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1. 发明授权

US09517121B2 Compliant blood vessel graft 有权
标题翻译：符合血管移植
公开(公告)号：US09517121B2
公开(公告)日：2016-12-13
申请号：US12482978
申请日：2009-06-11
申请人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F. Wolf
发明人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F. Wolf
IPC分类号： A61F2/06 , A61L27/14 , A61L27/36 , A61F2/90
CPC分类号： A61F2/06 , A61F2/90 , A61L27/14 , A61L27/3625
摘要： A graft includes a flexible, resilient, generally tubular external support and a blood vessel segment, carried within and having an ablumenal surface in contact with and supported by the tubular support, the graft being capable of resilient radial expansion in a manner mimicking the radial compliance properties of an artery.
摘要翻译：移植物包括柔性的，弹性的，大体上管状的外部支撑物和血管段，其承载在并具有与管状支撑件接触并由其支撑的缩小表面，所述移植物能够以模拟径向顺应性的方式弹性径向膨胀动脉的性质。

2. 发明授权

US08382814B2 Compliant blood vessel graft 有权
标题翻译：符合血管移植
公开(公告)号：US08382814B2
公开(公告)日：2013-02-26
申请号：US13209517
申请日：2011-08-15
申请人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F Wolf , Paul Human
发明人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F Wolf , Paul Human
IPC分类号： A61F2/06
CPC分类号： A61B17/11 , A61B5/1076 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2017/1139 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/95 , A61F2240/002
摘要： Stents and methods of using stents are provided. Stents of the invention provide external support structure for a blood vessel segment disposed within, wherein the stents are capable of resilient radial expansion in a manner mimicking the compliance properties of an artery. The stent may be formed of a knitted or braided mesh formed so as to provide the needed compliance properties. A venous graft with the stent and a vein segment disposed within is provided, wherein graft is capable of mimicking the compliance properties of an artery. Methods of selecting stents for downsizing and methods of using the stents of the invention in downsizing and smoothening are provided. Methods of replacing a section of an artery with a venous graft including a stent of the invention are provided. Methods of reducing intimal hyperplasia in implanted vein segment in a venous graft using stents of the invention are provided.
摘要翻译：提供支架和使用支架的方法。本发明的支架为设置在其内的血管段提供外部支撑结构，其中支架能够以模仿动脉的顺应性的方式弹性径向扩张。支架可以由形成的针织或编织网形成，以便提供所需的顺应性。提供具有支架和设置在其内的静脉段的静脉移植物，其中移植物能够模拟动脉的顺应性。提供了选择小型化支架的方法和使用本发明的支架在缩小和平滑方面的方法。提供了用包括本发明的支架的静脉移植物代替动脉的一部分的方法。提供了使用本发明的支架在静脉移植物中减少植入静脉段内膜增生的方法。

3. 发明授权

US5271898A Apparatus for testing blood/biomaterials/device interactions and characteristics 失效
标题翻译：用于测试血液/生物材料/器件相互作用和特性的装置
公开(公告)号：US5271898A
公开(公告)日：1993-12-21
申请号：US56450
申请日：1993-05-03
申请人： Michael F. Wolf , Paul V. Trescony , James R. Keogh
发明人： Michael F. Wolf , Paul V. Trescony , James R. Keogh
IPC分类号： G01N11/00 , G01N33/487 , G01N33/49
CPC分类号： G01N11/00 , G01N33/49 , Y10T436/117497
摘要： An apparatus designed to test blood, blood contacting biomaterials and devices such as materials and surface-modified materials; vascular grafts, stents, heart valves, catheters, leads, etc., for blood and material responses in vitro under physiological blood flow conditions. The apparatus consists of a stepper-motor driven circular disc(s), upon which a test vehicle, containing either the test materials, coating or device, is mounted. The test vehicle itself consists of a circular, closed-loop of polymer tubing containing a check valve.
摘要翻译：设计用于测试血液，血液接触生物材料和诸如材料和表面改性材料的装置的设备; 血管移植物，支架，心脏瓣膜，导管，引线等，用于在生理血流条件下的体外血液和物质反应。该设备由步进电机驱动的圆盘组成，其上安装有测试材料，涂层或装置的测试车辆。测试车辆本身由包含止回阀的聚合物管的圆形闭环组成。

