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1. 发明申请

US20080287954A1 PATIENT-SPECIFIC SURGICAL GUIDANCE TOOL AND METHOD OF USE 有权
标题翻译：患者特异性外科手术工具及其使用方法
公开(公告)号：US20080287954A1
公开(公告)日：2008-11-20
申请号：US12120547
申请日：2008-05-14
申请人： Manuela Kunz , John F. Rudan
发明人： Manuela Kunz , John F. Rudan
IPC分类号： A61F5/00
CPC分类号： A61B17/1764 , A61B17/142 , A61B17/15 , A61B17/1604 , A61B17/175 , A61B17/1757 , A61B17/1782 , A61B2017/568 , A61B2090/061 , A61B2090/067 , B33Y80/00
摘要： Presented is a preoperatively designed guidance tool for intraoperative use during bone or joint surgery wherein the guidance tool is specific to the anatomy of the patient being treated. The guidance tool comprises a body portion, a mating surface provided on the body portion for positioning the guidance tool on a corresponding registration surface of a patient's anatomy. The guidance tool further comprises at least one guide mechanism provided on the body portion for guiding a medical instrument at one or more preoperatively defined trajectories relative to a patient's anatomy. In the event of misalignment, the at least one guide mechanism is adjustable to alter the one or more preoperatively defined trajectories if necessary during intraoperative use. Also presented is a preoperative process for designing the guidance tool.
摘要翻译：提出了一种术前设计的用于骨或关节手术期间术中使用的引导工具，其中引导工具特异于被治疗患者的解剖结构。引导工具包括主体部分，设置在主体部分上的配合表面，用于将引导工具定位在患者解剖结构的相应对准表面上。引导工具还包括设置在主体部分上的至少一个引导机构，用于相对于患者的解剖结构在一个或多个预先确定的轨迹下引导医疗器械。在未对准的情况下，至少一个引导机构是可调节的，以在术中使用期间根据需要改变一个或多个术前定义的轨迹。还提出了一种用于设计指导工具的术前过程。

2. 发明授权

US06106579A Compositions and methods for dyeing and safe decolorizing of fibers, especially hair, and multi-part kit for repeatedly changing dyed fiber color 有权
标题翻译：用于染色和安全脱色的组合物和方法，特别是毛发，以及用于重复改变染色纤维颜色的多部件试剂盒
公开(公告)号：US06106579A
公开(公告)日：2000-08-22
申请号：US210022
申请日：1998-12-11
申请人： Manuela Kunz , Dominique Le Cruer , Christel Dousse
发明人： Manuela Kunz , Dominique Le Cruer , Christel Dousse
IPC分类号： D06L3/10 , A61K8/00 , A61K8/23 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/365 , A61K8/41 , A61K8/44 , A61K8/46 , A61K8/64 , A61Q5/08 , A61Q5/10 , D06L3/02 , D06P1/19 , D06P1/32 , D06P3/04 , D06P3/08 , D06P5/13 , A61K7/13 , A61K7/135
CPC分类号： A61K8/46 , A61K8/35 , A61K8/365 , A61K8/447 , A61K8/676 , A61Q5/08 , D06L3/025 , A61K2800/884
摘要： The method for decolorizing fibers includes applying a decolorizing composition according to the invention to dyed fibers and allowing the composition to act on the fibers for a sufficient time to remove dyed color from the dyed fibers. The decolorizing composition for fibers dyed with an oxidation hair dye composition and/or direct-dyeing hair dye compounds contains a combination of one or more .alpha.-oxo-carboxylic acids and/or physiologically compatible .alpha.-oxocarboxylic acid salts with at least one reductone, or with at least one reductone and at least one thiol compound, or with at least one reductone and at least one sulfite compound, or with at least one reductone and at least one thiol compound and at least one sulfite compound. A multi-part kit for repeatedly dyeing and subsequently decolorizing fibers, especially human hair, contains both a dye composition for dyeing the fibers and the above-described composition for reductive decolorizing of the dyed fibers.
摘要翻译：纤维脱色的方法包括将本发明的脱色组合物应用于染色纤维，并使组合物在纤维上起作用足够的时间以从染色纤维中除去染色。用氧化染发剂组合物和/或直接染发染料化合物染色的纤维的脱色组合物含有一种或多种α-氧代羧酸和/或与生理上相容的α-氧代羧酸盐与至少一种还原酮的组合，或至少一种还原酮和至少一种硫醇化合物，或至少一种还原酮和至少一种亚硫酸盐化合物，或至少一种还原酮和至少一种硫醇化合物和至少一种亚硫酸盐化合物。用于反复染色和随后脱色纤维，特别是人发的多部分试剂盒含有用于染色纤维的染料组合物和用于染色纤维的还原脱色的上述组合物。

