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1. 发明申请

US20110189063A1 IMMUNOCHROMATOGRAPHIC TEST PIECE, IMMUNOCHROMATOGRAPHIC TEST PIECE SET, IMMUNOCHROMATOGRAPHIC SYSTEM, AND IMMUNOCHROMATOGRAPHIC DEVICE 审中-公开
标题翻译：免疫组织化学检测试剂盒，免疫荧光检测试剂盒，免疫印迹系统和免疫印迹装置
公开(公告)号：US20110189063A1
公开(公告)日：2011-08-04
申请号：US13010175
申请日：2011-01-20
申请人： Masayoshi MOMIYAMA , Atsushi Hattori , Masayuki Ito
发明人： Masayoshi MOMIYAMA , Atsushi Hattori , Masayuki Ito
IPC分类号： B01J19/00
CPC分类号： B01J19/00
摘要： An immunochromatographic test piece measuring a concentration of a measurement object included in a solution includes a carrier causing the solution that includes the measurement object to flow from an upstream to a downstream of the carrier, and a plurality of color regions arranged at the carrier in series in a flow direction in which the solution flows through the carrier and spaced away from one another in the flow direction. The plurality of color regions each includes a capture reagent and is colored while capturing the measurement object included in the solution by the capture reagent. The plurality of color regions is formed at respective portions of the carrier, the respective portions having same dimensions and including same concentrations of the capture reagent per unit area.
摘要翻译：测量解决方案中包括的测量对象的浓度的免疫色谱测试件包括使包含测量对象的溶液从载体的上游流向下游的载体，以及串联布置在载体上的多个颜色区域在其中溶液流过载体并沿流动方向彼此间隔开的流动方向。多个颜色区域各自包含捕获试剂，并在捕获试剂捕获包含在溶液中的测量对象时着色。多个颜色区域形成在载体的相应部分处，各部分具有相同的尺寸并且包括相同浓度的每单位面积的捕获试剂。

2. 发明授权

US06819791B2 Color image analysis method 失效
标题翻译：彩色图像分析方法
公开(公告)号：US06819791B2
公开(公告)日：2004-11-16
申请号：US09742338
申请日：2000-12-22
申请人： Satoshi Fujita , Naoki Odani , Naoto Kagiyama , Masayoshi Momiyama
发明人： Satoshi Fujita , Naoki Odani , Naoto Kagiyama , Masayoshi Momiyama
IPC分类号： G06K900
CPC分类号： G01N21/6458 , G06T7/90 , G06T2207/10024 , G06T2207/10056 , G06T2207/10064
摘要： A color image analysis method makes it possible to analyze plural components of a compound individually through formation of an image. Initially, a picture or the image of the compound including the plurality of components is taken by a fluorescence digital image microscope. Then, one or more images of one of the components are extracted or divided from the image of the compound on the basis of color-phase, or color-phase and brightness.
摘要翻译：彩色图像分析方法可以通过形成图像来分别分析化合物的多个成分。首先，通过荧光数字图像显微镜拍摄包含多个成分的化合物的图像或图像。然后，根据颜色相位或颜色相位和亮度，从化合物的图像中提取或分割其中一个分量的一个或多个图像。

