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1. 发明授权

US5091527A Substrate for phospholipase 失效
标题翻译：磷脂基质
公开(公告)号：US5091527A
公开(公告)日：1992-02-25
申请号：US318075
申请日：1989-03-02
申请人： Martina Junius , Ulrich Neumann , Herbert von der Eltz
发明人： Martina Junius , Ulrich Neumann , Herbert von der Eltz
IPC分类号： C07C305/10 , C07C323/12 , C07C327/28 , C07F9/09 , C07F9/10 , C12Q1/44
CPC分类号： C07C305/10 , C07C323/12 , C07F9/10 , C12Q1/44
摘要： The present invention provides phospholipase substrates of the general formula: ##STR1## wherein A is an alkylene or alkenylene radical containing up to 16 carbon atoms, R is a hydrgen atom or an alkyl, alkenyl or acyl radical containing up to 20 carbon atoms or an optionally alkyl-substituted aryl or aralkyl radical containing up to 8 carbon atoms in the alkyl moiety, X is the residue of an aromatic hydroxy or thiol compound and each Y, independently of one another, is an oxygen or sulphur atom and Z is --SO.sub.3.sup..crclbar. or a radical of the general formula: ##STR2## wherein R.sup.1 can be a hydrogen atom or a radical of the general formula --(CH.sub.2).sub.n NR.sub.3.sup.2, in which n is 2, 3 or 4 and R.sup.2 is a hydrogen atom or a methyl radical, or is an inositol or serine (--CH.sub.2 --CH(NH.sub.2)--COOH) or glycerol residue.The present invention also provides a process for the optical determination of phospholipases using these substrates, as well as a reagent containing them.
摘要翻译：本发明提供以下通式的磷脂酶底物：其中A是含有至多16个碳原子的亚烷基或亚烯基，R是氢原子或烷基，烯基或含有至多20个碳原子的酰基或在烷基部分含有至多8个碳原子的任选的烷基取代的芳基或芳烷基，X是芳族羟基或硫醇化合物的残基，每个Y彼此独立地是氧原子或硫原子，Z为-SO 3（ - ）或下式通式的基团：其中R 1可以是氢原子或通式为 - （CH 2）n NR 33的基团，其中n为2， 3或4，R2为氢原子或甲基，或为肌醇或丝氨酸（-CH2-CH（NH2）-COOH）或甘油残基。本发明还提供了使用这些底物光学测定磷脂酶的方法以及含有它们的试剂。

2. 发明授权

US4786591A Process for determining the binding capacity of thyroxin-binding globulin 失效
标题翻译：确定甲状腺素结合球蛋白结合能力的方法
公开(公告)号：US4786591A
公开(公告)日：1988-11-22
申请号：US945785
申请日：1986-12-23
申请人： Brigitte Draeger , Winfried Albert , Martina Junius , Jurgen Rasch
发明人： Brigitte Draeger , Winfried Albert , Martina Junius , Jurgen Rasch
IPC分类号： G01N33/78 , G01N33/53 , G01N33/543 , G01N33/549
CPC分类号： G01N33/78 , Y10S436/817
摘要： The present invention provides a process for determining the binding capacity of thyroxin-binding globulin (TBG) according to the principle of heterogeneous enzyme immunoassay, wherein the serum sample to be investigated is incubated with enzyme-labelled T.sub.4 or T.sub.3 and immobilized antibody against TBG or T.sub.4, the phase are separated and the labelling enzyme is measured in one of the phases.
摘要翻译：本发明提供了一种根据异源酶免疫测定原理确定甲状腺素结合球蛋白（TBG）的结合能力的方法，其中待研究的血清样品与酶标记的T4或T3一起孵育，并针对TBG或 T4，分离相并在其中一个相中测量标记酶。

