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1. 发明授权

US09139816B2 Viral particle-like structure in physiological conditions, and method of forming it 有权
标题翻译：生理条件下的病毒颗粒状结构及其形成方法
公开(公告)号：US09139816B2
公开(公告)日：2015-09-22
申请号：US12849437
申请日：2010-08-03
申请人： Hiroshi Handa , Akira Nakanishi , Masaaki Kawano
发明人： Hiroshi Handa , Akira Nakanishi , Masaaki Kawano
IPC分类号： C12Q1/70 , A61K6/00 , A61K39/12 , C12N7/00 , C07K14/005 , A61K39/00
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5258 , C07K14/005 , C12N2710/22022 , C12N2710/22023 , Y02A50/467
摘要： There is provided a novel method of forming uniform viral particles under physiological conditions. The method of forming uniform-sized viral particle aggregates composed of viral protein is characterized by incubating a viral protein such as SV40 virus VP1 at pH 5.0 to 7.0, room temperature, in the presence of 130 mM to 170 mM sodium chloride and 1.5 mM to 2.5 mM divalent cation, and in the presence of a particle formation acceleration factor such as SV40 VP2. For encapsulation of a substance to be encapsulated in the viral particles, the substance to be encapsulated is included during the incubation.
摘要翻译：提供了一种在生理条件下形成均匀病毒颗粒的新方法。形成由病毒蛋白组成的均匀尺寸的病毒颗粒聚集体的方法的特征在于在室温下，在130mM至170mM氯化钠和1.5mM的存在下，将病毒蛋白如SV40病毒VP1在pH 5.0至7.0温度下孵育至 2.5mM二价阳离子，并且在存在颗粒形成加速因子如SV40 VP2的情况下。为了封装待包封在病毒颗粒中的物质，在孵育期间包括待包被的物质。

2. 发明申请

US20080131928A1 Viral Particle-Like Construct and Method of Forming the Same Under Physiological Conditions 审中-公开
标题翻译：病毒颗粒状构造及其在生理条件下形成的方法
公开(公告)号：US20080131928A1
公开(公告)日：2008-06-05
申请号：US11630954
申请日：2005-06-30
申请人： Hiroshi Handa , Akira Nakanishi , Masaaki Kawano
发明人： Hiroshi Handa , Akira Nakanishi , Masaaki Kawano
IPC分类号： C12P21/04 , C12N7/00 , C12N15/87
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5258 , C07K14/005 , C12N2710/22022 , C12N2710/22023 , Y02A50/467
摘要： There is provided a novel method of forming uniform viral particles under physiological conditions. The method of forming uniform-sized viral particle aggregates composed of viral protein is characterized by incubating a viral protein such as SV40 virus VP1 at pH 5.0 to 7.0, room temperature, in the presence of 130 mM to 170 mM sodium chloride and 1.5 mM to 2.5 mM divalent cation, and in the presence of a particle formation acceleration factor such as SV40 VP2. For encapsulation of a substance to be encapsulated in the viral particles, the substance to be encapsulated is included during the incubation.
摘要翻译：提供了一种在生理条件下形成均匀病毒颗粒的新方法。形成由病毒蛋白组成的均匀尺寸的病毒颗粒聚集体的方法的特征在于，在室温下，在130mM至170mM氯化钠和1.5mM的存在下，在pH 5.0至7.0的温度下孵育病毒蛋白如SV40病毒VP1 至2.5mM二价阳离子，并且在存在颗粒形成加速因子如SV40 VP2的情况下。为了封装待包封在病毒颗粒中的物质，在孵育期间包括待包被的物质。

3. 发明授权

US06634454B2 Driving apparatus for a vehicle 失效
公开(公告)号：US06634454B2
公开(公告)日：2003-10-21
申请号：US09995509
申请日：2001-11-27
申请人： Nobuo Sugitani , Osamu Tsurumiya , Makoto Murata , Masaaki Kawano
发明人： Nobuo Sugitani , Osamu Tsurumiya , Makoto Murata , Masaaki Kawano
IPC分类号： B62D506
CPC分类号： B62D5/001 , B62D1/12 , B62D6/001 , G05G9/047 , G05G2009/0474
摘要： The object of the present invention is to provide a driving apparatus for a vehicle, which is capable of improving the operability and safety of a vehicle driving by enabling a fine correction to the steering amount with a simple apparatus. The apparatus employs the first and second operation devices, for which the steering gains are differentiated for the improvement.

