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    • 5. 发明授权
    • Three-dimensional imaging with multiframe blind deconvolution
    • 具有多帧盲解卷积的三维成像
    • US07139067B2
    • 2006-11-21
    • US10661138
    • 2003-09-12
    • Richard Henry PohleMichael Forrest Reiley
    • Richard Henry PohleMichael Forrest Reiley
    • G01C3/08
    • G02B27/2228G01S7/4813G01S7/487G01S17/89G06T7/50
    • Methods and systems for three-dimensional imaging through turbulence such as produced by the Earth's atmosphere are described. A first light source may direct an output of pulses to a target through atmospheric turbulence. A first image sensor, for example a time of arrival sensor or focal plane, may receive light from the first light source and may be used to record two-dimensional images or image slices of the target. A second light source may also be used. A second image sensor may receive light reflected from the target. An atmospheric point spread function may be derived or calculated by a means for multiframe blind deconvolution from one or more images of the target received at the second image sensor. The point spread function may be used to deblur or improve the resolution of each of the two-dimensional image slices from the first image sensor. The two-dimensional image slices may be combined to form a three-dimensional image of the target.
    • 描述了通过地球大气层产生的湍流三维成像的方法和系统。 第一光源可以通过大气湍流将脉冲的输出引导到目标。 第一图像传感器,例如到达时间传感器或焦平面,可以接收来自第一光源的光,并且可以用于记录目标的二维图像或图像切片。 也可以使用第二光源。 第二个图像传感器可以接收从目标反射的光。 可以通过用于在第二图像传感器处接收的目标的一个或多个图像的多帧盲解卷积的装置来导出或计算大气点扩散函数。 点扩散函数可用于去除或提高来自第一图像传感器的每个二维图像切片的分辨率。 可以组合二维图像切片以形成目标的三维图像。
    • 6. 发明申请
    • Closed-loop control system for recycling products
    • 回收产品的闭环控制系统
    • US20050027555A1
    • 2005-02-03
    • US10899536
    • 2004-07-26
    • Michael ForrestDavid Schneider
    • Michael ForrestDavid Schneider
    • B29B17/00B29B17/02G06Q10/00G06F17/60B02C1/00B28B3/06
    • G06Q10/06B29B17/00B29B17/0042B29B17/02B29B2017/0089B29K2023/06B29K2023/12B29K2025/00B29K2025/06B29K2067/00B29K2105/065B29K2625/06B29K2711/12G06Q10/30Y02W30/62Y02W30/622Y02W90/20
    • A closed-loop control system for recycling products, such as food service ware. The system provides a “pure” stream of the products without major contaminants, which facilitates efficient re-fabrication of the product. The system includes collecting the used product from a selected group of users, isolating the used product from other waste, and delivering the product to a reprocessing center. The used product is washed and pelletized to form recycled pellets, which are combined with virgin pellets in ratios conforming with FDA regulations, to produce new recycled products. These new products are then sold back to the group of users, thus maintaining the system in a closed-loop. The recycled products may include plastic materials, such as polystyrene, polyethylene terephthalate, polypropylene, or high density polyethylene. When any of the above-mentioned plastic materials are in their expanded foam state, the system may be more economically feasible to operate. The group of users may include institutions such as school systems and food management services.
    • 一种用于回收产品的闭环控制系统,如食品服务。 该系统提供了一种“纯净”的产品流,没有主要污染物,这有助于产品的有效重新制造。 该系统包括从所选择的用户群中收集使用的产品,将废弃的产品与其他废物隔离,并将产品运送到后处理中心。 将所用的产品洗涤并造粒以形成再循环的颗粒,其与按照FDA规定的比例与原始颗粒结合,以生产新的再循环产品。 然后将这些新产品退回给用户组,从而将系统保持在闭环状态。 再生产品可以包括塑料材料,例如聚苯乙烯,聚对苯二甲酸乙二醇酯,聚丙烯或高密度聚乙烯。 当任何上述塑料材料处于其膨胀泡沫状态时,该系统在经济上可能更经济可操作。 用户组可能包括学校系统和食品管理服务等机构。
    • 7. 发明申请
    • Selective s1p1/edg1 receptor agonists
    • 选择性s1p1 / edg1受体激动剂
    • US20050070506A1
    • 2005-03-31
    • US10501176
    • 2003-01-14
    • George DohertyMichael ForrestRichard HajduJeffrey HaleLi ZhenSusanne MandalaSander MillsHugh RosenEdward Scolnick
    • George DohertyMichael ForrestRichard HajduJeffrey HaleLi ZhenSusanne MandalaSander MillsHugh RosenEdward Scolnick
    • A61K31/00A61K31/66G01N33/566
    • A61K31/66A61K31/00G01N33/566G01N2500/04
    • The present invention encompasses a method of treating an immunoregulatory abnormality in a mammalian patient in need of such treatment comprising administering to said patient a compound which is an agonist of the S1P1/Edg1 receptor in an amount effective for treating said immunoregulatory abnormality, wherein said compound possesses a selectivity for the S1P1/Edg1 receptor over the S1PR3/Edg3 receptor, said compound administered in an amount effective for treating said immunoregulatory abnormality. Pharmaceutical compositions are included. The invention also encompasses a method of identifying candidate compounds that are agonists of the S1P1/Edg1 receptor and which possesses a selectivity for the S1P1/Edg1 receptor over the S1PR3/Edg3 receptor. The invention further encompasses a method of treating a respiratory disease or condition in a mammalian patient in need of such treatment comprising administering to said patient a compound which is an agonist of the S1P1/Edg1 receptor in an amount effective for treating said respiratory disease or condition, wherein said compound possesses a selectivity for the S1P1/Edg1 receptor over the S1PR3/Edg3 receptor.
    • 本发明包括在需要这种治疗的哺乳动物患者中治疗免疫调节异常的方法,包括以有效治疗所述免疫调节异常的量向所述患者施用作为S1P1 / Edg1受体激动剂的化合物,其中所述化合物 对S1P1 / Edg1受体具有S1PR3 / Edg1受体的选择性,所述化合物以有效治疗所述免疫调节异常的量给药。 包括药物组合物。 本发明还包括鉴定作为S1P1 / Edg1受体的激动剂的候选化合物的方法,并且其具有S1P1 / Edg1受体超过S1PR3 / Edg3受体的选择性。 本发明还包括治疗需要这种治疗的哺乳动物患者的呼吸系统疾病或病症的方法,包括向所述患者施用有效治疗所述呼吸系统疾病或病症的S1P1 / Edg1受体激动剂的化合物 其中所述化合物对S1P1 / Edg1受体具有超过S1PR3 / Edg3受体的选择性。