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1. 发明授权

US09999462B2 Integrated cold plasma and high frequency plasma electrosurgical system and method 有权
公开(公告)号：US09999462B2
公开(公告)日：2018-06-19
申请号：US14725167
申请日：2015-05-29
申请人： Jerome Canady , Alexey Shashurin , Michael Keidar , Taisen Zhuang
发明人： Jerome Canady , Alexey Shashurin , Michael Keidar , Taisen Zhuang
IPC分类号： A61B18/12 , A61B18/04 , A61B18/00 , H05H1/46
CPC分类号： A61B18/1206 , A61B18/042 , A61B2018/00172 , A61B2018/00178 , A61B2018/00583 , H05H2001/4682 , H05H2245/122
摘要： A system that does conversion from regular hot plasma produced by ESU to cold plasma which is thermally harmless for the tissue. The system is comprised of Conversion Unit and Cold Plasma Probe. Output signal for ESU connects to CU along with Helium flow. The CU converts signal from ESU and send it to the output connector along with helium flow. Cold Plasma Probe is connected directly to the CU output. At the end of the CPP probe cold plasma is produced.

2. 发明申请

US20170217776A1 SYSTEM AND METHOD FOR MASS PRODUCTION OF GRAPHENE PLATELETS IN ARC PLASMA 审中-公开
公开(公告)号：US20170217776A1
公开(公告)日：2017-08-03
申请号：US15346380
申请日：2016-11-08
申请人： Michael Keidar , Alexey Shashurin
发明人： Michael Keidar , Alexey Shashurin
IPC分类号： C01B31/04 , C25B1/00 , C23C16/01
CPC分类号： C01B32/186 , B82Y30/00 , B82Y40/00 , C01B2204/02 , Y10S977/734 , Y10S977/843
摘要： A system and method for producing graphene includes a heating block, substrate, motor and collection device. The substrate is arranged about the heating block and is configured to receive heat from the heating block. A motor is connected to the substrate to rotate the substrate about the heating block. A cathode and anode are configured to direct a flux stream for deposit onto the rotating substrate. A collection device removes the deposited material from the rotating substrate. A heating element is embedded in the heating block and imparts heat to the heating block. The heating block is made of cement or other material that uniformly disperses the heat from the heating element throughout the heating block. The flux stream can be a carbon vapor, with the deposited flux being graphene.

3. 发明申请

US20140378892A1 System And Method For Cold Plasma Therapy 审中-公开
标题翻译：冷等离子体治疗系统与方法
公开(公告)号：US20140378892A1
公开(公告)日：2014-12-25
申请号：US14365478
申请日：2012-06-01
申请人： Michael Keidar , Charanjeet Guron , Barry Trink , Alexey Shashurin
发明人： Michael Keidar , Charanjeet Guron , Barry Trink , Alexey Shashurin
IPC分类号： A61N1/44
CPC分类号： A61N1/44 , A61B18/042 , A61B2018/00583
摘要： A device uses cold plasma to treat cancerous tumors. The device has a gas supply tube with a delivery end. The gas supply tube is configured to carry a gas to the delivery end. A syringe is provided having an opening. The syringe is connected to the supply tube and configured to carry the gas to the opening. A first electrode is positioned inside said syringe, and a second electrode is positioned adjacent to the opening. The first and second electrodes excite the gas to enter a cold plasma state prior to being discharged from the opening of the syringe. An endoscopic tube can be used instead of the syringe. An exhaust tube can be provided to remove gas introduced into the body cavity by the cold plasma jet.
摘要翻译：一种器件使用冷血浆治疗癌性肿瘤。该装置具有带有输送端的气体供给管。气体供给管构造成将气体携带到输送端。提供具有开口的注射器。注射器连接到供应管并构造成将气体携带到开口。第一电极位于所述注射器内部，并且第二电极定位成与开口相邻。在从注射器的开口排出之前，第一和第二电极激发气体进入冷等离子体状态。可以使用内窥镜管替代注射器。可以提供排气管以通过冷等离子体射流去除引入体腔内的气体。

