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1. 发明授权

US08372857B2 Substituted 4-hydroxypyrimidine-5-carboxamides 有权
标题翻译：取代的4-羟基嘧啶-5-甲酰胺
公开(公告)号：US08372857B2
公开(公告)日：2013-02-12
申请号：US13379701
申请日：2010-06-21
申请人： Matthew J. Clements , John S. Debenham , Jeffrey J. Hale , Christina Madsen-Duggan
发明人： Matthew J. Clements , John S. Debenham , Jeffrey J. Hale , Christina Madsen-Duggan
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： A61K31/4965 , A61K31/50 , A61K31/515 , C07D401/14
摘要： The present invention relates to substituted 4-hydroxypyrimidine-5-carboxamides useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
摘要翻译：本发明涉及用作HIF脯氨酰羟化酶抑制剂治疗贫血和类似病症的取代的4-羟基嘧啶-5-甲酰胺。

2. 发明授权

US5060439A Expansion joint cover assemblies 失效
标题翻译：膨胀接头盖组件
公开(公告)号：US5060439A
公开(公告)日：1991-10-29
申请号：US540071
申请日：1990-06-19
申请人： Matthew J. Clements , Maxim A. Fedor , Jerry T. Moffitt , Lisa Ye , John F. Wadsworth
发明人： Matthew J. Clements , Maxim A. Fedor , Jerry T. Moffitt , Lisa Ye , John F. Wadsworth
IPC分类号： E04B1/68
CPC分类号： E04B1/6815
摘要： Expansion joint cover assemblies are disclosed which are structured and dimensioned for use in covering expansion joints or spaces between adjacent structural sections of a building such as spaced floors or floor and wall sections. The assemblies include base members adapted to be positioned and secured to the adjacent structural sections and a leaf spring cover member fixedly interconnected to one of the base members at one end and bridging the expansion joint or space between the structural sections in a cantilever manner such that the cover member lies in a plane essentially flush with the floor section or sections and is structured and dimensioned to be slidably interconnected with the other base member to provide a secure, functionally effective and aesthetically pleasing assembly for accommodating translational relative movement of the structural sections.
摘要翻译：公开了膨胀接头盖组件，其结构和尺寸用于覆盖建筑物的相邻结构部分之间的膨胀接缝或空间，例如间隔开的地板或地板和壁部分。组件包括适于定位并固定到相邻结构部分的基部构件和在一端固定地互连到一个基部构件的板簧盖构件，并以悬臂方式桥接结构部分之间的膨胀接头或空间，使得盖构件位于基本上与地板部分齐平的平面中，并且其结构和尺寸被设计成与另一个基部构件滑动互连，以提供用于容纳结构部分的平移相对运动的安全的，功能有效的和美学上令人满意的组件。

3. 发明授权

US08669252B2 Prolylcarboxypeptidase inhibitors 有权
标题翻译：脯氨酰羧肽酶抑制剂
公开(公告)号：US08669252B2
公开(公告)日：2014-03-11
申请号：US13642584
申请日：2011-05-12
申请人： Dong-Ming Shen , John S. Debenham , Thomas H. Graham , Matthew J. Clements , Yong Zhang
发明人： Dong-Ming Shen , John S. Debenham , Thomas H. Graham , Matthew J. Clements , Yong Zhang
IPC分类号： A61K31/535 , A61K31/445 , A61K31/40 , A61K31/415 , C07D295/18 , C07D413/12 , C07D211/30 , C07D207/06 , C07D233/61 , C07D205/04
CPC分类号： C07C237/24 , A61K31/165 , A61K31/397 , A61K31/40 , A61K31/4164 , A61K31/4453 , A61K31/5375 , A61K31/5377 , A61K45/06 , C07C271/24 , C07C2601/02 , C07C2601/14 , C07D205/04 , C07D213/40 , C07D213/61 , C07D213/64 , C07D213/85 , C07D233/56 , C07D233/61 , C07D239/26 , C07D241/12 , C07D295/15 , C07D295/155
摘要： Compounds of structural formula I are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.
摘要翻译：结构式I的化合物是脯氨酰羧肽酶（PrCP）的抑制剂。本发明的化合物可用于预防和治疗与PrCP的酶活性相关的病症，例如异常代谢，包括肥胖症; 糖尿病; 代谢综合征; 肥胖相关疾病; 和糖尿病相关疾病。