3. 发明授权

US5244789A Process for the determination of phospholipase A in body fluids 失效
标题翻译：在体液中测定磷脂酶A的方法
公开(公告)号：US5244789A
公开(公告)日：1993-09-14
申请号：US756712
申请日：1991-09-09
申请人： Ulrich Neumann , Gudrun Schmidt , Martina Junius-Comer
发明人： Ulrich Neumann , Gudrun Schmidt , Martina Junius-Comer
IPC分类号： C12Q1/44
CPC分类号： C12Q1/44 , G01N2333/918 , G01N2405/04
摘要： The present invention provides a process for the determination of phospholipase A in body fluids, wherein the body fluid is incubated with a mixture containing a substrate having a fatty acid residue for the phospholipase and at least two emulsifiers of different chemical classes, namely, at least one neutral emulsifier and a bile acid salt, and the amount of the free fatty acids formed by the cleavage of the substrate is determined in known manner.
摘要翻译：本发明提供了一种用于测定体液中磷脂酶A的方法，其中将体液与含有磷脂酶的脂肪酸残基的底物和至少两种不同化学等级的乳化剂，即至少一种中性乳化剂和胆汁酸盐，并且以已知方式测定通过基底裂解形成的游离脂肪酸的量。

4. 发明申请

US20050142598A1 Oligonucleotides containing molecular rods 失效
标题翻译：含分子棒的寡核苷酸
公开(公告)号：US20050142598A1
公开(公告)日：2005-06-30
申请号：US11001785
申请日：2004-12-02
申请人： Dieter Heindl , Astrid Reiser , Karim Tabiti , Martina Junius , Alexander Hauber
发明人： Dieter Heindl , Astrid Reiser , Karim Tabiti , Martina Junius , Alexander Hauber
IPC分类号： C12N15/09 , C07H21/00 , C07H21/04 , C12P19/34 , C12Q1/68
CPC分类号： C07H21/00 , Y10S436/808
摘要： The invention is directed to an oligonucleotide comprising a molecular rod, wherein preferentially the molecular rod covalently connects the 3′ end of a first nucleotide residue with the 5′ end of a second nucleotide residue. Such oligonucleotides are highly advantageous for real time PCR melting curve analysis.
摘要翻译：本发明涉及包含分子棒的寡核苷酸，其中优先分子棒共价连接第一个核苷酸残基的3'末端与第二个核苷酸残基的5'末端。这样的寡核苷酸对于实时PCR融合曲线分析是非常有利的。

5. 发明授权

US4847376A Lipase substrates 失效
标题翻译：脂肪酶底物
公开(公告)号：US4847376A
公开(公告)日：1989-07-11
申请号：US858349
申请日：1986-05-01
申请人： Ulrich Neumann , Martina Junius , Hans-Georg Batz
发明人： Ulrich Neumann , Martina Junius , Hans-Georg Batz
IPC分类号： C07D265/38 , C07C69/00 , C07D209/34 , C07D209/36 , C12N9/20 , C12Q1/34 , C12Q1/44 , C12Q1/61 , G01N33/48 , G01N33/92
CPC分类号： C12Q1/44 , C12Q2334/00
摘要： The present invention provides a lipase substrate of the general formula: ##STR1## wherein A is an alkylene or alkenylene radical containing up to 16 carbon atoms, R and R.sub.1, which can be the same or different, each signify an alkyl, alkenyl or acyl radical containing up to 20 carbon atoms or an optionally alkyl-substituted aryl or aralkyl radical containing up to 8 carbon atoms in the alkyl moiety and wherein one of R and R.sub.1 can also be a hydrogen atom, X is the residue of an aromatic hydroxy or thiol compound, and each Y and Z, independently from each other, is --S-- or --O--, Z also --CH.sub.2 --.The present invention also provides a process and a reagent for the optical determination of lipase.
摘要翻译：本发明提供了通式如下的脂肪酶底物：其中A是含有至多16个碳原子的亚烷基或亚烯基，R和R 1可以相同或不同，表示烷基，烯基或酰基含有至多20个碳原子的基团或在烷基部分含有至多8个碳原子的任选烷基取代的芳基或芳烷基，其中R和R 1中的一个也可以是氢原子，X是芳族羟基的残基或硫醇化合物，每个Y和Z彼此独立地是-S-或-O-，Z也是-CH 2 - 。本发明还提供了用于光学测定脂肪酶的方法和试剂。

