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1. 发明授权

US10561810B2 O2-controller 有权
公开(公告)号：US10561810B2
公开(公告)日：2020-02-18
申请号：US12162764
申请日：2007-01-30
申请人： Josef Brunner , Marc Wysocki , Thomas Laubscher
发明人： Josef Brunner , Marc Wysocki , Thomas Laubscher
IPC分类号： A61M16/10 , A61M16/00
摘要： The invention relates to a device for the regulation of PEEP and FiO2 of a ventilator for achieving an arterial oxygen partial pressure in the blood of a mechanically ventilated patient. At reading which is representative of the success of the oxygen supply, i.e. the oxygen saturation of the blood is measured with the device, and assigned to one of three regions, which are defined by two characteristic lines. A first control loop is designed to optimise PEEP and FiO2 on assigning a reading to a region which demands a change of the settings, or to retaining the settings with an assignment to the normal region between the characteristic lines. This first control loop carries out such an optimisation at predefined temporal intervals on account of the representative reading (SaO2REP) and a predefined necessary supply intensity. The ventilator is subsequently activated accordingly. Therebetween, if necessary only FiO2 is increased or reduced with a second control loop, if between optimisations by way of the first control loop, the current representative value (SaO2REP) falls below a limit value (characteristic line) which is dependent on the supply intensity, which demands an immediate increase of the oxygen supply.

2. 发明申请

US20110257549A1 APPARATUS FOR ASSESSING THE STRESS ON THE CIRCULATION OF A PERSON DURING ASSISTED BREATHING BY MEANS OF A RESPIRATOR 有权
标题翻译：用于通过呼吸者的方式评估辅助呼吸期间人的循环压力的装置
公开(公告)号：US20110257549A1
公开(公告)日：2011-10-20
申请号：US12989475
申请日：2009-04-23
申请人： Marc Wysocki , Josef Brunner , Ricardo Lopez Gasco , Dominik Novotni , Thomas Laubscher , Gion Durisch
发明人： Marc Wysocki , Josef Brunner , Ricardo Lopez Gasco , Dominik Novotni , Thomas Laubscher , Gion Durisch
IPC分类号： A61B5/08
CPC分类号： A61B5/02028 , A61B5/087 , A61M16/0051 , A61M16/024 , A61M2016/0027 , A61M2016/0036 , A61M2230/205
摘要： The invention relates to an apparatus with sensing means suitable for sensing the inspiratory phase and the expiratory phase of each respiratory cycle of a respirated person from in each case at least one minimum and maximum amplitude of a circulation value within a single respiratory cycle, and with a computing device for calculating a variation of the amplitudes of the circulation value occurring within a said respiratory cycle. It is distinguished by the fact that the computing device is set up to assign each amplitude of the circulation value either to the inspiratory phase or to the expiratory phase and to determine the one extreme amplitude of the circulation value from the amplitudes assigned to the inspiratory phase and the other extreme amplitude of the circulation value from the amplitudes assigned to the expiratory phase, and to ascertain from the amplitude variation between the extreme amplitudes in the two phases of the respiratory cycle whether the haemodynamic stress caused by the assisted breathing is too high.
摘要翻译：本发明涉及一种具有感测装置的装置，适合于在每种情况下感测呼吸者的每个呼吸周期的吸气期和呼气阶段在单个呼吸周期内具有循环值的至少一个最小和最大振幅，并且与计算装置，用于计算在所述呼吸周期内发生的循环值的振幅的变化。其特征在于计算设备被设置为将循环值的每个幅度分配给吸气相或呼气相，并且从分配给吸气相的幅度确定循环值的一个极端幅度以及从分配给呼气相的振幅的循环值的另一个极端幅度，并且从呼吸周期的两个阶段中的极值幅度之间的振幅变化确定辅助呼吸引起的血液动力学应力是否过高。

