-04-23
申请号：US11977061
申请日：2007-10-23
申请人： Scott Huffer , Michael Thornton
发明人： Scott Huffer , Michael Thornton
IPC分类号： B65D1/36
CPC分类号： B65D75/327 , B65D2575/3245 , Y10S206/804
摘要： A self-opening blister package is provided having a packaging sleeve or carton and a formed tray. The tray includes one or more receptacle cups, which are dimensioned to receive one or more products, such as gum or the like. A peelable membrane is sealed to the tray flange. A leading edge of the membrane is attached to the sleeve. The membrane peels away from the tray when the tray is removed from the sleeve. The peeling action exposes the product contained in the one or more cups. Once the desired amount of product is extracted, the tray can be pushed back into the sleeve and the membrane rolls back over the tray.
摘要翻译：提供具有包装套筒或纸箱和成形托盘的自开泡罩包装。托盘包括一个或多个容器杯，其尺寸被设计成容纳一种或多种产品，例如口香糖等。可剥离膜被密封到托盘凸缘。膜的前缘附着在套筒上。当托盘从套筒中取出时，膜从托盘剥离。剥离动作使包含在一个或多个杯中的产品暴露。一旦提取出所需量的产品，托盘可被推回到套筒中，并且膜在托盘上回滚。

7. 发明申请

US20070251713A1 Meter base bracket apparatus and system 失效
标题翻译：仪表底座支架设备和系统
公开(公告)号：US20070251713A1
公开(公告)日：2007-11-01
申请号：US11179179
申请日：2005-07-12
申请人： Michael Thornton , Mickey Britain
发明人： Michael Thornton , Mickey Britain
IPC分类号： H01H13/04
CPC分类号： G01R11/04 , H02B1/03 , Y10S248/906
摘要： An electric meter base bracket apparatus and system. Embodiments include a meter bracket installed between studs of a dwelling or structure. The bracket includes several holes to install the bracket to the studs as well as feed-through holes for wiring to the dwelling. Bolts are included on the bracket to attach directly to the meter base. A hole can be cut through the siding so that the meter base and the bracket can connect. An alternative embodiment of the meter base bracket includes a pair of L-brackets that can be co-arranged to form an upper bracket and an additional pair of L-brackets arranged generally parallel to the first pair forming a lower bracket.
摘要翻译：电表底座支架装置及系统。实施例包括安装在住宅或结构的柱之间的仪表支架。支架包括几个孔，用于将支架安装到螺柱上，以及用于连接到住宅的馈通孔。支架上包含螺栓，直接连接到仪表底座。可以通过侧板切割一个孔，以便仪表底座和支架可以连接。仪表底座支架的另一个实施例包括一对L形托架，其可以被共同布置成形成上支架和一对大体上平行于第一对平行布置的左托架，形成下托架。

8. 发明申请

US20070092885A1 Secreted proteins 失效
公开(公告)号：US20070092885A1
公开(公告)日：2007-04-26
申请号：US11378616
申请日：2006-03-20
申请人： Henry Yue , Monique Yao , Ameena Gandhi , Mariah Baughn , Anita Swarnakar , Narinder Chawla , Madhusudan Sanjanwala , Michael Thornton , Vicki Elliott , Yan Lu , Kimberly Gietzen , Neil Burford , Li Ding , April Hafalia , Y. Tang , Olga Bandman , Bridget Warren , Cynthia Honchell , Dyung Lu , Kavitha Thangavelu , Sally Lee , Yuming Xu , Junming Yang , Preeti Lal , Bao Tran , Craig Ison , Brendan Duggan , Stephanie Sapperstein
发明人： Henry Yue , Monique Yao , Ameena Gandhi , Mariah Baughn , Anita Swarnakar , Narinder Chawla , Madhusudan Sanjanwala , Michael Thornton , Vicki Elliott , Yan Lu , Kimberly Gietzen , Neil Burford , Li Ding , April Hafalia , Y. Tang , Olga Bandman , Bridget Warren , Cynthia Honchell , Dyung Lu , Kavitha Thangavelu , Sally Lee , Yuming Xu , Junming Yang , Preeti Lal , Bao Tran , Craig Ison , Brendan Duggan , Stephanie Sapperstein
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , C12P21/04 , C07K14/705
CPC分类号： C12N15/1055 , A61K39/3955 , A61K47/64 , A61K47/643 , A61K2039/505 , C07K14/47 , C07K14/4711 , C07K14/4713 , C07K16/18 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/75 , C07K2317/76 , G01N33/5023
摘要： The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.

