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1. 发明授权

US08105666B2 Compliant polymeric coatings for insertable medical articles 有权
标题翻译：适用于可插入医疗用品的聚合物涂层
公开(公告)号：US08105666B2
公开(公告)日：2012-01-31
申请号：US11376671
申请日：2006-03-14
申请人： Michael J. Finley
发明人： Michael J. Finley
IPC分类号： B32B1/08 , B32B27/08 , B32B27/32 , B32B15/02 , F16L11/04 , A61F2/06 , A61F2/02 , A61F2/82 , A61M31/00 , A61M29/00
CPC分类号： A61L27/34 , A61F2/88 , A61F2002/30067 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/608 , A61L2420/08 , Y10T428/13 , Y10T428/1334 , Y10T428/1338 , Y10T428/1341 , Y10T428/1352 , Y10T428/1355 , Y10T428/1379 , Y10T428/1386 , Y10T428/1393 , Y10T428/31678 , Y10T428/31931
摘要： Compliant coatings for insertable medical articles are provided. In some aspects, the coating includes a diene polymer-containing layer, and a second coated layer that includes another polymer. The coating can be formed by coupling the polymer of the second coated layer to the first coated layer via latent reactive groups, such as photoreactive groups. In other aspects, the insertable medical article has a coating that provides different functional features to different surfaces of the article. The medical article can have a cylindrical shape with an interior surface having a first coating, and an exterior surface with a second coating, wherein the article also includes a plurality of openings.
摘要翻译：提供了可插入医疗用品的合适涂层。在一些方面，涂层包括含二烯聚合物的层和包含另一种聚合物的第二涂层。可以通过将潜在的反应性基团如光反应性基团将第二涂层的聚合物偶联到第一涂层来形成涂层。在其它方面，可插入医疗制品具有向制品的不同表面提供不同功能特征的涂层。医疗制品可以具有带有第一涂层的内表面和具有第二涂层的外表面的圆柱形形状，其中该制品还包括多个开口。

2. 发明授权

US07691476B2 Hydrophilic polymeric coatings for medical articles 有权
标题翻译：用于医疗用品的亲水性聚合物涂层
公开(公告)号：US07691476B2
公开(公告)日：2010-04-06
申请号：US11445806
申请日：2006-06-02
申请人： Michael J. Finley
发明人： Michael J. Finley
IPC分类号： B32B9/04
CPC分类号： A61L29/085 , A61L29/14 , A61L2400/10 , C09D5/00 , Y10T428/31504 , Y10T428/31551
摘要： The invention provides a durable, lubricious coating for a medical article that can be prepared from a first polymer that is synthetic, soluble in a polar liquid, and having first reactive groups, and a second polymer that is synthetic, hydrophilic, and that includes second reactive groups. The first reactive groups and a portion of the second reactive groups react to bond the first polymer to the second polymer. A portion of the second reactive groups remains unbonded which, upon neutralization, provide lubricious properties to the coating. In some aspects the coating is formed using a crosslinking agent having latent reactive groups. The coatings provide particularly long dry out times and are very useful for catheterization processes. In addition, the coatings can be subject to sterilization with ethylene oxide and retain very good durable and lubricious properties.
摘要翻译：本发明提供了一种用于医疗制品的耐久，润滑的涂层，其可以由合成的，可溶于极性液体的第一聚合物制备并具有第一反应性基团的第一聚合物，以及合成，亲水的第二聚合物，并且包括第二聚合物反应性基团。第一反应性基团和一部分第二反应性基团使第一聚合物与第二聚合物结合。第二反应性基团的一部分保持未结合，其在中和时向涂层提供润滑性质。在一些方面，使用具有潜在反应性基团的交联剂形成涂层。涂层提供特别长的干燥时间，并且对于导尿过程非常有用。此外，涂层可以与环氧乙烷进行灭菌，并保持非常好的持久和润滑性能。

