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1. 发明申请

US20100310474A1 PROTEIN CAGES FOR THE DELIVERY OF MEDICAL IMAGING AND THERAPEUTIC AGENTS 审中-公开
标题翻译：用于输送医学成像和治疗药物的蛋白质印刷
公开(公告)号：US20100310474A1
公开(公告)日：2010-12-09
申请号：US12752905
申请日：2010-04-01
申请人： Mark J. YOUNG , Trevor Douglas , Yves U. Idzerda
发明人： Mark J. YOUNG , Trevor Douglas , Yves U. Idzerda
IPC分类号： A61K49/22 , A61K49/18 , A61K49/04 , A61K49/00 , C12N5/071 , A61P35/00
CPC分类号： A61K31/70 , A61K49/0002 , A61K49/189 , B82Y5/00
摘要： The present invention is directed to novel compositions and methods utilizing delivery agents comprising protein cages, medical imaging agents and therapeutic agents.
摘要翻译：本发明涉及使用包含蛋白质笼，医学成像剂和治疗剂的递送剂的新型组合物和方法。

2. 发明申请

US20100021391A1 NOVEL NANOPARTICLES FOR BIOFILM TARGETING 审中-公开
标题翻译：用于生物指标的新型纳米颗粒
公开(公告)号：US20100021391A1
公开(公告)日：2010-01-28
申请号：US11777944
申请日：2007-07-13
申请人： Trevor Douglas , Mark J. Young , Peter Suci
发明人： Trevor Douglas , Mark J. Young , Peter Suci
IPC分类号： A61K49/14 , A61K49/04 , A61K49/22
CPC分类号： G01N33/569
摘要： The present invention is directed to novel compositions and methods utilizing nanoparticles comprising protein cages for delivery of imaging and antimicrobial agents to biofilm forming bacterial colonies.
摘要翻译：本发明涉及使用纳米颗粒的新型组合物和方法，所述纳米颗粒包含用于将成像和抗微生物剂递送至生物膜形成细菌菌落的蛋白质笼。

3. 发明申请

US20090256861A1 Device and Method for Managing the Orientation of Information Being Displayed on the Screen of a Device 审中-公开
标题翻译：用于管理在设备屏幕上显示的信息的方向的设备和方法
公开(公告)号：US20090256861A1
公开(公告)日：2009-10-15
申请号：US12343141
申请日：2008-12-23
申请人： Heiko K. Sacher , Andrew K. Wells , Mark J. Young
发明人： Heiko K. Sacher , Andrew K. Wells , Mark J. Young
IPC分类号： G09G5/32 , G09G5/00
CPC分类号： H04M1/0222 , G06F1/1624 , G06F1/1662 , G06F1/1677 , G06F2200/1614 , H04M1/0241
摘要： A hand-held device and method for managing the orientation of information being displayed on the screen of a hand-held device is provided for devices having a two part slidable housing including a first housing and a second housing where the two housings are adapted to slide separately in multiple directions relative to one another along a corresponding path substantially parallel to a front facing of the device between an opened position and a closed position. The method takes into account a detected use mode, such as whether the device is engaged in a voice call communication, and a detected device configuration to determine the orientation of the information to be displayed on the device screen. When the first housing is slid relative to the second housing between a closed position and an opened position in a first direction, the information is displayed having a portrait orientation. The information is displayed having a landscape orientation, when the first housing is slid relative to the second housing between a closed position and an opened position in a second direction. When the hand-held device is in a voice call and the first housing is slid relative to the second housing between an opened position and a closed position, the information is displayed having a portrait orientation. When the hand-held device is not in a voice call and the first housing is slid relative to the second housing between an opened position and a closed position, the orientation of the information being displayed is not changed.
摘要翻译：提供了一种用于管理正在显示在手持式装置的屏幕上的信息的方位的手持式装置和方法，该装置具有两部分可滑动的壳体，该两部分可滑动的壳体包括第一壳体和第二壳体，其中两个壳体适于滑动在相对于彼此的多个方向上沿着基本上平行于打开位置和关闭位置之间的装置的前面的对应路径分开。该方法考虑了检测到的使用模式，例如设备是否进行语音呼叫通信，以及检测到的设备配置以确定要在设备屏幕上显示的信息的方向。当第一壳体相对于第二壳体在第一方向上的关闭位置和打开位置之间滑动时，显示具有纵向取向的信息。当第一壳体相对于第二壳体在第二方向上的关闭位置和打开位置之间滑动时，信息被显示为具有横向。当手持装置处于语音呼叫中并且第一壳体相对于第二壳体在打开位置和关闭位置之间滑动时，显示具有纵向方向的信息。当手持装置不在语音呼叫中并且第一壳体相对于第二壳体在打开位置和关闭位置之间滑动时，正在显示的信息的取向不改变。

