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1. 发明公开

US20240076285A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY 审中-公开
公开(公告)号：US20240076285A1
公开(公告)日：2024-03-07
申请号：US18266199
申请日：2021-12-16
申请人： Shankar VENKATRAMAN , Jason KATZ , William R. ROUSH , Hans Martin SEIDEL , IFM Due, Inc.
发明人： Shankar Venkatraman , Jason Katz , William R. Roush , Hans Martin Seidel
IPC分类号： C07D401/14 , C07D401/12 , C07D405/14 , C07D417/14
CPC分类号： C07D401/14 , C07D401/12 , C07D405/14 , C07D417/14
摘要： This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

2. 发明授权

US08049022B2 Fluorosurfactants 失效
标题翻译：含氟表面活性剂
公开(公告)号：US08049022B2
公开(公告)日：2011-11-01
申请号：US12307145
申请日：2007-07-02
申请人： Wolfgang Hierse , Nikolai (Mykola) Ignatyev , Martin Seidel , Elvira Montenegro , Peer Kirsch , Andreas Bathe
发明人： Wolfgang Hierse , Nikolai (Mykola) Ignatyev , Martin Seidel , Elvira Montenegro , Peer Kirsch , Andreas Bathe
IPC分类号： C07C235/00 , C11D3/20
CPC分类号： B01F17/0035 , C07C235/08 , C07C237/08 , C07C323/60 , C07C329/16 , C07C381/00 , C09K3/16 , C09K3/18
摘要： The present invention relates to fatty acid alkanolamides or polyolamides containing at least one group Y, where Y stands for CF3—(CH2)a—O—, SF5—, CF3—(CH2)a—S—, CF3CF2S—, [CF3—(CH2)a]2N— or [CF3—(CH2)a]NH—, where a stands for an integer selected from the range from 0 to 5, or formula (I), where Rf stands for CF3—(CH2)r—, CF3—(CH2)r—O—, CF3—(CH2)r—S—, CF3CF2—S—, SF5—(CH2)r— or [CF3—(CH2)r]2N—, [CF3—(CH2)r]NH— or (CF3)2N—(CH2)r—, B stands for a single bond, O, NH, NR, CH2, C(O)—O, C(O), S, CH2—O, O—C(O), N—C(O), C(O)—N, O—C(O)—N, N—C(O)—N, O—SO2 or SO2—O, R stands for alkyl having 1 to 4 C atoms, b stands for 0 or 1 and c stands for 0 or 1, q stands for 0 or 1, where at least one radical from b and q stands for 1, and r stands for 0, 1, 2, 3, 4 or 5, to processes for the preparation of these compounds, and to uses of these surface-active compounds.
摘要翻译：本发明涉及含有至少一个Y基团的脂肪酸链烷醇酰胺或多元醇酰胺，其中Y代表CF 3 - （CH 2）a -O-，SF 5 - ，CF 3 - （CH 2）a -S-，CF 3 CF 2 S-，[CF 3 - （CH 2）a] 2N-或[CF 3 - （CH 2）a] NH-，其中a代表选自0至5的整数，或式（I），其中R f表示CF 3 - （CH 2）r - （CH 2）r -O-，CF 3 - （CH 2）r -S-，CF 3 CF 2 -S-，SF 5 - （CH 2）r - 或[CF 3 - （CH 2）r] 2N-，[CF 3 - CH 2）R] NH-或（CF 3）2 N-（CH 2）r - ，B代表单键，O，NH，NR，CH 2，C（O）-O，C（O），O-C（O），N-C（O），C（O）-N，O-C（O）-N，N-C（O）-N，O-SO 2或SO 2 -O 对于具有1至4个C原子的烷基，b代表0或1，c代表0或1，q代表0或1，其中至少一个b和q的基团代表1，r代表0,1 ，2,3,4或5，用于制备这些化合物的方法，以及这些表面活性化合物的用途。

