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1. 发明授权

US3677615A Drawer units and runners therefor 失效
标题翻译：抽屉单元及其运行器
公开(公告)号：US3677615A
公开(公告)日：1972-07-18
申请号：US3677615D
申请日：1971-03-12
申请人： HUDSON LESLIE GORDON
发明人： HUDSON LESLIE GORDON
IPC分类号： A47B88/04 , F16C32/00
CPC分类号： A47B88/43
摘要： The invention relates to a runner which is removably mounted in a support unit for sliding drawers, the runner including integrally cranked arm portions which engage in slots in uprights of the support unit and locking tongues which are adjustable when the runner is in position to provide against unintentional removal of the runner from the uprights.
摘要翻译：本发明涉及一种可移动地安装在用于滑动抽屉的支撑单元中的流道，流道包括一体化的曲柄臂部分，其与支撑单元的立柱中的狭槽啮合，并且当跑步者处于适当位置时能够调节的锁舌无意中从跑道上拆下跑步者。

2. 发明授权

US3935617A Fastening devices 失效
标题翻译：紧固装置
公开(公告)号：US3935617A
公开(公告)日：1976-02-03
申请号：US496986
申请日：1974-08-13
申请人： Leslie Gordon Hudson
发明人： Leslie Gordon Hudson
IPC分类号： E06B3/54 , A44B21/00 , E04B5/52
CPC分类号： E06B3/5481 , Y10T24/3459 , Y10T24/44017 , Y10T24/44906
摘要： The invention relates to a clip which can be used to releasably fasten a member such as a display panel in a frame. The clip has a configuration such that it can be mounted on the frame, and a stop for supporting the panel which is held by a resilient or flexible arm which moves towards or away from a body of the device in order to allow the panel to be mounted on or de-mounted from the frame.
摘要翻译：本发明涉及一种可用于将诸如显示面板的构件可释放地固定在框架中的夹子。夹子具有这样的构造，使得其可以安装在框架上，以及用于支撑面板的止动件，该止挡件由弹性或柔性臂保持，该弹性或柔性臂朝向或远离装置的主体移动，以允许面板为安装在框架上或从框架上拆卸。

3. 发明授权

US2281605A Fluid pressure control device 失效
公开(公告)号：US2281605A
公开(公告)日：1942-05-05
申请号：US25507039
申请日：1939-02-07
申请人： ALBERT LESLIE GORDON
发明人： SMITH HARVEY E
IPC分类号： B60S5/04 , G05D16/10
CPC分类号： B60S5/043 , G05D16/103 , Y10T137/2544 , Y10T137/36 , Y10T137/3615 , Y10T137/87241

4. 发明申请

US20080050837A1 LMNA GENE AND ITS INVOLVEMENT IN HUTCHINSON-GILFORD PROGERIA SYNDROME (HGPS) AND ARTERIOSCLEROSIS 有权
标题翻译： LMNA基因及其在HUTCHINSON-GILFORD PROGERIA SYNDROME（HGPS）和ARTERIOSCLEROSIS中的参与
公开(公告)号：US20080050837A1
公开(公告)日：2008-02-28
申请号：US11870234
申请日：2007-10-10
申请人： B. Eriksson , Francis Collins , Leslie Gordon , W. Brown
发明人： B. Eriksson , Francis Collins , Leslie Gordon , W. Brown
IPC分类号： C12Q1/68 , C07H21/00 , G01N33/00
CPC分类号： C07K14/47 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , G01N2500/04 , Y10T436/143333
摘要： Disclosed herein are point mutations in the LMNA gene that cause HGPS. These mutations activate a cryptic splice site within the LMNA gene, which leads to deletion of part of exon 11 and generation of a mutant Lamin A protein product that is 50 amino acids shorter than the normal protein. In addition to the novel Lamin A variant protein and nucleic acids encoding this variant, methods of using these molecules in detecting biological conditions associated with a LMNA mutation in a subject (e.g., HGPS, arteriosclerosis, and other age-related diseases), methods of treating such conditions, methods of selecting treatments, methods of screening for compounds that influence Lamin A activity, and methods of influencing the expression of LMNA or LMNA variants are also described. Oligonucleotides and other compounds for use in examples of the described methods are also provided, as are protein-specific binding agents, such as antibodies, that bind specifically to at least one epitope of a Lamin A variant protein preferentially compared to wildtype Lamin A, and methods of using such antibodies in diagnosis, treatment, and screening. Also provided are kits for carrying out the methods described herein.
摘要翻译：本文公开了导致HGPS的LMNA基因中的点突变。这些突变激活LMNA基因内的隐性剪接位点，导致部分外显子11的缺失和产生比正常蛋白短50个氨基酸的突变Lamin A蛋白产物。除了新型Lamin A变体蛋白和编码该变体的核酸之外，使用这些分子检测与受试者的LMNA突变相关的生物学条件（例如，HGPS，动脉硬化和其他与年龄相关的疾病）的方法，还描述了治疗这些病症，选择治疗方法，筛选影响Lamin A活性的化合物的方法，以及影响LMNA或LMNA变体表达的方法。还提供了用于所述方法的实施例的寡核苷酸和其它化合物，以及优选与野生型Lamin A相比特异性结合Lamin A变体蛋白的至少一个表位的蛋白质特异性结合剂，例如抗体，以及在诊断，治疗和筛查中使用这些抗体的方法。还提供了用于实施本文所述方法的试剂盒。