3. 发明授权

US09616187B2 Apparatus for regulating a mechanical ventilation 有权
公开(公告)号：US09616187B2
公开(公告)日：2017-04-11
申请号：US12162781
申请日：2007-01-30
申请人： Josef Brunner , Marc Wysocki , Thomas Laubscher
发明人： Josef Brunner , Marc Wysocki , Thomas Laubscher
IPC分类号： F16K31/02 , A61M16/00
CPC分类号： A61M16/0051 , A61M16/024 , A61M2230/202 , A61M2230/205 , A61M2230/005
摘要： The invention relates to a device, with which one is to prevent a patient who breathes on Ms own and who desires a lower CO2-partial-pressure than is achieved by the set Ventilation from tiring. It comprises the following means for the regulation of a changing intensity of a mechanical Ventilation: • means for determining a target frequency RRsp, • means for determining a spontaneous frequency RRspont • means for comparing the spontaneous frequency RRspont with the target frequency RRsp. wherein adapting a Ventilation target value (% MinVol, V′gAsp) on account of the result of the comparison of the spontaneous frequency RRspont with the target frequency RRsp and • means for adapting the parameters determining the intensity of the Ventilation, on account of the Ventilation target value (% MinVol, V′gAsp). This so-called pump support System (PSS) is activated (PSS on) when the patient breathes in an adequately spontaneous manner (Criterion 1). With an insufficient individual activity of the patient, his behavior is taken as a basis for the control of the regulation. The control or regulation of the Ventilation is assumed by a fixed setting of a Ventilation target value (% MinVol), or a CO2-controller, as soon as the patient breathes in a manner which is not spontaneous enough.

4. 发明申请

US20090301492A1 METHOD AND DEVICE FOR DETERMINING THE PEEP DURING THE RESPIRATION OF A PATIENT 有权
标题翻译：用于在患者呼吸期间确定PEEP的方法和装置
公开(公告)号：US20090301492A1
公开(公告)日：2009-12-10
申请号：US12514056
申请日：2007-11-14
申请人： Marc Wysocki , Thomas Laubscher , Gion Durisch , Josef Brunner
发明人： Marc Wysocki , Thomas Laubscher , Gion Durisch , Josef Brunner
IPC分类号： A61M16/00
CPC分类号： A61B5/085 , A61M16/024
摘要： The invention relates to a device for the automated determination of the PEEP of a patient. Said device comprises sensors and a suitable electronic system for determining a pressure-volume characteristic curve during a P/V manoeuvre. The electronic system is designed in such a way as to generate, specifically in terms of breathing pressure, the difference between “lung volume during exhalation (Vdef)” and “lung volume during inhalation (Vinf)”, and to determine the maximum value of said difference. The breathing pressure is then determined, for which the volume difference has a value defined in relation to the maximum value of the volume difference. The device calculates a PEEP value on the basis of said determined breathing pressure value.
摘要翻译：本发明涉及用于自动确定患者的PEEP的装置。所述装置包括用于在P / V操纵期间确定压力 - 体积特性曲线的传感器和合适的电子系统。电子系统被设计成特别地根据呼吸压力产生“呼气期间的肺容积（Vdef）”和“吸入期间的肺容积（Vinf）”之间的差异，并确定最大值说差异然后确定呼吸压力，其中体积差异具有相对于体积差的最大值定义的值。该设备基于所确定的呼吸压力值计算PEEP值。

5. 发明申请

US20090007915A1 APPARATUS FOR REGULATING A MECHANICAL VENTILATION 有权
标题翻译：用于调节机械通风的装置
公开(公告)号：US20090007915A1
公开(公告)日：2009-01-08
申请号：US12162781
申请日：2007-01-30
申请人： Josef Brunner , Marc Wysocki , Thomas Laubscher
发明人： Josef Brunner , Marc Wysocki , Thomas Laubscher
IPC分类号： A61M16/00
CPC分类号： A61M16/0051 , A61M16/024 , A61M2230/202 , A61M2230/205 , A61M2230/005
摘要： The invention relates to a device, with which one is to prevent a patient who breathes on Ms own and who desires a lower CO2-partial-pressure than is achieved by the set Ventilation from tiring. It comprises the following means for the regulation of a changing intensity of a mechanical Ventilation: • means for determining a target frequency RRsp, • means for determining a spontaneous frequency RRspont • means for comparing the spontaneous frequency RRspont with the target frequency RRsp. wherein adapting a Ventilation target value (% MinVol, V′gAsp) on account of the result of the comparison of the spontaneous frequency RRspont with the target frequency RRsp and • means for adapting the parameters determining the intensity of the Ventilation, on account of the Ventilation target value (% MinVol, V′gAsp). This so-called pump support System (PSS) is activated (PSS on) when the patient breathes in an adequately spontaneous manner (Criterion 1). With an insufficient individual activity of the patient, his behaviour is taken as a basis for the control of the regulation. The control or regulation of the Ventilation is assumed by a fixed setting of a Ventilation target value (% MinVol), or a CO2-controller, as soon as the patient breathes in a manner which is not spontaneous enough.
摘要翻译：本发明涉及一种装置，其中一种是防止呼吸自己的患者，并且希望比通过设定的通气达到的较低的二氧化碳分压比疲劳。它包括以下用于调节机械通气变化强度的方法：。用于确定目标频率RRsp的手段。用于确定自发频率RRspont的方法。用于将自发频率RRspont与目标频率RRsp进行比较的手段。其中根据自发频率RRspont与目标频率RRsp的比较的结果来适配通气目标值（％MinVol，V'gAsp）。考虑到通气目标值（％MinVol，V'gAsp），适应决定通气强度的参数的方法。当患者以充分自发的方式呼吸时，所谓的泵支持系统（PSS）被激活（PSS on）（标准1）。患者的个人活动不足，他的行为被视为控制监管的依据。只要患者以不足够自发的方式呼吸，就可以通过通气目标值（％MinVol）或二氧化碳控制器的固定设置来控制或调节通气。