3. 发明授权

US07541048B2 Coating compositions for bioactive agents 失效
标题翻译：生物活性剂的涂料组合物
公开(公告)号：US07541048B2
公开(公告)日：2009-06-02
申请号：US11099910
申请日：2005-04-06
申请人： David M. DeWitt , Michael J. Finley , Laurie R. Lawin
发明人： David M. DeWitt , Michael J. Finley , Laurie R. Lawin
IPC分类号： A61F2/00 , A61K9/14
CPC分类号： A61L31/16 , A61F2/86 , A61F2250/0067 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/222 , A61L2300/404 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/43 , A61L2300/602 , A61L2300/606 , C08L33/06 , C08L33/10 , C08L71/02
摘要： A coating composition and related method for use in applying a bioactive agent to a surface in a manner that will permit the bioactive agent to be released from the coating in vivo. The composition is particularly well suited for coating the surface of implantable medical device, such as a stent or catheter, in order to permit the device to release bioactive agent to the surrounding tissue over time. The composition includes a plurality of compatible polymers having different properties that can permit them to be combined together to provide an optimal combination of such properties as durability, biocompatibility, and release kinetics.
摘要翻译：用于将生物活性剂施用于表面的涂料组合物和相关方法，其方式将允许生物活性剂在体内从涂层中释放。组合物特别适用于涂覆可植入医疗装置（例如支架或导管）的表面，以便允许装置随着时间的推移将生物活性剂释放到周围组织。该组合物包括具有不同性质的多种相容性聚合物，其可以将它们组合在一起，以提供诸如耐久性，生物相容性和释放动力学之类的最佳组合。

4. 发明申请

US20080057298A1 Low friction particulate coatings 审中-公开
标题翻译：低摩擦颗粒涂层
公开(公告)号：US20080057298A1
公开(公告)日：2008-03-06
申请号：US11512022
申请日：2006-08-29
申请人： Michael J. Finley
发明人： Michael J. Finley
IPC分类号： B32B5/16 , B32B15/04 , A61L33/00 , B05D1/12 , G11B5/64
CPC分类号： A61L29/085 , A61L31/10 , Y10T428/254 , Y10T428/265 , Y10T428/31504 , Y10T428/31678 , C08L27/18
摘要： The invention provides a low-friction halogenated nano- or microparticulate coating and method for forming the coating on articles, such as implantable medical articles. The halogenated nano- or microparticles, desirably fabricated from PTFE, are present on the surface of the coating and covalently coupled to a coupling component, which facilitates formation of the coating. The coatings are biocompatible and can be formed on a selected portion of a medical device in a straightforward process. In some aspects the nano- or microparticulate coatings are formed on a system for the insertion of a medical device, wherein the system includes a catheter.
摘要翻译：本发明提供了低摩擦卤化纳米或微粒涂层和用于在诸如可植入医疗制品的物品上形成涂层的方法。期望由PTFE制成的卤化纳米颗粒或微粒存在于涂层的表面上并且共价偶联到偶联组分上，这有利于涂层的形成。涂层是生物相容的并且可以在简单的过程中形成在医疗装置的选定部分上。在一些方面，纳米或微粒涂层形成在用于插入医疗装置的系统上，其中该系统包括导管。

5. 发明授权

US06669681B2 Needleless connector 有权
公开(公告)号：US06669681B2
公开(公告)日：2003-12-30
申请号：US09903134
申请日：2001-07-11
申请人： Steven C. Jepson , Thomas E. Dudar , Rodrigo A. Montanez , Algirdas J. Bindokas , Michael J. Finley , Jason J. White , Camille Summers
发明人： Steven C. Jepson , Thomas E. Dudar , Rodrigo A. Montanez , Algirdas J. Bindokas , Michael J. Finley , Jason J. White , Camille Summers
IPC分类号： A61M500
CPC分类号： A61M39/045 , A61M2039/0036 , Y10S128/912
摘要： A needless connector is provided which utilizes a resealable preslit septum valve. The valve is resiliently restrained relative to a housing with the valve and housing configured to accept a standard male luer lock having a luer tip which penetrates the valve through the opening to extend within the housing and a luer locking flange of the luer lock extending about the housing. The valve includes a disk shaped upper portion covering the opening, a lower portion spaced from the housing and extending downward from the disk shaped portion into a passageway defined by the housing, and an annular skirt to attach the septum to the housing. The connector exhibits satisfactory leak pressure after multiple connections and disconnects to the luer lock fitting and long periods of indwell of the luer tip.