3. 发明授权

US09693878B2 Patient-specific guide for acetabular cup placement 有权
公开(公告)号：US09693878B2
公开(公告)日：2017-07-04
申请号：US13510342
申请日：2010-11-17
申请人： Manuela Kunz , John F. Rudan
发明人： Manuela Kunz , John F. Rudan
IPC分类号： A61F2/46 , A61B17/17 , A61B17/56 , A61F2/30 , A61B34/10
CPC分类号： A61F2/4609 , A61B17/1746 , A61B2017/568 , A61B2034/108 , A61F2/30942 , A61F2002/4687
摘要： Provided is a preoperatively designed guidance tool for intraoperative use during acetabular cup replacement surgery, comprising: a patient-specific template having at least one surface that registers with a selected surface of the patient's acetabulum; and a guide portion that provides an orientation or a position and orientation of an acetabular cup according to a preoperatively planned orientation or position and orientation. The guidance tool may further comprise a verification tool that cooperates with the guide portion and includes at least one mating surface that registers with a selected surface of the patient's anatomy, wherein correct positioning of the verification tool on the patient's anatomy confirms correct orientation of the patient-specific template in the patient's acetabulum. Also described herein are methods of acetabulum cup replacement surgery, and methods for transferring a preoperatively planned orientation or position and orientation of an acetabular cup to a patient during acetabulum cup replacement surgery.

4. 发明授权

US06171347B2 Compositions, methods and kits for reductively removing color from dyed hair 失效
标题翻译：用于从染发中还原性去除颜色的组合物，方法和试剂盒
公开(公告)号：US06171347B2
公开(公告)日：2001-01-09
申请号：US09101099
申请日：1998-07-01
申请人： Manuela Kunz , Dominique Le Cruer
发明人： Manuela Kunz , Dominique Le Cruer
IPC分类号： A61K713
CPC分类号： A61Q5/08 , A61K8/23 , A61K8/447 , A61K8/46 , A61K8/676 , C11D3/0042 , C11D3/38654 , D06L4/30 , D06P1/32 , D06P5/13 , D06P5/134 , D06P5/137
摘要： A multicomponent kit for coloring and later removing color from fibers is described, which consists of a first component and a second component. The first component includes a composition for oxidative dyeing of hair and the second component includes an aqueous or aqueous-alcoholic composition for reductive removal of color from dyed hair. The composition for reductive removal of color from hair has a pH of from 1.8 to 6 and is in the form of a gel, cream, emulsion, foam or solution. It contains from 1 to 50% by weight of one or more reductones, advantageously ascorbic and/or isoascorbic acid or salts thereof, and, in addition to the reductones, from 0.1 to 10% by weight of one or more thiols or a combination of from 0.1 to 10% by weight of one or more thiols and from 0.001 to 5% by weight of one or more sulfites. It also includes one or more pH adjusting agents and standard cosmetic additive ingredients.
摘要翻译：描述了一种用于着色和随后从纤维中除去颜色的多组分试剂盒，其由第一组分和第二组分组成。第一组分包括用于毛发氧化染色的组合物，第二组分包括水性或含水醇组合物，用于从染发中还原去除颜色。从头发还原去除颜色的组合物具有1.8至6的pH，并且呈凝胶，霜剂，乳液，泡沫或溶液的形式。它含有1至50重量％的一种或多种还原剂，有利地是抗坏血酸和/或异抗坏血酸或其盐，并且除还原剂外，还含有0.1至10重量％的一种或多种硫醇或 0.1至10重量％的一种或多种硫醇和0.001至5重量％的一种或多种亚硫酸盐。它还包括一种或多种pH调节剂和标准化妆品添加剂成分。