6. 发明授权

US09186070B2 Apparatus for assessing the stress on the circulation of a person during assisted breathing by means of a respirator 有权
标题翻译：用于通过呼吸器评估辅助呼吸期间人的循环压力的装置
公开(公告)号：US09186070B2
公开(公告)日：2015-11-17
申请号：US12989475
申请日：2009-04-23
申请人： Marc Wysocki , Josef Brunner , Ricardo Lopez Gasco , Dominik Novotni , Thomas Laubscher , Gion Durisch
发明人： Marc Wysocki , Josef Brunner , Ricardo Lopez Gasco , Dominik Novotni , Thomas Laubscher , Gion Durisch
IPC分类号： A61B5/02 , A61B5/087 , A61M16/00
CPC分类号： A61B5/02028 , A61B5/087 , A61M16/0051 , A61M16/024 , A61M2016/0027 , A61M2016/0036 , A61M2230/205
摘要： The invention relates to an apparatus with sensing means suitable for sensing the inspiratory phase and the expiratory phase of each respiratory cycle of a respirated person from in each case at least one minimum and maximum amplitude of a circulation value within a single respiratory cycle, and with a computing device for calculating a variation of the amplitudes of the circulation value occurring within a said respiratory cycle. It is distinguished by the fact that the computing device is set up to assign each amplitude of the circulation value either to the inspiratory phase or to the expiratory phase and to determine the one extreme amplitude of the circulation value from the amplitudes assigned to the inspiratory phase and the other extreme amplitude of the circulation value from the amplitudes assigned to the expiratory phase, and to ascertain from the amplitude variation between the extreme amplitudes in the two phases of the respiratory cycle whether the haemodynamic stress caused by the assisted breathing is too high.
摘要翻译：本发明涉及一种具有感测装置的装置，适合于在每种情况下感测呼吸者的每个呼吸周期的吸气期和呼气阶段在单个呼吸周期内具有循环值的至少一个最小和最大振幅，并且与计算装置，用于计算在所述呼吸周期内发生的循环值的振幅的变化。其特征在于计算设备被设置为将循环值的每个幅度分配给吸气相或呼气相，并且从分配给吸气相的幅度确定循环值的一个极端幅度以及从分配给呼气相的振幅的循环值的另一个极端幅度，并且从呼吸周期的两个阶段中的极值幅度之间的振幅变化确定辅助呼吸引起的血液动力学应力是否过高。

7. 发明申请

US20080314385A1 O2 - Controller 审中-公开
标题翻译： O2 - 控制器
公开(公告)号：US20080314385A1
公开(公告)日：2008-12-25
申请号：US12162764
申请日：2007-01-30
申请人： Josef Brunner , Marc Wysocki , Thomas Laubscher
发明人： Josef Brunner , Marc Wysocki , Thomas Laubscher
IPC分类号： A61M16/10
摘要： The invention relates to a device for the regulation of PEEP and FiO2 of a ventilator for achieving an arterial oxygen partial pressure in the blood of a mechanically ventilated patient. At reading which is representative of the success of the oxygen supply, i.e. the oxygen saturation of the blood is measured with the device, and assigned to one of three regions, which are defined by two characteristic lines. A first control loop is designed to optimise PEEP and FiO2 on assigning a reading to a region which demands a change of the settings, or to retaining the settings with an assignment to the normal region between the characteristic lines. This first control loop carries out such an optimisation at predefined temporal intervals on account of the representative reading (SaO2REP) and a predefined necessary supply intensity. The ventilator is subsequently activated accordingly. Therebetween, if necessary only FiO2 is increased or reduced with a second control loop, if between optimisations by way of the first control loop, the current representative value (SaO2REP) falls below a limit value (characteristic line) which is dependent on the supply intensity, which demands an immediate increase of the oxygen supply.
摘要翻译：本发明涉及一种用于调节机械通气患者的血液中用于实现动脉氧分压的通气机的PEEP和FiO2的装置。在代表氧供应成功的阅读中，即用装置测量血液的氧饱和度，并分配给由两条特征线限定的三个区域之一。第一个控制回路被设计为优化PEEP和FiO2，以将读数分配给需要改变设置的区域，或者通过赋予特征线之间的正常区域来保留设置。考虑到代表性读数（SaO2REP）和预定义的必需供应强度，该第一控制环路以预定义的时间间隔进行这种优化。随后呼吸机被相应地激活。如果需要，如果需要，仅通过第二控制回路增加或减少FiO2，如果在通过第一控制回路进行优化之间，则当前代表值（SaO2REP）低于取决于供应强度的极限值（特征线），这需要立即增加氧气供应。

