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1. 发明授权

US07901558B2 Integrated 2D gel electrophoresis method and system 有权
标题翻译：集成2D凝胶电泳方法及系统
公开(公告)号：US07901558B2
公开(公告)日：2011-03-08
申请号：US11278975
申请日：2006-04-07
申请人： Mario Curcio , Martin Kopp
发明人： Mario Curcio , Martin Kopp
IPC分类号： G01N27/26 , G01N27/447
CPC分类号： G01N27/44773 , G01N27/44795
摘要： Described is a process for the separation of a sample mixture for analytical reason based on two-dimensional gel electrophoresis. The method is involving a first separation in a first gel strip on the basis of isoelectric points and a second separation in a second gel on the basis of molecular size. When starting the separation in the second dimension the buffer solution for transferring the compounds separated in the first dimension into the second dimension gel is containing sodium dodecyl-sulfate (SDS) and by applying an electric field the SDS migrates electrokinetically into the first gel strip, and the compounds are being complexed simultaneously with SDS.
摘要翻译：描述了基于二维凝胶电泳的用于分析原因的样品混合物的分离方法。该方法涉及基于等电点在第一凝胶条中的第一分离，并且基于分子大小在第二凝胶中进行第二次分离。当在第二维开始分离时，用于将在第一维中分离的化合物转移到第二维凝胶中的缓冲溶液含有十二烷基硫酸钠（SDS），并且通过施加电场，SDS电动迁移到第一凝胶条中，并且化合物与SDS同时复合。

2. 发明授权

US07820023B2 Preconcentration interface coupling liquid chromatography to capillary electrophoresis 有权
标题翻译：预浓缩界面偶联液相色谱至毛细管电泳
公开(公告)号：US07820023B2
公开(公告)日：2010-10-26
申请号：US11169103
申请日：2005-06-28
申请人： Mario Curcio
发明人： Mario Curcio
IPC分类号： G01N27/447 , G01N30/02
CPC分类号： G01N27/44756 , G01N30/02 , G01N30/463 , G01N30/465 , G01N30/84 , G01N30/88 , G01N2030/8831 , B01D15/325
摘要： An arrangement for two-dimensional separation of a complex analyte mixture is provided comprising a first separation device for the separation in a first dimension and a second device for the separation in the second dimension. In the area of the interface between the first and the second device a concentration zone is arranged for concentrating the individual sample fractions or components, respectively, leaving the first device before introduction into the second device. The concentration zone is defined in a segment between two or more electrodes seen in flow direction of the sample or sample fractions to be separated. The concentration is achieved by applying a voltage between two electrodes with polarity opposite to the charge of the components of the fraction, sufficiently strong to win the dragging force of the hydrodynamic flow. The introduction into the second device is carried out by turning off the potential difference between the electrodes.
摘要翻译：提供了一种用于复杂分析物混合物的二维分离的装置，其包括用于在第一维中分离的第一分离装置和用于在第二维中分离的第二装置。在第一和第二装置之间的界面区域中，设置浓度区以分别集中各个样品级分或组分，留下第一装置，然后引入第二装置。浓缩区被定义在待分离的样品或样品部分的流动方向上看到的两个或更多个电极之间的段中。通过在两个电极之间施加极性与分数组分的电荷极性相反的电压来实现浓度，足够强以获得流体动力流的拖曳力。通过关闭电极之间的电位差来进行第二器件的引入。

3. 发明申请

US20100091273A1 Reference Light Source Device 审中-公开
标题翻译：参考光源装置
公开(公告)号：US20100091273A1
公开(公告)日：2010-04-15
申请号：US12420208
申请日：2009-04-08
申请人： Roman EGLI , Alan FURLAN , Mario CURCIO
发明人： Roman EGLI , Alan FURLAN , Mario CURCIO
IPC分类号： G01J1/10
CPC分类号： G01N21/278 , G01N21/6452 , G01N2201/06186
摘要： The present invention relates to a system for the optical detection of light from analytical samples, the system comprising an analytical instrument comprising an optical detection unit and a sample block unit for receiving a plurality of analytical samples, the system further comprising a calibration device for calibrating the optical detection unit of the analytical instrument, wherein the calibration device comprises a substrate and at least one electrically powered reference light source coupled to the substrate, said at least one reference light source emitting light being detected by the optical detection unit.
摘要翻译：本发明涉及一种用于光学检测来自分析样品的光的系统，该系统包括分析仪器，该分析仪器包括用于接收多个分析样品的光学检测单元和样品块单元，该系统还包括用于校准的校准装置所述分析仪器的光学检测单元，其中所述校准装置包括衬底和耦合到所述衬底的至少一个电力参考光源，所述至少一个参考光源发射由所述光学检测单元检测的光。

