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    • 3. 发明授权
    • Microwave-assisted chromatography preparation
    • 微波辅助色谱法制备
    • US07939785B2
    • 2011-05-10
    • US12020711
    • 2008-01-28
    • Michael Collins, Sr.Wyatt P. Hargett, Jr.James Edward ThomasE. Keller BarnhardtMichael Collins, Jr.
    • Michael Collins, Sr.Wyatt P. Hargett, Jr.James Edward ThomasE. Keller BarnhardtMichael Collins, Jr.
    • H05B6/64
    • H05B6/806F26B3/347F26B5/048F26B9/003F26B21/14G01N1/44G01N30/06G01N2030/567
    • An instrument and associated method are disclosed for preparing samples for column chromatography. The method includes the steps of applying microwave energy to a sample composition containing at least one solvent to encourage a chemical reaction and generate desired products, thereafter mixing an absorbent media with the sample to absorb the solvent, the media being compatible with liquid chromatography that will separate the expected products, being chemically inert to the expected products, and being added in an amount sufficient to provide a substantially dry mixture of the media and the sample, but less than an amount that overly broadens the resolution of the sample during liquid chromatography, thereafter applying microwave energy to the dry mixture of the media and the sample to thereby encourage the solvent to evaporate under the influence of the microwave energy, and thereafter adding the dry mixture of the media and the remaining sample to a liquid chromatography column and separating the components of the remaining sample for identification and purification purposes.
    • 公开了用于制备用于柱色谱法的样品的仪器和相关方法。 该方法包括以下步骤:向含有至少一种溶剂的样品组合物施加微波能量以促进化学反应并产生所需产物,然后将吸收介质与样品混合以吸收溶剂,该介质与液相色谱相容, 将期望的产品分离,对预期产品具有化学惰性,并且以足以提供介质和样品的基本上干燥的混合物的量加入,但小于在液相色谱法过度扩大样品分辨率的量, 然后将微波能量施加到介质和样品的干燥混合物中,从而促使溶剂在微波能量的影响下蒸发,然后将介质和剩余样品的干混合物加入液相色谱柱中, 剩余样品的组分用于鉴定和纯化目的。
    • 4. 发明申请
    • MICROWAVE-ASSISTED CHROMATOGRAPHY PREPARATION
    • 微波辅助色谱准备
    • US20080116363A1
    • 2008-05-22
    • US12020711
    • 2008-01-28
    • MICHAEL COLLINSWYATT HARGETTJAMES THOMASMICHAEL COLLINSE. BARNHARDT
    • MICHAEL COLLINSWYATT HARGETTJAMES THOMASMICHAEL COLLINSE. BARNHARDT
    • H05H3/02
    • H05B6/806F26B3/347F26B5/048F26B9/003F26B21/14G01N1/44G01N30/06G01N2030/567
    • An instrument and associated method are disclosed for preparing samples for column chromatography. The method includes the steps of applying microwave energy to a sample composition containing at least one solvent to encourage a chemical reaction and generate desired products, thereafter mixing an absorbent media with the sample to absorb the solvent, the media being compatible with liquid chromatography that will separate the expected products, being chemically inert to the expected products, and being added in an amount sufficient to provide a substantially dry mixture of the media and the sample, but less than an amount that overly broadens the resolution of the sample during liquid chromatography, thereafter applying microwave energy to the dry mixture of the media and the sample to thereby encourage the solvent to evaporate under the influence of the microwave energy, and thereafter adding the dry mixture of the media and the remaining sample to a liquid chromatography column and separating the components of the remaining sample for identification and purification purposes.
