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1. 发明授权

US6103267A Stabilized ascorbic acid, composition, and method of use 失效
标题翻译：稳定的抗坏血酸，组合物和使用方法
公开(公告)号：US6103267A
公开(公告)日：2000-08-15
申请号：US122828
申请日：1998-07-27
申请人： Mark A. Mitchnick , Garry Gwozdz
发明人： Mark A. Mitchnick , Garry Gwozdz
IPC分类号： A61K47/06 , A61K47/10 , A61K9/10 , A61K7/00 , A61K31/375
CPC分类号： A61K47/06 , A61K47/10 , A61K9/0014 , Y10S514/88 , Y10S514/937 , Y10S514/938
摘要： A dispersion for carrying at least one water-soluble material or water-dispersible material (especially ascorbic acid, Vitamin C) in a relatively stable form is described, the dispersion comprising an oil phase containing particles comprising water-soluble polymer, water-soluble material or water-dispersible material (ascorbic acid), and water. The dispersion preferably comprises particles which have number average diameter dimensions of less than 2 microns, more preferably less than 1 micron. The dispersion may comprise oil components such as, for example only, a mineral oil, silicone oil, or cosmetic oil. A method of forming a dispersion of solid particles which comprise water-soluble material or water-dispersible material (e.g., ascorbic acid) in a water-soluble polymer may comprise the steps of:a) forming a first solution of the water-soluble material or water-dispersible material (ascorbic acid), water and a water-soluble polymer,b) mixing the first solution with a second solution of a water in a surface active agent having an HLB of less than 12 or less than 10 and oil,c) dispersing the first solution and the second solution to form a mixture of the first solution and second solution, andd) cooling the mixture, solidifying the first solution to form particles dispersed in said oil. This method may have the emulsifying done at a temperature above 40.degree. C., preferably above 50.degree. C., more preferably above 55.degree. C.
摘要翻译：描述了用于以相对稳定的形式携带至少一种水溶性材料或水分散性材料（特别是抗坏血酸，维生素C）的分散体，该分散体包含含有水溶性聚合物，水溶性材料或水分散性材料（抗坏血酸）和水。分散体优选包含具有小于2微米，更优选小于1微米的数均粒径的颗粒。分散体可以包括油组分，例如仅矿物油，硅油或化妆油。在水溶性聚合物中形成包含水溶性材料或水分散性材料（例如抗坏血酸）的固体颗粒分散体的方法可以包括以下步骤：a）形成水溶性材料的第一溶液或水分散性材料（抗坏血酸），水和水溶性聚合物，b）将第一溶液与HLB小于12或小于10的表面活性剂和油的第二溶液混合， c）分散第一溶液和第二溶液以形成第一溶液和第二溶液的混合物，以及d）冷却混合物，固化第一溶液以形成分散在所述油中的颗粒。该方法可以在高于40℃，优选高于50℃，更优选高于55℃的温度下进行乳化。

2. 发明授权

US5756788A Silicone polymer-coated, hydrophobized metal oxides 失效
标题翻译：硅氧烷聚合物涂覆的疏水化金属氧化物
公开(公告)号：US5756788A
公开(公告)日：1998-05-26
申请号：US727714
申请日：1996-10-07
申请人： Mark A. Mitchnick , Anthony J. O'Lenick
发明人： Mark A. Mitchnick , Anthony J. O'Lenick
IPC分类号： A61K8/11 , A61K8/891 , A61Q17/04 , C07F7/08 , A61K7/112 , C07F3/06
CPC分类号： A61K8/11 , A61K8/891 , A61Q17/04 , C07F7/0859 , A61K2800/412
摘要： A process for making metal oxide hydrophobic by coating the metal oxide with a silicone polymer is disclosed. The hydrophobic metal oxide is prepared by contacting the metal oxide with a reactive silicone compound and then in a subsequent step the coated metal oxide is heated to 40.degree. to 100.degree. C. for between 1 and 10 hours. The resulting metal oxide is hydrophobic, non-reactive, not affected by water and can be applied to the skin for protection from ultraviolet light of the sun.
摘要翻译：公开了通过用硅氧烷聚合物涂覆金属氧化物制备金属氧化物疏水性的方法。通过使金属氧化物与活性硅氧烷化合物接触来制备疏水性金属氧化物，然后在随后的步骤中，将涂覆的金属氧化物加热至40℃至100℃，持续1至10小时。所得金属氧化物是疏水性的，不反应的，不受水影响，可以施加到皮肤上以防止太阳紫外线的照射。

