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1. 发明授权

US08598339B2 Withanolide isolated from Physalis longifolia and analogs and methods of use thereof 有权
标题翻译：从天竺葵和类似物中分离出的脱脂酸酯及其使用方法
公开(公告)号：US08598339B2
公开(公告)日：2013-12-03
申请号：US13363476
申请日：2012-02-01
申请人： Barbara N. Timmermann , Jeffrey Aube , Huaping Zhang , Rao Gollapudi , Mark S. Cohen , Abbas Samadi , Hashim Fakhsuddin-Motiwala
发明人： Barbara N. Timmermann , Jeffrey Aube , Huaping Zhang , Rao Gollapudi , Mark S. Cohen , Abbas Samadi , Hashim Fakhsuddin-Motiwala
IPC分类号： C07J71/00
CPC分类号： C07J71/001 , C07J17/00 , C07J17/005 , C07J41/0055 , C07J61/00
摘要： The present invention features novel withanolides, as well as analogs and salts thereof, for use in the treatment of proliferative disease, cardiovascular disease, neurodegenerative disease and inflammatory disease.
摘要翻译：本发明的特征在于用于治疗增殖性疾病，心血管疾病，神经退行性疾病和炎症性疾病的新颖的脱乙酰壳多糖及其类似物和盐。

2. 发明授权

US08179135B2 Low field electron paramagnetic resonance imaging with SQUID detection 有权
标题翻译：低场电子顺磁共振成像与SQUID检测
公开(公告)号：US08179135B2
公开(公告)日：2012-05-15
申请号：US12359576
申请日：2009-01-26
申请人： Inseob Hahn , Peter K. Day , Konstantin I. Penanen , Byeong H. Eom , Mark S. Cohen
发明人： Inseob Hahn , Peter K. Day , Konstantin I. Penanen , Byeong H. Eom , Mark S. Cohen
IPC分类号： G01V3/00
CPC分类号： G01R33/60 , G01R33/326
摘要： In one embodiment, a flux transformer with a gradiometer pickup coil is magnetically coupled to a SQUID, and a SQUID array amplifier comprising a plurality of SQUIDs, connected in series, is magnetically coupled to the output of the SQUID. Other embodiments are described and claimed.
摘要翻译：在一个实施例中，具有梯度计拾取线圈的磁通变压器磁耦合到SQUID，并且包括串联连接的多个SQUID的SQUID阵列放大器磁耦合到SQUID的输出端。描述和要求保护其他实施例。

3. 发明申请

US20120196815A1 Withanolide Isolated from Physalis longifolia and Analogs and Methods of Use Thereof 有权
标题翻译：从肌肉中分离的脱脂酸酯及其类似物及其使用方法
公开(公告)号：US20120196815A1
公开(公告)日：2012-08-02
申请号：US13363476
申请日：2012-02-01
申请人： Barbara N. Timmermann , Jeffrey Aube , Huaping Zhang , Rao Gollapudi , Mark S. Cohen , Abbas Samadi , Hashim Fakhruddin-Motiwala
发明人： Barbara N. Timmermann , Jeffrey Aube , Huaping Zhang , Rao Gollapudi , Mark S. Cohen , Abbas Samadi , Hashim Fakhruddin-Motiwala
IPC分类号： A61K31/704 , C07G3/00 , A61K31/58 , A61P35/00 , A61P9/12 , C12N5/07 , A61P25/16 , A61P25/28 , A61P25/00 , A61P11/06 , A61P19/02 , C07J71/00 , A61P9/10
CPC分类号： C07J71/001 , C07J17/00 , C07J17/005 , C07J41/0055 , C07J61/00
摘要： The present invention features novel withanolides, as well as analogs and salts thereof, for use in the treatment of proliferative disease, cardiovascular disease, neurodegenerative disease and inflammatory disease.
摘要翻译：本发明的特征在于用于治疗增殖性疾病，心血管疾病，神经退行性疾病和炎症性疾病的新颖的脱乙酰壳多糖及其类似物和盐。