3. 发明授权

US5061067A Electrophoresis pattern analyzer for genetic material 失效
标题翻译：遗传物质电泳图谱分析仪
公开(公告)号：US5061067A
公开(公告)日：1991-10-29
申请号：US330289
申请日：1989-03-29
申请人： Takekazu Yamamoto , Masakazu Nakagawa , Masayoshi Momiyama
发明人： Takekazu Yamamoto , Masakazu Nakagawa , Masayoshi Momiyama
IPC分类号： G01N33/50 , B01D57/02 , G01N27/447
CPC分类号： G01N27/44721
摘要： An electrophoresis pattern analyzer for genetic material of this invention comprises: an image data generating means for optically reading an electrophoresis specimen and outputting datum image data corresponding to a datum region and sample image data corresponding to at least one sample region; a datum band pattern retrieving means for retrieving datum band patterns concerning position coordinates of the bands of the datum region in the direction of electrophoresis and two-dimensional forms of the bands of the datum region from the datum image data; a sample band pattern retrieving means for retrieving sample band patterns concerning position coordinates of the bands of the sample region in the direction of electrophoresis and two-dimensional forms of the bands of the sample region from the sample image data; and a band pattern comparing means for comparing the datum band patterns with the sample band patterns and determining characteristics of the sample region. The electrophoresis pattern analyzer for genetic material of this invention provides advantages of more precise, less expensive and higher speed analysis and identification than the conventional visual analysis and identification.
摘要翻译：本发明的遗传物质电泳图谱分析装置包括：图像数据产生装置，用于光学读取电泳样本并输出对应于基准区域的数据图像数据和对应于至少一个采样区域的采样图像数据; 数据带图案检索装置，用于从基准图像数据中检索关于电泳方向上的基准区域的频带的位置坐标和基准区域的频带的二维形式的数据带图案; 样本带图案检索装置，用于从样本图像数据中检索关于样品区域的电泳方向的位置坐标和样本区域的带的二维形式的样本带图案; 以及频带图案比较装置，用于将数据带图案与样本带图案进行比较并确定样本区域的特征。本发明的遗传材料的电泳图谱分析仪提供比常规视觉分析和鉴定更精确，更便宜和更高速度的分析和识别的优点。

4. 发明授权

US6111258A Method for working in a specimen and a stage for the method 失效
标题翻译：在样品中工作的方法和该方法的阶段
公开(公告)号：US6111258A
公开(公告)日：2000-08-29
申请号：US238154
申请日：1999-01-28
申请人： Takekazu Yamamoto , Masayoshi Momiyama , Naoto Kagiyama , Naritoshi Kanai
发明人： Takekazu Yamamoto , Masayoshi Momiyama , Naoto Kagiyama , Naritoshi Kanai
IPC分类号： G01N21/64 , C12M1/00 , C12N15/09 , G01N1/06 , G01N27/447 , G01J1/88
CPC分类号： G01N21/6456
摘要： A method for working in a specimen includes the steps of (a) putting the specimen on a stage; (b) irradiating radiation to the specimen for excitation; (c) recording detected characteristics of the excited specimen by the radiation; (d) displaying the recorded characteristics on the stage; (e) storing the recorded characteristics of the excited specimen; (f) maintaining display of the stored characteristics on the stage; and (g) working on the specimen on the stage over the displayed characteristics. An operator may easily access to the specimen with a scalpel or a knife since the detected characteristics are displayed on the stage after the detection of the characteristics. Even if the detection requires harmful radiation such as ultraviolet light, the operator may work in the specimen after turning off such harmful radiation. Therefore, the operator does not have to wear any protection against the harmful radiation so as to work in the specimen more easily and efficiently. Further, according to the present invention, a very delicate specimen, such as deoxyribonucleic acid, may be analyzed with less deterioration of the specimen since the excitation radiation is not necessary during the work in the specimen. In fact, a momentary excitation radiation may be sufficient to display the necessary characteristics on the stage.
摘要翻译：在试样中加工的方法包括以下步骤：（a）将样品放在台上; （b）向试样照射辐射用于激发; （c）通过辐射记录被激发标本的检测特性; （d）在舞台上显示录制的特征; （e）存储所激发的样本的记录特征; （f）在台上保持存储特性的显示; 和（g）在展示的特征上对舞台上的标本进行工作。在检测到特征之后，检测到的特征被显示在舞台上，操作者可以用手术刀或刀片容易地接近样本。即使检测需要紫外线等有害辐射，操作人员也可以在关闭这种有害辐射后在样品中工作。因此，操作人员不必对有害辐射进行任何防护，从而更容易有效地对样品进行加工。此外，根据本发明，由于在试样中的工作中不需要激发辐射，因此可以分析样品的劣化较少的脱氧核糖核酸等非常精细的试样。事实上，瞬时的激发辐射可能足以在舞台上显示必要的特征。

