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1. 发明授权

US08763609B2 Determination of leak and respiratory airflow 失效
标题翻译：泄漏和呼吸气流的测定
公开(公告)号：US08763609B2
公开(公告)日：2014-07-01
申请号：US12649877
申请日：2009-12-30
申请人： Michael Berthon-Jones
发明人： Michael Berthon-Jones
IPC分类号： F16K31/00 , F16K31/02
CPC分类号： A61M16/0003 , A61M16/0057 , A61M16/0069 , A61M16/024 , A61M2016/0021 , A61M2016/0027 , A61M2016/0033 , A61M2016/0036 , A61M2205/15
摘要： Methods and apparatus for determining leak and respiratory airflow are disclosed. A pressure sensor (34) and a differential pressure sensor (32) have connection with a pneumotach (24) to derive instantaneous mask pressure and airflow respectively. A microcontroller (38) estimates a non-linear conductance of any leak path occurring at a mask (12) as being the low pass filtered instantaneous airflow divided by the low pass filtered square root of the instantaneous pressure. The instantaneous leak flow is then the conductance multiplied by the square root of the instantaneous pressure, and the respiratory airflow is calculated as being the instantaneous airflow minus the instantaneous leak flow. The time constants for the low pass filtering performed by the microcontroller (38) can be dynamically adjusted dependent upon sudden changes in the instantaneous leak flow.
摘要翻译：公开了用于确定泄漏和呼吸气流的方法和装置。压力传感器（34）和差压传感器（32）分别与喘振（24）连接以分别产生瞬时的掩模压力和气流。微控制器（38）估计出现在掩模（12）处的任何泄漏路径的非线性电导是低通滤波的瞬时气流除以瞬时压力的低通滤波平方根。瞬时泄漏流量是电导乘以瞬时压力的平方根，呼吸气流被计算为瞬时气流减去瞬时泄漏流量。由微控制器（38）执行的低通滤波的时间常数可以根据瞬时泄漏流的突然变化而动态调节。

2. 发明授权

US08511307B2 Administration of CPAP treatment pressure in presence of apnea 有权
公开(公告)号：US08511307B2
公开(公告)日：2013-08-20
申请号：US11237278
申请日：2005-09-28
申请人： Michael Berthon-Jones , Steven Paul Farrugia
发明人： Michael Berthon-Jones , Steven Paul Farrugia
IPC分类号： A61M16/00
CPC分类号： A61M16/0069 , A61B5/0205 , A61B5/4818 , A61B5/4836 , A61M16/00 , A61M16/0003 , A61M16/0051 , A61M16/024 , A61M16/06 , A61M16/0875 , A61M2016/0036
摘要： CPAP treatment apparatus is disclosed having a controllable flow generator (34, 38, 40) operable to produce breathable gas at a treatment pressure elevated above atmosphere to a patient by a delivery tube (32) coupled to a mask (30) having connection with a patient's airway. A sensor (44, 50, 56, 58) generates a signal representative of patient respiratory flow, that is provided to a controller (54, 62, 64). The controller (54, 62, 64) is operable to determine the occurrence of an apnea from a reduction in respiratory airflow below a threshold, and if an apnea has occurred, to determine the duration of the apnea and to cause the flow generator (34, 38) to increase the treatment pressure. In one preferred form the increase in pressure is zero if the treatment pressure before the apnea exceeds a pressure threshold. Below the pressure threshold the increase in pressure is an increasing function of the duration of the apnea multiplied by the difference between the pressure threshold and the current treatment pressure.

