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1. 发明授权

US10280462B2 Nucleic acid amplification primers for PCR-based clonality studies 有权
公开(公告)号：US10280462B2
公开(公告)日：2019-05-07
申请号：US14312583
申请日：2014-06-23
申请人： Jacobus Johannes Maria Van Dongen , Anthonie Willem Langerak , Eduardus Maria Dominicus Schuuring , Jesus Fernando San Miguel , Ramon Garcia Sanz , Antonio Parreira , John Lewis Smith , Frances Louise Lavender , Gareth John Morgan , Paul Anthony Stuart Evans , Michael Kneba , Michael Hummel , Elizabeth Anne Macintyre , Christian Bastard , Frederic Bernard Louis Davi , Monika Brüggemann
发明人： Jacobus Johannes Maria Van Dongen , Anthonie Willem Langerak , Eduardus Maria Dominicus Schuuring , Jesus Fernando San Miguel , Ramon Garcia Sanz , Antonio Parreira , John Lewis Smith , Frances Louise Lavender , Gareth John Morgan , Paul Anthony Stuart Evans , Michael Kneba , Michael Hummel , Elizabeth Anne Macintyre , Christian Bastard , Frederic Bernard Louis Davi , Monika Brüggemann
IPC分类号： C12Q1/68 , C12Q1/6883 , C12Q1/6886
摘要： The invention relates to PCR-based clonality studies for among others early diagnosis of lymphoproliferative disorders. Provided is a set of nucleic acid amplification primers comprising a forward primer, or a variant thereof, and a reverse primer, or a variant thereof, capable of amplifying a rearrangement selected from the group consisting of a VH-JH IGH rearrangement, a DH-JH IGH rearrangement, a VK-Jκ IGK rearrangement, a VK/intron-Kde IGK rearrangement, a Vλ-Jλ IGL rearrangement, a Vβ-Jβ TCRB rearrangement, a Dβ-Jβ TCRB rearrangement, a Vγ-Jγ TCRG rearrangement, a Vδ-Jδ TCRD rearrangement, a Dδ-Dδ TCRD rearrangement, a Dδ-Jδ TCRD rearrangement, a Vδ-Dδ TCRD rearrangement, or a translocation selected from t(11;14)(BCL1-IGH) and t(14;18)(BCL2-IGH). The primers can be used in PCR-based clonality studies for early diagnosis of lymphoproliferative disorders and detection of minimal residual disease (MRD). Also provided is a kit comprising at least one set of primers of the invention.

2. 发明申请

US20130204850A1 METHOD AND SYSTEM FOR COMPRESSING DATA RECORDS AND FOR PROCESSING COMPRESSED DATA RECORDS 有权
标题翻译：用于压缩数据记录和处理压缩数据记录的方法和系统
公开(公告)号：US20130204850A1
公开(公告)日：2013-08-08
申请号：US13576082
申请日：2011-02-04
申请人： Jörg Bienert , Michael Hummel , Norbert Heussler
发明人： Jörg Bienert , Michael Hummel , Norbert Heussler
IPC分类号： G06F17/30
CPC分类号： G06F17/30153 , G06F17/30324
摘要： System and method to compress data records by providing data records with a binary structure; dividing the data records into several bit vectors; reducing the size of each bit vector by dividing the bit vector into consecutive partial areas of equal size, each partial area consisting of n bits, classifying the partial areas as trivial partial areas, quasi-trivial partial areas and non-trivial partial areas, combining one non-trivial or several consecutive non-trivial partial areas into one so named R block, and removing the trivial partial areas; as well as combining one quasi-trivial or several consecutive quasi-trivial partial areas into one so named O block.
摘要翻译：通过提供具有二进制结构的数据记录来压缩数据记录的系统和方法; 将数据记录分为几个位向量; 通过将比特矢量分成相等大小的连续部分区域来减小每个比特矢量的大小，每个部分区域由n比特组成，将部分区域分类为平凡的部分区域，准琐碎的部分区域和非平凡的部分区域，组合一个非平凡或几个连续的非平凡的部分区域转换为一个如此命名的R区块，并移除微小的部分区域; 以及将一个准琐碎或几个连续的准琐碎部分区域组合成一个所谓的O块。