5. 发明授权

US5728531A Method of detecting nucleic acid 失效
标题翻译：检测核酸的方法
公开(公告)号：US5728531A
公开(公告)日：1998-03-17
申请号：US624116
申请日：1996-03-29
申请人： Yukio Yamada , Osamu Asami , Hiroko Uchiyama , Hidehiko Sugiyama , Satoshi Fujita , Takekazu Yamamoto , Naoto Kagiyama , Masayoshi Momiyama , Yasumitsu Kondoh
发明人： Yukio Yamada , Osamu Asami , Hiroko Uchiyama , Hidehiko Sugiyama , Satoshi Fujita , Takekazu Yamamoto , Naoto Kagiyama , Masayoshi Momiyama , Yasumitsu Kondoh
IPC分类号： G01N33/58 , C07H19/10 , C12N15/09 , C12Q1/68 , G01N33/53 , G01N37/00 , C07H21/04 , C12N15/00
CPC分类号： C12Q1/6804 , C07H19/10 , C12Q1/6834
摘要： A method of detecting nucleic acid utilizes hybridization between the nucleic acid to be detected which is present on an immobilizing support and a DNA probe which is complementary to at least a portion of the desired nucleotide sequence of the nucleic acid. The present DNA probe includes a hapten attached via a linker which a hapten is gibberellin or a gibberellin derivative. After hybridization by reaction between the nucleic acid to be detected and the DNA probe, the unreacted DNA probe is removed, and then labelled anti-hapten antibody is allowed to bind with the DNA probe of the hybrid and the labelling is used to detect the nucleic acid. Accordingly, stable detecting sensitivity may be achieved regardless of the label mixing ratio or labelling ratio, and thus regardless of the nucleotide sequence composition of the nucleic acid being tested.
摘要翻译：检测核酸的方法利用存在于固定化载体上的待检测核酸与与核酸的所需核苷酸序列的至少一部分互补的DNA探针之间的杂交。本DNA探针包括通过接头连接的半抗原，半抗原是赤霉素或赤霉素衍生物。在待检测核酸与DNA探针之间的反应杂交后，除去未反应的DNA探针，然后标记抗半抗原抗体与杂交体的DNA探针结合，并用标记物检测核酸酸。因此，无论标记混合比或标记比例如何，均可实现稳定的检测灵敏度，因此与所测核酸的核苷酸序列组成无关。

6. 发明申请

US20060078472A1 Microchannel chip system and detection chip 审中-公开
标题翻译：微通道芯片系统和检测芯片
公开(公告)号：US20060078472A1
公开(公告)日：2006-04-13
申请号：US11221944
申请日：2005-09-09
申请人： Masayoshi Momiyama , Yuji Iwata , Takashi Kawano
发明人： Masayoshi Momiyama , Yuji Iwata , Takashi Kawano
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01F9/0016 , B01F11/0002 , B01F13/0059 , B01L3/502761 , B01L2200/0668 , B01L2300/0636 , B01L2300/0825 , B01L2300/0877 , G01N21/6458
摘要： A microchannel chip system and a detection chip capable of improving detection precision are provided. The detection chip 1 of the microchannel chip system comprises a carrier retention section 13 capable of retaining a carrier supporting a second chemical substance which generates a signal by reacting with a first chemical substance and a microchannel flow channel 10 provided with a supply flow channel 14 which supplies a liquid material containing the first chemical substance to the carrier retention section 13. A carrier mobilization means (a protrusion 2) is provided for enhancing of the reactivity of the second chemical substance supported in the carrier 9 with the first chemical substance contained in the liquid material by moving the carrier retained in the detection chip 1.
摘要翻译：提供了能够提高检测精度的微通道芯片系统和检测芯片。微通道芯片系统的检测芯片1包括载体保持部分13，其能够保持支撑第二化学物质的载体，所述第二化学物质通过与第一化学物质和设置有供应流动通道14的微通道流动通道10反应产生信号，将含有第一化学物质的液体材料供应到载体保持部分13。提供载体动员装置（突起2），用于通过移动保持在检测芯片1中的载体来增加支撑在载体9中的第二化学物质与液体材料中所含的第一化学物质的反应性。