4. 发明申请

US20160138006A1 System And Method For Selective Ablation Of Cancer Cells With Cold Atmospheric Plasma 审中-公开
标题翻译：用冷气氛等离子体选择性消融癌细胞的系统和方法
公开(公告)号：US20160138006A1
公开(公告)日：2016-05-19
申请号：US14934129
申请日：2015-11-05
申请人： Jerome Canady , Alexey Shashurin , Michael Keidar , Taisen Zhuang , Arpitha Parthasarathy
发明人： Jerome Canady , Alexey Shashurin , Michael Keidar , Taisen Zhuang , Arpitha Parthasarathy
IPC分类号： C12N13/00 , A61B18/12 , A61B18/14 , A61B18/04
CPC分类号： C12N13/00 , A61B18/042 , A61B18/1206 , A61B18/14 , A61B2018/00172 , A61B2018/00178 , A61B2018/00583 , A61B2018/1286 , H05H1/46 , H05H2001/466 , H05H2245/122
摘要： A method for elevating a TRAIL-R1 expression in cancer cells to induce apoptosis. The method comprises the steps of receiving electrical energy having a specific voltage, frequency and power from an electrosurgical generator, up-converting the voltage and down-converting the frequency with a high voltage transformer having a primary coil and a secondary coil, the secondary coil having a larger number of turns than the primary coil, applying said converted electrical energy to an electrode in an electrosurgical hand piece, flowing an inert gas through said electrosurgical hand piece to produce a cold plasma at a distal end of said electrosurgical hand piece; and applying said cold plasma to cancer cells for 1 to 3 minutes. The inert gas may comprise, for example, helium or argon. In a preferred embodiment the cold plasma is applied to cancer cells for about 2 minutes.
摘要翻译：提高癌细胞中TRAIL-R1表达以诱导细胞凋亡的方法。该方法包括以下步骤：从电外科发生器接收具有特定电压，频率和功率的电能，对具有初级线圈和次级线圈的高压变压器进行上变频和下变频，次级线圈具有比初级线圈多的匝数，将所述转换的电能施加到电外科手杖中的电极，使惰性气体流过所述电外科手杖以在所述电外科手杖的远端处产生冷等离子体; 并将所述冷血浆应用于癌细胞1至3分钟。惰性气体可以包括例如氦或氩。在优选的实施方案中，将冷血浆施用于癌细胞约2分钟。

5. 发明授权

US08875485B2 Micro-cathode thruster and a method of increasing thrust output for a micro-cathode thruster 有权
标题翻译：微阴极推进器和增加微型阴极推进器推力输出的方法
公开(公告)号：US08875485B2
公开(公告)日：2014-11-04
申请号：US13081106
申请日：2011-04-06
申请人： Michael Keidar , Alexey Shashurin , Taisen Zhuang
发明人： Michael Keidar , Alexey Shashurin , Taisen Zhuang
IPC分类号： F03H1/00 , H05H1/02 , H05H1/10 , H05H1/50 , B64G1/40
CPC分类号： B64G1/405 , F03H1/0081 , F03H1/0087 , H05H1/50
摘要： A magnetically enhanced micro-cathode thruster assembly for providing long-lasting thrust is provided. The micro-cathode thruster assembly includes a tubular housing, a tubular cathode, an insulator, an anode and a magnetic field. The tubular housing includes an open distal end. The tubular cathode is housed within the housing and includes a distal end positioned proximate the open distal end of the housing. The insulator is in contact with the cathode forming an external cathode-insulator interface. The anode is housed within the housing, proximate the open distal end of the housing. The magnetic field is positioned at or about the external cathode-insulator interface and has magnetic field lines with an incidence angle of about 0 to about 90 degrees and preferably about 4 to about 30 degrees relative to the external cathode-insulator interface.
摘要翻译：提供了一种用于提供持久推力的磁力增强型微阴极推进器组件。微阴极推进器组件包括管状壳体，管状阴极，绝缘体，阳极和磁场。管状壳体包括敞开的远端。管状阴极容纳在壳体内并且包括靠近壳体的敞开的远端定位的远端。绝缘体与阴极接触形成外部阴极 - 绝缘体界面。阳极容纳在壳体内，靠近壳体的敞开的远端。磁场定位在外部阴极 - 绝缘体界面处或周围，并且具有相对于外部阴极 - 绝缘体界面具有约0至约90度，优选约4至约30度的入射角的磁场线。