4. 发明授权

US08057537B2 Compliant venous graft 有权
标题翻译：合并静脉移植
公开(公告)号：US08057537B2
公开(公告)日：2011-11-15
申请号：US10834360
申请日：2004-04-28
申请人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F. Wolf
发明人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F. Wolf
IPC分类号： A61F2/90
CPC分类号： A61F2/06 , A61F2/90 , A61L27/14 , A61L27/3625
摘要： A venous graft for replacement of a section of an artery and methods of making the graft. The graft comprises a flexible, resilient, generally tubular external support and a vein segment carried within and having an ablumenal surface in contact with and supported by the tubular support, the venous graft being capable of resilient radial expansion in a manner mimicking the radial compliance properties of an artery.
摘要翻译：用于替换动脉的一部分的静脉移植物和制造移植物的方法。移植物包括柔性的，弹性的，大体上管状的外部支撑件和承载在管状支撑件内并具有与管状支撑件接触并由其支撑的缩小表面的静脉段，静脉移植物能够以模拟径向顺应性的方式弹性径向膨胀的动脉。

5. 发明授权

US07759120B2 Seeding implantable medical devices with cells 失效
标题翻译：种植植入式医疗器械与细胞
公开(公告)号：US07759120B2
公开(公告)日：2010-07-20
申请号：US11515344
申请日：2006-09-01
申请人： Michael F. Wolf , Laurie A. Yunker , Paul V. Trescony
发明人： Michael F. Wolf , Laurie A. Yunker , Paul V. Trescony
IPC分类号： C12N11/08
CPC分类号： A61F2/062 , A61L27/16 , A61L27/3616 , A61L27/38 , A61L27/3808 , A61L27/507 , Y10S623/915 , Y10S623/916 , C08L27/18
摘要： Apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells, are described. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device. The introduction of the cells may occur after a blood centrifugation product, such as platelet-poor plasma, is applied to the luminal surface. After the cells are introduced, the device is then subjected to centrifugation around a longitudinal axis defined by the lumen. Axial centrifugation causes the cells to concentrate toward and adhere to the luminal surface. Shortly after axial centrifugation, the seeded device can be presented for implantation in a patient. The implantable medical device may be inserted into a protective sleeve prior to seeding the device with cells, and the sleeve may or may not be removed prior to implantation.
摘要翻译：描述了可植入医疗装置（例如血管假体）与细胞例如内皮细胞接种的装置和方法。本发明支持用轴向离心法将装置的腔表面接种的技术。将细胞悬浮液引入装置的内腔。在血液离心产物（如贫血小板血浆）应用于管腔表面后，细胞的引入可能发生。导入细胞后，将该装置围绕由内腔限定的纵向轴进行离心。轴向离心导致细胞浓缩并附着在管腔表面。在轴向离心后不久，可以将接种的装置用于植入患者体内。可植入的医疗装置可以在将装置与细胞接种之前插入保护套管中，并且在植入之前套筒可以被移除也可以不被移除。

6. 发明申请

US20090306764A1 Compliant Blood Vessel Graft 有权
标题翻译：符合血管移植
公开(公告)号：US20090306764A1
公开(公告)日：2009-12-10
申请号：US12482978
申请日：2009-06-11
申请人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F. Wolf
发明人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F. Wolf
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2/90 , A61L27/14 , A61L27/3625
摘要： A graft includes a flexible, resilient, generally tubular external support and a blood vessel segment, carried within and having an ablumenal surface in contact with and supported by the tubular support, the graft being capable of resilient radial expansion in a manner mimicking the radial compliance properties of an artery.
摘要翻译：移植物包括柔性的，弹性的，大体上管状的外部支撑物和血管段，其承载在并具有与管状支撑件接触并由其支撑的缩小表面，所述移植物能够以模拟径向顺应性的方式弹性径向膨胀动脉的性质。

7. 发明申请

US20090163987A1 Compliant Venous Graft 有权
标题翻译：合并静脉移植
公开(公告)号：US20090163987A1
公开(公告)日：2009-06-25
申请号：US12388702
申请日：2009-02-19
申请人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Narenk Douk , Michael F. Wolf
发明人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Narenk Douk , Michael F. Wolf
IPC分类号： A61F2/06 , A61B17/00
CPC分类号： A61F2/06 , A61F2/90 , A61L27/14 , A61L27/3625
摘要： A venous graft for replacement of a section of an artery and methods of making the graft. The graft comprises a flexible, resilient, generally tubular external support and a vein segment carried within and having an ablumenal surface in contact with and supported by the tubular support, the venous graft being capable of resilient radial expansion in a manner mimicking the radial compliance properties of an artery.
摘要翻译：用于替换动脉的一部分的静脉移植物和制造移植物的方法。移植物包括柔性的，弹性的，大体上管状的外部支撑件和承载在管状支撑件内并具有与管状支撑件接触并由其支撑的缩小表面的静脉段，静脉移植物能够以模拟径向顺应性的方式弹性径向膨胀的动脉。