5. 发明授权

US08177850B2 Joint placement methods and apparatuses 有权
标题翻译：联合放置方法和装置
公开(公告)号：US08177850B2
公开(公告)日：2012-05-15
申请号：US12339791
申请日：2008-12-19
申请人： John Rudan , Randy E. Ellis , Manuela Kunz
发明人： John Rudan , Randy E. Ellis , Manuela Kunz
IPC分类号： A61F2/32
CPC分类号： A61F2/4657 , A61B34/10 , A61B34/20 , A61B90/36 , A61B2034/105 , A61B2034/2055 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2002/3611 , A61F2002/3625 , A61F2002/4632
摘要： Systems and methods for determining placement of prosthetic components in joint including defining patient-specific frame of reference for joint, determining patient-specific postoperative range of motion of joint, evaluating patient-specific range of motion of joint, automatically planning placement of components balancing need for range of motion with prosthesis stability through bony coverage, and applying manual adjustments to the automatically planned placement of component by giving greater or lesser weight to need for range of motion or prosthesis stability through bony coverage. Apparatuses for defining center of prosthetic femoral head and axis of prosthetic femoral neck including primary cylinder, first alignment receptacle and second alignment receptacle, and a divot on exterior of primary cylinder, divot having normal parallel to longitudinal axis of second alignment receptacle and position of the divot being translated toward an opening of the first alignment receptacle on the primary cylinder. Methods for using apparatuses. Apparatus for mounting spatially tracked device to impactor for impacting prosthetic cup into reamed socket.
摘要翻译：用于确定假体组件在关节中的放置的系统和方法，包括确定关节的患者特定参考框架，确定患者特异性的术后关节运动范围，评估患者特定的关节运动范围，自动规划组件平衡需求的位置对于通过骨覆盖的假体稳定性的运动范围，以及通过给予更大或更小的重量来对通过骨覆盖的运动或假体稳定性的范围进行手动调整。用于定义假体股骨头的中心和假股骨颈的轴线的装置，包括主圆柱体，第一对准容器和第二对准容器，以及主圆柱体的外部上的凹部，具有平行于第二对准容器的纵向轴线的垂直轴线和在主缸上朝向第一对准插座的开口翻转。使用设备的方法用于将空间跟踪装置安装到冲击器的装置，用于将假杯撞击到铰接式插座中。