4. 发明授权

US07257475B2 Vehicle control system 有权
标题翻译：车辆控制系统
公开(公告)号：US07257475B2
公开(公告)日：2007-08-14
申请号：US10884013
申请日：2004-07-02
申请人： Hisao Asaumi , Masaaki Kawano , Osamu Tsurumiya
发明人： Hisao Asaumi , Masaaki Kawano , Osamu Tsurumiya
IPC分类号： B62D5/04
CPC分类号： B62D5/0463 , B62D5/0484 , H02J7/0063
摘要： A vehicle control system is provided for a vehicle that is steered by steer-by-wire, the system including a battery mounted in the vehicle, a steer-by-wire steering system that turns wheels by an electric motor that is operated by electric power supplied from the battery, a steering controller for controlling the operation of the steer-by-wire steering system, and an engine controller for controlling, by electric power supplied from the battery, the operation of an engine for making the vehicle travel. A booster circuit boosts the voltage applied to the steering controller so that, when the voltage of the battery decreases, the voltage applied to the engine controller falls below its minimum operating voltage before the voltage applied to the steering controller falls below its minimum operating voltage. With this arrangement, it is possible to provide fail-safe operation when there is a decrease in the voltage of the battery which supplies electricity to the steering controller.
摘要翻译：一种车辆控制系统，用于通过线控转向的车辆，包括安装在车辆中的电池的系统，由电力操作的电动机转动车轮的转向转向系统从电池供给的转向控制器，用于控制线控转向系统的操作的转向控制器，以及用于通过从电池提供的电力来控制用于使车辆行驶的发动机的操作的发动机控制器。升压电路提高施加到转向控制器的电压，使得当电池电压降低时，施加到发动机控制器的电压在施加到转向控制器的电压下降到低于其最小工作电压之前降低到其最小工作电压以下。通过这种布置，当向转向控制器供电时的电池的电压降低时，可以提供故障保护操作。

5. 发明授权

US07533757B2 Steering system and method of control 失效
标题翻译：转向系统和控制方法
公开(公告)号：US07533757B2
公开(公告)日：2009-05-19
申请号：US11265606
申请日：2005-11-02
申请人： Nobuo Sugitani , Yoshimitsu Akuta , Hisao Asaumi , Hitoshi Iwai , Masaaki Kawano , Takashi Nishimori
发明人： Nobuo Sugitani , Yoshimitsu Akuta , Hisao Asaumi , Hitoshi Iwai , Masaaki Kawano , Takashi Nishimori
IPC分类号： B62D5/04
CPC分类号： B62D5/003 , B62D5/006 , B62D5/0496
摘要： A steering system includes a steering wheel, a steering angle sensor detecting a steering angle, a steering motor steering road-wheels, a reaction motor imparting a reaction force to the steering wheel, an ECU driving the steering motor with respect to a detected steering angle and a temperature detecting unit detecting temperatures of the steering motor, the reaction motor or a constituent member involved in the temperatures of the motors. When the temperature detected is larger than a predetermined value, the ECU performs such that a ratio of the rotating angle to the steering angle is made smaller than one that is to result when the temperature is equal to or smaller than the predetermined value, or a reaction force that is to be imparted to the steering wheel is made larger.
摘要翻译：转向系统包括方向盘，检测转向角的转向角传感器，转向马达转向路面轮，向方向盘施加反作用力的反作用马达，相对于检测到的转向角度驱动转向马达的ECU 以及温度检测单元，其检测所述转向马达，所述反作用马达或与所述马达的温度有关的构成部件的温度。当检测到的温度大于预定值时，ECU执行使得旋转角度与转向角度的比率小于当温度等于或小于预定值时产生的旋转角度的比率，或者使赋予方向盘的反作用力变大。