4. 发明授权

US06984386B2 Nanoscale particles synthesized within an assembled virion 失效
标题翻译：在组装的病毒粒子内合成的纳米级颗粒
公开(公告)号：US06984386B2
公开(公告)日：2006-01-10
申请号：US09734206
申请日：2000-12-12
申请人： Trevor Douglas , Mark J. Young
发明人： Trevor Douglas , Mark J. Young
IPC分类号： A61K39/12
CPC分类号： A61K9/5184 , A61K47/6901 , C07K14/005 , C10M171/06 , C12N7/00 , C12N2710/14143 , C12N2770/14022 , C12N2770/14023 , G03C1/035 , G03C2200/38 , Y10S977/773 , Y10S977/802 , Y10S977/829 , Y10S977/83 , Y10S977/92
摘要： Virion-constrained nanoparticles comprising a shell of virion coat protein(s) surrounding an organic, inorganic and/or organo-metallic non-viral nanoparticle and methods of making and using.
摘要翻译：包含有机，无机和/或有机金属非病毒纳米颗粒周围的病毒粒子外壳蛋白的壳的病毒载体纳米颗粒及其制备和使用方法。

5. 发明授权

US06451603B1 Ribozyme nucleic acids and methods of use thereof for controlling viral pathogens 失效
标题翻译：核酶核酸及其用于控制病毒病原体的方法
公开(公告)号：US06451603B1
公开(公告)日：2002-09-17
申请号：US08362478
申请日：1995-03-02
申请人： David G. Atkins , Wayne L. Gerlach , Mark J. Young
发明人： David G. Atkins , Wayne L. Gerlach , Mark J. Young
IPC分类号： C07H2104
CPC分类号： C12N15/8283
摘要： The invention consists of a non-naturally occurring nucleic acid molecule capable of blocking or interfering with a replicative intermediate of a virus, a virusoid, or a viroid. The nucleic acid molecule may contain a ribozyme or a plurality of ribozymes. Alternatively, the nucleic acid molecule may be an antisense nucleic acid molecule. The ribozyme may be a hairpin ribozyme, a hammerhead ribozyme, an RNAase P ribozyme, a minizyme, or other catalytic RNA molecule. The virus may be an animal, a mammalian, a plant, a fungal, a protozoan, a yeast, a bacterial virus, or a human virus. The nucleic acid molecule may be expressed in the cell or it may be preformed and administered ex vivo. The present invention contemplates methods of controlling infection of a pathogenic infectious agent in a plant or animal.
摘要翻译：本发明由能够阻断或干扰病毒，病毒样或病毒的复制中间体的非天然存在的核酸分子组成。核酸分子可以含有核酶或多个核酶。或者，核酸分子可以是反义核酸分子。核酶可以是发夹核酶，锤头核酶，RNA酶P核酶，微型酶或其它催化RNA分子。病毒可以是动物，哺乳动物，植物，真菌，原生动物，酵母，细菌病毒或人类病毒。核酸分子可以在细胞中表达，或者其可以预先形成并且离体施用。本发明考虑了控制植物或动物中病原体感染因子感染的方法。