3. 发明授权

US08356594B2 Methods and apparatus for heart failure treatment 有权
标题翻译：心力衰竭治疗方法及装置
公开(公告)号：US08356594B2
公开(公告)日：2013-01-22
申请号：US12613035
申请日：2009-11-05
申请人： Anthony John Ujhazy , Jonathan Caldwell Wright , Glenn Richards , David John Bassin , Michael Berthon-Jones
发明人： Anthony John Ujhazy , Jonathan Caldwell Wright , Glenn Richards , David John Bassin , Michael Berthon-Jones
IPC分类号： A62B9/00
CPC分类号： A61B5/4836 , A61B5/0826 , A61B5/087 , A61B5/7282 , A61B5/746 , A61M16/0051 , A61M16/0057 , A61M16/0066 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M2016/0021 , A61M2016/0036 , A61M2205/3344 , A61M2230/005 , A61M2230/04 , A61M2230/10 , A61M2230/18 , A61M2230/40 , A61M2230/435 , A61M2230/63
摘要： Methods and apparatus for assessing the condition of and treating patients for heart failure by the delivery of continuous positive airway pressure are disclosed. Treatment of obstruction due to reflex vocal cord closure often experienced by heart failure patients is distinguished from treatment of upper airway obstruction typically associated with Obstructive Sleep Disorder Treatment may also be implemented by delivering synchronized cardiac pressure oscillations superimposed on a respiratory pressure level to provide assistance for the heart. Heart treatment pressure dose indicator may be calculated for prescribing and monitoring the delivery of treatment. The apparatus may also generate data to track heart failure condition that may be indicative of the degree of severity of heart failure based upon breathing patterns to assist in the diagnosis and management of heart failure patients.
摘要翻译：公开了通过递送持续气道正压通气来评估患者心力衰竭状况和治疗方法和装置。治疗由于心力衰竭患者经常发生的反射性声带闭合引起的阻塞与区别于通常与阻塞性睡眠障碍相关的上呼吸道阻塞治疗也可以通过递送叠加在呼吸压力水平上的同步心脏压力振荡来实现，以便为心脏可以计算心脏治疗压力剂量指标，用于处方和监测治疗的递送。该装置还可以生成跟踪心力衰竭状况的数据，该状况可以基于呼吸模式来指示心力衰竭的严重程度，以帮助心力衰竭患者的诊断和管理。

4. 发明申请

US20120227740A1 ADMINISTRATION OF CPAP TREATMENT PRESSURE IN PRESENCE OF APNEA 有权
标题翻译： APNEA存在的CPAP治疗压力的管理
公开(公告)号：US20120227740A1
公开(公告)日：2012-09-13
申请号：US13477505
申请日：2012-05-22
申请人： Michael Berthon-Jones , Steven Paul Farrugia
发明人： Michael Berthon-Jones , Steven Paul Farrugia
IPC分类号： A61M16/00 , A61M16/06
CPC分类号： A61M16/0069 , A61B5/0205 , A61B5/4818 , A61B5/4836 , A61M16/00 , A61M16/0003 , A61M16/0051 , A61M16/024 , A61M16/06 , A61M16/0875 , A61M2016/0036
摘要： CPAP treatment apparatus is disclosed having a controllable flow generator (34, 38, 40) operable to produce breathable gas at a treatment pressure elevated above atmosphere to a patient by a delivery tube (32) coupled to a mask (30) having connection with a patient's airway. A sensor (44, 50, 56, 58) generates a signal representative of patient respiratory flow, that is provided to a controller (54, 62, 64). The controller (54, pressure. In one preferred form the increase in pressure is zero if the treatment pressure before the apnea exceeds a pressure threshold. Below the pressure threshold the increase in pressure is an increasing function of the duration of the apnea multiplied by the difference between the pressure threshold and the current treatment pressure.
摘要翻译：公开了一种CPAP治疗装置，其具有可操作的流量发生器（34,38,40），其可操作以通过耦合到具有与一个或多个连接器的连接的掩模（30）的输送管（32）在处于高于大气的处理压力下向患者产生可呼吸气体病人的气道。传感器（44,50,56,58）产生代表患者呼吸流量的信号，其提供给控制器（54,62,64）。控制器（54，压力）在一个优选形式中，如果呼吸暂停之前的治疗压力超过压力阈值，则压力的增加为零。低于压力阈值时，压力的增加是呼吸暂停持续时间的乘积乘以压力阈值与当前治疗压力之间的差异。

5. 发明申请

US20120125336A1 ADJUSTMENT OF VENTILATOR PRESSURE-TIME PROFILE TO BALANCE COMFORT AND EFFECTIVENESS 审中-公开
标题翻译：通风机压力调节平衡舒适性和有效性
公开(公告)号：US20120125336A1
公开(公告)日：2012-05-24
申请号：US13363785
申请日：2012-02-01
申请人： Michael Berthon-Jones , Peter Bateman , Gordon Malouf
发明人： Michael Berthon-Jones , Peter Bateman , Gordon Malouf
IPC分类号： A61M16/00
CPC分类号： A61M16/0069 , A61M16/024 , A61M16/0858 , A61M2016/0036 , A61M2205/15 , A61M2205/3344
摘要： The invention is a ventilator whose servo-controller adjusts the degree of support by adjusting the profile of the pressure waveform as well as the pressure modulation amplitude. As the servo-controller increases the degree of support by increasing the pressure modulation amplitude, it also generates a progressively more square, and therefore efficient, pressure waveform; when the servo-controller decreases the degree of support by decreasing the pressure modulation amplitude, it also generates a progressively more smooth and therefore comfortable pressure waveform.
摘要翻译：本发明是一种呼吸机，其伺服控制器通过调节压力波形的轮廓以及压力调制幅度来调节支撑度。由于伺服控制器通过增加压力调制幅度来增加支撑度，因此它还产生逐渐更平方的因此有效的压力波形; 当伺服控制器通过降低压力调制幅度来降低支撑度时，它也产生逐渐更平滑且因此舒适的压力波形。

