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1. 发明授权

US5061341A Laser-ablating a marking in a coating on plastic articles 失效
标题翻译：激光雕刻在塑料制品上的标记
公开(公告)号：US5061341A
公开(公告)日：1991-10-29
申请号：US470187
申请日：1990-01-25
申请人： Maurice A. Kildal , Arthur P. Chipouras
发明人： Maurice A. Kildal , Arthur P. Chipouras
IPC分类号： B23K26/00 , B23K26/18 , B41F17/00 , B41M1/30 , B41M5/24
CPC分类号： B23K26/18 , B23K26/009 , B23K26/066 , B41M5/24
摘要： There is disclosed a method of laser-marking plastic articles without unduly damaging the plastic. The method comprises coating the plastic with a contrasting color layer, and intermediate the color layer and the plastic, a protective layer of a dried coverage of at least 1.5 g/m.sup.2.Optionally, the ablation can be carried out beyond the stripe portion to be marked, to clear away any debris from the white support that otherwise can be left behind by the ablation.

2. 发明授权

US5958339A Format for immunoassay in thin film 失效
标题翻译：薄膜免疫测定的格式
公开(公告)号：US5958339A
公开(公告)日：1999-09-28
申请号：US938460
申请日：1992-08-31
申请人： Robert Troconis Belly , Martha Miller Kopcienski , Caroline Erdrich , Maurice A. Kildal
发明人： Robert Troconis Belly , Martha Miller Kopcienski , Caroline Erdrich , Maurice A. Kildal
IPC分类号： G01N33/52 , G01N33/543 , G01N31/22
CPC分类号： G01N33/54386 , G01N33/525
摘要： The present invention provides a novel dry analytical element for determination of an analyte in a fluid sample in thin film immunoassay, particularly chemiluminescence, fluorescence and colorimetry immunoassay. There is provided an analytical element comprising a support member, a reagent matrix comprised of at least one layer of a porous material carried on the support member, the matrix including a read area, an absorbent material in contact with the matrix, and light absorbing or reflecting means integral to the absorbent material and/or positioned between the absorbant material and the read area for absorbing or blocking background signal generated by washed, removed label and other interferents from outside the read area prior to it moving back into the read area. The analytical element can comprises a cover depending on the type of immunoassay to be conducted.
摘要翻译：本发明提供了用于在薄膜免疫测定，特别是化学发光，荧光和比色法免疫测定中测定流体样品中分析物的新型干燥分析元件。提供了一种分析元件，其包括支撑构件，由至少一层承载在支撑构件上的多孔材料构成的试剂基质，所述基质包括读取区域，与基质接触的吸收材料，以及光吸收或反射装置与吸收材料成一体，和/或定位在吸收材料和读取区域之间，用于吸收或阻挡由洗涤的，去除的标签和其它干扰物在读取区域之外产生的背景信号，并将其返回读取区域之前。分析元件可以包括取决于要进行的免疫测定的类型的盖。

3. 发明授权

US5507388A Cartridge-free stacks of slide elements 失效
公开(公告)号：US5507388A
公开(公告)日：1996-04-16
申请号：US317972
申请日：1994-10-04
申请人： Maurice A. Kildal , Frank A. Richardson , Claude E. Monsees
发明人： Maurice A. Kildal , Frank A. Richardson , Claude E. Monsees
IPC分类号： G01N1/00 , B29C65/02 , B29C65/76 , B65D69/00 , G01N35/00 , G01N35/04 , B65D85/00
CPC分类号： B29C65/76 , B65D69/00 , G01N35/00029 , B29C65/02 , B29C66/137 , B29L2007/00 , B29L2031/40 , B29L2031/753 , G01N2035/00168 , G01N2035/00752 , Y10T156/1153 , Y10T29/49764 , Y10T29/49885 , Y10T428/24777
摘要： A stack of plastic articles and a process of forming the stack are disclosed. Preferably the stack is of heat-fusible plastic slide elements for use in a diagnostic analyzer, the elements being temporarily and non-destructively fused together so that the stack can be used free of a cartridge.In another embodiment, the stack can be of any plastic article temporarily fused to adjacent elements, one side edge of each element bearing a colorant and another bearing no colorant, so that a bar code for the stack is inherently formed simply by rotating each element to project outwardly the colored side edge or the side edge lacking colorant, prior to fusing the elements together.