3. 发明申请

US20060261557A1 Game including poseable characters on multi-panel game board 审中-公开
标题翻译：游戏包括多人游戏板上的姿势角色
公开(公告)号：US20060261557A1
公开(公告)日：2006-11-23
申请号：US11192904
申请日：2005-07-29
申请人： Matt Hyra , Michael Hummel , Jeff Donais , Justin Gary
发明人： Matt Hyra , Michael Hummel , Jeff Donais , Justin Gary
IPC分类号： A63F3/00
CPC分类号： A63F1/04 , A63F3/00 , A63F3/00028 , A63F3/00261 , A63F2003/00359 , A63F2003/00747 , A63F2003/00826
摘要： A game (10) includes a game board (16), a plurality of cards (14), a first figure (12A) and a second figure (12B). The game board (16) is formed from a plurality of separate panels (18) that are movable relative to one another. The first and second figures (12A, 12B) are movably positioned on the game board (16). The first figure (12A) includes two first figure components (220A, 220B) that move relative to one another to form a plurality of different poses. The first figure (12A) can initiate a confrontation with the second figure (12B) when the first figure (12A) is in one of the poses. In addition, the first figure (12A) can initiate the confrontation when the first figure (12A) has a predetermined position on the game board (16) relative to the second figure (12B). Alternatively, the pose that the first figure (12A) must be in to initiate the confrontation depends upon the relative positioning between the figures (12A, 12B) on the game board (16). In one embodiment, the outcome of the confrontation can be based at least partially on a panel parameter (454, 456A-C), a figure parameter (232, 234), a card parameter (344-348) and/or on a random parameter.
摘要翻译：游戏（10）包括游戏板（16），多个卡（14），第一图（12A）和第二图（12B）。游戏板（16）由可相对于彼此移动的多个分开的面板（18）形成。第一和第二图（12A，12B）可移动地位于游戏板（16）上。第一图（12A）包括相对于彼此移动以形成多个不同姿势的两个第一图形部件（220A，220B）。第一个数字（12A）可以在第一个数字（12 A）处于一个姿势时，与第二个数字（12 B）发生对抗。此外，当第一图（12A）相对于第二图（12B）具有游戏板（16）上的预定位置时，第一图（12A）可以启动对抗。或者，第一图（12A）必须处于开始对抗的姿势取决于游戏板（16）上的图形（12A，12B）之间的相对位置。在一个实施例中，对抗的结果可以至少部分地基于面板参数（454,456AC），图形参数（232,234），卡参数（344-348）和/或随机参数。

4. 发明申请

US20150099646A1 NUCLEIC ACID AMPLIFICATION PRIMERS FOR PCR-BASED CLONALITY STUDIES 审中-公开
标题翻译：用于PCR的克隆研究的核酸扩增引物
公开(公告)号：US20150099646A1
公开(公告)日：2015-04-09
申请号：US14312583
申请日：2014-06-23
申请人： Jacobus Johannes Maria Van Dongen , Anthonie Willem Langerak , Eduardus Maria Dominicus Schuuring , Jesus Fernando San Miquel , Ramon Garcia Sanz , Antonio Parreira , John Lewis Smith , Frances Louise Lavender , Gareth John Morgan , Paul Anthony Stuart Evans , Michael Kneba , Michael Hummel , Elizabeth Anne Macintyre , Christian Bastard
发明人： Jacobus Johannes Maria Van Dongen , Anthonie Willem Langerak , Eduardus Maria Dominicus Schuuring , Jesus Fernando San Miquel , Ramon Garcia Sanz , Antonio Parreira , John Lewis Smith , Frances Louise Lavender , Gareth John Morgan , Paul Anthony Stuart Evans , Michael Kneba , Michael Hummel , Elizabeth Anne Macintyre , Christian Bastard
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/112 , C12Q2600/156 , C12Q2600/16
摘要： The invention relates to PCR-based clonality studies for among others early diagnosis of lymphoproliferative disorders. Provided is a set of nucleic acid amplification primers comprising a forward primer, or a variant thereof, and a reverse primer, or a variant thereof, capable of amplifying a rearrangement selected from the group consisting of a VH-JH IGH rearrangement, a DH-JH IGH rearrangement, a VK-JK IGK rearrangement, a VK/intron-Kde IGK rearrangement, a Vλ-Jλ IGL rearrangement, a Vβ-Jβ TCRB rearrangement, a Dβ-Jβ TCRB rearrangement, a Vγ-Jγ TCRG rearrangement, a Vδ-Jδ TCRD rearrangement, a Dδ-Dδ TCRD rearrangement, a Dδ-Jδ TCRD rearrangement, a Vδ-Dδ TCRD rearrangement, or a translocation selected from t(11;14) (BCL1-IGH) and t(14;18) (BCL2-IGH). The primers can be used in PCR-based clonality studies for early diagnosis of lymphoproliferative disorders and detection of minimal residual disease (MRD). Also provided is a kit comprising at least one set of primers of the invention.
摘要翻译：本发明涉及基于PCR的克隆性研究，用于淋巴增生性疾病的早期诊断。提供了一组核酸扩增引物，其包含正向引物或其变体，以及能够扩增选自VH-JH IGH重排，DH- JH IGH重排，VK-JK IGK重排，VK /内含子-Kde IGK重排，Vλ-JλIGL重排，V＆Bgr; -J＆bgr; TCRB重排，D＆bgr; -J＆bgr; TCRB重排，Vγ-JγTCRG重排，Vδ-JδTCRD重排，Dδ-DδTCRD重排，Dδ-JδTCRD重排，Vδ-DδTCRD重排或选自t（11; 14）（ BCL1-IGH）和t（14; 18）（BCL2-IGH）。引物可用于基于PCR的克隆性研究，用于早期诊断淋巴增生性疾病和检测最小残留病（MRD）。还提供了包含本发明的至少一组引物的试剂盒。