6. 发明申请

US20080163873A1 DETERMINATION OF PATENCY OF THE AIRWAY 失效
标题翻译：确定航空公司的航班
公开(公告)号：US20080163873A1
公开(公告)日：2008-07-10
申请号：US11946500
申请日：2007-11-28
申请人： Michael Berthon-Jones
发明人： Michael Berthon-Jones
IPC分类号： A61M16/00
CPC分类号： A61M16/0066 , A61B5/087 , A61B5/7257 , A61F5/56 , A61M16/0006 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M16/0875 , A61M2016/0039 , A61M2230/60
摘要： Methods and apparatus for determining the occurrence of an apnea, patency and/or partial obstruction of the airway are disclosed. Respiratory air flow from a patient is measured to give an air flow signal. The determination of an apnea is performed by calculating the variance of the air flow signal over a moving time window and comparing the variance with a threshold value. One determination of partial obstruction of the airway is performed by detecting the inspiratory part of the air flow signal, scaling it to unity duration and area and calculating an index value of the amplitude of the scaled signal over a mid-portion. Alternatively, the index value is a measure of the flatness of the air flow signal over the mid-portion. One determination of patency of the airway is performed by applying an oscillatory pressure waveform of known frequency to a patient's airway, calculating the magnitude of the component of said air flow signal at the known frequency induced by the oscillatory pressure waveform and comparing the calculated magnitude with a threshold value. Alternatively, the air flow signal is analysed to detect the presence of a component due to cardiogenic activity.
摘要翻译：公开了用于确定气道呼吸暂停，通畅和/或部分阻塞的发生的方法和装置。测量来自患者的呼吸气流以产生气流信号。通过计算移动时间窗口上的空气流信号的方差并将该方差与阈值进行比较来执行呼吸暂停的确定。通过检测气流信号的吸气部分，将其缩放为单位持续时间和面积并计算中间部分上的缩放信号的幅度的指标值来执行气道部分阻塞的一个确定。或者，指数值是空气流动信号在中间部分上的平坦度的量度。通过将已知频率的振荡压力波形应用于患者的气道，计算由振荡压力波形引起的已知频率的所述空气流信号的分量的大小，并将计算出的大小与一个阈值。或者，分析空气流信号以检测由于心源性活动引起的组分的存在。

7. 发明授权

US07367337B2 Adjustment of ventilator pressure-time profile to balance comfort and effectiveness 有权
标题翻译：调节呼吸机压力 - 时间曲线以平衡舒适性和有效性
公开(公告)号：US07367337B2
公开(公告)日：2008-05-06
申请号：US10841302
申请日：2004-05-07
申请人： Michael Berthon-Jones , Peter Bateman , Gordon Malouf
发明人： Michael Berthon-Jones , Peter Bateman , Gordon Malouf
IPC分类号： A61M16/00
CPC分类号： A61M16/0069 , A61M16/024 , A61M16/0858 , A61M2016/0036 , A61M2205/15 , A61M2205/3344
摘要： The invention is a ventilator whose servo-controller adjusts the degree of support by adjusting the profile of the pressure waveform as well as the pressure modulation amplitude. As the servo-controller increases the degree of support by increasing the pressure modulation amplitude, it also generates a progressively more square, and therefore efficient, pressure waveform; when the servo-controller decreases the degree of support by decreasing the pressure modulation amplitude, it also generates a progressively more smooth and therefore comfortable pressure waveform.
摘要翻译：本发明是一种呼吸机，其伺服控制器通过调节压力波形的轮廓以及压力调制幅度来调节支撑度。由于伺服控制器通过增加压力调制幅度来增加支撑度，因此它还产生逐渐更平方的因此有效的压力波形; 当伺服控制器通过降低压力调制幅度来降低支撑度时，它也产生逐渐更平滑且因此舒适的压力波形。