3. 发明申请

US20110082312A1 PRODUCTION OF COMPOUNDS COMPRISING CF30 GROUPS 审中-公开
标题翻译：生产包含CF30组合物的化合物
公开(公告)号：US20110082312A1
公开(公告)日：2011-04-07
申请号：US12992959
申请日：2009-05-04
申请人： Nikolai (Mykola) Ignatyev , Wolfgang Hierse , Martin Seidel , Andreas Bathe , Jens Schroeter , Karsten Koppe , Thorsten Meier , Peter Barthen , Walter Frank
发明人： Nikolai (Mykola) Ignatyev , Wolfgang Hierse , Martin Seidel , Andreas Bathe , Jens Schroeter , Karsten Koppe , Thorsten Meier , Peter Barthen , Walter Frank
IPC分类号： C07C69/025 , C07C41/01 , C07C43/15 , C07C67/31 , C07C43/12 , C07C51/09 , C07C41/26 , C07C45/64 , C07C49/303 , C07C43/14
CPC分类号： C07C41/16 , B01F17/0035 , C07C43/12 , C07C43/126 , C07C43/137 , C07C43/17 , C07C43/123
摘要： The present invention relates to a process for the preparation of compounds containing CF3O groups using compounds containing at least one group Y, in which Y=—Hal, —OSO2(CF2)zF, —OSO2CzH2z+1 (z=1-10), —OSO2F, —OSO2Cl, —OC(O)CF3— or —OSO2Ar, to a process for the preparation of compounds containing CF3O groups using KOCF3 and/or RbOCF3, and to novel compounds containing CF3O groups, and to the use thereof.
摘要翻译：本发明涉及使用含有至少一个基团Y的化合物制备含有CF 3 O基团的化合物的方法，其中Y = -Hal，-OSO 2（CF 2）z F，-OSO 2 C z H 2 z + 1（z = 1-10）， -OSO 2 F，-OSO 2 Cl，-OC（O）CF 3 - 或-OSO 2 Ar，以及使用KOCF 3和/或RbOCF 3制备含有CF 3 O基团的化合物的方法，以及含有CF 3 O基团的新型化合物及其用途。

4. 发明授权

US5814517A DNA spacer regulatory elements responsive to cytokines and methods for their use 失效
标题翻译：响应于细胞因子的DNA间隔物调节元件及其使用方法
公开(公告)号：US5814517A
公开(公告)日：1998-09-29
申请号：US410779
申请日：1995-03-27
申请人： H. Martin Seidel , I. Peter Lamb
发明人： H. Martin Seidel , I. Peter Lamb
IPC分类号： C12Q1/68 , C12N15/85 , C07H21/04 , C12N15/11
CPC分类号： C12Q1/6897
摘要： The present invention provides oligonucleotide sequences comprising DNA regulatory elements of the general sequence TTN.sub.X AA that bind activated transcriptional regulatory proteins in response to signaling molecules, such as cytokines. Further, the present invention also provides DNA constructs comprising the oligonucleotide sequences, cells transfected with the DNA constructs, and methods of using the DNA constructs and transfected cells to provide for the controlled expression of structural genes, for the detection and recovery of transcriptional regulatory proteins, and for measuring the ability of compounds to act as agonist and antagonists of gene transcription.
摘要翻译：本发明提供了包含通用序列TTNXAA的DNA调节元件的寡核苷酸序列，其结合激活的转录调节蛋白以响应信号分子，例如细胞因子。此外，本发明还提供了包含寡核苷酸序列的DNA构建体，用DNA构建体转染的细胞，以及使用DNA构建体和转染细胞提供结构基因的受控表达以检测和回收转录调节蛋白的方法，并用于测量化合物作为基因转录激动剂和拮抗剂的能力。