4. 发明授权

US08372863B2 Tetrahydro-1H-pyrrolo fused pyridones 有权
标题翻译：四氢-1H-吡咯稠合吡啶酮
公开(公告)号：US08372863B2
公开(公告)日：2013-02-12
申请号：US12919199
申请日：2009-02-11
申请人： Matthew J. Clements , Vincent J. Colandrea , John S. Debenham , Jeffrey J. Hale , Christina B. Madsen-Duggan , Thomas F. Walsh
发明人： Matthew J. Clements , Vincent J. Colandrea , John S. Debenham , Jeffrey J. Hale , Christina B. Madsen-Duggan , Thomas F. Walsh
IPC分类号： A61K31/44 , C07D221/02
CPC分类号： C07D471/04
摘要： The present invention relates to tetrahydro-1H-pyrrolo fused pyridone compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
摘要翻译：本发明涉及可用作HIF脯氨酰羟化酶抑制剂治疗贫血和类似病症的四氢-1H-吡咯稠合吡啶酮化合物。

5. 发明申请

US20120142694A1 SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES 有权
标题翻译：取代的4-羟基嘧啶-5-羧酰胺
公开(公告)号：US20120142694A1
公开(公告)日：2012-06-07
申请号：US13379701
申请日：2010-06-21
申请人： Matthew J. Clements , John S. Debenham , Jeffrey J. Hale , Christina Madsen-Duggan
发明人： Matthew J. Clements , John S. Debenham , Jeffrey J. Hale , Christina Madsen-Duggan
IPC分类号： A61K31/506 , A61P7/06 , C07D401/14
CPC分类号： A61K31/4965 , A61K31/50 , A61K31/515 , C07D401/14
摘要： The present invention relates to substituted 4-hydroxypyrimidine-5-carboxamides useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
摘要翻译：本发明涉及用作HIF脯氨酰羟化酶抑制剂治疗贫血和类似病症的取代的4-羟基嘧啶-5-甲酰胺。

6. 发明申请

US20120108600A1 SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES 有权
公开(公告)号：US20120108600A1
公开(公告)日：2012-05-03
申请号：US13379536
申请日：2010-06-21
申请人： Matthew J. Clements , John S. Debenham , Jeffrey J. Hale , Christina Madsen-Duggan
发明人： Matthew J. Clements , John S. Debenham , Jeffrey J. Hale , Christina Madsen-Duggan
IPC分类号： A61K31/506 , A61P7/06 , C07D405/14
CPC分类号： C07D401/14 , C07D401/12
摘要： The present invention relates to substituted 4-hydroxypyrimidine-5-carboxamides useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.

7. 发明授权

US06662968B2 Product dispenser for variable stacked articles 失效
标题翻译：用于可变堆放物品的产品分配器
公开(公告)号：US06662968B2
公开(公告)日：2003-12-16
申请号：US10131738
申请日：2002-04-24
申请人： Matthew J. Clements
发明人： Matthew J. Clements
IPC分类号： B65H3120
CPC分类号： G07F11/24 , G07F11/04
摘要： A product dispenser of the type adapted to release articles from vertical stacks is disclosed, which is configured to dispense a variety of articles whether in bulk or singularly. The present vending apparatus provides a main housing that is configured to receive interchangeable release mechanisms, with each mechanism dependent upon whether the dispensed article(s) is generally flat or of the small round type distributed by bulk similar to candies. The bottom surface of the product compartment defined on the top of main housing is configured to allow variability in the type of products released from the vertically mounted product cartridge.
摘要翻译：公开了一种适于从垂直堆叠中释放物品的产品分配器，其被配置为分配多种物品，无论是批量还是单独的。本发明的自动售货装置提供一个主壳体，该主壳体构造成接收可互换的释放机构，每个机构取决于分配的物品是大致平坦的，还是散装类似于糖果的小型圆形。限定在主壳体顶部的产品隔室的底部表面被配置为允许从垂直安装的产品盒释放的产品类型的变化。

