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1. 发明授权

US09207152B2 Pretreatment apparatus and mass analyzing apparatus equipped with the same 有权
标题翻译：预处理装置和配备有其的质量分析装置
公开(公告)号：US09207152B2
公开(公告)日：2015-12-08
申请号：US13377154
申请日：2010-06-24
申请人： Makoto Nogami , Katsuhiro Kanda , Izumi Waki
发明人： Makoto Nogami , Katsuhiro Kanda , Izumi Waki
IPC分类号： G01N33/48 , G01N1/40 , G01N35/02 , G01N30/00 , H01J49/00
CPC分类号： G01N1/4055 , G01N35/025 , G01N2001/4061 , G01N2030/009 , H01J49/00
摘要： A biological sample preprocessing apparatus includes solid-phase extraction cartridges which purify/concentrate specific constituents of a biological sample, cartridge holders which hold one of the solid-phase extraction cartridges, a cartridge transport that carries the cartridge holders along a continuous track surface, a sample probe that discharges the biological sample into the solid-phase extraction cartridge held in the cartridge holders, a water-based solvent probe that discharges a water-based solvent into the solid-phase extraction cartridge held in the cartridge holder, an organic solvent probe that discharges an organic solvent into the solid-phase extraction cartridge held in the cartridge holder, a pressure loader that applies an air pressure load to the solid-phase extraction cartridge held in the cartridge holder, and a control unit that controls operation of the cartridge transport, the sample probe, the solvent probes, and the pressure loader, wherein sample addition and solvent addition alternate with pressure loading.
摘要翻译：生物样品预处理装置包括净化/浓缩生物样品的特定组分的固相萃取盒，固定一个固相萃取筒的盒保持器，沿连续轨迹表面承载盒保持器的盒输送器将生物样品排出到保持在盒保持器中的固相提取盒中的样品探针，将水性溶剂排放到保持在盒保持器中的固相萃取盒中的水性溶剂探针，有机溶剂探针将有机溶剂排放到保持在盒保持器中的固相提取盒中，对保持在盒保持器中的固相提取盒施加空气压力负荷的压力装载器和控制盒的操作的控制单元运输，样品探针，溶剂探针和压力装载机，其中样品添加溶剂添加与压力负荷交替。

2. 发明授权

US08952324B2 Mass analyzing apparatus, analyzing method and calibration sample 有权
标题翻译：质量分析仪器，分析方法和校准样品
公开(公告)号：US08952324B2
公开(公告)日：2015-02-10
申请号：US13978445
申请日：2011-12-27
申请人： Midori Sasaki , Terumi Tamura , Shinya Ito , Makoto Nogami
发明人： Midori Sasaki , Terumi Tamura , Shinya Ito , Makoto Nogami
IPC分类号： H01J49/26 , H01J49/00
CPC分类号： H01J49/0009
摘要： The mass analyzing apparatus of the present invention can achieve the speed-up and simplification of the formation of a calibration curve for quantifying an analysis object in a mass analyzing apparatus. The mass analyzing apparatus is provided with: a sample storage-dilution unit 1 for storing samples of the analysis object including a quantitative calibrator in which, with respect to one analysis object to be quantified, two or more kinds of compounds selected from the analysis object, a plurality of stable isotope compounds of the analysis object and a plurality of analogue compounds of the analysis object are mixed at respectively different concentrations; an ionizing unit 5 for ionizing a sample; a mass analyzing unit 6 for analyzing the ionized sample; and a data processing unit 7 in which, based on results of analysis of the quantitative calibrator carried out by the mass analyzing unit 6, two or more concentrations are measured, and the analysis object is quantified based on information of the measurement.
摘要翻译：本发明的质量分析装置可以实现加速和简化在质量分析装置中对分析对象进行定量的校准曲线的形成。质量分析装置具备：样本存储稀释单元1，用于存储包括定量校准器的分析对象的样本，其中对于要定量的一个分析对象，选自分析对象中的两种或更多种化合物分析对象的多个稳定的同位素化合物和分析对象的多个类似化合物分别以不同的浓度混合，用于电离样品的电离单元5; 用于分析电离样品的质量分析单元6; 以及数据处理单元7，其中，基于由质量分析单元6执行的定量校准器的分析结果，测量两个或更多个浓度，并且基于测量的信息量化分析对象。