    • 公开了用于制备用于柱色谱法的样品的仪器和相关方法。 该方法包括以下步骤:向含有至少一种溶剂的样品组合物施加微波能量以促进化学反应并产生所需产物,然后将吸收介质与样品混合以吸收溶剂,该介质与液相色谱相容, 将期望的产品分离,对预期产品具有化学惰性,并且以足以提供介质和样品的基本上干燥的混合物的量加入,但小于在液相色谱法过度扩大样品分辨率的量, 然后将微波能量施加到介质和样品的干燥混合物中,从而促使溶剂在微波能量的影响下蒸发,然后将介质和剩余样品的干混合物加入液相色谱柱中, 剩余样品的组分用于鉴定和纯化目的。
    • 5. 发明申请
    • Microwave-Assisted Chromatography Preparation
    • 微波辅助色谱法制备
    • US20060261058A1
    • 2006-11-23
    • US11456997
    • 2006-07-12
    • Michael CollinsWyatt HargettJames ThomasMichael CollinsE. Barnhardt
    • Michael CollinsWyatt HargettJames ThomasMichael CollinsE. Barnhardt
    • B01L9/00
    • H05B6/806F26B3/347F26B5/048F26B9/003F26B21/14G01N1/44G01N30/06G01N2030/567
    • An instrument and associated method are disclosed for preparing samples for column chromatography. The method includes the steps of applying microwave energy to a sample composition containing at least one solvent to encourage a chemical reaction and generate desired products, thereafter mixing an absorbent media with the sample to absorb the solvent, the media being compatible with liquid chromatography that will separate the expected products, being chemically inert to the expected products, and being added in an amount sufficient to provide a substantially dry mixture of the media and the sample, but less than an amount that overly broadens the resolution of the sample during liquid chromatography, thereafter applying microwave energy to the dry mixture of the media and the sample to thereby encourage the solvent to evaporate under the influence of the microwave energy, and thereafter adding the dry mixture of the media and the remaining sample to a liquid chromatography column and separating the components of the remaining sample for identification and purification purposes.
    • 公开了用于制备用于柱色谱法的样品的仪器和相关方法。 该方法包括以下步骤:向含有至少一种溶剂的样品组合物施加微波能量以促进化学反应并产生所需产物,然后将吸收介质与样品混合以吸收溶剂,该介质与液相色谱相容, 将期望的产品分离,对预期产品具有化学惰性,并且以足以提供介质和样品的基本上干燥的混合物的量加入,但小于在液相色谱法过度扩大样品分辨率的量, 然后将微波能量施加到介质和样品的干燥混合物中,从而促使溶剂在微波能量的影响下蒸发,然后将介质和剩余样品的干混合物加入液相色谱柱中, 剩余样品的组分用于鉴定和纯化目的。
    • 6. 发明申请
    • Microwave-assisted chromatography preparation
    • 微波辅助色谱法制备
    • US20060038118A1
    • 2006-02-23
    • US10923243
    • 2004-08-20
    • Michael CollinsWyatt HargettJames ThomasMichael CollinsE. Barnhardt
    • Michael CollinsWyatt HargettJames ThomasMichael CollinsE. Barnhardt
    • H05H3/02
    • H05B6/806F26B3/347F26B5/048F26B9/003F26B21/14G01N1/44G01N30/06G01N2030/567
    • An instrument and associated method are disclosed for preparing samples for column chromatography. The method includes the steps of applying microwave energy to a sample composition containing at least one solvent to encourage a chemical reaction and generate desired products, thereafter mixing an absorbent media with the sample to absorb the solvent, the media being compatible with liquid chromatography that will separate the expected products, being chemically inert to the expected products, and being added in an amount sufficient to provide a substantially dry mixture of the media and the sample, but less than an amount that overly broadens the resolution of the sample during liquid chromatography, thereafter applying microwave energy to the dry mixture of the media and the sample to thereby encourage the solvent to evaporate under the influence of the microwave energy, and thereafter adding the dry mixture of the media and the remaining sample to a liquid chromatography column and separating the components of the remaining sample for identification and purification purposes.
    • 公开了用于制备用于柱色谱法的样品的仪器和相关方法。 该方法包括以下步骤:向含有至少一种溶剂的样品组合物施加微波能量以促进化学反应并产生所需产物,然后将吸收介质与样品混合以吸收溶剂,该介质与液相色谱相容, 将期望的产品分离,对预期产品具有化学惰性,并且以足以提供介质和样品的基本上干燥的混合物的量加入,但小于在液相色谱法过度扩大样品分辨率的量, 然后将微波能量施加到介质和样品的干燥混合物中,从而促使溶剂在微波能量的影响下蒸发,然后将介质和剩余样品的干混合物加入液相色谱柱中, 剩余样品的组分用于鉴定和纯化目的。