6. 发明申请

US20180271579A1 MICRO-COLD ATMOSPHERIC PLASMA DEVICE 审中-公开
公开(公告)号：US20180271579A1
公开(公告)日：2018-09-27
申请号：US15936290
申请日：2018-03-26
申请人： Michael Keidar , Zitong Chen , Jonathan Sherman , Colin N. Young , Hayk Simonyan , Jerome Canady
发明人： Michael Keidar , Zitong Chen , Jonathan Sherman , Colin N. Young , Hayk Simonyan , Jerome Canady
IPC分类号： A61B18/04
CPC分类号： A61B18/042 , A61B2018/00577 , A61B2018/00583 , A61B2218/005
摘要： A micro-sized CAP (μCAP) employed to target glioblastoma tumors in the murine brain. Various plasma diagnostic techniques were applied to evaluate the physics of helium μCAP such as electron density, discharge voltage, and optical emission spectroscopy. The direct and indirect effects of μCAP on glioblastoma (U87MG-RedFluc) cancer cells in vitro were investigated and indicate that μCAP-generated short- and long-lived species and radicals [i.e. hydroxyl radical (OH), hydrogen peroxide (H2O2), nitrite (NO2-), et al] with increasing tumor cell death in a dose-dependent fashion. Translation of these findings to an in vivo setting demonstrates that intracranial μCAP is effective at preventing glioblastoma tumor growth in the mouse brain. The μCAP device can be safely used in mice, resulting in suppression of tumor growth. These initial observations establish the μCAP device as a potentially useful ablative therapy tool in the treatment of glioblastoma.

7. 发明申请

US20090056305A1 SCALABLE FLAT-PANEL NANO-PARTICLE MEMS/NEMS THRUSTER 有权
标题翻译：可扩展平板纳米颗粒MEMS / NEMS THRUSTER
公开(公告)号：US20090056305A1
公开(公告)日：2009-03-05
申请号：US11545037
申请日：2006-10-06
申请人： Brian E. Gilchrist , Alec D. Gallimore , Michael Keidar , Louis Musinski , Thomas M. Liu
发明人： Brian E. Gilchrist , Alec D. Gallimore , Michael Keidar , Louis Musinski , Thomas M. Liu
IPC分类号： F02D11/10
CPC分类号： F42B10/661 , B64G1/405 , F03H1/005
摘要： A scalable flat-panel nano-particle MEMS/NEMS thruster includes a grid having a plurality of electrodes to establish electrical fields. A liquid is disposed in a liquid reservoir of the grid. The liquid is positioned within the electrical fields. A plurality of nano-particles are suspended in the liquid. A plurality of MEMS and NEMS micron-size vias are disposed in the grid. The electrical fields extract the plurality of nano-particles from the liquid and accelerate the nano-particles in the vias to provide propulsion system thrust.
摘要翻译：可扩展的平板纳米颗粒MEMS / NEMS推进器包括具有多个电极以建立电场的格栅。液体设置在电网的液体储存器中。液体位于电场内。多个纳米颗粒悬浮在液体中。多个MEMS和NEMS微米尺寸通孔设置在电网中。电场从液体中提取多个纳米颗粒，并加速通孔中的纳米颗粒，以提供推进系统推力。

8. 发明授权

US06391164B1 Deposition of coatings and thin films using a vacuum arc with a non-consumable hot anode 失效
标题翻译：使用不可消耗热阳极的真空电弧沉积涂层和薄膜
公开(公告)号：US06391164B1
公开(公告)日：2002-05-21
申请号：US09603432
申请日：2000-06-23
申请人： Isak I. Beilis , Raymond L Boxman , Samuel Goldsmith , Michael Keidar , Hanan Rosenthal
发明人： Isak I. Beilis , Raymond L Boxman , Samuel Goldsmith , Michael Keidar , Hanan Rosenthal
IPC分类号： C23C1434
CPC分类号： H01J37/32055 , C23C14/325 , H01J37/32614
摘要： A process and apparatus for depositing thin films and coatings using a vacuum arc plasma source having hot, non-consumable anode is described. Plasma and macroparticles of the cathode material are emitted from the cathode. Part of this material arrives at the hot refractory anode, where it is re-evaporated without macroparticle generation. Substrates exposed to the vapor flow from the anode, but shielded from a direct line of sight with the cathode, are coated with cathode material without macroparticle inclusions.
摘要翻译：描述了使用具有热的非消耗性阳极的真空电弧等离子体源沉积薄膜和涂层的工艺和设备。阴极材料的等离子体和大颗粒从阴极发射。这种材料的一部分到达耐火难燃阳极，在那里它被再蒸发而不产生大颗粒。暴露于来自阳极的蒸汽流，但与阴极直接观察的屏蔽的基板被涂覆有没有大颗粒夹杂物的阴极材料。