5. 发明授权

US5707803A DNA regulatory elements responsive to cytokines and methods for their use 失效
标题翻译：响应于细胞因子的DNA调节元件及其使用方法
公开(公告)号：US5707803A
公开(公告)日：1998-01-13
申请号：US410780
申请日：1995-03-27
申请人： Ian Peter Lamb , H. Martin Seidel
发明人： Ian Peter Lamb , H. Martin Seidel
IPC分类号： C12N15/85 , C12Q1/68 , C12Q1/70 , C07H21/04 , C12N15/11 , C12N15/67
CPC分类号： C12N15/85 , C12Q1/6811 , C12Q1/6813 , C12Q1/6876 , C12Q1/701 , C12Q2600/136 , C12Q2600/158
摘要： The present invention provides oligonucleotide sequences comprising DNA regulatory elements comprising point mutations of Ly6E GAS element that bind activated transcriptional regulatory proteins in response to signaling molecules, such as cytokines. Further, the present invention also provides DNA constructs comprising the oligonucleotide sequences, cells transfected with the DNA constructs, and methods of using the DNA constructs and transfected cells to provide for the controlled expression of structural genes, for the detection and recovery of transcriptional regulatory proteins, and for measuring the ability of compounds to act as agonist and antagonists of gene transcription.
摘要翻译：本发明提供了包含DNA调节元件的寡核苷酸序列，其包括响应于信号分子例如细胞因子而结合活化的转录调节蛋白的Ly6E GAS元件的点突变。此外，本发明还提供了包含寡核苷酸序列的DNA构建体，用DNA构建体转染的细胞，以及使用DNA构建体和转染细胞提供结构基因的受控表达以检测和回收转录调节蛋白的方法，并用于测量化合物作为基因转录激动剂和拮抗剂的能力。

6. 发明授权

US08067625B2 Fluorosurfactants 失效
标题翻译：含氟表面活性剂
公开(公告)号：US08067625B2
公开(公告)日：2011-11-29
申请号：US12307291
申请日：2007-07-02
申请人： Wolfgang Hierse , Nikolai (Mykola) Ignatyev , Martin Seidel , Elvira Montenegro , Peer Kirsch , Andreas Bathe
发明人： Wolfgang Hierse , Nikolai (Mykola) Ignatyev , Martin Seidel , Elvira Montenegro , Peer Kirsch , Andreas Bathe
IPC分类号： C07C51/60 , C07H15/00
CPC分类号： C07C69/708 , C07C67/14 , C07C67/31 , C07C229/10 , C07C303/22 , C07C309/12 , C07C309/15 , C07C323/52 , C07C329/16 , C07C381/00 , C08K5/103 , C08K5/41 , D06M13/21 , D06M2200/00
摘要： The present invention relates to fatty acid esters of polyols or sulfonated fatty acid esters or sulfonated fatty acid amides containing at least one group Y, where Y stands for CF3—(CH2)a—O—, SF5—, CF3—(CH2)a—S—, CF3CF2S—, [CF3—(CH2)a]2N— or [CF3—(CH2)a]NH—, where a stands for an integer selected from the range from 0 to 5, or formula (I), where Rf stands for CF3—(CH2)r—, CF3—(CH2)r—O—, CF3—(CH2)r—S—, CF3CF2—S—, SF5—(CH2)t— or [CF3—(CH2)r]2N—, [CF3—(CH2)r]NH— or (CF3)2N—(CH2)r—, B stands for a single bond, O, NH, NR, CH2, C(O)—O, C(O), S, CH2—O, O—C(O), N—C(O), C(O)—N, O—C(O)—N, N—C(O)—N, O—SO2 or SO2—O, R stands for alkyl having 1 to 4 C atoms, b stands for 0 or 1 and c stands for 0 or 1, q stands for 0 or 1, where at least one radical from b and q stands for 1, and r stands for 0, 1, 2, 3, 4 or 5, to processes for the preparation of these compounds, and to uses of these surface-active compounds.
摘要翻译：本发明涉及含有至少一个Y基团的多元醇或磺化脂肪酸酯或磺化脂肪酸酰胺的脂肪酸酯，其中Y代表CF 3 - （CH 2）a -O-，SF 5 - ，CF 3 - （CH 2）a -S-，CF 3 CF 2 S-，[CF 3 - （CH 2）a] 2N-或[CF 3 - （CH 2）a] NH-，其中a代表选自0至5的整数，或式（I）其中Rf代表CF3-（CH2）r-，CF3-（CH2）r-O-，CF3-（CH2）r-S-，CF3CF2-S-，SF5-（CH2）t-或[CF3-（CH2 ）r] 2N - ，[CF 3 - （CH 2）r] NH-或（CF 3）2 N-（CH 2）r - ，B代表单键，O，NH，NR，CH 2，C（O） C（O），S，CH 2 -O，O-C（O），N-C（O） O-SO 2或SO 2 -O，R代表具有1至4个C原子的烷基，b代表0或1，c代表0或1，q代表0或1，其中至少有一个来自b和q的基团对于1，r代表0,1,2,3,4或5，用于制备这些化合物的方法，以及这些表面活性化合物的用途。