6. 发明授权

US5929586A Vehicular motor driving apparatus 失效
标题翻译：车用马达驱动装置
公开(公告)号：US5929586A
公开(公告)日：1999-07-27
申请号：US123662
申请日：1998-07-28
申请人： Yoshiki Noro , Yoshinobu Mukai , Masaaki Kawano
发明人： Yoshiki Noro , Yoshinobu Mukai , Masaaki Kawano
IPC分类号： B62D6/00 , B62D5/04 , G05B11/28
CPC分类号： B62D5/046
摘要： A vehicular motor driving apparatus includes a control unit 15 for drive-controlling a motor by PWM-drive-controlling a motor driving circuit based on a motor starting signal. The control unit has a drive controller for setting a drive frequency of a PWM-drive control signal to be an integral multiple of or (integer+0.5) times a channel frequency interval of channel frequencies allotted for AM radio broadcasts. As a result, radiation noise associated with harmonics of the PWM-drive control signal, when coincided with the channel frequencies used by AM radio broadcast stations, is removed along with the channel frequencies through radio receiver detection. When the radiation noise does not coincide with the in-use channel frequencies, it is offset by the channel frequency interval therefrom, thereby preventing its reception.
摘要翻译：车辆用电动机驱动装置包括：控制单元15，用于通过基于电动机起动信号的PWM驱动控制电动机驱动电路来驱动电动机。控制单元具有用于将PWM驱动控制信号的驱动频率设置为分配给AM无线电广播的信道频率的信道频率间隔的整数倍或（整数+ 0.5）倍的驱动控制器。结果，当与AM无线电广播站使用的信道频率一致时，与PWM驱动控制信号的谐波相关的辐射噪声与通过无线电接收机检测的信道频率一起被去除。当辐射噪声与使用中信道频率不一致时，其被信道频率间隔偏移，从而阻止其接收。

7. 发明申请

US20120164232A1 CONSTRUCT COATED WITH VIRUS COAT-CONSTITUTING PROTEIN AND METHOD FOR PRODUCING SAME 审中-公开
标题翻译：包装有病毒涂层蛋白的构造及其生产方法
公开(公告)号：US20120164232A1
公开(公告)日：2012-06-28
申请号：US13390631
申请日：2010-08-30
申请人： Hiroshi Handa , Koji Doi , Teruya Enomoto , Masaaki Kawano
发明人： Hiroshi Handa , Koji Doi , Teruya Enomoto , Masaaki Kawano
IPC分类号： A61K9/14 , A61K9/00 , B82Y5/00 , B82Y40/00
CPC分类号： A61K9/5184 , C07K14/005 , C12N15/87 , C12N15/88 , C12N2710/22022 , C12N2710/22023 , C12N2810/6009 , C12N2810/851
摘要： Disclosed is a construct comprising a virus coat protein usable as a carrier for drug delivery adaptable to various drugs. Specifically disclosed is a construct coated with a virus coat protein, comprising a virus coat protein and a construct coated therewith, wherein the virus coat protein is attached to the surface of the construct to form a layer of the protein thereon.
摘要翻译：公开了包含可用作适用于各种药物的药物递送载体的病毒外壳蛋白的构建体。具体公开的是涂覆有病毒外壳蛋白的构建体，其包含病毒外壳蛋白和包被的构建体，其中所述病毒外壳蛋白连接到构建体的表面以在其上形成蛋白质层。

8. 发明申请

US20060090954A1 Steering system and method of control 失效
公开(公告)号：US20060090954A1
公开(公告)日：2006-05-04
申请号：US11265606
申请日：2005-11-02
申请人： Nobuo Sugitani , Yoshimitsu Akuta , Hisao Asaumi , Hitoshi Iwai , Masaaki Kawano , Takashi Nishimori
发明人： Nobuo Sugitani , Yoshimitsu Akuta , Hisao Asaumi , Hitoshi Iwai , Masaaki Kawano , Takashi Nishimori
IPC分类号： B62D5/04
CPC分类号： B62D5/003 , B62D5/006 , B62D5/0496
摘要： A steering system includes a steering wheel, a steering angle sensor detecting a steering angle, a steering motor steering road-wheels, a reaction motor imparting a reaction force to the steering wheel, an ECU driving the steering motor with respect to a detected steering angle and a temperature detecting unit detecting temperatures of the steering motor, the reaction motor or a constituent member involved in the temperatures of the motors. When the temperature detected is larger than a predetermined value, the ECU performs such that a ratio of the rotating angle to the steering angle is made smaller than one that is to result when the temperature is equal to or smaller than the predetermined value, or a reaction force that is to be imparted to the steering wheel is made larger.