3. 发明申请

US20120079875A1 PRETREATMENT APPARATUS AND MASS ANALYZING APPARATUS EQUIPPED WITH THE SAME 有权
标题翻译：预装设备和配有同类设备的大规模分析设备
公开(公告)号：US20120079875A1
公开(公告)日：2012-04-05
申请号：US13377154
申请日：2010-06-24
申请人： Makoto Nogami , Katsuhiro Kanda , Izumi Waki
发明人： Makoto Nogami , Katsuhiro Kanda , Izumi Waki
IPC分类号： G01N1/10 , G01N1/28
CPC分类号： G01N1/4055 , G01N35/025 , G01N2001/4061 , G01N2030/009 , H01J49/00
摘要： A biological sample preprocessing apparatus includes solid-phase extraction cartridges which purify/concentrate specific constituents of a biological sample, cartridge holders which hold one of the solid-phase extraction cartridges, a cartridge transport that carries the cartridge holders along a continuous track surface, a sample probe that discharges the biological sample into the solid-phase extraction cartridge held in the cartridge holders, a water-based solvent probe that discharges a water-based solvent into the solid-phase extraction cartridge held in the cartridge holder, an organic solvent probe that discharges an organic solvent into the solid-phase extraction cartridge held in the cartridge holder, a pressure loader that applies an air pressure load to the solid-phase extraction cartridge held in the cartridge holder, and a control unit that controls operation of the cartridge transport, the sample probe, the solvent probes, and the pressure loader, wherein sample addition and solvent addition alternate with pressure loading.
摘要翻译：生物样品预处理装置包括净化/浓缩生物样品的特定组分的固相萃取盒，固定一个固相萃取筒的盒保持器，沿连续轨迹表面承载盒保持器的盒输送器将生物样品排出到保持在盒保持器中的固相提取盒中的样品探针，将水性溶剂排放到保持在盒保持器中的固相萃取盒中的水性溶剂探针，有机溶剂探针将有机溶剂排放到保持在盒保持器中的固相提取盒中，对保持在盒保持器中的固相提取盒施加空气压力负荷的压力装载器和控制盒的操作的控制单元运输，样品探针，溶剂探针和压力装载机，其中样品添加溶剂添加与压力负荷交替。

4. 发明申请

US20060216795A1 Sample preparation method, analysis system and preparation device 审中-公开
标题翻译：样品制备方法，分析系统及制备装置
公开(公告)号：US20060216795A1
公开(公告)日：2006-09-28
申请号：US11356114
申请日：2006-02-17
申请人： Katsuhiro Kanda , Yukie Sasakura , Tsuyoshi Ogino , Makoto Nogami
发明人： Katsuhiro Kanda , Yukie Sasakura , Tsuyoshi Ogino , Makoto Nogami
IPC分类号： C12P19/24
CPC分类号： C12N9/80 , C12N9/6427 , C12N11/14 , C12N11/18 , C12Y305/01052
摘要： The object of the present invention is to promote the efficiency and simplify a sample pretreatment step for analysis of molecules contained in the sample. In the present invention, a plurality of various enzymes necessary for pretreatment of sample for analysis of various molecules contained in the sample are immobilized on a solid phase separately for each kind of enzyme, and the enzyme reactions are carried out simultaneously. That is, a sample is reacted with plural kinds of enzymes under the same conditions, and contamination caused by the enzyme reactions is inhibited and the sample is subjected to a given pretreatment.
摘要翻译：本发明的目的是提高效率并简化用于分析样品中所含分子的样品预处理步骤。在本发明中，将用于分析样品中所含的各种分子的样品预处理所需的多种各种酶分别固定在固相上用于各种酶，并且酶反应同时进行。也就是说，样品在相同条件下与多种酶反应，并且抑制由酶反应引起的污染并且对样品进行给定的预处理。

5. 发明授权

US09128070B2 Analysis device 有权
标题翻译：分析装置
公开(公告)号：US09128070B2
公开(公告)日：2015-09-08
申请号：US13580249
申请日：2011-01-14
申请人： Makoto Nogami , Katsuhiro Kanda , Shinya Ito
发明人： Makoto Nogami , Katsuhiro Kanda , Shinya Ito
IPC分类号： G01N27/62 , C12M1/42 , G01N35/00 , G01N35/02 , G01N35/10
CPC分类号： G01N35/0098 , G01N1/405 , G01N35/025 , G01N2035/1053
摘要： Disclosed is an analysis device which can analyze substances with low blood concentration with high precision without having to make the device larger. The analysis device is composed of: a specimen disk equipped with specimen containers; a reagent disk equipped with reagent containers; a first disk equipped with first containers where purification of the subject component to be measured in the specimen is carried out; a second disk equipped with second containers where purification of the sample purified in the first container is carried out; and a mass spectrometry unit which measures the specimen purified in the second container.
摘要翻译：公开了一种能够高精度地分析血液浓度低的物质的分析装置，而不必使装置更大。分析装置包括：装有标本容器的标本盘; 装有试剂容器的试剂盘; 配备有第一容器的第一盘，其中进行在样品中待测量的被检体成分的净化; 配备有第二容器的第二盘，其中在第一容器中净化的样品的纯化被执行; 以及质量分析单元，其测量在第二容器中净化的样品。

