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1. 发明授权

US07141422B2 Transgenic trees exhibiting increased growth, biomass production and xylem fibre length, and methods for their production 有权
标题翻译：表现出增长的生物量，生物量生产和木质部纤维长度的转基因树及其生产方法
公开(公告)号：US07141422B2
公开(公告)日：2006-11-28
申请号：US10221296
申请日：2001-03-02
申请人： Maria Eriksson , Thomas Moritz , Maria Israelsson , Olof Olsson
发明人： Maria Eriksson , Thomas Moritz , Maria Israelsson , Olof Olsson
IPC分类号： C12N15/82 , C12N5/04
CPC分类号： C12N15/8242 , C12N15/8297
摘要： Important aims in nearly all tree-breeding programs around the world are to produce plants with increased growth rates and stem volumes, and shorter rotation times. Such trees would yield more biomass per area unit. Here the present inventors have shown that when over-expressing a key regulatory gene in the biosynthesis of the plant hormone gibberellin (GA) in hybrid aspen (Populus tremula×P. tremuloides), improvements in valuable traits such as growth rate and biomass are obtained. In addition, these trees also have longer xylem fibers than unmodified wild type plants. Long fibres are very desirable in the production of strong paper, but it has not (as yet) proved possible to influence this trait by traditional breeding techniques. A further advantage of the present invention is that it may reduce or eliminate the use of growth influencing chemicals in forestry.
摘要翻译：世界上几乎所有的树种育种计划的重要目标是生产具有增长速度和茎体积增加，旋转时间缩短的植物。这样的树木将产生每单位面积更多的生物量。这里，本发明人已经表明，当在杂交白杨（Populus tremulaxP. tremuloides）中植物激素赤霉素（GA）的生物合成中过度表达关键调节基因时，获得了有价值性状如生长速率和生物量的改善。此外，这些树木还具有比未修饰的野生型植物更长的木质部纤维。长纤维在生产强力纸方面是非常可取的，但迄今为止还没有证明可以通过传统的育种技术来影响这一特性。本发明的另一个优点是可以减少或消除在林业中对生长影响的化学品的使用。

2. 发明申请

US20050059071A1 LMNA gene and its involvement in hutchinson-gilford progeria syndrome (HGPS) and arteriosclerosis 有权
标题翻译： LMNA基因及其参与hutchinson-gilford progeria综合征（HGPS）和动脉硬化
公开(公告)号：US20050059071A1
公开(公告)日：2005-03-17
申请号：US10943400
申请日：2004-09-17
申请人： B. Maria Eriksson , Francis Collins , Leslie Gordon , W. Brown
发明人： B. Maria Eriksson , Francis Collins , Leslie Gordon , W. Brown
IPC分类号： C07K14/47 , C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , G01N2500/04 , Y10T436/143333
摘要： Disclosed herein are point mutations in the LMNA gene that cause HGPS. These mutations activate a cryptic splice site within the LMNA gene, which leads to deletion of part of exon 11 and generation of a mutant Lamin A protein product that is 50 amino acids shorter than the normal protein. In addition to the novel Lamin A variant protein and nucleic acids encoding this variant, methods of using these molecules in detecting biological conditions associated with a LMNA mutation in a subject (e.g., HGPS, arteriosclerosis, and other age-related diseases), methods of treating such conditions, methods of selecting treatments, methods of screening for compounds that influence Lamin A activity, and methods of influencing the expression of LMNA or LMNA variants are also described. Oligonucleotides and other compounds for use in examples of the described methods are also provided, as are protein-specific binding agents, such as antibodies, that bind specifically to at least one epitope of a Lamin A variant protein preferentially compared to wildtype Lamin A, and methods of using such antibodies in diagnosis, treatment, and screening. Also provided are kits for carrying out the methods described herein.
摘要翻译：本文公开了导致HGPS的LMNA基因中的点突变。这些突变激活LMNA基因内的隐性剪接位点，导致部分外显子11的缺失和产生比正常蛋白短50个氨基酸的突变Lamin A蛋白产物。除了新型Lamin A变体蛋白和编码该变体的核酸之外，使用这些分子检测与受试者的LMNA突变相关的生物学条件（例如，HGPS，动脉硬化和其他与年龄有关的疾病）的方法，还描述了治疗这些病症，选择治疗方法，筛选影响Lamin A活性的化合物的方法，以及影响LMNA或LMNA变体表达的方法。还提供了用于所述方法的实施例的寡核苷酸和其它化合物，以及优选与野生型Lamin A相比特异性结合Lamin A变体蛋白的至少一个表位的蛋白质特异性结合剂，例如抗体，以及在诊断，治疗和筛查中使用这些抗体的方法。还提供了用于实施本文所述方法的试剂盒。

