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1. 发明授权

US06221908B1 System for stimulating brain plasticity 有权
标题翻译：刺激大脑可塑性的系统
公开(公告)号：US06221908B1
公开(公告)日：2001-04-24
申请号：US09224510
申请日：1998-12-31
申请人： Michael P. Kilgard , Michael M. Merzenich
发明人： Michael P. Kilgard , Michael M. Merzenich
IPC分类号： A61K3122
CPC分类号： A61N1/36017 , A61N1/30 , A61N1/36025 , A61N1/36082
摘要： A system for stimulating brain plasticity releases acetylcholine into the learner's brain while the learner is receiving incoming stimuli or performing an activity during the learning process. It is believed that acetylcholine helps the brain in the learning and memorizing process. In one embodiment, the nucleus basalis region of the learner's brain is electrically stimulated to release acetylcholine, thereby aiding the learning and memorizing process. The electrical stimulation advantageously reduces the need for the learner to attach “behavioral importance” and to pay close attention on the incoming stimuli or activity to stimulate the release of acetylcholine. In other embodiments, delivery systems such as microinjection, implanted micro release devices or implanted photo-sensitive release devices may be used to release acetylcholine into the brain to aid the learning process.
摘要翻译：用于刺激大脑可塑性的系统将乙酰胆碱释放到学习者的大脑中，同时学习者在学习过程中接收到进入的刺激或进行活动。据信乙酰胆碱帮助大脑学习和记忆过程。在一个实施方案中，电刺激学习者脑的基底区以释放乙酰胆碱，从而有助于学习和记忆过程。电刺激有利地减少了学习者附加“行为重要性”的需要，并且密切注意进入的刺激或活动以刺激乙酰胆碱的释放。在其他实施方案中，可以使用诸如显微注射，植入的微型释放装置或植入的光敏释放装置等递送系统将乙酰胆碱释放到脑中以帮助学习过程。

2. 发明授权

US09089707B2 Systems, methods and devices for paired plasticity 有权
标题翻译：用于成对可塑性的系统，方法和装置
公开(公告)号：US09089707B2
公开(公告)日：2015-07-28
申请号：US12485040
申请日：2009-06-15
申请人： Michael P Kilgard , Lawrence James Cauller , Navzer Engineer , Christa McIntyre , Will Rosellini
发明人： Michael P Kilgard , Lawrence James Cauller , Navzer Engineer , Christa McIntyre , Will Rosellini
IPC分类号： A61N1/00 , A61N1/36 , G09B23/28 , A61M21/02 , H04R25/00 , A61F11/00 , A61M21/00
CPC分类号： A61N1/36167 , A61F11/00 , A61M21/00 , A61M21/02 , A61M2021/0016 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044 , A61M2021/0072 , A61M2021/0077 , A61M2205/3515 , A61M2230/06 , A61M2230/08 , A61M2230/10 , A61M2230/205 , A61M2230/30 , A61M2230/432 , A61M2230/50 , A61M2230/60 , A61M2230/65 , A61N1/36014 , A61N1/36053 , A61N1/36067 , A61N1/36082 , A61N1/36092 , A61N1/361 , A61N1/36103 , A61N1/36139 , A61N5/0618 , A61N5/0622 , G09B19/00 , G09B19/003 , G09B23/28 , H04R25/75
摘要： Systems, methods and devices for paired training include timing controls so that training and neural stimulation can be provided simultaneously. Paired trainings may include therapies, rehabilitation and performance enhancement training. Stimulations of nerves such as the vagus nerve that affect subcortical regions such as the nucleus basalis, locus coeruleus or amygdala induce plasticity in the brain, enhancing the effects of a variety of therapies, such as those used to treat tinnitus, stroke, traumatic brain injury and post-traumatic stress disorder.
摘要翻译：用于配对训练的系统，方法和装置包括时间控制，以便可以同时提供训练和神经刺激。配对培训可能包括治疗，康复和绩效增强培训。影响神经的神经刺激，如影响皮层下的区域，如基底核，坐骨神经或杏仁核诱导脑中的可塑性，增强各种疗法的作用，例如用于治疗耳鸣，中风，创伤性脑损伤和创伤后应激障碍。

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