6. 发明申请

US20130130401A1 Biological Sample Pretreatment Method and Apparatus 审中-公开
标题翻译：生物样品预处理方法和装置
公开(公告)号：US20130130401A1
公开(公告)日：2013-05-23
申请号：US13704541
申请日：2011-06-10
申请人： Katsuhiro Kanda , Makoto Nogami , Shinya Ito , Izumi Waki
发明人： Katsuhiro Kanda , Makoto Nogami , Shinya Ito , Izumi Waki
IPC分类号： G01N1/34
CPC分类号： G01N1/34 , G01N1/405 , G01N2035/1053 , Y10T436/255
摘要： A sample treatment apparatus is disclosed that allows a filtrate after reaction to be supplied to a solid phase extraction treatment without temporary collection. A necessary amount of a solid phase extracting agent is added to a solid phase extraction device for conditioning. An aqueous solution is added to the extracting agent and supernatants are discarded. A filter device is attached to an opening of the extraction and a sample is added into a filter reservoir. A hemolyzing agent is added to the sample, and they are stirred sufficiently to cause disruption of blood cells. A protein-denaturing solution is added to the mixture, and they stirred sufficiently to denature proteins contained in the sample. They are centrifuged to leave aggregate in the filter device, and the filtrate is supplied to the solid phase extracting agent through a filter unit without collecting the filtrate.
摘要翻译：公开了一种样品处理装置，其允许将反应后的滤液供应至固相萃取处理而不进行临时收集。将必要量的固相萃取剂加入到用于调理的固相萃取装置中。向提取剂中加入水溶液，弃去上清液。过滤装置连接到提取物的开口，并将样品加入到过滤器容器中。将溶血剂加入到样品中，并充分搅拌以引起血细胞破裂。将蛋白质变性溶液加入到混合物中，并充分搅拌以使包含在样品中的蛋白质变性。将它们离心以将聚集体留在过滤装置中，并将滤液通过过滤装置供应至固相萃取剂，而不收集滤液。

7. 发明申请

US20120058009A1 ANALYZER 审中-公开
标题翻译：分析仪
公开(公告)号：US20120058009A1
公开(公告)日：2012-03-08
申请号：US13201659
申请日：2010-01-18
申请人： Makoto Nogami , Yuichiro Hashimoto , Izumi Waki , Katsuhiro Kanda
发明人： Makoto Nogami , Yuichiro Hashimoto , Izumi Waki , Katsuhiro Kanda
IPC分类号： G01N33/48
CPC分类号： G01N33/49 , G01N1/4055 , G01N2001/4083 , H01J49/0009 , H01J49/0031 , H01J49/0036 , H01J49/0436
摘要： An analyzer includes a pretreatment device and a mass spectrometer. The pretreatment device includes a solid phase extraction mechanism. The mass spectrometer performs mass spectrometry on a sample pretreated by the pretreatment device and then subjected to ionization. The analyzer also includes a storage unit that stores data on dependence of signal intensities of the analyte substance to be measured and the internal standard upon the concentration of a substance inhibiting ionization in the sample, and that stores data on a recovery rate. The analyzer also includes a correcting unit that corrects measurement results of the sample and the internal standard on the basis of the data stored in the storage unit.
摘要翻译：分析仪包括预处理装置和质谱仪。预处理装置包括固相提取机构。质谱仪对由预处理装置预处理的样品进行质谱分析，然后进行电离。分析仪还包括存储单元，其存储关于待测量的待分析物质的信号强度与内标的数据，所述数据在样品中抑制电离物质的浓度，并且存储关于回收率的数据。分析器还包括校正单元，其基于存储在存储单元中的数据来校正样本的测量结果和内部标准。

