专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5234912A Pharmaceutical compositions comprising recombinant BPI proteins and a lipid carrier and uses thereof 失效
标题翻译：包含重组BPI蛋白质和脂质载体的药物组合物及其用途
公开(公告)号：US5234912A
公开(公告)日：1993-08-10
申请号：US766566
申请日：1991-09-27
申请人： Marian N. Marra , Randal W. Scott , James L. Snable , Craig G. Wilde
发明人： Marian N. Marra , Randal W. Scott , James L. Snable , Craig G. Wilde
IPC分类号： G01N33/53 , A61K9/127 , A61K35/14 , A61K38/00 , A61K47/24 , A61K47/26 , A61L27/34 , A61L29/08 , A61L31/10 , A61P9/00 , A61P37/08 , C07K14/47 , F02B75/02 , G01N33/68 , G01N33/92
CPC分类号： B82Y5/00 , A61K47/24 , A61K47/26 , A61K9/127 , A61L27/34 , A61L29/085 , A61L31/10 , C07K14/4742 , G01N33/68 , G01N33/92 , A61K38/00 , F02B2075/027
摘要： The present invention provides a composition comprising a BPI Protein and a lipid carrier. Additionally, this invention provides a method for solubilizing a BPI protein which comprises contacting the BPI Protein with a lipid carrier under conditions such that the BPI Protein is solubilized.
摘要翻译：本发明提供了包含BPI蛋白和脂质载体的组合物。此外，本发明提供了一种增溶BPI蛋白的方法，其包括在使BPI蛋白溶解的条件下使BPI蛋白与脂质载体接触。

2. 发明授权

US5171739A Treatment of endotoxin-associated shock and preventation thereof using a BPI protein 失效
标题翻译：使用BPI蛋白治疗内毒素相关性休克及其预防
公开(公告)号：US5171739A
公开(公告)日：1992-12-15
申请号：US681551
申请日：1991-04-05
申请人： Randal W. Scott , Marian N. Marra
发明人： Randal W. Scott , Marian N. Marra
IPC分类号： A61K38/00 , A61K9/08 , A61K35/14 , A61K35/16 , A61L27/00 , A61L29/00 , A61L31/00 , A61P31/00 , A61P39/02 , C07K14/47 , C07K14/52 , C07K14/76 , C07K16/00 , C12N15/00 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/04 , C12Q1/02 , C12R1/91 , F02B75/02 , G01N33/53 , G01N33/532 , G01N33/569 , G01N33/68 , G01N33/92
CPC分类号： B82Y5/00 , C07K14/4742 , C07K14/52 , G01N33/68 , G01N33/92 , A61K38/00 , F02B2075/027 , Y10S514/921
摘要： The present invention provides a method for preventing endotoxin-associated shock in a subject which comprises administering to the subject an amount of a BPI protein effective to bind to endotoxin so as to prevent endotoxin associated shock in the subject. This invention further provides a method for treating a subject suffering from endotoxin-associated shock which comprises administering to the subject an amount of a BPI protein effective to bind endotoxin so as to treat the subject suffering from endotoxin-associated shock.
摘要翻译：本发明提供了一种用于预防受试者内毒素相关性休克的方法，其包括向受试者施用一定量的有效结合内毒素的BPI蛋白质，以防止受试者内毒素相关的休克。本发明还提供了治疗患有内毒素相关性休克的受试者的方法，其包括向受试者施用一定量的有效结合内毒素的BPI蛋白质，以治疗患有内毒素相关性休克的受试者。