6. 发明授权

US5849041A Oxidation hair dye composition and method of dyeing hair using same 失效
标题翻译：氧化染发剂组合物和使用该染发剂的方法
公开(公告)号：US5849041A
公开(公告)日：1998-12-15
申请号：US811614
申请日：1997-03-05
申请人： Manuela Kunz , Dominique Le Cruer
发明人： Manuela Kunz , Dominique Le Cruer
IPC分类号： A61K8/00 , A61K8/34 , A61K8/36 , A61K8/365 , A61K8/39 , A61K8/41 , A61K8/49 , A61K8/66 , A61K8/73 , A61Q5/10 , D06P1/32 , D06P1/642 , D06P3/08 , D06P3/12 , D06P5/06 , A61K7/13
CPC分类号： A61Q5/10 , A61K8/411 , A61K8/66
摘要： The composition for oxidative dyeing of keratin fibers has a pH of from 6 to 9.5 and contains a developer/coupler combination, an oxygen-oxidoreductase/substrate system and a peroxidase. The coupler substance includes a substituted m-phenylenediamine of formula I ##STR1## wherein R.sup.1 is a C.sub.1 - to C.sub.6 -alkoxy group, an unsubstituted alkyl group having from one to six carbon atoms, a C.sub.1 - to C.sub.6 -alkyl group substituted with a hydroxy group, a halogen atom or a C.sub.1 - to C.sub.6 -alkoxy group; and R.sup.2, R.sup.3 are each, independently of each other, a hydrogen atom, another unsubstituted C.sub.1 - to C.sub.6 -alkyl group, an unsubstituted C.sub.1 - to C.sub.6 -ether group having at most two oxygen atoms, another C.sub.1 - to C.sub.6 -alkyl group substituted with a hydroxy group, a halogen atom or a C.sub.1 - to C.sub.6 -alkoxy group substituent or an ether group substituted with a hydroxy group, a halogen atom or a C.sub.1 - to C.sub.6 -alkoxy group, and S represents a hydrogen atom or a further alkyl group having from one to six carbon atoms, or a physiologically compatible salt of the m-phenylenediamine of the formula (I).
摘要翻译：角蛋白纤维的氧化染色用组合物的pH为6〜9.5，含有显色剂/偶联剂组合物，氧 - 氧化还原酶/底物系统和过氧化物酶。成色剂物质包括式I的取代的间苯二胺，其中R 1是C 1 -C 6烷氧基，未取代的具有1至6个碳原子的烷基，C 1至C 6烷基被羟基，卤素原子或C 1 -C 6烷氧基取代; 和R 2，R 3各自独立地为氢原子，另外未取代的C 1〜C 6烷基，至少2个氧原子的未取代的C 1〜C 6 - 醚基，C 1〜C 6烷基被羟基，卤素原子或C 1至C 6烷氧基取代基取代或被羟基，卤素原子或C 1 -C 6烷氧基取代的醚基，S表示氢原子或具有1至6个碳原子的另外的烷基，或式（I）的间苯二胺的生理上相容的盐。

7. 发明授权

US08444651B2 Patient-specific surgical guidance tool and method of use 有权
标题翻译：患者特异性手术指导工具及使用方法
公开(公告)号：US08444651B2
公开(公告)日：2013-05-21
申请号：US12120547
申请日：2008-05-14
申请人： Manuela Kunz , John F. Rudan
发明人： Manuela Kunz , John F. Rudan
IPC分类号： A61B17/60 , A61B5/05 , A61F2/00
CPC分类号： A61B17/1764 , A61B17/142 , A61B17/15 , A61B17/1604 , A61B17/175 , A61B17/1757 , A61B17/1782 , A61B2017/568 , A61B2090/061 , A61B2090/067 , B33Y80/00
摘要： Presented is a preoperatively designed guidance tool for intraoperative use during bone or joint surgery wherein the guidance tool is specific to the anatomy of the patient being treated. The guidance tool comprises a body portion, a mating surface provided on the body portion for positioning the guidance tool on a corresponding registration surface of a patient's anatomy. The guidance tool further comprises at least one guide mechanism provided on the body portion for guiding a medical instrument at one or more preoperatively defined trajectories relative to a patient's anatomy. In the event of misalignment, the at least one guide mechanism is adjustable to alter the one or more preoperatively defined trajectories if necessary during intraoperative use. Also presented is a preoperative process for designing the guidance tool.
摘要翻译：提出了一种术前设计的用于骨或关节手术期间术中使用的引导工具，其中引导工具特异于被治疗患者的解剖结构。引导工具包括主体部分，设置在主体部分上的配合表面，用于将引导工具定位在患者解剖结构的相应对准表面上。引导工具还包括设置在主体部分上的至少一个引导机构，用于相对于患者的解剖结构在一个或多个预先确定的轨迹下引导医疗器械。在未对准的情况下，至少一个引导机构是可调节的，以在术中使用期间根据需要改变一个或多个术前定义的轨迹。还提出了一种用于设计指导工具的术前过程。