6. 发明授权

US06180389B2 Virion-constrained nanoparticles comprising a plant virion coat protein shell and encapsulated guest molecules 失效
标题翻译：包含植物病毒粒子外壳蛋白壳和包封的客体分子的病毒载体纳米颗粒
公开(公告)号：US06180389B2
公开(公告)日：2001-01-30
申请号：US08775366
申请日：1997-01-03
申请人： Trevor Douglas , Mark J. Young
发明人： Trevor Douglas , Mark J. Young
IPC分类号： C12N700
CPC分类号： A61K9/5184 , A61K47/6901 , C07K14/005 , C10M171/06 , C12N7/00 , C12N2710/14143 , C12N2770/14022 , C12N2770/14023 , G03C1/035 , G03C2200/38 , Y10S977/773 , Y10S977/802 , Y10S977/829 , Y10S977/83 , Y10S977/92
摘要： A virion-constrained nanoparticle of the invention comprises a shell of a virion coat protein(s) that encapsulates a core non-viral material, which is organic, inorganic or organometallic in nature. A particularly preferred virion coat is that of cowpea chlorotic mottle virus (CCMV). Encapsulation of a desired particle is effected by adjusting reaction conditions, e.g., by lowering the pH of a solution containing the virion protein and the non-viral substance. Processes for producing the virion-constrained nanoparticles of the invention are also described.
摘要翻译：本发明的病毒粒子约束的纳米颗粒包含封装核心非病毒材料的病毒粒子外壳蛋白的外壳，核心非病毒材料本质上是有机的，无机的或有机金属的。特别优选的病毒粒子是cow豆褪绿斑马鱼病毒（CCMV）。通过调节反应条件例如通过降低含有病毒粒子蛋白质和非病毒物质的溶液的pH来实现所需颗粒的封装。还描述了用于制备本发明的病毒粒子约束纳米颗粒的方法。

7. 发明授权

US5941584A Roast lifting tool 失效
标题翻译：起重工具
公开(公告)号：US5941584A
公开(公告)日：1999-08-24
申请号：US991067
申请日：1997-12-15
申请人： Mark J. Young , Lars T. Jonasson , James L. Bryce
发明人： Mark J. Young , Lars T. Jonasson , James L. Bryce
IPC分类号： A47J37/07 , A47J43/18 , B65G7/12
CPC分类号： B65G7/12 , A47J37/0786 , A47J43/18
摘要： A lifting tool for roasted meat, having a main handle with a longitudinal handle axis, a first handle end and a second handle end. A pair of tines are spaced apart, each having a tine base end and a tine tip end and being formed with a substantially continuous curve which is concave when viewed from the second handle end. A pair of cross members connect the first handle end to the tine base ends. Preferably, an auxiliary handle is provided, having a gripping region and being affixed such that the curve of the tines is concave when viewed from the gripping region. The auxiliary handle preferably has an auxiliary handle base section which extends upwards from the cross members and an auxiliary handle set-back section which connects the auxiliary handle base section to the gripping region and which extends towards the second handle end. The lifting tool preferably has a stabilizing prong having a longitudinal prong axis which is parallel to the handle axis, and a prong tip which is pointed. It is also preferred for each of the tine tip ends to be contoured with a sloped surface and rounded.
摘要翻译：一种用于烤肉的起重工具，具有纵向手柄轴线的主把手，第一把手端部和第二把手端部。一对尖齿间隔开，每个齿具有齿尖基端和齿尖端，并且形成有从第二把手端观察时为凹形的基本上连续的曲线。一对横向构件将第一手柄端连接到叉形基端。优选地，提供辅助手柄，具有抓握区域并且被固定，使得当从握持区域观察时，尖齿的曲线是凹形的。辅助手柄优选地具有从横向构件向上延伸的辅助手柄基部部分和辅助手柄固定部分，其将辅助手柄基部部分连接到抓握区域并且朝向第二手柄端部延伸。起重工具优选具有一个具有平行于手柄轴线的纵向叉轴的稳定叉和尖端的叉尖。还优选的是，每个齿尖端部具有倾斜表面并且是圆形的。