4. 发明授权

US5384947A Cartridge-free stacks of slide elements 失效
标题翻译：无盒式滑块
公开(公告)号：US5384947A
公开(公告)日：1995-01-31
申请号：US37176
申请日：1993-03-26
申请人： Maurice A. Kildal , Frank A. Richardson , Claude E. Monsees
发明人： Maurice A. Kildal , Frank A. Richardson , Claude E. Monsees
IPC分类号： G01N1/00 , B29C65/02 , B29C65/76 , B65D69/00 , G01N35/00 , G01N35/04 , B32B31/12 , B32B33/00
CPC分类号： B29C65/76 , B65D69/00 , G01N35/00029 , B29C65/02 , B29C66/137 , B29L2007/00 , B29L2031/40 , B29L2031/753 , G01N2035/00168 , G01N2035/00752 , Y10T156/1153 , Y10T29/49764 , Y10T29/49885 , Y10T428/24777
摘要： A stack of plastic articles and a process of forming the stack are disclosed. Preferably the stack is of heat-fusible plastic slide elements for use in a diagnostic analyzer, the elements being temporarily and non-destructively fused together so that the stack can be used free of a cartridge. In another embodiment, the stack can be of any plastic article temporarily fused to adjacent elements, one side edge of each element bearing a colorant and another bearing no colorant, so that a bar code for the stack is inherently formed simply by rotating each element to project outwardly the colored side edge or the side edge lacking colorant, prior to fusing the elements together.
摘要翻译：公开了一叠塑料制品和形成叠层的工艺。优选地，该堆叠是用于诊断分析仪中的可热熔塑性滑动元件，该元件暂时地和非破坏性地融合在一起，使得该堆叠可以不用于盒。在另一个实施例中，堆叠可以是临时熔合到相邻元件的任何塑料制品，每个元件的一个侧边缘承载着色剂，而另一个没有着色剂，从而简单地通过将每个元件旋转到在将元件融合在一起之前向外突出着色侧边缘或侧边缺少着色剂。

5. 发明授权

US5330625A Round potentiometric slide elements and method of using the same 失效
标题翻译：圆形电位滑动元件及其使用方法
公开(公告)号：US5330625A
公开(公告)日：1994-07-19
申请号：US965824
申请日：1992-10-23
申请人： Martin F. Muszak , Thomas R. Kissel , Maurice A. Kildal
发明人： Martin F. Muszak , Thomas R. Kissel , Maurice A. Kildal
IPC分类号： G01N27/30 , G01N27/333
CPC分类号： G01N27/307
摘要： There are disclosed an ISE slide element and potentiometric measurement of assaying, using a slide element that is positionally insensitive about an axis of symmetry. This is achieved by accessing one of the electrodes in the center of the slide element, and the other in an annular groove centered on the element center, both for liquid contact and electrometer contact. Preferably, electrometer contact occurs at a side of the electrode opposite to the side contacted with liquid.
摘要翻译：公开了一种ISE滑动元件和电位测量的测定，使用对对称轴位置不敏感的滑动元件。这是通过访问滑动元件的中心中的一个电极，另一个在以元件中心为中心的环形槽中实现的，用于液体接触和静电计量接触。优选地，静电计接触发生在电极的与液体接触的一侧相反的一侧。

6. 发明申请

US20120071643A1 SYSTEM AND METHODS FOR PURIFYING BIOLOGICAL MATERIALS 审中-公开
标题翻译：用于净化生物材料的系统和方法
公开(公告)号：US20120071643A1
公开(公告)日：2012-03-22
申请号：US13201415
申请日：2010-02-13
申请人： Jeffrey L. Helfer , Rhiannon R. Gaborski , Maurice A. Kildal
发明人： Jeffrey L. Helfer , Rhiannon R. Gaborski , Maurice A. Kildal
IPC分类号： C07H21/00 , B01D43/00 , B82Y99/00
CPC分类号： B01L3/0275 , B01L2200/0631 , B01L2300/0609 , B01L2300/0681 , C12N15/1003 , G01N1/34 , G01N1/405 , G01N2001/4016 , G01N2035/1053
摘要： Fluid sample purification systems and methods are provided for isolating molecules of interest in a fluid sample. The fluid sample purification system has a housing with a distal end and distal opening adapted for the passage of a fluid and a proximal end and proximal opening adapted for passage of a fluid. A distal retainer is located inside the housing and above the distal opening. A proximal retainer is located inside the housing between the distal retainer and the proximal opening, or is located adjacent to, in contact with, or over the proximal opening. The system also comprises adsorption material, e.g., functionalized particles, inside the housing and confined between the distal retainer and the proximal retainer. The adsorption material adsorbs undesirable material while simultaneously rejecting desirable materials. Methods are also provided for isolating molecules of interest using the fluid sample purification system.
摘要翻译：提供流体样品纯化系统和方法用于在流体样品中分离感兴趣的分子。流体样品净化系统具有壳体，其具有适于流体通过的远端和远端开口，以及适于通过流体的近端和近端开口。远侧保持器位于壳体内部和远端开口上方。近侧保持器位于外壳内部的远侧保持器和近端开口之间，或者位于邻近的开口处，或者邻近的开口处。该系统还包括在壳体内部的吸附材料，例如功能化颗粒，并被限制在远侧保持器和近端保持器之间。吸附材料吸收不需要的材料，同时排除所需的材料。还提供了使用流体样品纯化系统分离感兴趣分子的方法。