7. 发明授权

US07750032B2 Compounds and compositions as PPAR modulators 失效
标题翻译：化合物和组合物作为PPAR调节剂
公开(公告)号：US07750032B2
公开(公告)日：2010-07-06
申请号：US11815096
申请日：2006-02-03
申请人： Christopher Cow , Robert Epple , Xing Wang , Yongping Xie , Hans Martin Seidel
发明人： Christopher Cow , Robert Epple , Xing Wang , Yongping Xie , Hans Martin Seidel
IPC分类号： C07D213/64 , C07D265/30 , C07D233/64 , C07D231/12 , C07D413/10 , C07D401/04 , A61K31/4155 , A61K31/4178 , A61K31/4164 , A61K31/4439 , A61K31/5377
CPC分类号： C07D249/08 , C07D401/04 , C07D403/04 , C07D405/04
摘要： The invention provides trisubstituted pyrazoles and imidazoles of Formula I: wherein L2, q, R13, R14, R15, R16, Z1 and Z2 are as described in the Summary of the Invention; and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the peroxisome proliferator-activated receptor (PPAR) families, particularly the activity of PPARδ.
摘要翻译：本发明提供式I的三取代吡唑和咪唑：其中L2，q，R13，R14，R15，R16，Z1和Z2如发明概述所述; 以及使用这些化合物治疗或预防与过氧化物酶体增殖物激活受体（PPAR）家族的活性相关的疾病或病症的方法，特别是PPARδ的活性。

8. 发明申请

US20090320718A1 FLUOROSURFACTANTS 审中-公开
标题翻译：氟化物
公开(公告)号：US20090320718A1
公开(公告)日：2009-12-31
申请号：US12307218
申请日：2007-07-02
申请人： Wolfgang Hierse , Nikolai (Mykola) Ignatyev , Martin Seidel , Elvira Montenegro , Peer Kirsch , Andreas Bathe
发明人： Wolfgang Hierse , Nikolai (Mykola) Ignatyev , Martin Seidel , Elvira Montenegro , Peer Kirsch , Andreas Bathe
IPC分类号： C09D7/12 , C07C211/03 , C07C303/02
CPC分类号： C07C323/66 , A61K8/70 , A61Q19/00 , B01F17/0035 , B03D1/01 , B03D1/012 , B03D1/014 , B03D1/016 , B03D2203/005 , C07C211/15 , C07C211/21 , C07C211/28 , C07C215/08 , C07C215/24 , C07C217/08 , C07C217/10 , C07C309/10 , C07C309/14 , C07C323/52 , C11D1/004
摘要： The present invention relates to the use of end groups Y, where Y stands for CF3(CH2)aS— or CF3CF2S— or [CF3—(CH2)a]2N—, where a stands for an integer selected from the range from 0 to 5, as end group in surface-active compounds, to corresponding novel compounds, and to processes for the preparation of these compounds.
摘要翻译：本发明涉及端基Y的用途，其中Y代表CF 3（CH 2）a -S-或CF 3 CF 2 S-或[CF 3 - （CH 2）a] 2 N-，其中a代表选自0〜 5，作为表面活性化合物中的端基，相应的新化合物，以及这些化合物的制备方法。