5. 发明申请

US20100164182A1 MULTI-PART OIL SCRAPER RING FOR INTERNAL COMBUSTION ENGINES 审中-公开
标题翻译：用于内燃机的多部分油刮环
公开(公告)号：US20100164182A1
公开(公告)日：2010-07-01
申请号：US11990048
申请日：2006-07-18
申请人： Michael Hummel , Alexandros Mizoglou
发明人： Michael Hummel , Alexandros Mizoglou
IPC分类号： F16J9/06
CPC分类号： F16J9/06 , F16J9/069 , F16J9/16
摘要： In the case of a multi-part oil scraper ring (10) for internal combustion engines, having a U-shaped expanding-spring ring (1), which is provided with axial indentations (2), for forming radially outwardly aligned resilient limbs (3, 4) which are connected to one another by means of radially inwardly situated webs (5), and having at least two annular lamellae (7, 8) which are provided with in each case parallel flanks (7a, 7b; 8a, 8b) and are stacked via their flanks as stacking planes (SE) to a height (hL) and are arranged between the resilient limbs of the expanding-spring ring in order to define a nominal height of the oil scraper ring, according to the invention, an at least three-part oil scraper ring of a minimum axial installation height and with an improved oil-scraping effect should be obtained in that at least in each case one of the flanks (7a, 7b; 8a, 8b) of the lamellae has, in its radially inwardly situated wall region, a cut-out (11) which has a support face (12) for the engagement of the resilient limbs (3, 4) of the expanding-spring ring and is shaped such that the nominal height of the oil scraper ring is determined exclusively by the stack height (hL) of the lamellae (7, 8).
摘要翻译：在用于内燃机的多部分刮油环（10）的情况下，具有设置有轴向压痕（2）的U形膨胀弹簧圈（1），用于形成径向向外对准的弹性臂 3，4），它们通过径向向内定位的腹板（5）彼此连接，并且具有至少两个环形薄片（7,8），每个环形薄片分别具有平行的侧面（7a，7b; 8a，8b）），并且通过其侧面作为堆叠平面（SE）堆叠到高度（hL），并且布置在膨胀弹簧环的弹性臂之间以便限定刮油环的标称高度，根据本发明，应该获得具有最小轴向安装高度并且具有改进的刮油效果的至少三部分的刮油环，其中至少在每种情况下，薄片的侧翼（7a，7b; 8a，8b）中的一个具有在其径向向内定位的壁区域中具有切口（11），该切口（11）具有支撑面（12）膨胀弹簧环的弹性臂（3,4）的接合被成形为使得刮油环的标称高度仅由片层（7,8）的叠层高度（hL）确定。