6. 发明授权

US06595964B2 Luer activated thread coupler 失效
公开(公告)号：US06595964B2
公开(公告)日：2003-07-22
申请号：US09748580
申请日：2000-12-22
申请人： Michael J. Finley , Mark Williamson
发明人： Michael J. Finley , Mark Williamson
IPC分类号： A61M5178
CPC分类号： A61M39/045 , A61M39/10 , A61M39/26 , A61M2039/0036 , A61M2039/1033 , A61M2039/1072 , Y10S604/905
摘要： A coupler for receiving a threaded male luer fitting in sealed relationship includes a housing having an attachment end, a conduit end opposite the attachment end and defining a central passageway for providing fluid communication between the luer fitting and a conduit. An arrangement is attached to the housing for establishing a sealed connection between a luer tip and the central passageway. The conduit end has a relatively larger diameter than the attachment end and defines a shoulder at a junction of the attachment end and the conduit end. A resilient member is disposed on the attachment end adjacent the shoulder for exerting an axially directed compressive force upon the male luer fitting as it is threadably engaged upon the attachment end.

7. 发明授权

US06569125B2 Pre-slit injection site and tapered cannula 失效
标题翻译：预切口注射部位和锥形插管
公开(公告)号：US06569125B2
公开(公告)日：2003-05-27
申请号：US09907234
申请日：2001-07-17
申请人： Steven C. Jepson , Thomas E. Dudar , Michael J. Finley , Vincent C. Desecki
发明人： Steven C. Jepson , Thomas E. Dudar , Michael J. Finley , Vincent C. Desecki
IPC分类号： A61M528
CPC分类号： A61J1/2089 , A61J1/10 , A61J1/1406 , A61J1/1475 , A61J1/201 , A61J1/2055 , A61J1/2096 , A61M5/162 , A61M39/045 , A61M39/1011 , A61M39/14 , A61M2039/1033 , A61M2039/1066 , A61M2039/1072 , A61M2205/195 , A61M2205/197 , Y10S604/905
摘要： A pre-slit injection site (34) includes a housing (40) with a flow path therethrough. A first end (42) of the housing (40) carries a pre-slit septum (52). One form of a blunt cannula (98), usable with the injection site (34), carries a locking member (100). When the pre-slit injection site (34) slidably receives the blunt cannula (98), the locking member (100) latches to the injection site (34) and creates a mechanically coupled unit. Another form of the cannula (280) includes a tube having a tapered distal end region (298) and having elongate discharge slots (294) for reducing contact surface area and for directing the flow laterally out of the cannula. The cannula may also include a rounded lead post (330), an annular barb (394), and axially oriented grooves (268).
摘要翻译：预狭缝注射部位（34）包括具有穿过其中的流动通道的壳体（40）。壳体（40）的第一端（42）承载预切口隔膜（52）。可与注射部位（34）一起使用的钝性插管（98）的一种形式承载锁定构件（100）。当预狭缝注射部位（34）可滑动地接收钝头套管（98）时，锁定构件（100）锁定到注射部位（34）并产生机械耦合单元。套管（280）的另一种形式包括具有锥形远端区域（298）并且具有细长的排出槽（294）的管子，用于减少接触表面积并将流体横向导引出套管。插管还可以包括圆形引导柱（330），环形倒钩（394）和轴向定向的凹槽（268）。