3. 发明授权

US6093801A Recombinant analogs of bactericidal/permeability increasing protein 失效
标题翻译：重组类似物的杀菌/渗透性增加蛋白
公开(公告)号：US6093801A
公开(公告)日：2000-07-25
申请号：US25543
申请日：1998-02-18
申请人： Randal W. Scott , Marian N. Marra
发明人： Randal W. Scott , Marian N. Marra
IPC分类号： A61K38/00 , C07K14/47 , C07K14/52 , F02B75/02 , G01N33/68 , C07K14/00 , A61K38/03 , A61K38/17 , C07K14/435
CPC分类号： B82Y5/00 , C07K14/4742 , C07K14/52 , G01N33/68 , A61K38/00 , F02B2075/027 , Y10S530/829
摘要： The present invention provides a composition comprising a BPI Protein and an anionic compound which composition exhibits (1) no bacterial activity and (2) endotoxin neutralizing activity. Also, this invention provides methods for using BPI Proteins.
摘要翻译：本发明提供了包含BPI蛋白和阴离子化合物的组合物，该组合物显示出（1）无细菌活性和（2）内毒素中和活性。此外，本发明提供了使用BPI蛋白质的方法。

4. 发明授权

US5334584A Recombinant, non-glycosylated bpi protein and uses thereof 失效
标题翻译：重组非糖基化bpi蛋白及其用途
公开(公告)号：US5334584A
公开(公告)日：1994-08-02
申请号：US990044
申请日：1992-12-14
申请人： Randal W. Scott , Marian N. Marra
发明人： Randal W. Scott , Marian N. Marra
IPC分类号： A61K38/00 , C07K14/47 , C07K14/52 , F02B75/02 , G01N33/68 , A61K37/02 , A61K35/14
CPC分类号： B82Y5/00 , C07K14/4742 , C07K14/52 , G01N33/68 , A61K38/00 , F02B2075/027
摘要： The present invention provides a method for preventing endotoxin-associated shock in a subject which comprises administering to the subject an amount of a BPI protein effective to bind to endotoxin so as to prevent endotoxin associated shock in the subject. This invention further provides a method for treating a subject suffering from endotoxin-associated shock which comprises administering to the subject an amount of a BPI protein effective to bind endotoxin so as to treat the subject suffering from endotoxin-associated shock.
摘要翻译：本发明提供了一种用于预防受试者内毒素相关性休克的方法，其包括向受试者施用一定量的有效结合内毒素的BPI蛋白质，以防止受试者内毒素相关的休克。本发明还提供了治疗患有内毒素相关性休克的受试者的方法，其包括向受试者施用一定量的有效结合内毒素的BPI蛋白质，以治疗患有内毒素相关性休克的受试者。

5. 发明授权

US5770694A Genetically engineered BPI variant proteins 失效
标题翻译：基因工程BPI变体蛋白
公开(公告)号：US5770694A
公开(公告)日：1998-06-23
申请号：US915720
申请日：1992-07-22
申请人： Randal W. Scott , Marian N. Marra
发明人： Randal W. Scott , Marian N. Marra
IPC分类号： C07K14/47 , C07K14/00 , A61K38/03 , A61K38/17 , C07K14/435
CPC分类号： B82Y5/00 , C07K14/4742
摘要： The present invention provides a composition comprising a BPI Protein and an anionic compound which composition exhibits (1) no bactericidal activity and (2) endotoxin neutralizing activity. Also, this invention provides methods for using BPI Proteins.
摘要翻译：本发明提供包含BPI蛋白质和阴离子化合物的组合物，该组合物表现出（1）无杀菌活性和（2）内毒素中和活性。此外，本发明提供了使用BPI蛋白质的方法。