4. 发明授权

US09442109B2 Centrifugal force based microfluidic system and method for the automated analysis of samples 有权
标题翻译：基于离心力的微流体系统和样品自动分析方法
公开(公告)号：US09442109B2
公开(公告)日：2016-09-13
申请号：US12781473
申请日：2010-05-17
申请人： Rijk Edwin Oosterbroek , Mario Curcio , Stephan Korner , Brigitte Niederberger
发明人： Rijk Edwin Oosterbroek , Mario Curcio , Stephan Korner , Brigitte Niederberger
IPC分类号： C12M1/00 , G01N33/543 , B01L3/00
CPC分类号： G01N33/54326 , B01L3/502761 , B01L2200/0668 , B01L2300/0803 , B01L2400/0409 , B01L2400/043
摘要： Centrifugal force based microfluidic systems for the automated analysis of fluids involving the use of magnetically responsive particles and methods thereof are disclosed. A magnet is fixed to a supporting device of the system in correspondence to a retention zone of the system so as to rotate therewith and to generate a magnetic field which magnetically manipulates the magnetically responsive particles contained in a reaction chamber of the system.
摘要翻译：公开了用于自动分析涉及使用磁响应颗粒的流体的基于离心力的微流体系统及其方法。磁体被固定到系统的支撑装置上，与系统的保持区相对应，以便与其一起转动，并产生一个磁场，该磁场对包含在该系统的反应室中的磁响应颗粒进行磁操作。

5. 发明授权

US08394336B2 Biochemical assay 有权
标题翻译：生化试验
公开(公告)号：US08394336B2
公开(公告)日：2013-03-12
申请号：US11260913
申请日：2005-10-28
申请人： Mario Curcio
发明人： Mario Curcio
IPC分类号： G01N27/00
CPC分类号： G01N33/558
摘要： A biochemical assay is provided comprising a substrate being capable of binding at least a target analyte and eventually other constituents contained in a biological sample, a test zone on the substrate for sample application, a non-immobilized conjugate reagent provided in the test zone for labeling the analyte, the conjugate reagent being capable of specific binding to the analyte but remaining unbound to the substrate, and a flow path for transporting a washing liquid through the test zone and washing an excess of unbound conjugate reagent away from the test zone. The test zone is also a detection area for detecting the labeled analyte.
摘要翻译：提供了生物化学测定法，其包括能够结合至少目标分析物和最终结合生物样品中包含的其他成分的底物，用于样品施用的底物上的测试区域，用于标记的测试区域中提供的非固定化缀合物试剂所述分析物，所述缀合试剂能够特异性结合分析物但保持未结合到所述基底;以及流动路径，用于将洗涤液体输送通过所述测试区并将过量的未结合的缀合物洗涤离开所述测试区。测试区也是用于检测标记分析物的检测区域。

6. 发明申请

US20070144907A1 Integrated two-dimensional gel electrophoresis 审中-公开
标题翻译：集成二维凝胶电泳
公开(公告)号：US20070144907A1
公开(公告)日：2007-06-28
申请号：US11643729
申请日：2006-12-21
申请人： Martin Kopp , Roger Sandoz , Mario Curcio , Michael Glauser
发明人： Martin Kopp , Roger Sandoz , Mario Curcio , Michael Glauser
IPC分类号： C07K1/26 , G01N27/00
CPC分类号： G01N27/44773 , C07K1/26 , C07K1/285
摘要： A disposable electrophoresis device for separation of a complex protein sample, using two-dimensional gel electrophoresis and method thereof are disclosed. The device comprises a carrier with a first area for a first dimension gel strip and a second area for a second dimension gel, where the two areas are directly in contact with each other. The device further comprises a body made of a hard component and an elastic component layer at a variable distance from the carrier. The body further comprises at least one cavity for external actuation of at least one valve, wherein the valve is represented by the elastic component layer.
摘要翻译：公开了使用二维凝胶电泳分离复合蛋白质样品的一次性电泳装置及其方法。该装置包括具有用于第一尺寸凝胶带的第一区域和用于第二维度凝胶的第二区域的载体，其中两个区域彼此直接接触。该装置还包括一个由硬质部件制成的主体和一个距离载体可变距离的弹性部件层。该主体还包括用于至少一个阀的外部致动的至少一个空腔，其中该阀由弹性部件层表示。

