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1. 发明授权

US08563746B2 Cyclic benzimidazole derivatives useful as anti-diabetic agents 有权
标题翻译：可用作抗糖尿病药的环状苯并咪唑衍生物
公开(公告)号：US08563746B2
公开(公告)日：2013-10-22
申请号：US13125329
申请日：2009-10-19
申请人： Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion , Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka
发明人： Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion , Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka
IPC分类号： A61K31/4184 , A61K31/5377 , A61K31/497 , C07D235/26 , C07D235/28 , C07D401/10 , C07D401/06 , C07D409/04 , C07D403/10 , C07D413/10 , C07D413/14 , C07D417/04
CPC分类号： C07D235/28 , C07D235/26 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/06 , C07D417/04
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译：结构式（I）的新型化合物是AMP-蛋白激酶的活化剂，可用于治疗，预防和抑制AMPK活化蛋白激酶介导的疾病。本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖症，高胆固醇血症和高血压。

2. 发明授权

US08410284B2 Cyclic benzimidazole derivatives useful as anti-diabetic agents 有权
标题翻译：可用作抗糖尿病药的环状苯并咪唑衍生物
公开(公告)号：US08410284B2
公开(公告)日：2013-04-02
申请号：US13124898
申请日：2009-10-12
申请人： Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka , Brett C. Bookser
发明人： Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka , Brett C. Bookser
IPC分类号： A61K31/675 , C07F9/00 , C07F9/6506
CPC分类号： C07F9/65068 , C07F9/65583 , C07F9/657181
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, Metabolic Syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译：结构式（I）的新型化合物是AMP-蛋白激酶的活化剂，可用于治疗，预防和抑制AMPK活化蛋白激酶介导的疾病。本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖，高胆固醇血症和高血压。

3. 发明授权

US08329914B2 Cyclic benzimidazole derivatives useful as anti-diabetic agents 有权
标题翻译：可用作抗糖尿病药的环状苯并咪唑衍生物
公开(公告)号：US08329914B2
公开(公告)日：2012-12-11
申请号：US13125345
申请日：2009-10-22
申请人： Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka , Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion
发明人： Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka , Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion
IPC分类号： A61K31/675 , A61K31/4184 , C07F9/06 , C07D235/06 , C07D235/24
CPC分类号： C07F9/65068 , A61K31/366 , A61K31/397 , A61K31/4184 , A61K31/4412 , A61K45/06 , C07F9/65583 , C07F9/65742 , A61K2300/00
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译：结构式（I）的新型化合物是AMP-蛋白激酶的活化剂，可用于治疗，预防和抑制AMPK活化蛋白激酶介导的疾病。本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖症，高胆固醇血症和高血压。

4. 发明申请

US20100316079A1 SUB-WAVELENGTH GRATING INTEGRATED VCSEL 有权
公开(公告)号：US20100316079A1
公开(公告)日：2010-12-16
申请号：US12795643
申请日：2010-06-07
申请人： Connie J. Chang-Hasnain , Michael Chung-Yi Huang , Ye Zhou , Carlos Fernando Rondina Mateus
发明人： Connie J. Chang-Hasnain , Michael Chung-Yi Huang , Ye Zhou , Carlos Fernando Rondina Mateus
IPC分类号： H01S5/34 , H01S5/187 , H01S5/183
CPC分类号： G02B5/1809 , G02B5/0816 , G02B5/1861 , G02B26/001 , G02B26/0808 , G02B26/0833 , G02B27/42 , G02B27/4255 , G02B27/4261 , H01S5/0655 , H01S5/18319 , H01S5/1835 , H01S5/18355 , H01S5/18366 , H01S5/187
摘要： A vertical cavity surface emitting laser (VCSEL) is described using a sub-wavelength grating (SWG) structure that has a very broad reflection spectrum and very high reflectivity. The grating comprises segments of high and low refractive index materials with an index differential between the high and low index materials. By way of example, a SWG reflective structure is disposed over a low index cavity region and above another reflective layer (either SWG or DBR). In one embodiment, the SWG structure is movable, such as according to MEMS techniques, in relation to the opposing reflector to provide wavelength selective tuning. The SWG-VCSEL design is scalable to form the optical cavities for a range of SWG-VCSELs at different wavelengths, and wavelength ranges.