3. 再颁专利

USRE42982E1 Antimicrobial release system 有权
标题翻译：抗菌药物释放系统
公开(公告)号：USRE42982E1
公开(公告)日：2011-11-29
申请号：US12074194
申请日：2008-02-29
申请人： Mark A. Mitchnick
发明人： Mark A. Mitchnick
IPC分类号： A61M5/32 , A61M25/00 , A61L33/00 , B05D3/00 , A61F13/00 , A61F2/00
CPC分类号： A61L31/16 , A61F2310/00389
摘要： The present invention relates to medical devices that are inserted or implanted into patients and that have antimicrobial coatings that release free radicals into the vicinity of the device. These devices may have coatings that alter their rate of flow release or elution release of an antibacterial agent from a coating on the device upon external stimulation. The coating should therefore be responsive to external control such as by heating, external RF stimulus, sonic control, visible or ultraviolet light exposure and the like. By having control of the release rate, and in some structures without invasion of the patient by mechanical means in addition to the device itself, the release rate can be in response to need at the implant site. The class of compounds to be released are free radical generating or initiating compounds, or compounds that release free radicals upon immersion or stimulation, the free radicals acting as the antimicrobial agent. Medical devices that are inserted or implanted into patients and have antimicrobial coatings that release free radicals into the vicinity of the device. These devices may have coatings that alter their rate of flow release or elution release of an antibacterial agent from a coating on the device upon external stimulation. The coating should therefore be responsive to external control such as heating, external RF stimulus, sonic control, visible or ultraviolet light exposure and the like. By having control of the release rate, and in some structures without invasion of the patient by mechanical means in addition to the device itself, the release rate can be in response to need at the implant site. The compounds released comprise free radicals or free radical generating compounds that release free radicals upon immersion or stimulation, the free radicals acting as the antimicrobial agent.
摘要翻译：本发明涉及插入或植入患者体内并具有将自由基释放到装置附近的抗微生物涂层的医疗装置。这些装置可以具有涂层，其可以在外部刺激时改变抗菌剂从装置上的涂层的流量释放或洗脱释放速率。因此，涂层应该是通过加热，外部RF刺激，声音控制，可见光或紫外光照射等外部控制来响应的。通过控制释放速率，并且在一些结构中，除了装置本身之外，还没有通过机械手段侵入患者，释放速率可以是在植入部位的需要。要释放的化合物类是自由基产生或引发化合物，或在浸渍或刺激时释放自由基的化合物，作为抗微生物剂的自由基。插入或植入患者并具有将自由基释放到装置附近的抗微生物涂层的医疗装置。这些装置可以具有涂层，其可以在外部刺激时改变抗菌剂从装置上的涂层的流量释放或洗脱释放速率。因此，涂层应对外部控制，如加热，外部RF刺激，声波控制，可见光或紫外线曝光等。通过控制释放速率，并且在一些结构中，除了装置本身之外，还没有通过机械手段侵入患者，释放速率可以是在植入部位的需要。释放的化合物包括自由基或自由基产生化合物，其在浸渍或刺激时释放自由基，自由基用作抗微生物剂。