9. 发明申请

US20110135718A1 VIRAL PARTICLE-LIKE STRUCTURE IN PHYSIOLOGICAL CONDITIONS, AND METHOD OF FORMING IT 审中-公开
标题翻译：生理条件下的病毒颗粒状结构及其形成方法
公开(公告)号：US20110135718A1
公开(公告)日：2011-06-09
申请号：US12849437
申请日：2010-08-03
申请人： Hiroshi HANDA , Akira Nakanishi , Masaaki Kawano
发明人： Hiroshi HANDA , Akira Nakanishi , Masaaki Kawano
IPC分类号： A61K9/48 , C12P21/00 , A61K48/00 , A61P43/00
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5258 , C07K14/005 , C12N2710/22022 , C12N2710/22023 , Y02A50/467
摘要： There is provided a novel method of forming uniform viral particles under physiological conditions. The method of forming uniform-sized viral particle aggregates composed of viral protein is characterized by incubating a viral protein such as SV40 virus VP1 at pH 5.0 to 7.0, room temperature, in the presence of 130 mM to 170 mM sodium chloride and 1.5 mM to 2.5 mM divalent cation, and in the presence of a particle formation acceleration factor such as SV40 VP2. For encapsulation of a substance to be encapsulated in the viral particles, the substance to be encapsulated is included during the incubation.
摘要翻译：提供了一种在生理条件下形成均匀病毒颗粒的新方法。形成由病毒蛋白组成的均匀尺寸的病毒颗粒聚集体的方法的特征在于在室温下，在130mM至170mM氯化钠和1.5mM的存在下，将病毒蛋白如SV40病毒VP1在pH 5.0至7.0温度下孵育至 2.5mM二价阳离子，并且在存在颗粒形成加速因子如SV40 VP2的情况下。为了封装待包封在病毒颗粒中的物质，在孵育期间包括待包被的物质。

10. 发明授权

US07726692B2 Steering handle and steering system 失效
标题翻译：转向手柄和转向系统
公开(公告)号：US07726692B2
公开(公告)日：2010-06-01
申请号：US10580920
申请日：2004-10-21
申请人： Takafumi Ozaki , Paul Baron , Kazuhiko Satou , Tatsuya Amano , Hisao Asaumi , Masaaki Kawano , Hirokazu Kitazawa , Kunio Shirakawa , Osamu Tsurumiya , Yoshinobu Mukai , Kazuhisa Watanabe
发明人： Takafumi Ozaki , Paul Baron , Kazuhiko Satou , Tatsuya Amano , Hisao Asaumi , Masaaki Kawano , Hirokazu Kitazawa , Kunio Shirakawa , Osamu Tsurumiya , Yoshinobu Mukai , Kazuhisa Watanabe
IPC分类号： B62D1/12 , B62D1/04
CPC分类号： B62D1/12 , B62D1/04 , B62D5/006 , Y10T74/20256 , Y10T74/20732 , Y10T74/20834
摘要： In a steering handle grasped and rotated by both hands of a driver, an axis of a steering shaft included in the steering handle is inclined so as to be higher in level in a forward direction of a vehicle body, and a left grip grasped by a left hand and a right grip grasped by a right hand are rotatable in opposite directions about an axis perpendicular to the axis of the steering shaft. Accordingly, an upper half of the driver's body sitting on a seat and leaning backwards and a plane of rotation of the steering handle are substantially parallel to each other, thereby ensuring that the driver can rotate the steering handle without stretching and withdrawing his or her arms. Moreover, when the steering handle is rotated, the driver's wrists can be prevented from being twisted unnaturally, leading to an easy steering operation.
摘要翻译：在由驾驶员的双手握持并旋转的转向柄中，包括在转向手柄中的转向轴的轴线倾斜成在车身前方高度高，左手柄被左手和右手握持的右把手可绕垂直于转向轴的轴线的相反方向旋转。因此，坐在座椅上并向后倾斜的驾驶员身体的上半部和转向手柄的旋转平面基本上彼此平行，从而确保驾驶员能够旋转转向手柄而不拉伸和撤回他或她的手臂。此外，当转向手柄旋转时，可以防止驾驶员的手腕扭曲不自然，导致转向操作容易。

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