9. 发明申请

US20110088594A1 FLUOROSURFACTANTS 审中-公开
标题翻译：氟化物
公开(公告)号：US20110088594A1
公开(公告)日：2011-04-21
申请号：US12997356
申请日：2009-05-15
申请人： Eckhard Claus , Fanny Schooren , Martin Seidel , Wolfgang Hierse , Peer Kirsch
发明人： Eckhard Claus , Fanny Schooren , Martin Seidel , Wolfgang Hierse , Peer Kirsch
IPC分类号： C09D7/12 , C07C311/16 , C07C69/76 , C07C67/14 , C07C67/08
CPC分类号： C07C69/78 , B01F17/0035 , C07C69/76 , C07C311/16
摘要： The present invention relates to compounds of the formulae (I), (II) and (III), to the use of compounds containing at least one perfluoro-tert-butoxy group and at least one substituted or unsubstituted aromatic end group as surface-active agent, and to a process for the preparation of compounds of the formula (II).
摘要翻译：本发明涉及使用含有至少一个全氟叔丁氧基和至少一个取代或未取代的芳族端基作为表面活性的化合物的式（I），（II）和（III）的化合物试剂，以及制备式（II）化合物的方法。

10. 发明申请

US20100152081A1 Fluorosurfactants 审中-公开
标题翻译：含氟表面活性剂
公开(公告)号：US20100152081A1
公开(公告)日：2010-06-17
申请号：US12307325
申请日：2007-07-02
申请人： Wolfgang Hierse , Nikolai (Mykola) Ignatyev , Martin Seidel , Elvira Montenegro , Peer Kirsch , Andreas Bathe
发明人： Wolfgang Hierse , Nikolai (Mykola) Ignatyev , Martin Seidel , Elvira Montenegro , Peer Kirsch , Andreas Bathe
IPC分类号： C10M135/28 , C09D5/00 , A62D1/00 , D06M13/256 , C10M131/12 , C10M133/08 , C10M135/22 , C10M105/14 , C11D1/24 , C07C303/02 , C07C309/34 , C07C309/29
CPC分类号： C07C309/42 , B01F17/0035 , C07C309/43 , C07C309/46 , C07C309/47 , C07C323/66 , C07C381/00 , C11D1/002 , C11D1/004 , C11D1/22 , C11D3/245 , C11D3/3418 , C11D7/34
摘要： The invention relates to compounds comprising an aryl sulfonate group, a spacer and a Y group, wherein Y represents CF3—(CH2)a—O—, SF5—, CF3—(CH2)a—S—, CF3CF2S—, [CF3—(CH2)a]2N— or [CF3—(CH2)a]NH—, a represents a whole number selected from the range of 0 to 5 or (formula I), Rf represents CF3—(CH2)r—, CF3—(CH2)r—O—, CF3—(CH2)r—S—, CF3CF2—S—, SF5—(CH2)r— or [CF3—(CH2)r]2N—, [CF3—(CH2)r]NH— or (CF3)2N—(CH2)r—, B represents a simple bond, O, NH, NR, CH2, C(O)—O, C(O), S, CH2—O, O—C(O), N—C(O)1C(O)—N, O—C(O)—N, N—C(O)—N, O—SO2 or SO2—O, R represents alkyl having 1 to 4 C-atoms, b represents 0 or 1 and c represents 0 or 1, q represents 0 or 1, at least one radical from b and q represents 1, and r represents 0, 1, 2, 3, 4 or 5. The invention also relates to a method for the production of said compounds and to the uses of said surface-active compounds.
摘要翻译：本发明涉及包含芳基磺酸酯基，间隔基和Y基团的化合物，其中Y表示CF 3 - （CH 2）a -O-，SF 5 - ，CF 3 - （CH 2）a -S-，CF 3 CF 2 S-，[CF 3 - （CH2）a] 2N-或[CF3-（CH2）a] NH-，a表示选自0至5或（式I）范围内的整数，Rf表示CF 3 - （CH 2）r - ，CF 3 - （CH2）r-O-，CF3-（CH2）r-S-，CF3CF2-S-，SF5-（CH2）r-或[CF3-（CH2）r] 2N-，[CF3-（CH2） NH - 或（CF 3）2 N - （CH 2）r - ，B表示简单键，O，NH，NR，CH 2，C（O）-O，C（O），S，CH 2 -O，O-C O），N-C（O）1C（O）-N，O-C（O）-N，N-C（O）-N，O-SO 2或SO 2 -O，R表示具有1〜原子，b表示0或1，c表示0或1，q表示0或1，b和q中的至少一个基团表示1，r表示0,1,2,3,4或5.本发明也涉及生产所述化合物的方法和所述表面活性化合物的用途。

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