3. 发明授权

US07807878B2 Transgenic trees exhibiting increased growth, biomass production and xylem fibre length, and methods for their production 有权
标题翻译：表现出增长的生物量，生物量生产和木质部纤维长度的转基因树及其生产方法
公开(公告)号：US07807878B2
公开(公告)日：2010-10-05
申请号：US11590211
申请日：2006-10-30
申请人： Maria Eriksson , Thomas Moritz , Maria Israelsson , Oloff Olsson
发明人： Maria Eriksson , Thomas Moritz , Maria Israelsson , Oloff Olsson
IPC分类号： C12N15/82 , C12N5/04 , A01H5/00 , A01H5/10
CPC分类号： C12N15/8242 , C12N15/8297
摘要： Important aims in nearly all tree-breeding programs around the world are to produce plants with increased growth rates and stem volumes, and shorter rotation times. Such trees would yield more biomass per area unit. Here the present inventors have shown that when over-expressing a key regulatory gene in the biosynthesis of the plant hormone gibberellin (GA) in hybrid aspen (Populus tremula×P. tremuloides), improvements in valuable traits such as growth rate and biomass are obtained. In addition, these trees also have longer xylem fibres than unmodified wild type plants. Long fibers are very desirable in the production of strong paper, but it has not (as yet) proved possible to influence this trait by traditional breeding techniques. A further advantage of the present invention is that it may reduce or eliminate the use of growth influencing chemicals in forestry.
摘要翻译：世界上几乎所有的树种育种计划的重要目标是生产具有增长速度和茎体积增加，旋转时间缩短的植物。这样的树木将产生每单位面积更多的生物量。本发明人已经表明，当杂交白杨（Populus tremula×P。tremuloides）中植物激素赤霉素（GA）的生物合成过程中，关键调控基因过度表达时，获得了生长速度和生物量等有价值性状的改善。此外，这些树木还具有比未修饰的野生型植物更长的木质部纤维。长纤维在生产强力纸方面是非常可取的，但迄今为止还没有证明可以通过传统的育种技术来影响这一特性。本发明的另一个优点是可以减少或消除在林业中对生长影响的化学品的使用。

4. 发明申请

US20070061924A1 Transgenic trees exhibiting increased growth, biomass production and xylem fibre length, and methods for their production 有权
标题翻译：表现出增长的生物量，生物量生产和木质部纤维长度的转基因树及其生产方法
公开(公告)号：US20070061924A1
公开(公告)日：2007-03-15
申请号：US11590211
申请日：2006-10-30
申请人： Maria Eriksson , Thomas Moritz , Maria Israelsson , Oloff Olsson
发明人： Maria Eriksson , Thomas Moritz , Maria Israelsson , Oloff Olsson
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12N15/8242 , C12N15/8297
摘要： Important aims in nearly all tree-breeding programs around the world are to produce plants with increased growth rates and stem volumes, and shorter rotation times. Such trees would yield more biomass per area unit. Here the present inventors have shown that when over-expressing a key regulatory gene in the biosynthesis of the plant hormone gibberellin (GA) in hybrid aspen (Populus tremula×P. tremuloides), improvements in valuable traits such as growth rate and biomass are obtained. In addition, these trees also have longer xylem fibres than unmodified wild type plants. Long fibres are very desirable in the production of strong paper, but it has not (as yet) proved possible to influence this trait by traditional breeding techniques. A further advantage of the present invention is that it may reduce or eliminate the use of growth influencing chemicals in forestry.
摘要翻译：世界上几乎所有的树种育种计划的重要目标是生产具有增长速度和茎体积增加，旋转时间缩短的植物。这样的树木将产生每单位面积更多的生物量。这里，本发明人已经表明，当在杂交白杨（Populus tremulaxP. tremuloides）中植物激素赤霉素（GA）的生物合成中过度表达关键调节基因时，获得了有价值性状如生长速率和生物量的改善。此外，这些树木还具有比未修饰的野生型植物更长的木质部纤维。长纤维在生产强力纸方面是非常可取的，但迄今为止还没有证明可以通过传统的育种技术来影响这一特性。本发明的另一个优点是可以减少或消除在林业中对生长影响的化学品的使用。

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