6. 发明授权

US5308834A Treatment of endotoxin-associated shock and prevention thereof using a BPI protein 失效
标题翻译：使用BPI蛋白处理内毒素相关性休克及其预防
公开(公告)号：US5308834A
公开(公告)日：1994-05-03
申请号：US990662
申请日：1992-12-14
申请人： Randal W. Scott , Marian N. Marra
发明人： Randal W. Scott , Marian N. Marra
IPC分类号： A61K38/00 , C07K14/47 , C07K14/52 , F02B75/02 , G01N33/68 , A61K37/02
CPC分类号： C07K14/4742 , B82Y5/00 , C07K14/52 , G01N33/68 , A61K38/00 , F02B2075/027
摘要： The present invention provides a method for preventing endotoxin-associated shock in a subject which comprises administering to the subject an amount of a BPI protein effective to bind to endotoxin so as to prevent endotoxin associated shock in the subject. This invention further provides a method for treating a subject suffering from endotoxin-associated shock which comprises administering to the subject an amount of a BPI protein effective to bind endotoxin so as to treat the subject suffering from endotoxin-associated shock.
摘要翻译：本发明提供了一种用于预防受试者内毒素相关性休克的方法，其包括向受试者施用一定量的有效结合内毒素的BPI蛋白质，以防止受试者内毒素相关的休克。本发明还提供了治疗患有内毒素相关性休克的受试者的方法，其包括向受试者施用一定量的有效结合内毒素的BPI蛋白质，以治疗患有内毒素相关性休克的受试者。

7. 发明授权

US5089274A Use of bactericidal/permeability increasing protein or biologically active analogs thereof to treat endotoxin-related disorders 失效
标题翻译：使用杀菌剂/渗透性增加蛋白质或生物活性成分，以治疗内毒素相关疾病
公开(公告)号：US5089274A
公开(公告)日：1992-02-18
申请号：US468696
申请日：1990-01-22
申请人： Marian N. Marra , Randal W. Scott
发明人： Marian N. Marra , Randal W. Scott
IPC分类号： A61K35/14 , A61K31/00 , A61K31/715 , A61K38/00 , A61P7/00 , A61P7/06 , A61P29/00 , A61P31/00 , A61P31/04 , C07K14/47 , C07K14/52 , F02B75/02
CPC分类号： B82Y5/00 , C07K14/4742 , C07K14/52 , A61K38/00 , F02B2075/027 , Y10S530/829
摘要： The present invention provides a method of inhibiting lipopolysaccharide (LPS)-mediated stimulation of cells. This method comprises contacting the cells, in the presence of a cell-stimulating amount of lipopolysaccharide, with Bactericidal/Permeability Increasing Protein (BPI) in an amount effective to inhibit cell stimulation.
摘要翻译：本发明提供抑制脂多糖（LPS）介导的细胞刺激的方法。该方法包括使细胞在细胞刺激量的脂多糖的存在下与有效抑制细胞刺激的量的杀菌/渗透性增加蛋白（BPI）接触。

8. 发明授权

US5032574A Novel antimicrobial peptide 失效
标题翻译：新型抗菌肽
公开(公告)号：US5032574A
公开(公告)日：1991-07-16
申请号：US199206
申请日：1988-05-26
申请人： Craig G. Wilde , Joseph E. Griffith , Marian N. Marra , Randal W. Scott
发明人： Craig G. Wilde , Joseph E. Griffith , Marian N. Marra , Randal W. Scott
IPC分类号： C12N15/09 , A61K38/00 , A61P31/04 , C07K1/14 , C07K1/18 , C07K1/20 , C07K14/47 , C12N5/10 , C12P21/02 , C12R1/91
CPC分类号： C07K14/4723 , A61K38/00
摘要： This invention provides a purified polypeptide useful as an antimicrobial agent. This purified polypeptide has been derived from human granulocytes, and has a molecular weight of about 3,700 daltons and the N-terminal amino acid sequence val-cys-ser-cys-arg-leu-val-phe-cys-arg-arg-thr-glu- leu-arg-val-gly-asn-cys-leu-ile-gly-gly-val-ser-phe-thr-try-cys-thr-arg-val. This invention also provides methods for producing this polypeptide, pharmaceutical compositions containing the polypeptide, and uses thereof.
摘要翻译：本发明提供了可用作抗微生物剂的纯化多肽。该纯化的多肽已经衍生自人粒细胞，分子量约为3,700道尔顿，N-末端氨基酸序列为val-cys-ser-cys-arg-leu-val-phe-cys-arg-arg-thr -glu-leu-arg-val-gly-asn-cys-leu-ile-gly-gly-val-ser-phe-thr-try-cys-thr-ar-val-val。本发明还提供了生产该多肽的方法，含该多肽的药物组合物及其用途。