8. 发明申请

US20120245647A1 Patient-Specific Guide for Acetabular Cup Placement 有权
标题翻译：髋臼杯放置患者指南
公开(公告)号：US20120245647A1
公开(公告)日：2012-09-27
申请号：US13510342
申请日：2010-11-17
申请人： Manuela Kunz , John F. Rudan
发明人： Manuela Kunz , John F. Rudan
IPC分类号： A61B17/56
CPC分类号： A61F2/4609 , A61B17/1746 , A61B2017/568 , A61B2034/108 , A61F2/30942 , A61F2002/4687
摘要： Provided is a preoperatively designed guidance tool for intraoperative use during acetabular cup replacement surgery, comprising: a patient-specific template having at least one surface that registers with a selected surface of the patient's acetabulum; and a guide portion that provides an orientation or a position and orientation of an acetabular cup according to a preoperatively planned orientation or position and orientation. The guidance tool may further comprise a verification tool that cooperates with the guide portion and includes at least one mating surface that registers with a selected surface of the patient's anatomy, wherein correct positioning of the verification tool on the patient's anatomy confirms correct orientation of the patient-specific template in the patient's acetabulum. Also described herein are methods of acetabulum cup replacement surgery, and methods for transferring a preoperatively planned orientation or position and orientation of an acetabular cup to a patient during acetabulum cup replacement surgery.
摘要翻译：提供了一种用于在髋臼杯置换手术期间术中使用的术前设计的引导工具，包括：具有至少一个表面的患者特异性模板，所述表面与患者髋臼的选定表面对齐; 以及引导部分，其根据术前计划的取向或位置和取向提供髋臼杯的取向或位置和取向。引导工具还可以包括验证工具，该验证工具与引导部分配合并且包括与患者解剖结构的选定表面对齐的至少一个配合表面，其中验证工具在患者解剖结构上的正确定位确认了患者的正确取向特异性模板在患者的髋臼。本文还描述了髋臼杯置换手术的方法，以及用于在髋臼杯置换手术期间将髋臼杯的术前计划的取向或位置和取向转移到患者的方法。

9. 发明申请

US20090164024A1 JOINT PLACEMENT METHODS AND APPARATUSES 有权
标题翻译：联合放置方法和装置
公开(公告)号：US20090164024A1
公开(公告)日：2009-06-25
申请号：US12339791
申请日：2008-12-19
申请人： John Rudan , Randy E. Ellis , Manuela Kunz
发明人： John Rudan , Randy E. Ellis , Manuela Kunz
IPC分类号： A61F2/34
CPC分类号： A61F2/4657 , A61B34/10 , A61B34/20 , A61B90/36 , A61B2034/105 , A61B2034/2055 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2002/3611 , A61F2002/3625 , A61F2002/4632
摘要： Systems and methods for determining placement of prosthetic components in joint including defining patient-specific frame of reference for joint, determining patient-specific postoperative range of motion of joint, evaluating patient-specific range of motion of joint, automatically planning placement of components balancing need for range of motion with prosthesis stability through bony coverage, and applying manual adjustments to the automatically planned placement of component by giving greater or lesser weight to need for range of motion or prosthesis stability through bony coverage. Apparatuses for defining center of prosthetic femoral head and axis of prosthetic femoral neck including primary cylinder, first alignment receptacle and second alignment receptacle, and a divot on exterior of primary cylinder, divot having normal parallel to longitudinal axis of second alignment receptacle and position of the divot being translated toward an opening of the first alignment receptacle on the primary cylinder. Methods for using apparatuses. Apparatus for mounting spatially tracked device to impactor for impacting prosthetic cup into reamed socket.
摘要翻译：用于确定假体组件在关节中的放置的系统和方法，包括确定关节的患者特定参考框架，确定患者特异性的术后关节运动范围，评估患者特定的关节运动范围，自动规划组件平衡需求的位置对于通过骨覆盖的假体稳定性的运动范围，以及通过给予更大或更小的重量来对通过骨覆盖的运动或假体稳定性的范围进行手动调整。用于定义假体股骨头的中心和假股骨颈的轴线的装置，包括主圆柱体，第一对准容器和第二对准容器，以及主圆柱体的外部上的凹部，具有平行于第二对准容器的纵向轴线的垂直轴线和在主缸上朝向第一对准插座的开口翻转。使用设备的方法用于将空间跟踪装置安装到冲击器的装置，用于将假杯撞击到铰接式插座中。

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