5. 发明授权

US07602784B2 Method and apparatus to permit data transmission to traverse firewalls 有权
标题翻译：允许数据传输穿越防火墙的方法和装置
公开(公告)号：US07602784B2
公开(公告)日：2009-10-13
申请号：US10468439
申请日：2002-02-19
申请人： Christopher Piche , Md. Shahbadatullah Khan , David Everett Marwood , Michael Chung
发明人： Christopher Piche , Md. Shahbadatullah Khan , David Everett Marwood , Michael Chung
IPC分类号： H04L12/28
CPC分类号： H04L63/0209 , H04L29/12009 , H04L29/12424 , H04L29/12509 , H04L29/12528 , H04L29/12537 , H04L61/2535 , H04L61/2567 , H04L61/2575 , H04L61/2578 , H04L63/0263 , H04L63/029
摘要： Currently data transmission over the Internet between two client computers where both client computers are protected by firewalls is problematic, since firewalls block incoming packets. A method is provided for permitting packet based data transmission between a first client computer C1 protected by a first NAPT or NAT firewall and a second client computer C2 protected by a second NAPT or NAT firewall to traverse the first and the second firewalls. The method can also be applied to other devices, such as routers, using NAT or NAPT.
摘要翻译：目前在两台客户端计算机之间通过Internet进行的数据传输都是由防火墙保护的，因为防火墙阻止传入的数据包。提供了一种用于允许在由第一NAPT或NAT防火墙保护的第一客户端计算机C1和由第二NAPT或NAT防火墙保护的第二客户端计算机C2之间进行基于分组的数据传输以遍历第一和第二防火墙的方法。该方法也可以应用于其他设备，如路由器，使用NAT或NAPT。

6. 发明授权

US07522594B2 Method and apparatus to permit data transmission to traverse firewalls 有权
标题翻译：允许数据传输穿越防火墙的方法和装置
公开(公告)号：US07522594B2
公开(公告)日：2009-04-21
申请号：US11220539
申请日：2005-09-08
申请人： Christopher Piche , Shahadat Khan , Michael Chung
发明人： Christopher Piche , Shahadat Khan , Michael Chung
IPC分类号： H04L12/28
CPC分类号： H04L63/029 , H04L29/12009 , H04L29/12509 , H04L29/12528 , H04L29/12537 , H04L61/2567 , H04L61/2575 , H04L61/2578
摘要： Currently data transmission over the Internet between two client computers where both client computers are protected by firewalls is problematic, since firewalls block incoming packets. A method is provided for identifying the firewalls protecting a first client computer C1 protected by a first NAPT or NAT firewall and a second client computer C2 protected by a second NAPT or NAT firewall and allowing communications between the computers to traverse the first and the second firewalls.
摘要翻译：目前在两台客户端计算机之间通过Internet进行的数据传输都是由防火墙保护的，因为防火墙阻止传入的数据包。提供了一种用于识别保护由第一NAPT或NAT防火墙保护的第一客户端计算机C1的防火墙和由第二NAPT或NAT防火墙保护的第二客户端计算机C2并允许计算机之间的通信遍历第一和第二防火墙的方法。

7. 发明授权

US08189643B2 Sub-wavelength grating integrated VCSEL 有权
标题翻译：子波长光栅集成VCSEL
公开(公告)号：US08189643B2
公开(公告)日：2012-05-29
申请号：US12795641
申请日：2010-06-07
申请人： Connie J. Chang-Hasnain , Michael Chung-Yi Huang , Ye Zhou , Carlos Fernando Rondina Mateus
发明人： Connie J. Chang-Hasnain , Michael Chung-Yi Huang , Ye Zhou , Carlos Fernando Rondina Mateus
IPC分类号： H01S5/00
CPC分类号： G02B5/1809 , G02B5/0816 , G02B5/1861 , G02B26/001 , G02B26/0808 , G02B26/0833 , G02B27/42 , G02B27/4255 , G02B27/4261 , H01S5/0655 , H01S5/18319 , H01S5/1835 , H01S5/18355 , H01S5/18366 , H01S5/187
摘要： A vertical cavity surface emitting laser (VCSEL) is described using a sub-wavelength grating (SWG) structure that has a very broad reflection spectrum and very high reflectivity. The grating comprises segments of high and low refractive index materials with an index differential between the high and low index materials. By way of example, a SWG reflective structure is disposed over a low index cavity region and above another reflective layer (either SWG or DBR). In one embodiment, the SWG structure is movable, such as according to MEMS techniques, in relation to the opposing reflector to provide wavelength selective tuning. The SWG-VCSEL design is scalable to form the optical cavities for a range of SWG-VCSELs at different wavelengths, and wavelength ranges.
摘要翻译：使用具有非常宽的反射光谱和非常高的反射率的亚波长光栅（SWG）结构来描述垂直腔表面发射激光器（VCSEL）。光栅包括具有高折射率材料和低折射率材料之间的折射率差的高折射率材料和低折射率材料的片段。作为示例，SWG反射结构设置在低折射率空腔区域上并且在另一反射层（SWG或DBR）上方。在一个实施例中，SWG结构可以例如根据MEMS技术相对于相对的反射器是可移动的，以提供波长选择性调谐。 SWG-VCSEL设计可扩展，以形成不同波长和波长范围的一系列SWG-VCSEL的光学腔。