7. 发明申请

US20060099719A1 Biochemical assay 有权
标题翻译：生化试验
公开(公告)号：US20060099719A1
公开(公告)日：2006-05-11
申请号：US11260913
申请日：2005-10-28
申请人： Mario Curcio
发明人： Mario Curcio
IPC分类号： G01N33/558
CPC分类号： G01N33/558
摘要： A biochemical assay is provided comprising a substrate being capable of binding at least a target analyte and eventually other constituents contained in a biological sample, a test zone on the substrate for sample application, a non-immobilized conjugate reagent provided in the test zone for labelling the analyte, the conjugate reagent being capable of specific binding to the analyte but remaining unbound to the substrate, and a flow path for transporting a washing liquid through the test zone and washing an excess of unbound conjugate reagent away from the test zone. The test zone is also a detection area for detecting the labelled analyte.
摘要翻译：提供了生物化学测定法，其包括能够结合至少目标分析物和最终结合生物样品中包含的其他成分的底物，用于样品施用的底物上的测试区域，用于标记的测试区域中提供的非固定化缀合物试剂所述分析物，所述缀合试剂能够特异性结合分析物但保持未结合到所述基底;以及流动路径，用于将洗涤液体输送通过所述测试区并将过量的未结合的缀合物洗涤离开所述测试区。测试区也是用于检测标记分析物的检测区域。

8. 发明公开

US20240182149A1 Energy recovery system for marine vessels 审中-公开
公开(公告)号：US20240182149A1
公开(公告)日：2024-06-06
申请号：US18285238
申请日：2022-04-10
申请人： Mario Curcio
发明人： Mario Curcio
IPC分类号： B63J3/04
CPC分类号： B63J3/04 , B63J2003/046
摘要： An energy recovery system 100 for a marine vessel 200 is herein disclosed comprising at least one water turbine 101, 102 with vertical axis 105, 106 respectively arranged aft and off center, that is either port side or starboard side, with respect to a rotational axis 211 of a respective propeller but at a distance from the propeller and from the rotational axis of the propeller such as to be at least partially in a wake range 21′ of the propeller in order to recover at least part of the dissipated rotational power. A vessel 200 comprising at least one energy recovery system 100 and a method for recovering at least part of the energy dissipated by the marine vessel are herein also disclosed.

9. 发明申请

US20090016932A1 Micro Chamber 有权
标题翻译：微室
公开(公告)号：US20090016932A1
公开(公告)日：2009-01-15
申请号：US12142019
申请日：2008-06-19
申请人： Mario Curcio , Carlo Effenhauser , Michael Glauser
发明人： Mario Curcio , Carlo Effenhauser , Michael Glauser
IPC分类号： B01J19/00 , B05D3/04 , B01F15/00 , B01F15/02
CPC分类号： B01F13/0084 , B01F13/0064 , B01F13/0071 , B01J19/0093 , B01J2219/00783 , B01J2219/00833 , B01J2219/00837 , B01J2219/0086 , B01J2219/00889 , B01L3/5027 , B01L2300/0867 , B01L2300/165 , B01L2400/0694 , B01L2400/088
摘要： A microfluidic device is provided including at least one chamber accessible by microfiuidic channels characterized in that the surface of the channels and the chambers are patterned and comprise hydrophilic and hydrophobic areas. The surface energy in correspondence of the areas, i.e., the capillary force, being such that a liquid can be guided along the hydrophilic path, enter the chamber from one side, wet part of one surface of the chamber as a thin layer without touching the opposite surface of the chamber, thus avoiding to fill the volume inside the chamber in correspondence of the hydrophilic pattern until a second liquid, either sequentially or in parallel, comes to wet part of the opposite surface of the chamber and eventually touches the first liquid layer, resulting in a sudden coalescence and efficient mixing between the liquids.
摘要翻译：提供了一种微流体装置，其包括至少一个可通过微流体通道进入的腔室，其特征在于通道和腔室的表面被图案化并且包括亲水和疏水区域。对应于面积的表面能，即毛细管力，使得液体可以沿着亲水路径被引导，从一侧进入腔室，将腔室的一个表面的湿部分作为薄层而不接触因此避免了填充室内的体积，与亲水图形相对应，直到第二液体顺序地或平行地到达室的相对表面的湿润部分，并最终接触第一液体层，导致液体之间突然的聚结和有效的混合。

10. 发明公开

US20240092472A1 Autopilot system for marine vessels 审中-公开
公开(公告)号：US20240092472A1
公开(公告)日：2024-03-21
申请号：US18276023
申请日：2022-02-20
申请人： Mario Curcio
发明人： Mario Curcio
IPC分类号： B63H25/04 , B63H25/06
CPC分类号： B63H25/04 , B63H25/06 , B63H2025/045 , B63H2025/066
摘要： An autopilot system for automatically steering a marine vessel is disclosed. The marine vessel comprises two electric motors connected to respective propulsors, two rudders, a rudder steering mechanism and a navigation system for determining the vessel position with respect to an intended course. The autopilot system can operate according to one or more autopilot modes comprising at least a motor steering autopilot mode wherein the autopilot system is configured to automatically control the rudder steering mechanism in order to lock the rudders at a fixed angle, and based on a feedback from the navigation system to independently and dynamically adjust power supply to each of the propulsors by independently and dynamically regulating electric power supply to the respective electric motors in order to maintain the vessel on course.

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