9. 发明申请

US20150342663A1 Integrated Cold Plasma and High Frequency Plasma Electrosurgical System and Method 有权
标题翻译：综合冷等离子体和高频等离子体电外科系统及方法
公开(公告)号：US20150342663A1
公开(公告)日：2015-12-03
申请号：US14725167
申请日：2015-05-29
申请人： Jerome Canady , Alexey Shashurin , Michael Keidar , Taisen Zhuang
发明人： Jerome Canady , Alexey Shashurin , Michael Keidar , Taisen Zhuang
IPC分类号： A61B18/12 , A61B18/04 , A61B18/14
CPC分类号： A61B18/1206 , A61B18/042 , A61B2018/00172 , A61B2018/00178 , A61B2018/00583 , H05H2001/4682 , H05H2245/122
摘要： A system that does conversion from regular hot plasma produced by ESU to cold plasma which is thermally harmless for the tissue. The system is comprised of Conversion Unit and Cold Plasma Probe. Output signal for ESU connects to CU along with Helium flow. The CU converts signal from ESU and send it to the output connector along with helium flow. Cold Plasma Probe is connected directly to the CU output. At the end of the CPP probe cold plasma is produced.
摘要翻译：由ESU产生的常规热等离子体转换成对组织无害的冷等离子体的系统。该系统由转换单元和冷等离子探头组成。 ESU的输出信号与氦气流一起连接到CU。 CU转换来自ESU的信号，并将其发送到输出连接器以及氦气流。冷等离子探头直接连接到CU输出。在CPP探头的末端生产冷等离子体。

10. 发明申请

US20130327637A1 SYSTEM AND METHOD FOR MASS PRODUCTION OF GRAPHENE PLATELETS IN ARC PLASMA 审中-公开
标题翻译：在等离子体中生产石墨片的系统和方法
公开(公告)号：US20130327637A1
公开(公告)日：2013-12-12
申请号：US13910699
申请日：2013-06-05
申请人： Michael KEIDAR , Alexey SHASHURIN
发明人： Michael KEIDAR , Alexey SHASHURIN
IPC分类号： C01B31/04
CPC分类号： C01B32/186 , B82Y30/00 , B82Y40/00 , C01B2204/02 , Y10S977/734 , Y10S977/843
摘要： A system and method for producing graphene includes a heating block, substrate, motor and collection device. The substrate is arranged about the heating block and is configured to receive heat from the heating block. A motor is connected to the substrate to rotate the substrate about the heating block. A cathode and anode are configured to direct a flux stream for deposit onto the rotating substrate. A collection device removes the deposited material from the rotating substrate. A heating element is embedded in the heating block and imparts heat to the heating block. The heating block is made of cement or other material that uniformly disperses the heat from the heating element throughout the heating block. The flux stream can be a carbon vapor, with the deposited flux being graphene.
摘要翻译：一种用于制造石墨烯的系统和方法包括加热块，基底，马达和收集装置。基板围绕加热块布置并且被配置为从加热块接收热量。电机连接到基板上以围绕加热块旋转基板。阴极和阳极被配置为引导通量流以沉积到旋转的基板上。收集装置从旋转基板去除沉积的材料。将加热元件嵌入加热块中并将热量加热到加热块。加热块由水泥或其他材料制成，其将来自加热元件的热均匀分散在整个加热块中。助熔剂流可以是碳蒸气，沉积的助焊剂是石墨烯。

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