8. 发明授权

US08059690B2 Sub-wavelength grating integrated VCSEL 有权
标题翻译：子波长光栅集成VCSEL
公开(公告)号：US08059690B2
公开(公告)日：2011-11-15
申请号：US12795643
申请日：2010-06-07
申请人： Connie J. Chang-Hasnain , Michael Chung-Yi Huang , Ye Zhou , Carlos Fernando Rondina Mateus
发明人： Connie J. Chang-Hasnain , Michael Chung-Yi Huang , Ye Zhou , Carlos Fernando Rondina Mateus
IPC分类号： H01S5/00
CPC分类号： G02B5/1809 , G02B5/0816 , G02B5/1861 , G02B26/001 , G02B26/0808 , G02B26/0833 , G02B27/42 , G02B27/4255 , G02B27/4261 , H01S5/0655 , H01S5/18319 , H01S5/1835 , H01S5/18355 , H01S5/18366 , H01S5/187
摘要： A vertical cavity surface emitting laser (VCSEL) is described using a sub-wavelength grating (SWG) structure that has a very broad reflection spectrum and very high reflectivity. The grating comprises segments of high and low refractive index materials with an index differential between the high and low index materials. By way of example, a SWG reflective structure is disposed over a low index cavity region and above another reflective layer (either SWG or DBR). In one embodiment, the SWG structure is movable, such as according to MEMS techniques, in relation to the opposing reflector to provide wavelength selective tuning. The SWG-VCSEL design is scalable to form the optical cavities for a range of SWG-VCSELs at different wavelengths, and wavelength ranges.
摘要翻译：使用具有非常宽的反射光谱和非常高的反射率的亚波长光栅（SWG）结构来描述垂直腔表面发射激光器（VCSEL）。光栅包括具有高折射率材料和低折射率材料之间的折射率差的高折射率材料和低折射率材料的片段。作为示例，SWG反射结构设置在低折射率空腔区域上并且在另一反射层（SWG或DBR）上方。在一个实施例中，SWG结构可以例如根据MEMS技术相对于相对的反射器是可移动的，以提供波长选择性调谐。 SWG-VCSEL设计可扩展，以形成不同波长和波长范围的一系列SWG-VCSEL的光学腔。

9. 发明申请

US20110263533A1 NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS 有权
标题翻译：新型循环苄嘧啶衍生物作为抗糖尿病药物有用
公开(公告)号：US20110263533A1
公开(公告)日：2011-10-27
申请号：US13124898
申请日：2009-10-12
申请人： Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka , Brett C. Bookser
发明人： Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka , Brett C. Bookser
IPC分类号： A61K31/675 , C07F9/40 , C07F9/6574 , A61P35/00 , A61P3/04 , A61P3/06 , A61P9/12 , C07F9/6506 , A61P3/10
CPC分类号： C07F9/65068 , C07F9/65583 , C07F9/657181
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, Metabolic Syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译：结构式（I）的新型化合物是AMP-蛋白激酶的活化剂，可用于治疗，预防和抑制AMPK活化蛋白激酶介导的疾病。本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖，高胆固醇血症和高血压。

10. 发明申请

US20090125605A1 Method and System for Managing Folders of Email Accounts and Voice Messages 审中-公开
标题翻译：用于管理电子邮件帐户和语音留言的文件夹的方法和系统
公开(公告)号：US20090125605A1
公开(公告)日：2009-05-14
申请号：US11990460
申请日：2005-10-05
申请人： Michael Chung
发明人： Michael Chung
IPC分类号： G06F15/16
CPC分类号： H04L51/22 , H04L51/14 , H04M3/533
摘要： A system for managing access to folders of an email account so that some folders can be viewed by Internet users other than the email account owner One way of access is simply by typing an Internet address in an Internet browser Contents can also be posted by any Internet user to those publicly accessible folders. One way of posting is simply by sending an email addressed to that folder A voice message management system manages multiple voice message boxes for each subscriber for later retrieval such as one main incoming message box and an advertisement voice message box for storing targeted advertising messages. The incoming voice messages are routed to their respective boxes based on their type, preferably without ringing the user's telephone at the time of delivery. An email and voice message management system for monitoring and managing respective inboxes, folders or boxes of multiple email and voice communication accounts.
摘要翻译：用于管理对电子邮件帐户的文件夹的访问的系统，以便除电子邮件帐户所有者以外的其他用户可以查看某些文件夹。只有在Internet浏览器中键入Internet地址才能访问一种方式内容也可以由任何Internet发布用户到这些可公开访问的文件夹。发送的一种方式是简单地通过发送寻址到该文件夹的电子邮件。语音消息管理系统为每个订户管理多个语音消息盒以供稍后检索，例如一个主要传入消息盒和用于存储目标广告消息的广告语音消息盒。输入的语音消息基于它们的类型被路由到它们各自的框，优选地在发送时不响应用户的电话。一种电子邮件和语音留言管理系统，用于监控和管理多个电子邮件和语音通信帐户的各个收件箱，文件夹或盒子。

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