7. 发明授权

US5532125A Method for assaying nucleic acids 失效
标题翻译：核酸分析方法
公开(公告)号：US5532125A
公开(公告)日：1996-07-02
申请号：US44098
申请日：1993-04-06
申请人： Satoshi Fujita , Naoto Kagiyama , Masayoshi Momiyama
发明人： Satoshi Fujita , Naoto Kagiyama , Masayoshi Momiyama
IPC分类号： C07F9/09 , C07F9/12 , C07H21/00 , C12Q1/42 , C12Q1/68
CPC分类号： C07F9/12 , C12Q1/42 , C12Q1/6816
摘要： A method for assaying nucleic acids or similar compounds comprises binding a sample such as a nucleic acid to phosphatase; reacting the phosphatase with a 3-hydroxy-2-naphthoic acid-2'-phenyl anilide phosphate; irradiating the reaction product with an excited light; and detecting fluorescence emitted therefrom.
摘要翻译：用于测定核酸或类似化合物的方法包括将样品例如核酸与磷酸酶结合; 使磷酸酯酶与3-羟基-2-萘甲酸-2'-苯基苯胺磷酸酯反应; 用激发光照射反应产物; 并检测从其发出的荧光。

8. 发明授权

US5484700A Method for assaying nucleic acids using naphthol derivative phosphate 失效
标题翻译：使用萘酚衍生物磷酸分析核酸的方法
公开(公告)号：US5484700A
公开(公告)日：1996-01-16
申请号：US806189
申请日：1991-12-13
申请人： Satoshi Fujita , Naoto Kagiyama , Masayoshi Momiyama
发明人： Satoshi Fujita , Naoto Kagiyama , Masayoshi Momiyama
IPC分类号： C07F9/12 , C07F9/6541 , C12Q1/42 , C12Q1/68
CPC分类号： C07F9/6541 , C07F9/12 , C12Q1/42 , C12Q1/6816 , C12Q2334/30 , C12Q2334/70
摘要： Methods for detecting nucleic acids in a sample, using naphthol derivative phosphates, are provided. Nucleic acids present in a sample are contacted with phosphatase, producing a modified phosphatase. A naphthol derivative phosphate is contacted with the modified phosphatase to produce a reaction product. Any reaction product formed is detected by irradiating it with an excited light and detecting a fluorescence emitted from the reaction product. Naphthol derivative phosphates useful in these methods are also provided. Methods for production of naphthol derivative phosphates are also provided.
摘要翻译：提供了使用萘酚衍生物磷酸盐检测样品中核酸的方法。存在于样品中的核酸与磷酸酶接触，产生修饰的磷酸酶。将萘酚衍生物磷酸酯与改性磷酸酶接触以产生反应产物。通过用激发光照射并检测从反应产物发出的荧光来检测形成的任何反应产物。还提供了可用于这些方法的萘酚衍生物磷酸酯。还提供了生产萘酚衍生物磷酸盐的方法。