9. 发明授权

US06265187B1 Recombinant endotoxin-neutralizing proteins 失效
标题翻译：重组内毒素中和蛋白
公开(公告)号：US06265187B1
公开(公告)日：2001-07-24
申请号：US08431517
申请日：1995-05-01
申请人： Randal W. Scott , Marian N. Marra
发明人： Randal W. Scott , Marian N. Marra
IPC分类号： C12N1509
CPC分类号： B82Y5/00 , A61K38/00 , A61K51/08 , A61K2123/00 , C07K14/47 , C07K14/4742 , C07K14/52 , C07K2319/00 , F02B2075/027 , G01N33/68
摘要： In general, the invention features a recombinant endotoxin-neutralizing polypeptide (RENP) characterized by (i) an amino acid sequence, (ii) an amino acid sequence and structure that facilitates selective and specific binding to lipopolysaccharide and (iii) once bound to the lipopolysaccharide, provides endotoxin-neutralizing activity. Preferably, the RENP is composed of an amino acid sequence similar to, but not identical to, an amino acid sequence of BPI, LBP, or both. Preferably, the RENP contains an LPS-binding domain derived from the amino acid sequence of BPI, LBP, or both. Preferably, the RENPs are covalently bound to a molecule which enhances the half-life of the polypeptide. The RENPs of the invention can be used in pharmaceutical compositions for therapeutic and prophylactic regimens, as well as in various in vitro and in vivo diagnostic methods.
摘要翻译：通常，本发明的特征在于重组内毒素中和多肽（RENP），其特征在于（i）氨基酸序列，（ii）促进对脂多糖的选择性和特异性结合的氨基酸序列和结构，以及（iii）一旦结合到脂多糖，提供内毒素中和活性。优选地，RENP由与BPI，LBP或两者的氨基酸序列相似但不相同的氨基酸序列组成。优选地，RENP含有衍生自BPI，LBP或两者的氨基酸序列的LPS结合结构域。优选地，RENP共价结合到增强多肽半衰期的分子。本发明的RENP可用于治疗和预防方案的药物组合物，以及各种体外和体内诊断方法。

10. 发明授权

US5210027A DNA encoding novel antimicrobial polypeptide and methods for obtaining such polypeptide 失效
标题翻译：编码新型抗微生物多肽的DNA和获得这种多肽的方法
公开(公告)号：US5210027A
公开(公告)日：1993-05-11
申请号：US730341
申请日：1991-07-15
申请人： Craig G. Wilde , Joseph E. Griffith , Marian N. Marra , Randal W. Scott
发明人： Craig G. Wilde , Joseph E. Griffith , Marian N. Marra , Randal W. Scott
IPC分类号： A61K38/00 , C07K14/47 , C12N1/21 , C12N15/12
CPC分类号： C07K14/4723 , A61K38/00
摘要： This invention provides a purified polypeptide useful as an antimicrobial agent. This purified polypeptide has been derived from human granulocytes, and has a molecular weight of about 3,700 daltons and the N-terminal amino acid sequence val-cys-ser-cys-arg-leu-val-phe-cys-arg-arg-thr-glu-leu-arg-val-gly-asn-cys-leu-ilu-gly-gly-val-ser-phe-thr-tyr-cys-cys-thr-arg-val. This invention also provides methods for producing this polypeptide, pharmaceutical compositions containing the polypeptide, and uses thereof.
摘要翻译：本发明提供了可用作抗微生物剂的纯化多肽。该纯化的多肽已经衍生自人粒细胞，分子量约为3,700道尔顿，N-末端氨基酸序列为val-cys-ser-cys-arg-leu-val-phe-cys-arg-arg-thr -glu-leu-arg-val-gly-作为n-cys-leu-ilu-gly-gly-val-ser-phe-thr-tyr-cys-cys-thr-arg-val。本发明还提供了生产该多肽的方法，含该多肽的药物组合物及其用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式