9. 发明授权

US07061770B2 System and method for guidingly mounting a power module to a processor 有权
标题翻译：将功率模块引导到处理器的系统和方法
公开(公告)号：US07061770B2
公开(公告)日：2006-06-13
申请号：US10639276
申请日：2003-08-12
申请人： David Mayer , Michael Thornton
发明人： David Mayer , Michael Thornton
IPC分类号： H05K5/00 , H05K5/04 , H05K5/06
CPC分类号： G06F1/185 , G06F1/184 , G06F1/186 , G06F1/188 , H01R12/7005 , H01R12/721 , H05K7/1431
摘要： A system having a power module mount adapted to support a power module side-by-side with a card-based processor, and a connectivity guide adapted to guide the power module along a direct path between electrically connected and disconnected relationships with the card-based processor. A method for mounting a power module to a processor involving engaging the power module with a connectivity guide disposed adjacent the processor, moving the power module toward the processor via the connectivity guide, and mating edge connectors of the power module and the processor.
摘要翻译：一种具有功率模块安装座的系统，其适于与基于卡的处理器并排地支撑功率模块，以及连接引导件，适于沿着与基于卡的处理器的电连接和断开的关系之间的直接路径引导功率模块处理器。一种用于将功率模块安装到处理器的方法，所述方法包括使所述功率模块与邻近所述处理器设置的连接引导件接合，通过所述连接引导件将所述功率模块朝向所述处理器以及所述功率模块和所述处理器的配合边缘连接器移动。

10. 发明授权

US6057315A Antibacterial agents 失效
公开(公告)号：US6057315A
公开(公告)日：2000-05-02
申请号：US269492
申请日：1999-03-29
申请人： John Michael Domagala , Edmund Lee Ellsworth , Michael Andrew Stier , Liren Huang , Ronald George Micetich , Rajeshwar Singh , Stephen Keith Wrigley , Shouming Wang , Michael Roe , David Michael Thornton
发明人： John Michael Domagala , Edmund Lee Ellsworth , Michael Andrew Stier , Liren Huang , Ronald George Micetich , Rajeshwar Singh , Stephen Keith Wrigley , Shouming Wang , Michael Roe , David Michael Thornton
IPC分类号： C07D487/04 , C07D498/04 , C07D513/04 , A61K31/517 , A61K31/536
CPC分类号： C07D487/04 , C07D513/04
摘要： Described are antibacterial agents of formula (I): X is O, S or N--R.sub.8 ; R.sub.1, R.sub.2, R.sub.3 and R.sub.8 are independently H, straight or branched alkyl of 1-6 carbons, cycloalkyl of 3-6 carbons, alkenyl or alkynyl of from 2 to 6 atoms, R heterocyclic ring of from 5-8 atoms with 1-3 heteroatoms as nitrogen, oxygen or sulfur, or phenyl, all of which rings may be optionally substituted up to 3 times by halogen, OR, NR.sub.2, NR'COR', CN, CO.sub.2 R' or CONR.sub.2 ', halogen, CN, CO.sub.2 R, COR, CON(R).sub.2, CON(R").sub.2, SR, SON, SCO.sub.2 R or SCON(R).sub.2 ; R.sub.4 is H, straight or branched alkyl of from 1-6 carbon atoms, alkenyl or alkynyl of from 2 to 6 atoms, heterocyclic ring of from 5-8 atoms with 1-3 heteroatoms as nitrogen, oxygen or sulfur or phenyl, all of which rings may be optionally substituted up to 3 times by halogen, OR, NR.sub.2, NR'COR', CN, CO.sub.2 R' or CONR.sub.2 ', halogen, CN, NO.sub.2, N(R).sub.2, NRCOR, NRCOR", COR, CO.sub.2 R, CON(R).sub.2, CON(R").sub.2, NRCON(R).sub.2, NRCO.sub.2 R; R.sub.5 is 1-6 straight or branched alkyl, a cycloalkyl of 3-6 carbons, alkenyl or alkynyl of from 2 to 6 atoms, heterocyclic ring of from 5-8 atoms with 1-3 heteroatoms as nitrogen, oxygen or sulfur or phenyl, all of which rings may be optionally substituted up to 3 times by halogen, OR, NR.sub.2, NR'COR', CN, CO.sub.2 R' or CONR.sub.2 ', halogen, OR, N(R).sub.2, NRCOR, NRCOR", COR, CON(R).sub.2, CON(R").sub.2, SR or SO.sub.2 R; R.sub.6, R.sub.7 are independently H, straight or branched alkyl of 1-6 carbons, cycloalkyl of 3-6 carbons, COR, COR", SO.sub.2 NR.sub.2, CONR.sub.2 and these may be optionally substituted by any of the groups listed for R.sub.5 ; R is H, straight or branched alkyl of 1-6 carbon atoms, cycloalkyl of from 3-6 carbon atoms, heterocyclic ring of from 5-8 atoms with 1-3 heteroatoms as nitrogen, oxygen or sulfur, or pheny, all of which may be optionally substituted by halogen, OR', NR'.sub.2, NR'COR', CN, CO.sub.2 R', CONR'.sub.2, R' is H, alkyl of from 1-3 carbon atoms or Ph; R" is part of a naturally occurring amino acid connected via an amide or acyl bond as determined by the formula; halogen is any one of fluoro, chloro, bromo or iodo; or a pharmaceutically acceptable salt.

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