4. 发明申请

US20120182014A1 MAGNETIC RESONANCE MICROCOIL AND METHOD OF USE 审中-公开
标题翻译：磁共振微球及其使用方法
公开(公告)号：US20120182014A1
公开(公告)日：2012-07-19
申请号：US13390035
申请日：2010-08-11
申请人： Debra Strick Rivera , Jack W. Judy , Mark S. Cohen , Dixie J. Mills
发明人： Debra Strick Rivera , Jack W. Judy , Mark S. Cohen , Dixie J. Mills
IPC分类号： G01R33/44
CPC分类号： A61B5/055 , A61B5/4094 , A61B5/6846 , G01R33/287 , G01R33/34084
摘要： A magnetic resonance imaging device includes an elongate flexible member having a proximal end, a distal end, and a lumen extending between the proximal end and the distal end and a solenoid coil affixed to the distal end of the elongate flexible member, the solenoid coil having a plurality of wire turns, the solenoid coil connected to a twisted-pair of leads extending proximally along the length of the flexible member. A connector is disposed at the proximal end of the elongate flexible member, the connector operatively coupled to the twisted-pair of leads. In an alternative embodiment, a coaxial cable substitutes for the lumen-containing elongate flexible member.
摘要翻译：磁共振成像装置包括具有近端，远端和在近端和远端之间延伸的内腔的细长柔性构件和固定到细长柔性构件的远端的螺线管线圈，螺线管线圈具有多个线圈，螺线管线圈连接到沿着柔性构件的长度向近侧延伸的双绞线。连接器设置在细长柔性构件的近端处，连接器可操作地连接到双绞线引线。在替代实施例中，同轴电缆代替含内腔的细长柔性构件。

5. 发明申请

US20090295390A1 LOW FIELD ELECTRON PARAMAGNETIC RESONANCE IMAGING WITH SQUID DETECTION 有权
标题翻译：低场电子参考谐波成像与检测
公开(公告)号：US20090295390A1
公开(公告)日：2009-12-03
申请号：US12359576
申请日：2009-01-26
申请人： Inseob Hahn , Peter K Day , Konstantin I Penanen , Byeong H. Eom , Mark S Cohen
发明人： Inseob Hahn , Peter K Day , Konstantin I Penanen , Byeong H. Eom , Mark S Cohen
IPC分类号： G01R33/60 , G01R33/32
CPC分类号： G01R33/60 , G01R33/326
摘要： In one embodiment, a flux transformer with a gradiometer pickup coil is magnetically coupled to a SQUID, and a SQUID array amplifier comprising a plurality of SQUIDs, connected in series, is magnetically coupled to the output of the SQUID. Other embodiments are described and claimed.
摘要翻译：在一个实施例中，具有梯度计拾取线圈的磁通变压器磁耦合到SQUID，并且包括串联连接的多个SQUID的SQUID阵列放大器磁耦合到SQUID的输出端。描述和要求保护其他实施例。

6. 发明授权

US07286871B2 Method and apparatus for reducing contamination of an electrical signal 有权
标题翻译：减少电信号污染的方法和装置
公开(公告)号：US07286871B2
公开(公告)日：2007-10-23
申请号：US10344776
申请日：2001-08-15
申请人： Mark S. Cohen
发明人： Mark S. Cohen
IPC分类号： A61B5/04
CPC分类号： A61B5/04004 , A61B5/04017 , A61B5/4094
摘要： The method of reducing contamination of electrical signals recorded in the presence of repeated interference contamination comprises obtaining an electrical signal recorded in the presence of a contaminating signal, and detecting a timing signal that occurs at a fixed time point during the electrical signal relative to the onset of the contaminating signal. The electrical signal is digitized, wherein the digitizing begins with the timing signal. A plurality of digitized electrical signals is analyzed, wherein the electrical signals are synchronized with respect to the timing signal, to obtain an estimated contaminating signal that is subtracted from the digitized electrical signal. This method can be used with electrophysiological signals, such as EEG, ECG, EMG and galvanic skin response, and for elimination of noise associated with concurrently used methods such as MRI. The method of noise reduction is applicable to recordings of other electrical signals, including audio recordings.
摘要翻译：在存在重复的干扰污染的情况下减少记录的电信号的污染的方法包括获得在存在污染信号的情况下记录的电信号，以及检测在电信号期间相对于起始点的固定时间点发生的定时信号的污染信号。电信号被数字化，其中数字化以定时信号开始。分析多个数字化电信号，其中电信号相对于定时信号同步，以获得从数字化电信号中减去的估计污染信号。该方法可用于电生理信号，如EEG，ECG，EMG和电流皮肤反应，以及消除与同时使用的方法如MRI相关的噪声。噪声降低的方法适用于包括音频记录在内的其他电信号的记录。

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