9. 发明申请

US20090317900A1 CHROMATOGRAPHY DEVICE 审中-公开
标题翻译：色谱装置
公开(公告)号：US20090317900A1
公开(公告)日：2009-12-24
申请号：US12480940
申请日：2009-06-09
申请人： Atsushi HATTORI , Masayoshi MOMIYAMA
发明人： Atsushi HATTORI , Masayoshi MOMIYAMA
IPC分类号： C12M1/00 , G01N30/02
CPC分类号： G01N30/90 , C12Q1/34 , G01N33/70 , G01N2333/978
摘要： A chromatography device includes a sample introducing portion for introducing a sample in a liquid state and provided at an upstream side of a flow of the sample, a developing means including a creatinine detecting portion, at which a creatinine detection reagent for detecting creatinine in the sample is provided, and a substance-to-be-detected detecting portion, at which a substance-to-be-detected detecting reagent for detecting a substance included in the sample is provided, and a liquid absorbing portion for absorbing liquid included in the sample in order to allow the sample to flow to a down stream side towards the liquid absorbing portion, wherein the sample introducing portion, the developing means and the water absorbing portion are provided on a board in this order from the upstream side to the downstream side in order to quantify the substance, which is included in the sample and which is to be detected.
摘要翻译：色谱装置包括用于将液体状态的样品引入并设置在样品流的上游侧的样品导入部，包含肌酸酐检测部的显影装置，在该肌酸酐检测部中检测样品中的肌酸酐的肌酸酐检测试剂以及被检物检测部，在该物质检测部上设置有用于检测样品中所含物质的被检测物质，以及用于吸收样品中所含的液体的液体吸收部为了允许样品向下游侧流向液体吸收部分，其中样品引入部分，显影装置和吸水部分从上游侧到下游侧依次设置在板上为了量化样品中包含的物质，要检测的物质。

10. 发明申请

US20070111301A1 Biological information inspection system 审中-公开
标题翻译：生物信息检查系统
公开(公告)号：US20070111301A1
公开(公告)日：2007-05-17
申请号：US10580460
申请日：2004-11-25
申请人： Satoshi Fujita , Masayoshi Momiyama
发明人： Satoshi Fujita , Masayoshi Momiyama
IPC分类号： C12M1/34
CPC分类号： G01N35/00029 , G01N2035/00158 , G01N2035/00851
摘要： In a biological information inspection system capable of accumulating highly reproducible biological information in a plurality of inspection means and making a multifactorial analysis of related information, simplification and downsizing of the system is achieved. The biological information inspection system 10 of the present invention comprises a sensor chip 20 holding a sample such as genes, a sensor chip holding portion 11 in which the sensor chip 20 is placed, and a data reading portion 13 for acquiring image data of a detection portion 21 and a marker portion 21 of the sensor chip 20. The system further comprises a data calculation unit 16 for executing a plurality of programs for acquiring biological information data from the image data of the detection portion 21. Which of the inspection means the sensor chip 20 corresponds to is identified from the read image data of the marker portion 23. Then the data calculation unit 16 executes a program for the one of the inspection means corresponding to the detection portion 21, thereby detecting biological information peculiar to the sample held on the detection portion 21 from the image data of the detection portion 21. Accordingly, information of the marker portion 23 and information of the detection portion 21 can be acquired by the same mechanism (the data reading portion 13).
摘要翻译：在能够在多个检查装置中积累高度可再现的生物信息并对相关信息进行多因素分析的生物信息检查系统中，实现了系统的简化和缩小。本发明的生物信息检查系统10包括：保存有基因的样本的传感器芯片20，放置有传感器芯片20的传感器芯片保持部11，以及用于获取检测图像数据的数据读取部13 部分21和传感器芯片20的标记部分21.系统还包括数据计算单元16，用于执行用于从检测部分21的图像数据获取生物信息数据的多个程序。检查装置中的哪一个是传感器芯片20对应于从标记部分23的读取的图像数据识别。然后，数据计算单元16执行与检测部分21相对应的检查装置中的一个的程序，从而检测保持在样本上的样本特有的生物信息来自检测部分21的图像数据的检测部分21.因此，标记部分23的信息和检测部分21的信息可以通过相同的机构（数据读取部分13）来获取反射部分21。

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