8. 发明申请

US20110295157A1 Compliant Blood Vessel Graft 有权
标题翻译：符合血管移植
公开(公告)号：US20110295157A1
公开(公告)日：2011-12-01
申请号：US13209517
申请日：2011-08-15
申请人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F. Wolf , Paul Human
发明人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F. Wolf , Paul Human
IPC分类号： A61B5/103
CPC分类号： A61B17/11 , A61B5/1076 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2017/1139 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/95 , A61F2240/002
摘要： Stents and methods of using stents are provided. Stents of the invention provide external support structure for a blood vessel segment disposed within, wherein the stents are capable of resilient radial expansion in a manner mimicking the compliance properties of an artery. The stent may be formed of a knitted or braided mesh formed so as to provide the needed compliance properties. A venous graft with the stent and a vein segment disposed within is provided, wherein graft is capable of mimicking the compliance properties of an artery. Methods of selecting stents for downsizing and methods of using the stents of the invention in downsizing and smoothening are provided. Methods of replacing a section of an artery with a venous graft including a stent of the invention are provided. Methods of reducing intimal hyperplasia in implanted vein segment in a venous graft using stents of the invention are provided.
摘要翻译：提供支架和使用支架的方法。本发明的支架为设置在其内的血管段提供外部支撑结构，其中支架能够以模仿动脉的顺应性的方式弹性径向扩张。支架可以由形成的针织或编织网形成，以便提供所需的顺应性。提供具有支架和设置在其内的静脉段的静脉移植物，其中移植物能够模拟动脉的顺应性。提供了选择小型化支架的方法和使用本发明的支架在缩小和平滑方面的方法。提供了用包括本发明的支架的静脉移植物代替动脉的一部分的方法。提供了使用本发明的支架在静脉移植物中减少植入静脉段内膜增生的方法。

9. 发明申请

US20120116495A1 Compliant Venous Graft 审中-公开
标题翻译：合并静脉移植
公开(公告)号：US20120116495A1
公开(公告)日：2012-05-10
申请号：US13351591
申请日：2012-01-17
申请人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F. Wolf
发明人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F. Wolf
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2/90 , A61L27/14 , A61L27/3625
摘要： A venous graft for replacement of a section of an artery and methods of making the graft. The graft comprises a flexible, resilient, generally tubular external support and a vein segment carried within and having an ablumenal surface in contact with and supported by the tubular support, the venous graft being capable of resilient radial expansion in a manner mimicking the radial compliance properties of an artery.
摘要翻译：用于替换动脉的一部分的静脉移植物和制造移植物的方法。移植物包括柔性的，弹性的，大体上管状的外部支撑件和承载在管状支撑件内并具有与管状支撑件接触并由其支撑的缩小表面的静脉段，静脉移植物能够以模拟径向顺应性的方式弹性径向膨胀的动脉。

10. 发明授权

US08172746B2 Compliant venous graft 有权
标题翻译：合并静脉移植
公开(公告)号：US08172746B2
公开(公告)日：2012-05-08
申请号：US12388702
申请日：2009-02-19
申请人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Narenk Douk , Michael F. Wolf
发明人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Narenk Douk , Michael F. Wolf
IPC分类号： A61F2/04
CPC分类号： A61F2/06 , A61F2/90 , A61L27/14 , A61L27/3625
摘要： A venous graft for replacement of a section of an artery and methods of making the graft. The graft comprises a flexible, resilient, generally tubular external support and a vein segment carried within and having an ablumenal surface in contact with and supported by the tubular support, the venous graft being capable of resilient radial expansion in a manner mimicking the radial compliance properties of an artery.
摘要翻译：用于替换动脉的一部分的静脉移植物和制造移植物的方法。移植物包括柔性的，弹性的，大体上管状的外部支撑件和承载在管状支撑件内并具有与管状支撑件接触并由其支撑的缩小表面的静脉段，静脉移植物能够以模拟径向顺应性的方式弹性径向膨胀的动脉。

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