5. 发明授权

US07595929B1 Grooved backside acoustic termination of acousto-optic devices 有权
标题翻译：凹槽背面声光学终端的声光器件
公开(公告)号：US07595929B1
公开(公告)日：2009-09-29
申请号：US11809295
申请日：2007-05-30
申请人： Leslie Gordon , Ronald Charles Dwelle , Jon Fowler
发明人： Leslie Gordon , Ronald Charles Dwelle , Jon Fowler
IPC分类号： G02F1/33
CPC分类号： G02F1/33
摘要： An acousto-optic device having at least one groove on the backside improves acoustic termination of the device. The grooves can be added early in device fabrication and are compatible with batch processing, thereby avoiding the separate device handling. Grooving can be performed on the cell, before it is mounted to a batch plate. This simplifies batch plate processing by using a backside that remains parallel to the bondface.
摘要翻译：在背面具有至少一个凹槽的声光装置改善了装置的声音终止。凹槽可以在器件制造早期加入并与批处理兼容，从而避免了单独的器件处理。在将其安装到批量板之前，可以在电池上进行开槽。这通过使用与接合面平行的背面来简化批处理板处理。

6. 发明申请

US20080285913A1 Method and apparatus for high resolution coherent optical imaging 审中-公开
标题翻译：用于高分辨率相干光学成像的方法和装置
公开(公告)号：US20080285913A1
公开(公告)日：2008-11-20
申请号：US11825008
申请日：2007-07-03
申请人： Victor Xiao Dong Yang , I. Alex Vitkin , Louie M. WongKeeSong , Sharon Katz , Margaret Leslie Gordon , Brian C. Wilson , Alvin Ho Kwan Mok
发明人： Victor Xiao Dong Yang , I. Alex Vitkin , Louie M. WongKeeSong , Sharon Katz , Margaret Leslie Gordon , Brian C. Wilson , Alvin Ho Kwan Mok
IPC分类号： G02B6/28
CPC分类号： A61B5/6852 , A61B1/00096 , A61B1/00172 , A61B1/05 , A61B5/0066 , G01N21/4795
摘要： A method and an apparatus for examining the sub-surface microstructure of a sample are provided. Radiation from a plurality of optical radiation sources travels along a first optical path. In the first optical path, a device focuses the optical radiation from each of the optical sources into a plurality of respective focal points along the first optical path to provide substantially continuous coverage of a selected portion of the first optical path. Then, a sample on the first optical path within the selected length extending into the sample is scanned along said selected portion of the first optical path.
摘要翻译：提供了一种用于检查样品的亚表面微观结构的方法和装置。来自多个光辐射源的辐射沿着第一光路行进。在第一光路中，设备将来自每个光源的光辐射沿着第一光路聚焦到多个相应的焦点中，以提供第一光路的选定部分的基本连续的覆盖。然后，沿着第一光路的所述选定部分扫描延伸到样品中的所选长度内的第一光路上的样品。

7. 发明授权

US2003928A Stripping and discharging dyed textiles 失效
标题翻译：剥皮和放电染色纺织品
公开(公告)号：US2003928A
公开(公告)日：1935-06-04
申请号：US66118033
申请日：1933-03-16
申请人： ICI LTD , JOHN GWYNANT EVANS , LESLIE GORDON LAWRIE
IPC分类号： D06P5/13
CPC分类号： D06P5/138 , Y10S516/07