8. 发明授权

US09176037B2 Specimen processing system 有权
标题翻译：标本处理系统
公开(公告)号：US09176037B2
公开(公告)日：2015-11-03
申请号：US13387229
申请日：2010-08-10
申请人： Katsuhiro Kanda , Makoto Nogami , Izumi Waki
发明人： Katsuhiro Kanda , Makoto Nogami , Izumi Waki
IPC分类号： B01L99/00 , G01N1/40 , G01N35/02 , G01N35/04 , G01N35/00 , G01N35/10
CPC分类号： G01N1/4055 , G01N1/405 , G01N35/025 , G01N2035/00485 , G01N2035/00544 , G01N2035/0455 , G01N2035/1058
摘要： Disclosed is a specimen processing system that includes means 91 circularly disposed to carry a reaction vessel 2 used for separating and extracting desired substances from a specimen to be processed, a plurality of processing steps, executed as processing progresses along a transport line for the reaction vessel 2 on the transport means 91, for conducting various processes upon the specimen to be processed that is accommodated in the reaction vessel 2, suctioning and discharging means 94 that dispenses the specimen from a specimen container 1 supplied to the system, into the reaction vessel 2, and a filtering vessel section 2b provided as a part of the reaction vessel 2. This system configuration allows realization of a rapid preprocessing system capable of reducing the number of disposable parts of a low carry-over type, suppressing a decrease in cost performance, operating with high collection efficiency, and employing compact devices.
摘要翻译：公开了一种样本处理系统，其包括循环地设置为携带用于从待处理样品中分离和提取所需物质的反应容器2的装置91，沿着沿着反应容器的输送线的加工进行的多个处理步骤 2在运送装置91上，对于容纳在反应容器2中的待处理样品进行各种处理，从供给到系统的检体容器1分配试样的抽吸排出单元94进入反应容器2 以及作为反应容器2的一部分设置的过滤容器部分2b。该系统构造允许实现能够减少低循环型的一次性部件的数量的快速预处理系统，抑制成本性能的降低，运行效率高，采用紧凑型设备。

9. 发明授权

US08865418B2 Immunoanalytical method and system using mass spectrometry technology 有权
标题翻译：免疫分析方法和使用质谱技术的系统
公开(公告)号：US08865418B2
公开(公告)日：2014-10-21
申请号：US13146952
申请日：2010-02-09
申请人： Katsuhiro Kanda , Makoto Nogami , Izumi Waki
发明人： Katsuhiro Kanda , Makoto Nogami , Izumi Waki
IPC分类号： G01N33/53 , G01N31/00 , G01N33/68
CPC分类号： G01N33/6848
摘要： An immunoanalytical system in which, after a sample such as a patient's serum is subjected to a pretreatment by an immunological pretreatment device, the sample is subjected to light detection by an immunological photometric detection system. Subsequently, the mass spectrometric pretreatment device performs a pretreatment, and the mass spectrometric detection system performs mass spectrometry. The mass spectrometric detection system performs mass spectrometry on components contained in a supernatant. A signal intensity and peak area for each of components are calculated from an obtained chromatograph. A quantitative value measured based on the immunoanalytical method is calculated for each of the components on the basis of the relative ratios of the components.
摘要翻译：一种免疫分析系统，其中在诸如患者血清的样品经由免疫预处理装置进行预处理之后，通过免疫光度检测系统对样品进行光检测。随后，质谱预处理装置进行预处理，质谱检测系统进行质谱分析。质谱检测系统对上清液中所含的组分进行质谱分析。从获得的色谱图中计算各组分的信号强度和峰面积。基于组分的相对比例，对每个组分计算基于免疫分析方法测量的定量值。

10. 发明申请

US20120322139A1 ANALYSIS DEVICE 有权
标题翻译：分析装置
公开(公告)号：US20120322139A1
公开(公告)日：2012-12-20
申请号：US13580249
申请日：2011-01-14
申请人： Makoto Nogami , Katsuhiro Kanda , Shinya Ito
发明人： Makoto Nogami , Katsuhiro Kanda , Shinya Ito
IPC分类号： G01N27/62 , C12M1/42
CPC分类号： G01N35/0098 , G01N1/405 , G01N35/025 , G01N2035/1053
摘要： Disclosed is an analysis device which can analyze substances with low blood concentration with high precision without having to make the device larger. The analysis device is composed of: a specimen disk equipped with specimen containers; a reagent disk equipped with reagent containers; a first disk equipped with first containers where purification of the subject component to be measured in the specimen is carried out; a second disk equipped with second containers where purification of the sample purified in the first container is carried out; and a mass spectrometry unit which measures the specimen purified in the second container.
摘要翻译：公开了一种能够高精度地分析血液浓度低的物质的分析装置，而不必使装置更大。分析装置包括：装有标本容器的标本盘; 装有试剂容器的试剂盘; 配备有第一容器的第一盘，其中进行在样品中待测量的被检体成分的净化; 配备有第二容器的第二盘，其中在第一容器中净化的样品的纯化被执行; 以及质量分析单元，其测量在第二容器中净化的样品。

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