8. 发明申请

US20080099023A1 Method And Apparatus For Adjusting Respiratory Mask Sealing Force 有权
标题翻译：调节呼吸面罩密封力的方法和装置
公开(公告)号：US20080099023A1
公开(公告)日：2008-05-01
申请号：US11666869
申请日：2005-11-09
申请人： Michael Berthon-Jones
发明人： Michael Berthon-Jones
IPC分类号： A62B18/08
CPC分类号： A61M16/0622 , A61M16/0003 , A61M16/0066 , A61M16/06 , A61M16/0605 , A61M16/0633 , A61M16/065 , A61M16/0683 , A61M16/0694 , A61M16/0816 , A61M16/0833 , A61M16/0858 , A61M16/0875 , A61M16/20 , A61M2016/0027 , A61M2205/3331
摘要： A mask assembly includes a mask with an inflatable bladder. The internal pressure of the inflatable bladder can be set to be higher than the delivered therapeutic pressure. The pressure offset may be constant, or it may vary over the range of therapeutic pressures. Thus, the force necessary to maintain a contact seal between the mask and the patient can be reduced, thereby providing a system that is more comfortable to the patient, which increases patient compliance.
摘要翻译：面罩组件包括具有可膨胀囊的面罩。可膨胀气囊的内部压力可以设定为高于输送的治疗压力。压力偏移可以是恒定的，或者它可以在治疗压力的范围内变化。因此，可以减少在面罩和患者之间保持接触密封所需的力，从而提供对患者更舒适的系统，这增加了患者的依从性。

9. 发明授权

US07055522B2 Patient-ventilator synchronization using dual phase sensors 有权
标题翻译：患者通气机同步使用双相传感器
公开(公告)号：US07055522B2
公开(公告)日：2006-06-06
申请号：US10986471
申请日：2004-11-11
申请人： Michael Berthon-Jones
发明人： Michael Berthon-Jones
IPC分类号： F16K31/02
CPC分类号： A61M16/0069 , A61M16/0066 , A61M16/024 , A61M2016/0021 , A61M2016/0036 , A61M2230/60
摘要： An improved ventilator which delivers ventilatory support that is synchronized with the phase of the patent's respiratory efforts and guarantees a targeted minimum ventilation. Improved synchronization is achieved through an instantaneous respiratory phase determination process based upon measured respiratory airflow as well as measured respiratory effort using an effort sensor accessory, preferably a suprastemal notch sensor. The ventilator processes a respiratory airflow signal, a respiratory effort signal and their respective rates of change to determine a phase using standard fuzzy logic methods. A calculated pressure amplitude is adjusted based upon the calculated phase and a smooth pressure waveform template to deliver synchronized ventilation.
摘要翻译：一种改进的呼吸机，其提供与专利呼吸努力的阶段同步的通气支持，并确保有针对性的最小通气。通过基于测量的呼吸气流的瞬时呼吸相位确定过程以及使用力传感器附件，优选地超临界陷波传感器测量的呼吸努力来实现改进的同步。呼吸机处理呼吸气流信号，呼吸努力信号及其各自的变化率，以使用标准模糊逻辑方法确定相位。计算的压力幅度根据计算的相位和平滑压力波形模板进行调整，以提供同步通气。

10. 发明申请

US20060084877A1 Methods and apparatus for heart failure treatment 审中-公开
标题翻译：心力衰竭治疗方法及装置
公开(公告)号：US20060084877A1
公开(公告)日：2006-04-20
申请号：US11165705
申请日：2005-06-24
申请人： Anthony Ujhazy , Jonathan Wright , Glenn Richards , David Bassin , Michael Berthon-Jones
发明人： Anthony Ujhazy , Jonathan Wright , Glenn Richards , David Bassin , Michael Berthon-Jones
IPC分类号： A61B5/02 , A61B5/08 , A61M16/00
CPC分类号： A61B5/4836 , A61B5/0826 , A61B5/087 , A61B5/7282 , A61B5/746 , A61M16/0051 , A61M16/0057 , A61M16/0066 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M2016/0021 , A61M2016/0036 , A61M2205/3344 , A61M2230/005 , A61M2230/04 , A61M2230/10 , A61M2230/18 , A61M2230/40 , A61M2230/435 , A61M2230/63
摘要： Methods and apparatus for assessing the condition of and treating patients for heart failure by the delivery of continuous positive airway pressure are disclosed. Airflow of the patient is measured to determine occurrences of central apneas. A heart failure index is calculated from a count of the number of central apneas that have occurred. The present heart failure index can be compared with a previously calculated heart failure index to determine how the patient's heart failure disease has changed and how it should be treated.
摘要翻译：公开了通过递送持续气道正压通气来评估患者心力衰竭状况和治疗方法和装置。测量患者的气流以确定中枢性呼吸暂停的发生。从发生的中枢性呼吸暂停的次数计算心力衰竭指数。可以将目前的心力衰竭指数与以前计算的心力衰竭指数进行比较，以确定患者的心力衰竭疾病如何改变以及如何治疗。

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