8. 发明申请

US20090041671A1 PROTEIN CAGES FOR THE DELIVERY OF MEDICAL IMAGING AND THERAPEUTIC AGENTS 审中-公开
标题翻译：用于输送医学成像和治疗药物的蛋白质印刷
公开(公告)号：US20090041671A1
公开(公告)日：2009-02-12
申请号：US12130512
申请日：2008-05-30
申请人： Mark J. Young , Trevor Douglas , Yves U. Idzerda
发明人： Mark J. Young , Trevor Douglas , Yves U. Idzerda
IPC分类号： A61K49/14
CPC分类号： A61K31/70 , A61K49/0002 , A61K49/189 , B82Y5/00
摘要： The present invention is directed to novel compositions and methods utilizing delivery agents comprising protein cages, medical imaging agents and therapeutic agents.
摘要翻译：本发明涉及使用包含蛋白质笼，医学成像剂和治疗剂的递送剂的新型组合物和方法。

9. 发明申请

US20080302669A1 Composite Nanomaterials for Photocatalytic Hydrogen Production and Method of Their Use 审中-公开
标题翻译：用于光催化氢生产的复合纳米材料及其使用方法
公开(公告)号：US20080302669A1
公开(公告)日：2008-12-11
申请号：US11914522
申请日：2006-05-16
申请人： John W. Peters , Mark J. Young , Trevor Douglas , Timothy E. Elgren
发明人： John W. Peters , Mark J. Young , Trevor Douglas , Timothy E. Elgren
IPC分类号： C25B1/02
CPC分类号： C12N11/14 , C12N9/0067 , C12P3/00
摘要： The present invention is directed to a composite material for photocatalytic H2 production comprising: 1) a polymer gel; 2) a photocatalyst; and a protein based H2 catalyst. The invention also relates to a method to produce H2, comprising reacting an electron donor with a composite material comprising 1) a polymer gel, 2) a photocatalyst, and 3) a protein based H2 catalyst.
摘要翻译：本发明涉及一种用于光催化H2生产的复合材料，包括：1）聚合物凝胶; 2）光催化剂; 和基于蛋白质的H 2催化剂。本发明还涉及产生H 2的方法，包括使电子给体与复合材料反应，所述复合材料包括1）聚合物凝胶，2）光催化剂，和3）基于蛋白质的H 2催化剂。

10. 发明授权

US07324121B2 Adaptive manipulators 失效
标题翻译：自适应操纵器
公开(公告)号：US07324121B2
公开(公告)日：2008-01-29
申请号：US10894775
申请日：2004-07-20
申请人： Mark J. Young
发明人： Mark J. Young
IPC分类号： G06T17/40
CPC分类号： G06T19/20 , G06T2219/2016
摘要： A method of repositioning a manipulator in relation to a viewport is provided in a system for interacting with a three-dimensional object configured with a manipulator. The object and the manipulator are drawn in the viewport and the position of the manipulator is constrained to lie along the viewing axis between the viewport and the object. The manipulator is represented by a geometry corresponding to the function of the manipulator. The position of the manipulator is modified as needed so that it is not obscured by other objects in the scene. Furthermore, the position of the manipulator is modified as needed following a rotation or scaling operation so that it is oriented for ease of selection by a user.
摘要翻译：在用于与配置有机械手的三维物体相互作用的系统中提供了相对于视口重新定位操纵器的方法。物体和操纵器被绘制在视口中，并且操纵器的位置被限制在视口和物体之间的观察轴上。操纵器由对应于操纵器的功能的几何形状表示。操纵器的位置根据需要进行修改，使其不会被场景中的其他物体遮蔽。此外，在旋转或缩放操作之后，根据需要修改操纵器的位置，使得其被定向以便于用户的选择。

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