8. 发明授权

US5957898A Needleless connector 失效
公开(公告)号：US5957898A
公开(公告)日：1999-09-28
申请号：US81728
申请日：1998-05-20
申请人： Steven C. Jepson , Thomas E. Dudar , Rodrigo A. Montanez , Algirdas J. Bindokas , Michael J. Finley , Jason J. White , Camille Summer , Samuel Ding , Lewis E. Daniels
发明人： Steven C. Jepson , Thomas E. Dudar , Rodrigo A. Montanez , Algirdas J. Bindokas , Michael J. Finley , Jason J. White , Camille Summer , Samuel Ding , Lewis E. Daniels
IPC分类号： A61M39/02 , A61M5/14 , A61M39/04 , A61M5/00
CPC分类号： A61M39/045 , A61M2005/1404 , A61M2039/0036 , A61M2039/263 , Y10S128/912
摘要： A needless connector is provided which utilizes a resealable preslit septum valve. The valve is resiliently restrained relative to a housing with the valve and housing configured to accept a standard male luer lock having a luer tip which penetrates the valve through the opening to extend within the housing and a luer locking flange of the luer lock extending about the housing. The valve includes a disk shaped upper portion covering the opening, a lower portion spaced from the housing and extending downward from the disk shaped portion into a passageway defined by the housing, and an annular skirt to attach the septum to the housing. The connector exhibits satisfactory leak pressure after multiple connections and disconnects to the luer lock fitting and long periods of indwell of the luer tip.

9. 外观设计

USD321251S Cannula receiver 失效
公开(公告)号：USD321251S
公开(公告)日：1991-10-29
申请号：US320245
申请日：1989-03-07
申请人： Steve C. Jepson , Thomas E. Dudar , Vince C. Desecki , Michael J. Finley
设计人： Steve C. Jepson , Thomas E. Dudar , Vince C. Desecki , Michael J. Finley

10. 发明授权

US08163327B2 Hydrophilic polymeric coatings for medical articles 有权
标题翻译：用于医疗用品的亲水性聚合物涂层
公开(公告)号：US08163327B2
公开(公告)日：2012-04-24
申请号：US12753613
申请日：2010-04-02
申请人： Michael J. Finley
发明人： Michael J. Finley
IPC分类号： B05D3/10 , B05D1/36 , A61M25/00 , B32B27/00
CPC分类号： A61L29/085 , A61L29/14 , A61L2400/10 , C09D5/00 , Y10T428/31504 , Y10T428/31551
摘要： The invention provides a durable, lubricious coating for a medical article that can be prepared from a first polymer that is synthetic, soluble in a polar liquid, and having first reactive groups, and a second polymer that is synthetic, hydrophilic, and that includes second reactive groups. The first reactive groups and a portion of the second reactive groups react to bond the first polymer to the second polymer. A portion of the second reactive groups remains unbonded which, upon neutralization, provide lubricious properties to the coating. In some aspects the coating is formed using a crosslinking agent having latent reactive groups. The coatings provide particularly long dry out times and are very useful for catheterization processes. In addition, the coatings can be subject to sterilization with ethylene oxide and retain very good durable and lubricious properties.
摘要翻译：本发明提供了一种用于医疗制品的耐久，润滑的涂层，其可以由合成的，可溶于极性液体的第一聚合物制备并具有第一反应性基团的第一聚合物，以及合成的，亲水的第二聚合物，并且包括第二聚合物反应性基团。第一反应性基团和一部分第二反应性基团使第一聚合物与第二聚合物结合。第二反应性基团的一部分保持未结合，其在中和时向涂层提供润滑性质。在一些方面，使用具有潜在反应性基团的交联剂形成涂层。涂层提供特别长的干燥时间，并且对于导尿过程非常有用。此外，涂层可以与环氧乙烷进行灭菌，并保持非常好的持久和润滑性能。

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