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    • 8. 发明授权
    • Method for producing n-(phosphonomethyl) glycine
    • 制备n-(膦酰基甲基)甘氨酸的方法
    • US06730813B2
    • 2004-05-04
    • US10204037
    • 2002-08-16
    • Martin HitzlerFranz ThalhammerBenedikt Hammer
    • Martin HitzlerFranz ThalhammerBenedikt Hammer
    • C07F930
    • C07F9/3813
    • The invention relates to a method for producing N-(phosphonomethyl)glycine involving the following steps: (a) oxidizing N-(phosphonomethyl)iminodiacetic acid (PMIDA) with peroxides or oxygen in an aqueous medium and in the presence of a heterogeneous catalyst at a temperature ranging from 50 to 150° C.; (b) subsequently separating the solid catalyst out of the aqueous reaction suspension of step (a); (c) concentrating the clear reaction solution from step (b), especially by evaporation, and; (d) separating the N-(phosphonomethyl)glycine out of the concentrated reaction solution from step (c), especially by filtration. According to the invention, the aqueous reaction solution from step (d) (mother liquor) is returned with small amounts of N-(phosphonomethyl)glycine and byproducts to step (b) (catalyst separation) and/or to step (c) (concentration). This results in distinctly increasing the yield with a constant product purity and in noticeably reducing the amount of mother liquor.
    • 本发明涉及一种生产N-(膦酰基甲基)甘氨酸的方法,包括以下步骤:(a)在水性介质中和在多相催化剂存在下,用过氧化物或氧气氧化N-(膦酰基甲基)亚氨基二乙酸(PMIDA) 温度范围为50至150℃; (b)随后将固体催化剂从步骤(a)的水性反应悬浮液中分离出来; (c)浓缩步骤(b)的澄清反应溶液,特别是通过蒸发浓缩; (d)从步骤(c)的浓缩反应溶液中分离出N-(膦酰基甲基)甘氨酸,特别是通过过滤。 根据本发明,将步骤(d)的反应液(母液)与少量N-(膦酰基甲基)甘氨酸和副产物返回到步骤(b)(催化剂分离)和/或步骤(c)( 浓度)。 这导致以恒定的产物纯度显着提高产率,并显着降低母液的量。