6. 发明授权

US07575506B2 Automatic spreading adjustment 有权
标题翻译：自动扩散调整
公开(公告)号：US07575506B2
公开(公告)日：2009-08-18
申请号：US12044545
申请日：2008-03-07
申请人： Detlef Ebert , Michael Hummel
发明人： Detlef Ebert , Michael Hummel
IPC分类号： A22C11/00
CPC分类号： A22C11/10 , A22C11/125 , B65B9/12
摘要： An apparatus for producing a plaited portion on a packaging casing material which accommodates a filling material, in particular sausage meat, wherein the plaited portion is at least approximately filling material-free at least during the formation thereof, including: a first displacer unit and a second displacer unit which is displaceable reversibly in a linear movement with respect to the first displacer unit, and a drive unit for at least the drive for the linear movement of the second displacer unit, wherein provided between the drive unit and the second displacer unit is at least one drive force transmission unit which transmits the drive force produced by the drive unit to the second displacer unit and which is pivotable reversibly about a pivot point, the position of which is adjustable.
摘要翻译：一种用于在容纳填充材料，特别是香肠肉的包装外壳材料上生产编织部分的装置，其中至少在其形成期间，编织部分至少几乎不填充材料，包括：第一置换器单元和第二置换器单元，其相对于第一置换器单元以线性运动可逆地移位;以及驱动单元，用于至少驱动第二置换器单元的线性运动的驱动单元，其中设置在驱动单元和第二置换器单元之间至少一个驱动力传递单元，其将由所述驱动单元产生的驱动力传递到所述第二置换器单元，并且所述至少一个驱动力传递单元绕枢转点可枢转地枢转，所述枢转点的位置是可调节的。

7. 发明申请

US20060032411A1 Modular Pallet and Method 失效
标题翻译：模块托盘和方法
公开(公告)号：US20060032411A1
公开(公告)日：2006-02-16
申请号：US10710917
申请日：2004-08-12
申请人： Michael Hummel , John Conner , Gregory Dobie , Craig Wright
发明人： Michael Hummel , John Conner , Gregory Dobie , Craig Wright
IPC分类号： B65D19/12
CPC分类号： B65D19/0097 , B65D2519/00034 , B65D2519/00069 , B65D2519/00273 , B65D2519/00293 , B65D2519/00298 , B65D2519/00323 , B65D2519/00338 , B65D2519/00572 , B65D2519/00756 , B65D2519/00766 , B65D2519/0099
摘要： A pallet is formed of two or more sections formed of plastic materials. The sections are adjustably fixed together using elongated connectors dimensioned to fit closely in channels with each of the connectors extending between a channel of one section and a channel of an adjoining section. The sections and the connectors are adjustably secured together by means of mechanical fasteners. Spaced apertures are provided through each of the channels and similarly spaced apertures are provided through each of the connectors whereby the dimensions of the pallet are adjustable. Pallets are provided that can be nested in an inverted orientation without increasing the thickness of the inverted pair greater than the thickness of a single pallet.
摘要翻译：托盘由塑料材料形成的两个或多个部分形成。这些部分可调节地固定在一起，使用尺寸适于紧密地配合在通道中的细长连接器，每个连接器在一个部分的通道和相邻部分的通道之间延伸。这些部分和连接器通过机械紧固件可调节地固定在一起。通过每个通道提供间隔的孔，并且通过每个连接器提供类似的间隔开的孔，由此托盘的尺寸是可调节的。提供的托盘可以以倒置的方式嵌套，而不会增加反转对的厚度大于单个托盘的厚度。

8. 发明申请

US20110143902A1 AUTOMATIC DISPLACER CLEARANCE ADJUSTMENT 有权
标题翻译：自动换位器间隙调整
公开(公告)号：US20110143902A1
公开(公告)日：2011-06-16
申请号：US12967996
申请日：2010-12-14
申请人： Detlef Ebert , Michael Hummel
发明人： Detlef Ebert , Michael Hummel
IPC分类号： B31C1/00
CPC分类号： A22C11/10 , A22C11/104 , A22C11/105 , A22C11/108
摘要： An apparatus and method producing a plait-like portion on a tubular packaging casing, which accommodates a filling material includes a plait-like portion at least approximately free of filling material, extending along a longitudinal plait-axis. The apparatus comprises a first displacer unit with a first pair of displacer elements reversibly movable between an opened and a closed position perpendicular to the longitudinal plait-axis. A displacer clearance is created between the first pair of displacer elements, which surrounds the longitudinal plait-axis, in which the tubular packaging casing is being gathered, when the first pair of displacer elements is in the closed position. The apparatus comprises a second displacer unit with a second pair of displacer elements also being reversibly movable between an opened and a closed position perpendicular to the longitudinal plait-axis. A displacer clearance is created between the second pair of displacer elements, similar to first pair of displacer elements.
摘要翻译：容纳填充材料的管状包装壳体上产生辫状部分的装置和方法包括至少大致不含填充材料的辫状部分，沿着纵向辫轴延伸。该装置包括第一置换器单元，该第一置换器单元具有第一对置换器元件，其可在垂直于纵向纵轴的开放位置和闭合位置之间可逆地移动。当第一对置换器元件处于关闭位置时，在第一对置换器元件之间产生置换器间隙，该第一对置换器元件围绕纵向排列轴线，其中管状包装壳体被收集。该装置包括具有第二对置换器元件的第二置换器单元，其也可在垂直于纵向排列轴的打开位置和闭合位置之间可逆地移动。类似于第一对置换器元件，在第二对置换器元件之间产生置换器间隙。