4. 发明授权

US6045650A Hydrophilic materials and their method of preparation 失效
标题翻译：亲水材料及其制备方法
公开(公告)号：US6045650A
公开(公告)日：2000-04-04
申请号：US931623
申请日：1997-09-16
申请人： Mark A. Mitchnick , Garry Gwozdz , William A. Hendrickson
发明人： Mark A. Mitchnick , Garry Gwozdz , William A. Hendrickson
IPC分类号： B01J2/00 , C09C3/06 , C09C3/08 , C09C3/12 , B05B31/00
CPC分类号： C09C3/08 , B01J2/006 , C09C3/06 , C09C3/12 , C01P2002/84 , C01P2004/60 , C01P2004/80 , C01P2006/60 , C01P2006/90 , Y10T428/2993
摘要： A process is described for applying a solid coating onto a surface of an article. The surface of an article has a first physical property measurable as a degree of hydrophobicity and/or hydrophilicity. A liquid coating of an oxidizable material containing at least one element other than carbon, hydrogen, oxygen and nitrogen is applied onto the surface of the article. The oxidizable material is oxidized on the surface to attach an oxidized material having said at least one element other than carbon, oxygen, nitrogen and hydrogen onto said surface. This process thereby changes the first physical property with respect to its hydrophobicity and/or hydrophilicity. The process is relatively gentle to the underlying surface, at least in part because of the moderate temperatures which may be used for oxidation, and a wide range of properties may be provided onto the surface by appropriate selection and/or mixing of the liquid material and selection of the surface. The process is particularly useful with particulate materials.
摘要翻译：描述了将固体涂层施加到制品的表面上的方法。制品的表面具有可测量为疏水性和/或亲水性的第一物理性质。将包含至少一种除碳，氢，氧和氮之外的元素的可氧化材料的液体涂层施加到制品的表面上。可氧化材料在表面上被氧化，以将具有除了碳，氧，氮和氢以外的至少一种元素的氧化材料附着到所述表面上。因此，该方法相对于其疏水性和/或亲水性而改变第一物理性质。该方法至少部分地由于可用于氧化的中等温度而相对温和，并且可以通过适当选择和/或混合液体材料和选择表面。该方法对颗粒材料特别有用。

5. 发明授权

US5733531A Composite UV sunblock compositions 失效
标题翻译：复合UV防晒组合物
公开(公告)号：US5733531A
公开(公告)日：1998-03-31
申请号：US251740
申请日：1994-06-01
申请人： Mark A. Mitchnick , Garry T. Gwozdz , Fortunato J. Micale
发明人： Mark A. Mitchnick , Garry T. Gwozdz , Fortunato J. Micale
IPC分类号： A61K8/00 , A61K8/04 , A61K8/11 , A61K8/27 , A61K8/31 , A61K8/33 , A61K8/35 , A61K8/36 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/90 , A61K8/92 , A61K8/97 , A61K8/98 , A61Q17/04 , A61K7/42 , A61K7/44 , A61K9/10 , A61K9/14
CPC分类号： A61K8/922 , A61K8/0283 , A61K8/27 , A61K8/31 , A61K8/35 , A61K8/37 , A61K8/40 , A61K8/445 , A61K8/4946 , A61Q17/04 , A61K2800/262 , A61K2800/412 , Y10S514/844 , Y10S514/847 , Y10S514/938
摘要： The invention encompasses topical sunblock formulae for shielding skin from ultraviolet radiation, and a composite sunblocking component thereof. The sunblocking component of the formula includes an effective amount of a plurality of particles having diameters in the range of about 0.01-100 microns, each particle including a matrix and a UV-attenuating compound incorporated into the matrix. The composite sunblocking component may include a particle that is colored or transparent, depending upon the matrix, UV-attenuating compound and the particle size. The sunblocking component is dispersible in water and thus in water-based dermatological carriers. The formula includes these particles dispersed within a dermatologically acceptable liquid carrier in at least an amount sufficient to shield substantially all of the skin over which the formula is applied from hazardous effects of ultraviolet radiation.
摘要翻译：本发明包括用于屏蔽皮肤免受紫外线辐射的局部防晒霜配方及其复合防晒组合物。式的防晒组分包括有效量的直径在约0.01-100微米范围内的多个颗粒，每个颗粒包括掺入基质中的基质和UV-衰减化合物。复合防晒组分可以包括着色或透明的颗粒，这取决于基质，UV-衰减化合物和颗粒大小。防晒组分可分散在水中，因此分散在水性皮肤病学载体中。该配方包括这些颗粒分散在皮肤病学可接受的液体载体内，其至少足以基本上屏蔽由紫外线辐射的有害作用施用配方的所有皮肤。

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