6. 发明授权

US4737466A N-acyldihydroresorufin derivatives, processes for their preparation, reagents containing them and the use thereof for determining hydrogen peroxide, peroxidate-acting compounds or peroxidase 失效
标题翻译： N-酰基二氢代芬芬衍生物，其制备方法，含有它们的试剂及其用于测定过氧化氢，过氧化物作用化合物或过氧化物酶
公开(公告)号：US4737466A
公开(公告)日：1988-04-12
申请号：US884372
申请日：1986-07-11
申请人： Christian Klein , Herbert Von Der Eltz , Rupert Herrmann , Martina Junius
发明人： Christian Klein , Herbert Von Der Eltz , Rupert Herrmann , Martina Junius
IPC分类号： G01N33/50 , C07D265/38 , C12Q1/20 , C12Q1/26 , C12Q1/28 , G01N33/52 , G01N33/72
CPC分类号： C07D265/38 , C12Q1/28 , C12Q2326/00 , Y10S436/904 , Y10T436/206664
摘要： The present invention provides N-acylidihydroresorufin derivatives of the general formula: ##STR1## wherein R.sup.1 is a lower alkyl, aryl or aralkyl radical, which can be substituted by carboxyl or sulphonic acid residues, R.sup.2, R.sup.3 and R.sup.4, which can be the same or different, are hydrogen or halogen atoms or lower alkyl or lower alkoxy radicals, Y is an --NR.sup.5 R.sup.6 or --OR.sup.7 group, wherein R.sup.5 and R.sup.6 are, in each case, hydrogen atoms or lower alkyl radicals, which can be substituted by carboxyl or sulphonic acid residues, or together represent a hydrocarbon bridge optionally interrupted by hereto atoms and R.sup.7 is a lower alkyl radical which can be substituted by a lower alkoxy or poly-lower alkoxy radical.
摘要翻译：本发明提供以下通式的N-酰基二氢代芬芬衍生物：其中R 1是低级烷基，芳基或芳烷基，其可以被羧基或磺酸残基取代，R 2，R 3和R 4，其可以相同或不同，为氢或卤素原子或低级烷基或低级烷氧基，Y为-NR5R6或-OR7基团，其中R5和R6各自为氢原子或低级烷基，可取代或者一起代表任选被该原子间隔的烃桥，并且R7是可被低级烷氧基或多 - 低级烷氧基取代的低级烷基。

7. 发明授权

US07541448B2 Oligonucleotides containing molecular rods 失效
标题翻译：含分子棒的寡核苷酸
公开(公告)号：US07541448B2
公开(公告)日：2009-06-02
申请号：US11001785
申请日：2004-12-02
申请人： Dieter Heindl , Astrid Reiser , Karim Tabiti , Martina Junius , Alexander Hauber
发明人： Dieter Heindl , Astrid Reiser , Karim Tabiti , Martina Junius , Alexander Hauber
IPC分类号： C07H21/02 , C07H21/04 , C07H19/04 , G01N33/53 , C12Q1/68
CPC分类号： C07H21/00 , Y10S436/808
摘要： The invention is directed to an oligonucleotide comprising a molecular rod, wherein preferentially the molecular rod covalently connects the 3′ end of a first nucleotide residue with the 5′ end of a second nucleotide residue. Such oligonucleotides are highly advantageous for real time PCR melting curve analysis.
摘要翻译：本发明涉及包含分子棒的寡核苷酸，其中优先分子棒共价连接第一个核苷酸残基的3'末端与第二个核苷酸残基的5'末端。这样的寡核苷酸对于实时PCR融合曲线分析是非常有利的。