9. 发明申请

US20080309022A1 Two-Part Oil Scraper Ring for Internal Combustion Engines 审中-公开
标题翻译：内燃机两部分刮油环
公开(公告)号：US20080309022A1
公开(公告)日：2008-12-18
申请号：US11990046
申请日：2006-07-18
申请人： Michael Hummel , Alexandros Mizoglou
发明人： Michael Hummel , Alexandros Mizoglou
IPC分类号： F16J9/20
CPC分类号： F16J9/06 , F16J9/069
摘要： In the case of a two-part oil scraper ring (10) for internal combustion engines, having a U-shaped expanding-spring ring (1), which is provided with axial indentations (2), for forming radially outwardly aligned resilient limbs (3, 4) which are connected to one another by means of radially inwardly situated webs (5), and having an annular body (7) which is provided with in each case parallel flanks (7a, 7b) and a running face (9), according to the invention, a minimum axial installation height with an improved oil-scraping effect should be obtained in that the flanks (7a, 7b) of the annular body have, in their radially inwardly situated wall region, cut-outs (11) which have a support face (12) for the engagement of the resilient limbs (3, 4) of the expanding-spring ring and are shaped such that the nominal height of the oil scraper ring is determined exclusively by the height of the annular body (7).
摘要翻译：在用于内燃机的两部分油刮环（10）的情况下，具有设置有轴向压痕（2）的U形膨胀弹簧环（1），用于形成径向向外对准的弹性臂 3,4），它们通过径向向内定位的腹板（5）彼此连接，并且具有环形体（7），每个环形体均设有平行的侧面（7a，7b）和行进面（9）根据本发明，应该获得具有改进的刮油效果的最小轴向安装高度，因为环形体的侧面（7a，7b）在其径向向内定位的壁区域中具有切口（11）其具有用于接合膨胀弹簧环的弹性臂（3,4）的支撑面（12），并且成形为使得刮油环的标称高度仅由环形体的高度确定（ 7）。

10. 发明申请

US20080202849A1 Billboard fall arrest system 审中-公开
标题翻译：广告牌摔跤系统
公开(公告)号：US20080202849A1
公开(公告)日：2008-08-28
申请号：US12070839
申请日：2008-02-20
申请人： Michael Russo , Michael Hummel
发明人： Michael Russo , Michael Hummel
IPC分类号： A62B35/00 , E04G3/32
CPC分类号： A62B35/0056
摘要： A billboard fall arrest system comprises a track member which attaches with mounting brackets to either the vertical upright members of the billboard or to the horizontal ledger members. The track member may further comprise extended curved sections which extend into the area of the walkaround catwalk, thereby allowing a worker to be secured to the fall arrest system with a single lanyard while moving to the ladder at the walkaround catwalk. A sliding member slidably engages the track member, where the sliding member travels along or in the track member as the worker moves relative to the track member. A safety line is attached at one end to the sliding member and attached at the other end to a safety harness worn by the worker.
摘要翻译：广告牌坠落拦截系统包括轨道构件，其将安装支架连接到广告牌的垂直直立构件或水平分类帐构件。轨道构件还可以包括延伸到逐步走道的区域中的延伸的弯曲部分，从而允许工人在移动到步行路口上的梯子的同时用单个挂绳固定到防坠落系统。滑动构件可滑动地接合轨道构件，当工作人员相对于轨道构件移动时，滑动构件沿轨道构件行进或移动。安全线一端连接到滑动构件，另一端连接到工作人员佩戴的安全带上。

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