8. 发明申请

US20090024008A1 METHOD AND A DEVICE FOR SIMPLIFYING A DIAGNOSTIC ASSESSMENT OF A MECHANICALLY VENTILATED PATIENT 审中-公开
标题翻译：用于简化机械通气患者诊断评估的方法和装置
公开(公告)号：US20090024008A1
公开(公告)日：2009-01-22
申请号：US12162778
申请日：2007-01-30
申请人： Josef Brunner , Marc Wysocki , Ivo Mettier
发明人： Josef Brunner , Marc Wysocki , Ivo Mettier
IPC分类号： A61B5/08 , A61B5/01
摘要： The invention relates to a method for acquiring several changing values and representing the acquired values on a monitoring screen, as well as to a device with a screen in order, on this, to represent changing values acquired during ventilation of the patient. The device comprises means for acquiring at least three changing values of different origin, and means for representing the values, which permit the acquired values to be qualitatively represented on the screen together in a single graphic element. This graphic element has a pictorial representation of a lung shape. The invention is characterised in that the means for representing the values are designed such that a volume change of the ventilated lung which is detected within each breath, is represented in an animated manner by way of size change of the lung shape corresponding to this corresponding volume change.
摘要翻译：本发明涉及一种用于在监视屏幕上获取多个变化值并表示所获取的值的方法，以及具有屏幕的装置，用于表示在病人通气期间获取的变化值。该装置包括用于获取不同原点的至少三个变化值的装置，以及用于表示值的装置，其允许在单个图形元素中将所获取的值在屏幕上定性表示。该图形元件具有肺形状的图示。本发明的特征在于，用于表示值的装置被设计成使得在每个呼吸中检测到的通气肺的体积变化以动画方式通过与该对应体积对应的肺形状的大小变化来表示更改。

9. 发明授权

US08528553B2 Method and device for determining the PEEP during the respiration of a patient 有权
标题翻译：用于在患者呼吸期间确定PEEP的方法和装置
公开(公告)号：US08528553B2
公开(公告)日：2013-09-10
申请号：US12514056
申请日：2007-11-14
申请人： Marc Wysocki , Thomas Laubscher , Gion Durisch , Josef Brunner
发明人： Marc Wysocki , Thomas Laubscher , Gion Durisch , Josef Brunner
IPC分类号： A61M16/00
CPC分类号： A61B5/085 , A61M16/024
摘要： The invention relates to a device for the automated determination of the PEEP of a patient. Said device comprises sensors and a suitable electronic system for determining a pressure-volume characteristic curve during a P/V maneuver. The electronic system is designed in such a way as to generate, specifically in terms of breathing pressure, the difference between “lung volume during exhalation (Vdef)” and “lung volume during inhalation (Vinf)”, and to determine the maximum value of said difference. The breathing pressure is then determined, for which the volume difference has a value defined in relation to the maximum value of the volume difference. The device calculates a PEEP value on the basis of said determined breathing pressure value.
摘要翻译：本发明涉及用于自动确定患者的PEEP的装置。所述装置包括用于在P / V操纵期间确定压力 - 体积特性曲线的传感器和合适的电子系统。电子系统被设计成特别地根据呼吸压力产生“呼气期间的肺容积（Vdef）”和“吸入期间的肺容积（Vinf）”之间的差异，并确定最大值说差异然后确定呼吸压力，其中体积差异具有相对于体积差的最大值定义的值。该设备基于所确定的呼吸压力值计算PEEP值。

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