8. 发明授权

US5204242A Substituted phenols 失效
标题翻译：取代苯酚
公开(公告)号：US5204242A
公开(公告)日：1993-04-20
申请号：US761335
申请日：1991-09-17
申请人： Martina Junius-Comer , Bernd Vogt , Rupert Herrmann
发明人： Martina Junius-Comer , Bernd Vogt , Rupert Herrmann
IPC分类号： C07C37/00 , C07C39/24 , C07C39/27 , C07C43/178 , C07C59/52 , C07C59/56 , C07C69/732 , C07C205/56 , C07C215/48 , C07C215/66 , C07C235/34 , C07C309/24 , C07C309/68 , C07C311/13 , C07C311/27 , G01N31/22 , G03C7/34
CPC分类号： C07C235/34 , C07C205/56 , C07C309/24 , C07C311/27 , C07C39/27 , C07C59/52 , C07C59/56 , G03C7/346
摘要： The present invention provides a colorimetric process for the detection of an oxidative coupling reaction in which a coupling component is reacted with a developer component in the presence of an oxidation agent to give a colored material, wherein, as coupling component, there is used a compound of the general formula: ##STR1## in which X is a bromine or chlorine atom, n is 1, 2 or 3, Y is COOR, CONRR', SO.sub.3 R, SO.sub.2 NRR', OR, NRR' or NRR'R".sym. and R, R' and R", independently of one another, are hydrogen atoms or C.sub.1 -C.sub.3 -alkyl radicals.The present invention also provides a reagent which contains the above compound, as well as new substituted phenols and a process for the preparation thereof.
摘要翻译：本发明提供了一种用于检测氧化偶联反应的比色方法，其中偶联组分在氧化剂存在下与显影剂组分反应，得到着色材料，其中作为偶联组分，使用化合物其中X是溴或氯原子，其中n是1,2或3，Y是COOR，CONRR'，SO3R，SO2NRR'，OR，NRR'或NRR'R “（+）”和“R”，“R”和“R”彼此独立地是氢原子或C1-C3-烷基。本发明还提供了含有上述化合物的试剂，以及新的取代酚类及其制备方法。

9. 发明授权

US4988497A Process for the optical determination of lipase 失效
标题翻译：脂肪酶光学测定方法
公开(公告)号：US4988497A
公开(公告)日：1991-01-29
申请号：US353098
申请日：1989-05-17
申请人： Ulrich Neumann , Martina Junius , Hans-Georg Batz
发明人： Ulrich Neumann , Martina Junius , Hans-Georg Batz
IPC分类号： C07D265/38 , C07C69/00 , C07D209/34 , C07D209/36 , C12N9/20 , C12Q1/34 , C12Q1/44 , C12Q1/61 , G01N33/48 , G01N33/92
CPC分类号： C12Q1/44 , C12Q2334/00
摘要： The present invention provides a lipase substrate of the general formula: ##STR1## wherein A is an alkalene or alkenylene radical containing up to 16 carbon atoms, R and R.sub.1, which can be the same or different, each signify an alkyl, alkenyl or acyl radical containing up to 20 carbon atoms or an optionally alkyl-substituted aryl or aralkyl radical containing up to 8 carbon atoms in the alkyl moiety and wherein one of R and R.sub.1 can also be a hydrogen atom, X is the residue of an aromatic hydroxy or thiol compound, and each Y and Z, independently from each other, is --S-- or --O--, Z also --CH.sub.2 --.The present invention also provides a process and a reagent for the optical determination of lipase.

10. 发明授权

US6057120A Redox-active compounds and their use 失效
标题翻译：氧化还原活性化合物及其用途
公开(公告)号：US6057120A
公开(公告)日：2000-05-02
申请号：US934784
申请日：1997-09-22
申请人： Dieter Heindl , Rupert Herrmann , Joachim Hones , Hans-Peter Josel , Martina Junius-Comer , Hartmut Merdes , Axel Schmidt , Ernst Selbertinger
发明人： Dieter Heindl , Rupert Herrmann , Joachim Hones , Hans-Peter Josel , Martina Junius-Comer , Hartmut Merdes , Axel Schmidt , Ernst Selbertinger
IPC分类号： C07D241/38 , C07D241/46 , C07D401/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C12Q1/26 , G01N31/22 , G01N33/52 , C12Q1/00 , G01N33/53
CPC分类号： C07D241/38 , C07D401/14 , C12Q1/26 , G01N31/22 , G01N33/52 , Y10S435/968
摘要： The invention concerns the use of redox-active compounds for the production of detection reagents for a method for the determination of an analyte as well as reagent kits that contain these redox-active compounds. In addition new redox-active compounds are disclosed.
摘要翻译：本发明涉及氧化还原活性化合物用于生产用于测定分析物的方法的检测试剂以及含有这些氧化还原活性化合物的试剂盒的用途。此外，还公开了新的氧化还原活性化合物。

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