8. 发明授权

US07242833B2 Method and apparatus for high resolution coherent optical imaging 有权
标题翻译：用于高分辨率相干光学成像的方法和装置
公开(公告)号：US07242833B2
公开(公告)日：2007-07-10
申请号：US10311358
申请日：2001-07-10
申请人： Victor Xiao Dong Yang , I. Alex Vitkin , Louis M. WongKeeSong , Sharon Katz , Margaret Leslie Gordon , Brian C. Wilson , Alvin Ho Kwan Mok
发明人： Victor Xiao Dong Yang , I. Alex Vitkin , Louis M. WongKeeSong , Sharon Katz , Margaret Leslie Gordon , Brian C. Wilson , Alvin Ho Kwan Mok
IPC分类号： G02B6/04 , A61B1/07
CPC分类号： A61B5/6852 , A61B1/00096 , A61B1/00172 , A61B1/05 , A61B5/0066 , G01N21/4795
摘要： A method and an apparatus for examining the subsurface microstructure of a sample are provided. Radiation from a plurality of optical radiation sources travels along a first optical path. In the first optical path, a device focuses the optical radiati n from each of the optical sources into a plurality of respective focal points along the first optical path to provide substantially continuous coverage of a selected portion of the first optical path. Then, a sample on the first optical path within the selected length extending into the sample is scanned along said selected portion of the first optical path.
摘要翻译：提供了一种用于检查样品的地下微结构的方法和装置。来自多个光辐射源的辐射沿着第一光路行进。在第一光路中，器件将光学辐射从每个光源聚焦到沿着第一光路的多个相应的焦点中，以提供对第一光路的选定部分的基本连续的覆盖。然后，沿着第一光路的所述选定部分扫描延伸到样品中的所选长度内的第一光路上的样品。

9. 发明申请

US20050059071A1 LMNA gene and its involvement in hutchinson-gilford progeria syndrome (HGPS) and arteriosclerosis 有权
标题翻译： LMNA基因及其参与hutchinson-gilford progeria综合征（HGPS）和动脉硬化
公开(公告)号：US20050059071A1
公开(公告)日：2005-03-17
申请号：US10943400
申请日：2004-09-17
申请人： B. Maria Eriksson , Francis Collins , Leslie Gordon , W. Brown
发明人： B. Maria Eriksson , Francis Collins , Leslie Gordon , W. Brown
IPC分类号： C07K14/47 , C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , G01N2500/04 , Y10T436/143333
摘要： Disclosed herein are point mutations in the LMNA gene that cause HGPS. These mutations activate a cryptic splice site within the LMNA gene, which leads to deletion of part of exon 11 and generation of a mutant Lamin A protein product that is 50 amino acids shorter than the normal protein. In addition to the novel Lamin A variant protein and nucleic acids encoding this variant, methods of using these molecules in detecting biological conditions associated with a LMNA mutation in a subject (e.g., HGPS, arteriosclerosis, and other age-related diseases), methods of treating such conditions, methods of selecting treatments, methods of screening for compounds that influence Lamin A activity, and methods of influencing the expression of LMNA or LMNA variants are also described. Oligonucleotides and other compounds for use in examples of the described methods are also provided, as are protein-specific binding agents, such as antibodies, that bind specifically to at least one epitope of a Lamin A variant protein preferentially compared to wildtype Lamin A, and methods of using such antibodies in diagnosis, treatment, and screening. Also provided are kits for carrying out the methods described herein.
摘要翻译：本文公开了导致HGPS的LMNA基因中的点突变。这些突变激活LMNA基因内的隐性剪接位点，导致部分外显子11的缺失和产生比正常蛋白短50个氨基酸的突变Lamin A蛋白产物。除了新型Lamin A变体蛋白和编码该变体的核酸之外，使用这些分子检测与受试者的LMNA突变相关的生物学条件（例如，HGPS，动脉硬化和其他与年龄有关的疾病）的方法，还描述了治疗这些病症，选择治疗方法，筛选影响Lamin A活性的化合物的方法，以及影响LMNA或LMNA变体表达的方法。还提供了用于所述方法的实施例的寡核苷酸和其它化合物，以及优选与野生型Lamin A相比特异性结合Lamin A变体蛋白的至少一个表位的蛋白质特异性结合剂，例如抗体，以及在诊断，治疗和筛查中使用这些抗体的方法。还提供了用于实施本文所述方法的试剂盒。

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