8. 发明申请

US20170081287A1 ANTIDIABETIC TRICYCLIC COMPOUNDS 有权
公开(公告)号：US20170081287A1
公开(公告)日：2017-03-23
申请号：US15310488
申请日：2015-05-19
申请人： Tesfaye BIFTU , Purakkattle BIJU , Timothy A. BLIZZARD , Zhengxia CHEN , Matthew J. CLEMENTS , Mingxiang CUI , Jessica L. FRIE , William K. HAGMANN , Bin HU , Hubert JOSIEN , Anilkumar G. NAIR , Christopher W. PLUMMER , Cheng ZHU , Merck Sharp & Dohme Corp.
发明人： Tesfaye Biftu , Purakkattle Biju , Timothy A. Blizzard , Zhengxia Chen , Matthew J. Clements , Mingxiang Cui , Jessica L. Frie , William K. Hagmann , Bin Hu , Hubert Josien , Anilkumar G. Nair , Christopher W. Plummer , Cheng Zhu
IPC分类号： C07D221/16 , A61K31/438 , C07D405/12 , C07D401/12 , A61K31/444 , C07C61/39 , A61K31/192 , A61K31/4725 , A61K31/4709 , A61K31/538 , C07D413/12 , A61K31/55 , C07D215/14 , A61K31/47 , C07D401/04 , A61K45/06
CPC分类号： C07D221/16 , A61K31/192 , A61K31/366 , A61K31/397 , A61K31/435 , A61K31/438 , A61K31/444 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/4985 , A61K31/538 , A61K31/55 , A61K45/06 , C07C61/39 , C07C2602/08 , C07C2603/12 , C07D215/14 , C07D401/04 , C07D401/12 , C07D405/12 , C07D413/12 , A61K2300/00
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

9. 发明申请

US20090239876A1 Substituted 4-Hydroxypyrimidine-5-Carboxamides 有权
标题翻译：取代的4-羟基嘧啶-5-羧酰胺
公开(公告)号：US20090239876A1
公开(公告)日：2009-09-24
申请号：US12381468
申请日：2009-03-12
申请人： Matthew J. Clements , John S. Debenham , Jeffrey J. Hale , Christian B. Madsen-Duggan , Thomas F. Walsh
发明人： Matthew J. Clements , John S. Debenham , Jeffrey J. Hale , Christian B. Madsen-Duggan , Thomas F. Walsh
IPC分类号： A61K31/501 , A61K31/497 , A61K31/506 , C07D403/04 , C07D401/04 , C07D405/14 , C07D415/00 , C07D401/14
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/04 , C07D417/14
摘要： The present invention relates to substituted 4-hydroxypyrimidine-5-carboxamides useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
摘要翻译：本发明涉及用作HIF脯氨酰羟化酶抑制剂治疗贫血和类似病症的取代的4-羟基嘧啶-5-甲酰胺。

10. 发明申请

US20080269279A1 Substituted furo[2,3-B] pyridine derivatives as cannabinoid-1 receptor modulators 审中-公开
标题翻译：取代的呋喃并[2,3-B]吡啶衍生物作为大麻素-1受体调节剂
公开(公告)号：US20080269279A1
公开(公告)日：2008-10-30
申请号：US12082013
申请日：2008-04-07
申请人： Matthew J. Clements , John S. Debenham , Jeffrey J. Hale , Christina B. Madsen-Duggan , Thomas F. Walsh , Andrey V. Peresypkin , Roy Helmy
发明人： Matthew J. Clements , John S. Debenham , Jeffrey J. Hale , Christina B. Madsen-Duggan , Thomas F. Walsh , Andrey V. Peresypkin , Roy Helmy
IPC分类号： A61K31/4355 , C07D471/04 , A61P25/00 , A61P3/04
CPC分类号： C07D491/048
摘要： Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, Alzheimer's disease, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, cirrhosis of the liver, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and the promotion of wakefulness.
摘要翻译：结构式（I）的新型化合物是大麻素-1（CB1）受体的拮抗剂和/或反向激动剂，可用于治疗，预防和抑制由CB1受体介导的疾病。本发明的化合物可用作治疗精神病，记忆缺陷，认知障碍，阿尔茨海默病，偏头痛，神经病，包括多发性硬化症和神经 - 巴利综合征的神经炎症性疾病以及病毒性脑炎的炎症性后遗症的中枢作用药物脑血管意外，头部创伤，焦虑障碍，压力，癫痫，帕金森病，运动障碍和精神分裂症。这些化合物还可用于治疗药物滥用障碍，治疗肥胖或进食障碍，以及治疗哮喘，便秘，慢性肠假性梗阻，肝硬化，非酒精性脂肪性肝病（NAFLD ），非酒精性脂肪性肝炎（NASH），以及促进觉醒。

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