7. 发明授权

US4394990A Web cinching and winding apparatus and method 失效
标题翻译：网络收卷卷绕装置及方法
公开(公告)号：US4394990A
公开(公告)日：1983-07-26
申请号：US218592
申请日：1980-12-19
申请人： Maurice A. Kildal , Stephen J. Hassall
发明人： Maurice A. Kildal , Stephen J. Hassall
IPC分类号： B65H18/16 , B65H19/30 , B65H17/08
CPC分类号： B65H18/16 , B65H19/30 , B65H2301/41346 , B65H2301/4173
摘要： To cinch a web end portion onto a core, the core is center driven by a core driving mechanism at an outer peripheral speed in excess of the speed at which the web end portion is fed to and threaded around the core. After the web end portion is cinched onto the core and the web wound to form a roll of predetermined diameter, the core drive mechanism is disengaged from the core to terminate the core center drive. The outer surface of the roll further substantially simultaneously engages a roll surface drive mechanism which is normally spaced from the core for surface driving the roll.
摘要翻译：为了将卷筒纸端部固定到芯部上，芯部以中心驱动机构以外圆周速度超过纤维网端部部分被送入并围绕芯线旋转的速度。在腹板末端部分固定在芯体上并且卷绕成卷材以形成预定直径的卷筒之后，芯部驱动机构与芯部脱离以终止芯部中心驱动。辊的外表面基本上同时地接合辊表面驱动机构，该辊表面驱动机构通常与芯部间隔开以表面驱动辊。

8. 发明授权

US06541243B1 Perfusion chamber for electrophysiological testing of oocytes 失效
标题翻译：灌注室用于卵母细胞的电生理检测
公开(公告)号：US06541243B1
公开(公告)日：2003-04-01
申请号：US09586633
申请日：2000-06-05
申请人： Eric W. Harris , Thomas H. Lanthorn , Maurice A. Kildal
发明人： Eric W. Harris , Thomas H. Lanthorn , Maurice A. Kildal
IPC分类号： C12M300
CPC分类号： C12M41/46 , C12M29/10
摘要： A perfusion chamber includes a porous oocyte support structure. A continuously sloped top surface and a receiving well in the support structure entrap the underside of the oocyte, thereby localizing the cell in a predetermined fixed position within the reach of dedicated voltage-clamp microelectrodes. A test solution is delivered continuously at the top of the chamber, above the oocyte, and withdrawn from the bottom of the chamber, below the oocyte. The porosity of the support material enables the continuous perfusion of test solution around the membrane of the oocyte, including its bottom portion that is held firmly in contact with the holding well. The geometry of the holding well is selected such as to ensure the automatic and precise placement of the oocyte by gravity and to optimize the pressure distribution over its membrane, thereby minimizing the probability of rupture or other damage to the cell. The entire top surface of the support structure is sloped inward toward the substantially central well, and the bottom of the well is contoured to conform to the shape of an oocyte of average size.
摘要翻译：灌注室包括多孔卵母细胞支持结构。支撑结构中的连续倾斜的顶表面和接收孔捕获卵母细胞的下侧，从而将细胞定位在专用电压钳微电极范围内的预定固定位置。测试溶液在卵母细胞上方的室顶部连续输送，并从卵母细胞下方的腔室底部排出。支撑材料的孔隙率使得测试溶液能够连续地灌注在卵母细胞的膜周围，包括其保持牢固地与保持阱接触的底部。选择保持孔的几何形状，以确保通过重力自动和精确地放置卵母细胞，并优化其膜上的压力分布，从而最小化破裂或其他细胞损伤的可能性。支撑结构的整个顶表面朝着基本上中心的井向内倾斜，并且孔的底部被轮廓化以符合平均尺寸的卵母细胞的形状。

9. 发明授权

US5329686A Slide frame and manufacturing process 失效
标题翻译：滑动框架和制造过程
公开(公告)号：US5329686A
公开(公告)日：1994-07-19
申请号：US810942
申请日：1991-12-19
申请人： Maurice A. Kildal , Frank A. Richardson , Brendan N. Leather , Claude E. Monsees
发明人： Maurice A. Kildal , Frank A. Richardson , Brendan N. Leather , Claude E. Monsees
IPC分类号： G01N31/22 , B29C65/00 , B29C65/08 , B29C65/56 , B29C67/00 , G01N33/48 , G01N35/00 , B23P11/00
CPC分类号： G01N35/00029 , B29C65/567 , B29C65/568 , B29C66/472 , B29C66/5346 , B29C66/7485 , B29C66/81422 , B29C66/81423 , B29C66/8322 , B29C67/0044 , B29C65/08 , G01N2035/00138 , G01N2035/00168 , Y10T29/4987 , Y10T29/49915
摘要： A novel slide test element and method of making are described. Both feature a lip coined in the sidewall of a recess shaped in a frame member to hold the reaction member bearing the detecting reagents. The lip then overhangs the reaction member, once assembled. Assembly occurs by bending the frame member with the lip facing outwardly, thus forcing the lip to part a distance sufficient to allow the reaction member to be inserted. An optional stacking and fusing procedure is also described to facilitate shipment of frame members prior to assembly.
摘要翻译：描述了一种新颖的滑动测试元件及其制造方法。两者都具有在形成在框架构件中的凹部的侧壁中的唇部，以保持具有检测试剂的反作用构件。一旦组装，唇缘就突出反应构件。装配通过使框架构件弯曲而使面向外的唇部弯曲，从而迫使唇部部分足够的距离以允许反作用构件被插入。还描述了可选的堆叠和熔合过程，以便于在组装之前装运框架构件。

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